Combined transcriptomic- 1H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes

Journal of Proteome Research

Volumn 10, Issue 12, 2011, Pages 5493-5502

  Ellero Simatos, Sandrine ^a,b   Claus, Sandrine P ^c   Benelli, Chantal ^a   Forest, Claude ^a   Letourneur, Franck ^d   Cagnard, Nicolas ^a   Beaune, Philippe H ^a   De Waziers, Isabelle ^a  

^a INSERM   (France)

^b AGROPARISTECH   (France)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d INSTITUT COCHIN   (France)

Author keywords

environmental metabolic disruptor; glyceroneogenesis; phosphenolpyruvate carboxykinase; phthalate; PPAR

Indexed keywords

AMINO ACID DERIVATIVE; ASPARTIC ACID; CELL NUCLEUS RECEPTOR; FATTY ACID; GLUTAMINE; LACTIC ACID; MONOETHYLHEXYL PHTHALATE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (PYROPHOSPHATE); PHTHALIC ACID DERIVATIVE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOSOL; ENERGY BALANCE; ESTERIFICATION; GENE EXPRESSION; GLYCERONEOGENESIS; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; METABOLIC DISORDER; METABONOMICS; MOUSE; NONHUMAN; OBESITY; POLLUTANT; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR UPREGULATION; TRANSCRIPTOMICS;

ADIPOCYTES; ADIPOGENESIS; ADULT; CULTURE MEDIA; DIETHYLHEXYL PHTHALATE; FATTY ACIDS, NONESTERIFIED; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLYCEROL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PPAR GAMMA; PRIMARY CELL CULTURE; TIME FACTORS; TRIGLYCERIDES;

EID: 82755198859     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200765v     Document Type: Article

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