메뉴 건너뛰기




Volumn 33, Issue 11, 2011, Pages 1590-1608

Focus on phosphodiesterase inhibitors for the treatment of erectile dysfunction in older men

Author keywords

Erectile dysfunction; Phosphodiesterase inhibitor; Sildenafil; Tadalafil; Vardenafil

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AMIODARONE; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; BENDROFLUMETHIAZIDE; CARVEDILOL; CIMETIDINE; CLARITHROMYCIN; CYTOCHROME P450 3A4; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ERYTHROMYCIN; GLYCERYL TRINITRATE; INDINAVIR; ITRACONAZOLE; KETOCONAZOLE; LABETALOL; METOPROLOL; PHOSPHODIESTERASE V; PROCAINAMIDE; PROSTAGLANDIN E1; QUINIDINE; RITONAVIR; SAQUINAVIR; SILDENAFIL; SOTALOL; TADALAFIL; TESTOSTERONE; VARDENAFIL;

EID: 82855162720     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2011.09.029     Document Type: Review
Times cited : (11)

References (90)
  • 1
    • 0028036149 scopus 로고
    • Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study
    • Feldman H.A., Goldstein I., Hatzichristou D.G., et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994, 151:54-61.
    • (1994) J Urol , vol.151 , pp. 54-61
    • Feldman, H.A.1    Goldstein, I.2    Hatzichristou, D.G.3
  • 2
    • 0041700224 scopus 로고    scopus 로고
    • Sexual function in men older than 50 years of age: results from the Health Professionals Follow-Up Study
    • Bacon C.G., Mittleman M.A., Kawachi I., et al. Sexual function in men older than 50 years of age: results from the Health Professionals Follow-Up Study. Ann Intern Med 2003, 139:161-168.
    • (2003) Ann Intern Med , vol.139 , pp. 161-168
    • Bacon, C.G.1    Mittleman, M.A.2    Kawachi, I.3
  • 3
    • 22244468054 scopus 로고    scopus 로고
    • Chapter 1: the management of erectile dysfunction: an AUA update
    • Montague D.K., Jarow J.P., Broderick G.A., et al. Chapter 1: the management of erectile dysfunction: an AUA update. J Urol 2005, 174:230-239. 5.
    • (2005) J Urol , vol.174 , Issue.5 , pp. 230-239
    • Montague, D.K.1    Jarow, J.P.2    Broderick, G.A.3
  • 4
    • 70450210454 scopus 로고    scopus 로고
    • Hormonal testing and pharmacologic treatment of erectile dysfunction: a clinical practice guideline from the American College of Physicians
    • Qaseem A., Snow V., Denberg T.D., et al. Hormonal testing and pharmacologic treatment of erectile dysfunction: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2009, 151:639-649.
    • (2009) Ann Intern Med , vol.151 , pp. 639-649
    • Qaseem, A.1    Snow, V.2    Denberg, T.D.3
  • 6
    • 0028909591 scopus 로고
    • Assessment and treatment of impotence
    • O'Keefe, Hunt D.K. Assessment and treatment of impotence. Med Clin North Am 1995, 79:415-434.
    • (1995) Med Clin North Am , vol.79 , pp. 415-434
    • O'Keefe1    Hunt, D.K.2
  • 7
    • 61449117843 scopus 로고    scopus 로고
    • Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions
    • Nehra A. Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clin Proc 2009, 84:139-148.
    • (2009) Mayo Clin Proc , vol.84 , pp. 139-148
    • Nehra, A.1
  • 8
    • 70450211304 scopus 로고    scopus 로고
    • Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis
    • Tsertsvadze A., Fink H.A., Yazdi F., et al. Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis. Ann Intern Med 2009, 151:650-661.
    • (2009) Ann Intern Med , vol.151 , pp. 650-661
    • Tsertsvadze, A.1    Fink, H.A.2    Yazdi, F.3
  • 9
    • 0037166642 scopus 로고    scopus 로고
    • Sildenafil for male erectile dysfunction
    • Fink H.A., Mac Donald R., Rutks I.R., et al. Sildenafil for male erectile dysfunction. Arch Intern Med 2002, 162:1349-1360.
    • (2002) Arch Intern Med , vol.162 , pp. 1349-1360
    • Fink, H.A.1    Mac Donald, R.2    Rutks, I.R.3
  • 10
    • 74049102684 scopus 로고    scopus 로고
    • Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications
    • Eardley I., Lee J.C., Shabsign R., et al. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med 2010, 7:244-255.
    • (2010) J Sex Med , vol.7 , pp. 244-255
    • Eardley, I.1    Lee, J.C.2    Shabsign, R.3
  • 11
    • 35648976611 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors: state of the therapeutics class
    • Carson C.C. Phosphodiesterase type 5 inhibitors: state of the therapeutics class. Urol Clin North Am 2007, 34:507-515.
    • (2007) Urol Clin North Am , vol.34 , pp. 507-515
    • Carson, C.C.1
  • 12
    • 0036755020 scopus 로고    scopus 로고
    • The efficacy of sildenafil citrate (Viagra) in clinical populations: an update
    • Carson C.C., Burnett A.L., Levine L.A., et al. The efficacy of sildenafil citrate (Viagra) in clinical populations: an update. Urology 2002, 60(Suppl 2B):12-27.
    • (2002) Urology , vol.60 , Issue.SUPPL 2B , pp. 12-27
    • Carson, C.C.1    Burnett, A.L.2    Levine, L.A.3
  • 13
    • 33644937450 scopus 로고    scopus 로고
    • Treating erectile dysfunction when PDE5 inhibitors fail
    • McMahon C.N., Smith C.J., Shabsign R. Treating erectile dysfunction when PDE5 inhibitors fail. BMJ 2006, 332:589-592.
    • (2006) BMJ , vol.332 , pp. 589-592
    • McMahon, C.N.1    Smith, C.J.2    Shabsign, R.3
  • 14
    • 28544444480 scopus 로고    scopus 로고
    • An open-label, multicentre, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in men naïve to phosphodiesterase 5 inhibitor therapy
    • Eardley I., Mirone V., Montorsi F., et al. An open-label, multicentre, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in men naïve to phosphodiesterase 5 inhibitor therapy. BJU Int 2005, 96:1323-1332.
    • (2005) BJU Int , vol.96 , pp. 1323-1332
    • Eardley, I.1    Mirone, V.2    Montorsi, F.3
  • 15
    • 1642341195 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind crossover study to evaluate patient preference between tadalafil and sildenafil
    • von Keitz A., Rajfer J., Segal S., et al. A multicenter, randomized, double-blind crossover study to evaluate patient preference between tadalafil and sildenafil. Eur Urol 2004, 45:499-507.
    • (2004) Eur Urol , vol.45 , pp. 499-507
    • von Keitz, A.1    Rajfer, J.2    Segal, S.3
  • 16
    • 0345095481 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, crossover study of patient preference for tadalafil 20 mg or sildenafil citrate 50 mg during initiation of treatment for erectile dysfunction
    • Govier F., Potempa A.J., Kaufman J., et al. A multicenter, randomized, double-blind, crossover study of patient preference for tadalafil 20 mg or sildenafil citrate 50 mg during initiation of treatment for erectile dysfunction. Clin Ther 2003, 25:2709-2723.
    • (2003) Clin Ther , vol.25 , pp. 2709-2723
    • Govier, F.1    Potempa, A.J.2    Kaufman, J.3
  • 17
    • 33747694337 scopus 로고    scopus 로고
    • Prospective, randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors
    • Tolra J.R., Campana J.M., Ciutat L.F., et al. Prospective, randomized, open-label, fixed-dose, crossover study to establish preference of patients with erectile dysfunction after taking the three PDE-5 inhibitors. J Sex Med 2006, 3:901-909.
    • (2006) J Sex Med , vol.3 , pp. 901-909
    • Tolra, J.R.1    Campana, J.M.2    Ciutat, L.F.3
  • 18
    • 33750357114 scopus 로고    scopus 로고
    • Management of sildenafil treatment failures
    • Kendirci M., Tanriverdi O., Trost L., et al. Management of sildenafil treatment failures. Curr Opin Urol 2006, 16:449-459.
    • (2006) Curr Opin Urol , vol.16 , pp. 449-459
    • Kendirci, M.1    Tanriverdi, O.2    Trost, L.3
  • 19
    • 2642539623 scopus 로고    scopus 로고
    • Tadalafil in the treatment of erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy: a randomized, double-blind, placebo controlled trial
    • Montorsi F., Nathan H.P., McCullough A., et al. Tadalafil in the treatment of erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy: a randomized, double-blind, placebo controlled trial. J Urol 2004, 172:1036-1041.
    • (2004) J Urol , vol.172 , pp. 1036-1041
    • Montorsi, F.1    Nathan, H.P.2    McCullough, A.3
  • 20
    • 11144355591 scopus 로고    scopus 로고
    • Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa
    • Morelli A., Filippi S., Mancini R., et al. Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinol 2004, 145:2253-2263.
    • (2004) Endocrinol , vol.145 , pp. 2253-2263
    • Morelli, A.1    Filippi, S.2    Mancini, R.3
  • 21
    • 64249111575 scopus 로고    scopus 로고
    • Tadalafil and vardenafil vs sildenafil: a review of patient-preference studies
    • Mirone V., Fusco F., Rossi A., et al. Tadalafil and vardenafil vs sildenafil: a review of patient-preference studies. BJU Int 2009, 103:1212-1217.
    • (2009) BJU Int , vol.103 , pp. 1212-1217
    • Mirone, V.1    Fusco, F.2    Rossi, A.3
  • 22
    • 33750340662 scopus 로고    scopus 로고
    • Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction
    • Shabsigh R., Seftel A.D., Rosen R.C., et al. Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction. Urology 2006, 68:689-696.
    • (2006) Urology , vol.68 , pp. 689-696
    • Shabsigh, R.1    Seftel, A.D.2    Rosen, R.C.3
  • 23
    • 82855167614 scopus 로고    scopus 로고
    • Eli Lilly, Indianapolis, IN
    • Cialis [package insert] 2011, Eli Lilly, Indianapolis, IN.
    • (2011) Cialis [package insert]
  • 24
    • 60249094895 scopus 로고    scopus 로고
    • Effect of sildenafil on middle-aged sexually active males with no erectile complaints: a randomized placebo-controlled double-blind study
    • Gruenwald I., Leiba R., Vardi Y. Effect of sildenafil on middle-aged sexually active males with no erectile complaints: a randomized placebo-controlled double-blind study. Eur Urol 2009, 55:969-978.
    • (2009) Eur Urol , vol.55 , pp. 969-978
    • Gruenwald, I.1    Leiba, R.2    Vardi, Y.3
  • 25
    • 29544443156 scopus 로고    scopus 로고
    • Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference)
    • Kostis J.B., Jackson G., Rosen R., et al. Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). Am J Cardiol 2005, 96:313-321.
    • (2005) Am J Cardiol , vol.96 , pp. 313-321
    • Kostis, J.B.1    Jackson, G.2    Rosen, R.3
  • 26
    • 82855167613 scopus 로고    scopus 로고
    • Pfizer Inc, New York, NY
    • Viagra [package insert] 2011, Pfizer Inc, New York, NY.
    • (2011) Viagra [package insert]
  • 27
    • 82855175856 scopus 로고    scopus 로고
    • Bayer Health Care Pharmaceuticals, Wayne, NJ
    • Levitra [package insert] 2011, Bayer Health Care Pharmaceuticals, Wayne, NJ.
    • (2011) Levitra [package insert]
  • 28
    • 0037370684 scopus 로고    scopus 로고
    • Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction
    • Rajogopalan P., Mazzu A., Xia C., et al. Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction. J Clin Pharmacol 2003, 43:260-267.
    • (2003) J Clin Pharmacol , vol.43 , pp. 260-267
    • Rajogopalan, P.1    Mazzu, A.2    Xia, C.3
  • 29
    • 34547766493 scopus 로고    scopus 로고
    • Current safety and tolerability issues in men with erectile dysfunction receiving PDE5 inhibitors
    • Helstrom W.J.G. Current safety and tolerability issues in men with erectile dysfunction receiving PDE5 inhibitors. Int J Clin Pract 2007, 61:1547-1554.
    • (2007) Int J Clin Pract , vol.61 , pp. 1547-1554
    • Helstrom, W.J.G.1
  • 30
    • 0037350305 scopus 로고    scopus 로고
    • Long-term use of sildenafil
    • Carson C.C. Long-term use of sildenafil. Expert Opin Pharmacother 2003, 4:397-495.
    • (2003) Expert Opin Pharmacother , vol.4 , pp. 397-495
    • Carson, C.C.1
  • 31
    • 4043140681 scopus 로고    scopus 로고
    • Efficacy of sildenafil citrate at 12 hours after dosing: re-exploring the therapeutic window
    • Moncada I., Jara J., Subira D., et al. Efficacy of sildenafil citrate at 12 hours after dosing: re-exploring the therapeutic window. Eur Urol 2004, 46:357-360.
    • (2004) Eur Urol , vol.46 , pp. 357-360
    • Moncada, I.1    Jara, J.2    Subira, D.3
  • 32
    • 41349107245 scopus 로고    scopus 로고
    • Randomized, double-blind, crossover trial of sildenafil in men with mild to moderate erectile dysfunction: efficacy at 8 and 12 hours postdose
    • McCullough A.R., Steidle C.P., Klee B., et al. Randomized, double-blind, crossover trial of sildenafil in men with mild to moderate erectile dysfunction: efficacy at 8 and 12 hours postdose. Urology 2008, 71:686-692.
    • (2008) Urology , vol.71 , pp. 686-692
    • McCullough, A.R.1    Steidle, C.P.2    Klee, B.3
  • 33
    • 0038353576 scopus 로고    scopus 로고
    • Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial
    • Porst H., Padma-Nathan H., Giuliano F., et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing: a randomized controlled trial. Urology 2003, 62:121-126.
    • (2003) Urology , vol.62 , pp. 121-126
    • Porst, H.1    Padma-Nathan, H.2    Giuliano, F.3
  • 34
    • 0347129566 scopus 로고    scopus 로고
    • Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy
    • Schwartz E.J., Wong P., Graydon R.J. Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 2004, 171:771-774.
    • (2004) J Urol , vol.171 , pp. 771-774
    • Schwartz, E.J.1    Wong, P.2    Graydon, R.J.3
  • 35
    • 33744922617 scopus 로고    scopus 로고
    • Optimisation of PDE5 inhibitor therapy in men with erectile dysfunction: converting "non-responders" into "responders."
    • Eardley I. Optimisation of PDE5 inhibitor therapy in men with erectile dysfunction: converting "non-responders" into "responders.". Eur Urol 2006, 50:31-33.
    • (2006) Eur Urol , vol.50 , pp. 31-33
    • Eardley, I.1
  • 36
    • 72149091708 scopus 로고    scopus 로고
    • Effect of chronic sildenafil on penile endothelial function: a randomized, double-blind, placebo-controlled study
    • Vardi Y., Appel B., Offer Y., et al. Effect of chronic sildenafil on penile endothelial function: a randomized, double-blind, placebo-controlled study. J Urol 2009, 182:2850-2855.
    • (2009) J Urol , vol.182 , pp. 2850-2855
    • Vardi, Y.1    Appel, B.2    Offer, Y.3
  • 37
    • 31144472113 scopus 로고    scopus 로고
    • Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors
    • Sommer F., Schulza W. Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors. World J Urol 2005, 23:385-392.
    • (2005) World J Urol , vol.23 , pp. 385-392
    • Sommer, F.1    Schulza, W.2
  • 38
    • 40649127751 scopus 로고    scopus 로고
    • Early penile rehabilitation following radical prostatectomy: Cleveland Clinic experience
    • Raina R., Pahlajani G., Agarwal A., et al. Early penile rehabilitation following radical prostatectomy: Cleveland Clinic experience. Int J Impot Res 2008, 20:121-126.
    • (2008) Int J Impot Res , vol.20 , pp. 121-126
    • Raina, R.1    Pahlajani, G.2    Agarwal, A.3
  • 39
    • 51849117153 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy
    • Padma-Nathan I.I., McCullough A.R., Levine A.R., et al. Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy. Int J Impot Res 2008, 20:479-486.
    • (2008) Int J Impot Res , vol.20 , pp. 479-486
    • Padma-Nathan, I.I.1    McCullough, A.R.2    Levine, A.R.3
  • 40
    • 38649122369 scopus 로고    scopus 로고
    • Return of nocturnal erections and erectile function after bilateral nerve-sparing radical prostatectomy in men treated nightly with sildenafil citrate: subanalysis of a longitudinal randomized double-blind placebo-controlled triad
    • McCullough A.R., Levina L.A., Padma-Nathan H. Return of nocturnal erections and erectile function after bilateral nerve-sparing radical prostatectomy in men treated nightly with sildenafil citrate: subanalysis of a longitudinal randomized double-blind placebo-controlled triad. J Sex Med 2008, 5:476-484.
    • (2008) J Sex Med , vol.5 , pp. 476-484
    • McCullough, A.R.1    Levina, L.A.2    Padma-Nathan, H.3
  • 41
    • 57649184019 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application
    • Hatzimouratidis K., Burnett A.L., Hatzichristou D., et al. Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application. Eur Urol 2009, 55:334-347.
    • (2009) Eur Urol , vol.55 , pp. 334-347
    • Hatzimouratidis, K.1    Burnett, A.L.2    Hatzichristou, D.3
  • 42
    • 33745866247 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial
    • Porst H., Giuliano F., Glina S., et al. Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial. Eur Urol 2006, 50:351-359.
    • (2006) Eur Urol , vol.50 , pp. 351-359
    • Porst, H.1    Giuliano, F.2    Glina, S.3
  • 43
    • 33846073648 scopus 로고    scopus 로고
    • Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study in the US
    • Rajfer J., Aliotta P.J., Steidle C.P., et al. Tadalafil dosed once a day in men with erectile dysfunction: a randomized, double-blind, placebo-controlled study in the US. Int J Impot Res 2007, 19:95-103.
    • (2007) Int J Impot Res , vol.19 , pp. 95-103
    • Rajfer, J.1    Aliotta, P.J.2    Steidle, C.P.3
  • 44
    • 39749105966 scopus 로고    scopus 로고
    • Efficacy of tadalafil once daily in men with diabetes mellitus and erectile dysfunction
    • Hatzichristou D., Gambla M., Rubio-Aurioles E., et al. Efficacy of tadalafil once daily in men with diabetes mellitus and erectile dysfunction. Diabet Med 2008, 25:138-146.
    • (2008) Diabet Med , vol.25 , pp. 138-146
    • Hatzichristou, D.1    Gambla, M.2    Rubio-Aurioles, E.3
  • 45
    • 51349111890 scopus 로고    scopus 로고
    • Long term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction
    • Porst H., Rajfer J., Casabe A.D., et al. Long term safety and efficacy of tadalafil 5 mg dosed once daily in men with erectile dysfunction. J Sex Med 2008, 5:2160-2169.
    • (2008) J Sex Med , vol.5 , pp. 2160-2169
    • Porst, H.1    Rajfer, J.2    Casabe, A.D.3
  • 46
    • 44149125039 scopus 로고    scopus 로고
    • Comparable efficacy of once-daily versus on-demand vardenafil in men with mild-to-moderate erectile dysfunction: findings of the RESTORE study
    • Zumbe J., Porst H., Sommer F., et al. Comparable efficacy of once-daily versus on-demand vardenafil in men with mild-to-moderate erectile dysfunction: findings of the RESTORE study. Eur Urol 2008, 54:204-212.
    • (2008) Eur Urol , vol.54 , pp. 204-212
    • Zumbe, J.1    Porst, H.2    Sommer, F.3
  • 47
    • 78650006374 scopus 로고    scopus 로고
    • Onset of efficacy of tadalafil once daily in men with erectile dysfunction: a randomized, double-blind, placebo controlled trial
    • Seftel A., Goldfischer E., Kim E.D., et al. Onset of efficacy of tadalafil once daily in men with erectile dysfunction: a randomized, double-blind, placebo controlled trial. J Urol 2011, 185:243-248.
    • (2011) J Urol , vol.185 , pp. 243-248
    • Seftel, A.1    Goldfischer, E.2    Kim, E.D.3
  • 48
    • 62349122858 scopus 로고    scopus 로고
    • Efficacy and safety of tadalafil once daily: considerations for the practical application of a daily dosing option
    • Donatucci C.F., Wong D.G., Giuliano F., et al. Efficacy and safety of tadalafil once daily: considerations for the practical application of a daily dosing option. Curr Med Res Opin 2008, 24:3383-3392.
    • (2008) Curr Med Res Opin , vol.24 , pp. 3383-3392
    • Donatucci, C.F.1    Wong, D.G.2    Giuliano, F.3
  • 49
    • 29544435476 scopus 로고    scopus 로고
    • Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on α-blocker interactions
    • Kloner R.A. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on α-blocker interactions. Am J Cardiol 2005, 96(12B Suppl):42M-46M.
    • (2005) Am J Cardiol , vol.96 , Issue.12 B SUPPL
    • Kloner, R.A.1
  • 50
    • 0035027524 scopus 로고    scopus 로고
    • Efficacy and safety of sildenafil citrate for the treatment of erectile dysfunction in men with cardiovascular disease
    • Olsson A.M., Persson C.A. Efficacy and safety of sildenafil citrate for the treatment of erectile dysfunction in men with cardiovascular disease. Int J Clin Pract 2001, 55:171-176.
    • (2001) Int J Clin Pract , vol.55 , pp. 171-176
    • Olsson, A.M.1    Persson, C.A.2
  • 51
    • 36349001124 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors, visual changes, and nonarteritic anterior ischemic optic neuropathy: is there a link?
    • Haztimouratidis K. Phosphodiesterase type 5 inhibitors, visual changes, and nonarteritic anterior ischemic optic neuropathy: is there a link?. Curr Urol Rep 2007, 8:482-490.
    • (2007) Curr Urol Rep , vol.8 , pp. 482-490
    • Haztimouratidis, K.1
  • 52
    • 33645731017 scopus 로고    scopus 로고
    • Ocular safety in patients using sildenafil citrate therapy for erectile dysfunction
    • Laties A., Sharlip I. Ocular safety in patients using sildenafil citrate therapy for erectile dysfunction. J Sex Med 2006, 3:12-27.
    • (2006) J Sex Med , vol.3 , pp. 12-27
    • Laties, A.1    Sharlip, I.2
  • 53
    • 0031049985 scopus 로고    scopus 로고
    • Incidence of nonarteritic anterior ischemic optic neuropathy
    • Hattenhauer M.G., Leavitt J.A., Hodge D.O., et al. Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 1997, 123:103-107.
    • (1997) Am J Ophthalmol , vol.123 , pp. 103-107
    • Hattenhauer, M.G.1    Leavitt, J.A.2    Hodge, D.O.3
  • 54
    • 35748944904 scopus 로고    scopus 로고
    • Erectile dysfunction drugs and risk of anterior ischaemic optic neuropathy: casual or causal association
    • Danesh-Meyer H.V., Levin L.A. Erectile dysfunction drugs and risk of anterior ischaemic optic neuropathy: casual or causal association. Br J Ophthalmol 2007, 91:1551-1555.
    • (2007) Br J Ophthalmol , vol.91 , pp. 1551-1555
    • Danesh-Meyer, H.V.1    Levin, L.A.2
  • 55
    • 33947113884 scopus 로고    scopus 로고
    • Visual loss associated with erectile dysfunction drugs
    • Dundar S.O. Visual loss associated with erectile dysfunction drugs. Can J Ophthalmol 2007, 42:10-12.
    • (2007) Can J Ophthalmol , vol.42 , pp. 10-12
    • Dundar, S.O.1
  • 56
    • 33645052699 scopus 로고    scopus 로고
    • Sildenafil citrate use and the incidence of nonarteritic anterior ischemic optic neuropathy
    • Gorkin L., Hvidsten K., Sobel R.E., Siegel R. Sildenafil citrate use and the incidence of nonarteritic anterior ischemic optic neuropathy. Int J Clin Pract 2006, 60:500-503.
    • (2006) Int J Clin Pract , vol.60 , pp. 500-503
    • Gorkin, L.1    Hvidsten, K.2    Sobel, R.E.3    Siegel, R.4
  • 57
    • 0032807071 scopus 로고    scopus 로고
    • Role of aspirin in reducing the frequency of second eye involvement in patients with non-arteritic anterior ischaemic optic neuropathy
    • Salomon O., Huna-Baron R., Steinberg D.M., et al. Role of aspirin in reducing the frequency of second eye involvement in patients with non-arteritic anterior ischaemic optic neuropathy. Eye 1999, 13(Pt 3A):357-359.
    • (1999) Eye , vol.13 , Issue.PART 3A , pp. 357-359
    • Salomon, O.1    Huna-Baron, R.2    Steinberg, D.M.3
  • 58
    • 68849116084 scopus 로고    scopus 로고
    • Sudden hearing loss from PDE-5 inhibitors: a possible cellular stress etiology
    • Maddox P.T., Saunders J., Chandrasekhar S.S. Sudden hearing loss from PDE-5 inhibitors: a possible cellular stress etiology. Laryngoscope 2009, 119:1586-1589.
    • (2009) Laryngoscope , vol.119 , pp. 1586-1589
    • Maddox, P.T.1    Saunders, J.2    Chandrasekhar, S.S.3
  • 59
    • 68149126337 scopus 로고    scopus 로고
    • Effect of phosphodiesterase-5 inhibitor on hearing
    • Okuyugu S., Guven O.E., Akoglu E. Effect of phosphodiesterase-5 inhibitor on hearing. J Laryngol Otol 2009, 123:718-732.
    • (2009) J Laryngol Otol , vol.123 , pp. 718-732
    • Okuyugu, S.1    Guven, O.E.2    Akoglu, E.3
  • 60
    • 84878120975 scopus 로고    scopus 로고
    • Sudden sensorineural hearing loss associated with vardenafil
    • Snodgrass A.J., Campbell H.M., Mace D.L., et al. Sudden sensorineural hearing loss associated with vardenafil. Pharmacotherapy 2010, 30:112.
    • (2010) Pharmacotherapy , vol.30 , pp. 112
    • Snodgrass, A.J.1    Campbell, H.M.2    Mace, D.L.3
  • 61
    • 0242523778 scopus 로고    scopus 로고
    • Salvage of sildenafil failures referred from primary care physicians
    • Atiemo H.O., Szostak M.J., Sklar G.N. Salvage of sildenafil failures referred from primary care physicians. J Urol 2003, 170:2356-2358.
    • (2003) J Urol , vol.170 , pp. 2356-2358
    • Atiemo, H.O.1    Szostak, M.J.2    Sklar, G.N.3
  • 62
    • 0036754094 scopus 로고    scopus 로고
    • Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction
    • McCullough A.R., Barada J.H., Fawzy A., et al. Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction. Urology 2002, 60(Suppl 2B):28-38.
    • (2002) Urology , vol.60 , Issue.SUPPL 2B , pp. 28-38
    • McCullough, A.R.1    Barada, J.H.2    Fawzy, A.3
  • 63
    • 0035156333 scopus 로고    scopus 로고
    • A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction
    • Meuleman E., Cuzin B., Opsomer R.J., et al. A dose-escalation study to assess the efficacy and safety of sildenafil citrate in men with erectile dysfunction. BJU Int 2001, 87:75-81.
    • (2001) BJU Int , vol.87 , pp. 75-81
    • Meuleman, E.1    Cuzin, B.2    Opsomer, R.J.3
  • 64
    • 33847384579 scopus 로고    scopus 로고
    • Early sildenafil optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction
    • McCullough A.R., Kaminetsky J.C., Crowley A.R., et al. Early sildenafil optimization and personalized instruction improves the frequency, flexibility, and success of sexual intercourse in men with erectile dysfunction. Int J Impot Res 2007, 19:154-160.
    • (2007) Int J Impot Res , vol.19 , pp. 154-160
    • McCullough, A.R.1    Kaminetsky, J.C.2    Crowley, A.R.3
  • 65
    • 13844292783 scopus 로고    scopus 로고
    • Sildenafil citrate and vacuum device combination enhances sexual satisfaction in erectile dysfunction after radical prostatectomy
    • Raina R., Agarwal A., Allamaneni S.S., et al. Sildenafil citrate and vacuum device combination enhances sexual satisfaction in erectile dysfunction after radical prostatectomy. Urology 2005, 65:350-364.
    • (2005) Urology , vol.65 , pp. 350-364
    • Raina, R.1    Agarwal, A.2    Allamaneni, S.S.3
  • 66
    • 0038825150 scopus 로고    scopus 로고
    • Viability and safety of combination drug therapies for erectile dysfunction
    • Steers W.D. Viability and safety of combination drug therapies for erectile dysfunction. J Urol 2003, 170(2 Pt 2):S20-S23.
    • (2003) J Urol , vol.170 , Issue.2 PART 2
    • Steers, W.D.1
  • 67
    • 34548354234 scopus 로고    scopus 로고
    • Which patients with sexual dysfunction are suitable for testosterone replacement therapy?
    • Morelli A., Corona G., Filippi S., et al. Which patients with sexual dysfunction are suitable for testosterone replacement therapy?. J Endocrinol Invest 2007, 30:880-888.
    • (2007) J Endocrinol Invest , vol.30 , pp. 880-888
    • Morelli, A.1    Corona, G.2    Filippi, S.3
  • 68
    • 14744283305 scopus 로고    scopus 로고
    • Effect of 12 month oral testosterone on testosterone deficiency symptoms in symptomatic elderly males with low-normal gonadal status
    • Haren M., Chapman I., Coates P., et al. Effect of 12 month oral testosterone on testosterone deficiency symptoms in symptomatic elderly males with low-normal gonadal status. Age Aging 2005, 34:125-130.
    • (2005) Age Aging , vol.34 , pp. 125-130
    • Haren, M.1    Chapman, I.2    Coates, P.3
  • 69
    • 1842789810 scopus 로고    scopus 로고
    • Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging
    • Cavallini G., Caracciolo S., Vitali G., et al. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Urology 2004, 63:641-646.
    • (2004) Urology , vol.63 , pp. 641-646
    • Cavallini, G.1    Caracciolo, S.2    Vitali, G.3
  • 70
    • 0033978087 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms
    • Rabkin J.G., Wagner G.J., Rabkin R. A double-blind, placebo-controlled trial of testosterone therapy for HIV-positive men with hypogonadal symptoms. Arch Gen Psychiatry 2000, 57:141-147.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 141-147
    • Rabkin, J.G.1    Wagner, G.J.2    Rabkin, R.3
  • 71
    • 0036858514 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update
    • AACE Hypogonadism Task Force
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update. Endocr Pract 2002, 8:440-456. AACE Hypogonadism Task Force.
    • (2002) Endocr Pract , vol.8 , pp. 440-456
  • 72
    • 0036933689 scopus 로고    scopus 로고
    • High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction
    • McMahon C.G. High dose sildenafil citrate as a salvage therapy for severe erectile dysfunction. Int J Impot Res 2002, 14:533-536.
    • (2002) Int J Impot Res , vol.14 , pp. 533-536
    • McMahon, C.G.1
  • 73
    • 33746804604 scopus 로고    scopus 로고
    • Vardenafil rescue rates of sildenafil nonresponders: objective assessment of 327 patients with erectile dysfunction
    • Brisson T.E., Broderick G.A., Thiel D.D., et al. Vardenafil rescue rates of sildenafil nonresponders: objective assessment of 327 patients with erectile dysfunction. Urology 2006, 68:397-401.
    • (2006) Urology , vol.68 , pp. 397-401
    • Brisson, T.E.1    Broderick, G.A.2    Thiel, D.D.3
  • 74
    • 33748964326 scopus 로고    scopus 로고
    • Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective
    • Jackson G., Montorsi P., Cheitlin M.D. Cardiovascular safety of sildenafil citrate (Viagra): an updated perspective. Urology 2006, 68(Suppl 3A):47-60.
    • (2006) Urology , vol.68 , Issue.SUPPL 3A , pp. 47-60
    • Jackson, G.1    Montorsi, P.2    Cheitlin, M.D.3
  • 75
    • 0033522152 scopus 로고    scopus 로고
    • Effects of sildenafil citrate on human hemodynamics
    • Jackson G., Benjamin N., Jackson N., et al. Effects of sildenafil citrate on human hemodynamics. Am J Cardiol 1999, 83:13C-20C.
    • (1999) Am J Cardiol , vol.83
    • Jackson, G.1    Benjamin, N.2    Jackson, N.3
  • 76
    • 57349196418 scopus 로고    scopus 로고
    • The use of phosphodiesterase 5 inhibitors with concomitant medications
    • Corona G., Razzoli E., Forti G., et al. The use of phosphodiesterase 5 inhibitors with concomitant medications. J Endocrinol Invest 2008, 31:799-808.
    • (2008) J Endocrinol Invest , vol.31 , pp. 799-808
    • Corona, G.1    Razzoli, E.2    Forti, G.3
  • 77
    • 0242460582 scopus 로고    scopus 로고
    • Cardiovascular effects of tadalafil in patients on common antihypertensive therapies
    • Kloner R.A., Mitchell M., Emmick J.T. Cardiovascular effects of tadalafil in patients on common antihypertensive therapies. Am J Cardiol 2003, 92(9A):47M-57M.
    • (2003) Am J Cardiol , vol.92 , Issue.9 A
    • Kloner, R.A.1    Mitchell, M.2    Emmick, J.T.3
  • 78
    • 30744463281 scopus 로고    scopus 로고
    • Efficacy of tadalafil in the treatment of erectile dysfunction in hypertensive men on concomitant thiazide diuretic therapy
    • Kloner R.A., Sadovsky R., Johnson E.G., et al. Efficacy of tadalafil in the treatment of erectile dysfunction in hypertensive men on concomitant thiazide diuretic therapy. Int J Impot Res 2005, 17:450-454.
    • (2005) Int J Impot Res , vol.17 , pp. 450-454
    • Kloner, R.A.1    Sadovsky, R.2    Johnson, E.G.3
  • 79
    • 34248182116 scopus 로고    scopus 로고
    • Sildenafil is well tolerated by erectile dysfunction patients taking antihypertensive medications, including those on multidrug regimens
    • Bohm M., Burkart M., Baumann G. Sildenafil is well tolerated by erectile dysfunction patients taking antihypertensive medications, including those on multidrug regimens. Curr Drug Saf 2007, 2:5-8.
    • (2007) Curr Drug Saf , vol.2 , pp. 5-8
    • Bohm, M.1    Burkart, M.2    Baumann, G.3
  • 80
    • 28444487883 scopus 로고    scopus 로고
    • Safety and efficacy of vardenafil, a selective phosphodiesterase 5 inhibitor, in patients with erectile dysfunction and arterial hypertension treated with multiple antihypertensives
    • van Ahlen H., Wahle K., Kupper W., et al. Safety and efficacy of vardenafil, a selective phosphodiesterase 5 inhibitor, in patients with erectile dysfunction and arterial hypertension treated with multiple antihypertensives. J Sex Med 2005, 2:856-864.
    • (2005) J Sex Med , vol.2 , pp. 856-864
    • van Ahlen, H.1    Wahle, K.2    Kupper, W.3
  • 81
    • 29144533834 scopus 로고    scopus 로고
    • Erectile dysfunction and subsequent cardiovascular disease
    • Thompson I.M., Tangen C.M., Goodman P.J., et al. Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005, 294:2996-3002.
    • (2005) JAMA , vol.294 , pp. 2996-3002
    • Thompson, I.M.1    Tangen, C.M.2    Goodman, P.J.3
  • 82
    • 54049112309 scopus 로고    scopus 로고
    • The relationship between erectile dysfunction and cardiovascular disease. Part II: the role of PDE-5 inhibition in sexual dysfunction and cardiovascular disease
    • Kapur V., Chien C.V., Fuess J.E., et al. The relationship between erectile dysfunction and cardiovascular disease. Part II: the role of PDE-5 inhibition in sexual dysfunction and cardiovascular disease. Rev Cardiovasc Med 2008, 9:187-195.
    • (2008) Rev Cardiovasc Med , vol.9 , pp. 187-195
    • Kapur, V.1    Chien, C.V.2    Fuess, J.E.3
  • 83
    • 61449149483 scopus 로고    scopus 로고
    • A population-based longitudinal study of erectile dysfunction and future coronary artery disease
    • Inman B.A., St.Sauver J.L., Jacobson D.J., et al. A population-based longitudinal study of erectile dysfunction and future coronary artery disease. Mayo Clin Proc 2009, 84:108-113.
    • (2009) Mayo Clin Proc , vol.84 , pp. 108-113
    • Inman, B.A.1    St Sauver, J.L.2    Jacobson, D.J.3
  • 84
    • 38149064395 scopus 로고    scopus 로고
    • Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: results from the Krimpen Study
    • Schouten B.W., Bohnen A.M., Bosch J.L., et al. Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: results from the Krimpen Study. Int J Impot Res 2008, 20:92-99.
    • (2008) Int J Impot Res , vol.20 , pp. 92-99
    • Schouten, B.W.1    Bohnen, A.M.2    Bosch, J.L.3
  • 85
    • 0242552045 scopus 로고    scopus 로고
    • Time course of the interaction between tadalafil and nitrates
    • Kloner R.A., Hutter A.M., Emmick J.T., et al. Time course of the interaction between tadalafil and nitrates. J Am Coll Cardiol 2003, 42:1855-1860.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1855-1860
    • Kloner, R.A.1    Hutter, A.M.2    Emmick, J.T.3
  • 86
    • 75849123577 scopus 로고    scopus 로고
    • Urodynamic effects of once daily tadalafil in men with lower urinary tract symptoms secondary to clinical benign prostatic hyperplasia: a randomized, placebo controlled 12 week clinical trial
    • Dmochowski R., Roehrborn C., Klise S., et al. Urodynamic effects of once daily tadalafil in men with lower urinary tract symptoms secondary to clinical benign prostatic hyperplasia: a randomized, placebo controlled 12 week clinical trial. J Urol 2010, 183:1092-1097.
    • (2010) J Urol , vol.183 , pp. 1092-1097
    • Dmochowski, R.1    Roehrborn, C.2    Klise, S.3
  • 87
    • 77549088284 scopus 로고    scopus 로고
    • Combination of alfuzosin and tadalafil exerts an additive relaxant effect on human detrusor and prostatic tissues in vitro
    • Oger S., Behr-Roussel D., Gorny D., et al. Combination of alfuzosin and tadalafil exerts an additive relaxant effect on human detrusor and prostatic tissues in vitro. Eur Urol 2010, 57:699-707.
    • (2010) Eur Urol , vol.57 , pp. 699-707
    • Oger, S.1    Behr-Roussel, D.2    Gorny, D.3
  • 88
    • 33846810223 scopus 로고    scopus 로고
    • Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized, double-blind trial
    • McVary K.T., Monnig W., Camps J.L., et al. Sildenafil citrate improves erectile function and urinary symptoms in men with erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia: a randomized, double-blind trial. J Urol 2007, 177:1071-1077.
    • (2007) J Urol , vol.177 , pp. 1071-1077
    • McVary, K.T.1    Monnig, W.2    Camps, J.L.3
  • 89
    • 50949119951 scopus 로고    scopus 로고
    • Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study
    • Roehrborn C.G., McVary K.T., Elion-Mboussa A., et al. Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study. J Urol 2008, 180:1228-1234.
    • (2008) J Urol , vol.180 , pp. 1228-1234
    • Roehrborn, C.G.1    McVary, K.T.2    Elion-Mboussa, A.3
  • 90
    • 51349092065 scopus 로고    scopus 로고
    • Comparative efficacy assessment of tamsulosin vs tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study
    • Bechara A., Romano S., Casabe A., et al. Comparative efficacy assessment of tamsulosin vs tamsulosin plus tadalafil in the treatment of LUTS/BPH. Pilot study. J Sex Med 2008, 5:2170-2178.
    • (2008) J Sex Med , vol.5 , pp. 2170-2178
    • Bechara, A.1    Romano, S.2    Casabe, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.