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Volumn 5, Issue 6, 2011, Pages 745-761

Biomarkers to optimize the treatment of nicotine dependence

Author keywords

CYP2A6; dopamine; nicotine dependence; nicotine metabolite ratio; pharmacogenetic; smoking; tobacco

Indexed keywords

AMFEBUTAMONE; BIOLOGICAL MARKER; CYTOCHROME P450 2A6; DOPAMINE; NICOTINE; NICOTINE GUM; NICOTINE PATCH; NICOTINIC RECEPTOR; OPIATE RECEPTOR; PLACEBO; VARENICLINE;

EID: 82755195600     PISSN: 17520363     EISSN: 17520371     Source Type: Journal    
DOI: 10.2217/bmm.11.91     Document Type: Review
Times cited : (15)

References (126)
  • 1
    • 56149083852 scopus 로고    scopus 로고
    • Smoking-attributable mortality, years of potential life lost, and productivity losses-United States, 2000-2004
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Smoking-attributable mortality, years of potential life lost, and productivity losses -United States, 2000-2004. MMWR Morb. Mortal. Wkly Rep. 57, 1226-1228 (2008).
    • (2008) MMWR Morb. Mortal. Wkly Rep. , vol.57 , pp. 1226-1228
  • 2
    • 3142592957 scopus 로고    scopus 로고
    • United States Department of Health and Human Services Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta, GA, USA
    • United States Department of Health and Human Services. The Health Consequences of Smoking: A Report of the Surgeon General. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta, GA, USA (2004).
    • (2004) The Health Consequences of Smoking: A Report of the Surgeon General
  • 3
    • 77956640415 scopus 로고    scopus 로고
    • Vital signs: Current cigarette smoking among adults aged ≥18 years -United States, 2009
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Vital signs: current cigarette smoking among adults aged ≥18 years -United States, 2009. MMWR Morb. Mortal. Wkly Rep. 59, 1135-1140 (2010).
    • (2010) MMWR Morb. Mortal. Wkly Rep. , vol.59 , pp. 1135-1140
  • 4
    • 79953297129 scopus 로고    scopus 로고
    • Cigarette smoking -United States, 1965-2008
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Cigarette smoking -United States, 1965-2008. MMWR Morb. Mortal. Wkly Rep. 60, 109-113 (2011).
    • (2011) MMWR Morb. Mortal. Wkly Rep. , vol.60 , pp. 109-113
  • 5
    • 77953571583 scopus 로고    scopus 로고
    • Exploring scenarios to dramatically reduce smoking prevalence: A simulation model of the three-part cessation process
    • Levy DT, Mabry PL, Graham AL, Orleans CT, Abrams DB. Exploring scenarios to dramatically reduce smoking prevalence: a simulation model of the three-part cessation process. Am. J. Public Health 100, 1253-1259 (2010).
    • (2010) Am. J. Public Health , vol.100 , pp. 1253-1259
    • Levy, D.T.1    Mabry, P.L.2    Graham, A.L.3    Orleans, C.T.4    Abrams, D.B.5
  • 8
    • 66949150586 scopus 로고    scopus 로고
    • Predictors of enrollment in a smoking cessation clinical trial after eligibility screening
    • Dahm JL, Cook E, Baugh K et al. Predictors of enrollment in a smoking cessation clinical trial after eligibility screening. J. Nat. Med. Assoc. 101, 450-455 (2009).
    • (2009) J. Nat. Med. Assoc. , vol.101 , pp. 450-455
    • Dahm, J.L.1    Cook, E.2    Baugh, K.3
  • 10
    • 0942301180 scopus 로고    scopus 로고
    • Shape of the relapse curve and long-term abstinence among untreated smokers
    • DOI 10.1111/j.1360-0443.2004.00540.x
    • Hughes JR, Keely J, Naud S. Shape of the relapse curve and long-term abstinence among untreated smokers. Addiction 99, 29-38 (2004). (Pubitemid 38142221)
    • (2004) Addiction , vol.99 , Issue.1 , pp. 29-38
    • Hughes, J.R.1    Keely, J.2    Naud, S.3
  • 11
    • 33748654008 scopus 로고    scopus 로고
    • Current and emerging pharmacotherapies for treating tobacco dependence
    • DOI 10.1517/14728214.11.3.429
    • Schnoll RA, Lerman C. Current and emerging pharmacotherapies for treating tobacco dependence. Exp. Op. Emerg. Drugs 11, 429-444 (2006). (Pubitemid 44386368)
    • (2006) Expert Opinion on Emerging Drugs , vol.11 , Issue.3 , pp. 429-444
    • Schnoll, R.A.1    Lerman, C.2
  • 12
    • 0024502697 scopus 로고
    • Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis
    • DOI 10.1016/0006-8993(89)91518-7
    • Mifsud JC, Hernandez L, Hoebel BG. Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis. Brain Res. 478, 365-367 (1989). (Pubitemid 19033493)
    • (1989) Brain Research , vol.478 , Issue.2 , pp. 365-367
    • Mifsud, J.-C.1    Hernandez, L.2    Hoebel, B.G.3
  • 13
    • 0031470773 scopus 로고    scopus 로고
    • Nicotine activates and desensitizes midbrain dopamine neurons
    • DOI 10.1038/37120
    • Pidoplichko VI, DeBiasi M, Williams JT, Dani JA. Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390, 401-404 (1997). (Pubitemid 28027320)
    • (1997) Nature , vol.390 , Issue.6658 , pp. 401-404
    • Pidoplichko, V.I.1    DeBiasi, M.2    Wiliams, J.T.3    Dani, J.A.4
  • 14
    • 2542466748 scopus 로고    scopus 로고
    • Nicotine amplifies reward-related dopamine signals in striatum
    • DOI 10.1038/nn1244
    • Rice ME, Cragg SJ. Nicotine amplifies reward-related dopamine signals in striatum. Nat. Neurosci. 7, 583-584 (2004). (Pubitemid 38691894)
    • (2004) Nature Neuroscience , vol.7 , Issue.6 , pp. 583-584
    • Rice, M.E.1    Cragg, S.J.2
  • 15
    • 0141987867 scopus 로고    scopus 로고
    • Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists
    • DOI 10.1016/S0006-8993(03)03532-7
    • Rao TS, Correa LD, Adams P, Santori EM, Sacaan AI. Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists. Brain Res. 990, 203-208 (2003). (Pubitemid 37244076)
    • (2003) Brain Research , vol.990 , Issue.1-2 , pp. 203-208
    • Rao, T.S.1    Correa, L.D.2    Adams, P.3    Santori, E.M.4    Sacaan, A.I.5
  • 16
    • 27644454004 scopus 로고    scopus 로고
    • Is there a common molecular pathway for addiction?
    • DOI 10.1038/nn1578, PII N1578
    • Nestler EJ. Is there a common molecular pathway for addiction? Nat. Neurosci. 8, 1445-1449 (2005). (Pubitemid 41573654)
    • (2005) Nature Neuroscience , vol.8 , Issue.11 , pp. 1445-1449
    • Nestler, E.J.1
  • 17
    • 0041530276 scopus 로고    scopus 로고
    • Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat
    • DOI 10.1007/s00213-003-1445-7
    • Cryan JF, Bruijnzeel AW, Skjei KL, Markou A. Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat. Psychopharmacology (Berl.) 168, 347-358 (2003). (Pubitemid 36920920)
    • (2003) Psychopharmacology , vol.168 , Issue.3 , pp. 347-358
    • Cryan, J.F.1    Bruijnzeel, A.W.2    Skjei, K.L.3    Markou, A.4
  • 18
    • 0032492857 scopus 로고    scopus 로고
    • Dramatic decreases in brain reward function during nicotine withdrawal
    • DOI 10.1038/30001
    • Epping-Jordan MP, Watkins SS, Koob GF, Markou A. Dramatic decreases in brain reward function during nicotine withdrawal. Nature 393, 76-79 (1998). (Pubitemid 28240257)
    • (1998) Nature , vol.393 , Issue.6680 , pp. 76-79
    • Epping-Jordan, M.P.1    Watkins, S.S.2    Koob, G.F.3    Markou, A.4
  • 19
    • 0027471275 scopus 로고
    • Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
    • DOI 10.1016/0165-0173(93)90008-N
    • Kalivas PW, Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res. Rev. 18, 75-113 (1993). (Pubitemid 23090012)
    • (1993) Brain Research Reviews , vol.18 , Issue.1 , pp. 75-113
    • Kalivas, P.W.1
  • 20
    • 0026638085 scopus 로고
    • Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area
    • Sesack SR, Pickel VM. Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J. Comp. Neurol. 320, 145-160 (1992).
    • (1992) J. Comp. Neurol. , vol.320 , pp. 145-160
    • Sesack, S.R.1    Pickel, V.M.2
  • 21
    • 32844473764 scopus 로고    scopus 로고
    • Roles of pedunculopontine tegmental cholinergic receptors in brain stimulation reward in the rat
    • DOI 10.1007/s00213-005-0252-8
    • Chen J, Nakamura M, Kawamura T, Takahashi T, Nakahara D. Roles of pedunculopontine tegmental cholinergic receptors in brain stimulation reward in the rat. Psychopharmacology (Berl.) 184, 514-522 (2006). (Pubitemid 43255868)
    • (2006) Psychopharmacology , vol.184 , Issue.3-4 , pp. 514-522
    • Chen, J.1    Nakamura, M.2    Kawamura, T.3    Takahashi, T.4    Nakahara, D.5
  • 22
    • 0035282788 scopus 로고    scopus 로고
    • Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei
    • Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux JP. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J. Neurosci. 21, 1452-1463 (2001). (Pubitemid 32182187)
    • (2001) Journal of Neuroscience , vol.21 , Issue.5 , pp. 1452-1463
    • Klink, R.1    De Kerchove D'Exaerde, A.2    Zoli, M.3    Changeux, J.-P.4
  • 23
    • 10644254858 scopus 로고    scopus 로고
    • Precise localization of a7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area
    • DOI 10.1523/JNEUROSCI.3009-04.2004
    • Jones IW, Wonnacott S. Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area. J. Neurosci. 24, 11244-11252 (2004). (Pubitemid 39658259)
    • (2004) Journal of Neuroscience , vol.24 , Issue.50 , pp. 11244-11252
    • Jones, I.W.1    Wonnacott, S.2
  • 25
    • 40949099176 scopus 로고    scopus 로고
    • Monoamine oxidase inhibition for tobacco pharmacotherapy
    • DOI 10.1038/sj.clpt.6100474, PII 6100474
    • George TP, Weinberger AH. Monoamine oxidase inhibition for tobacco pharmacotherapy. Clin. Pharm. Ther. 83, 619-621 (2008). (Pubitemid 351417061)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.4 , pp. 619-621
    • George, T.P.1    Weinberger, A.H.2
  • 26
    • 0028934093 scopus 로고
    • Preproenkephalin mRNA and methionine-enkephalin content are increased in mouse striatum after treatment with nicotine
    • Dhatt RK, Gudehithlu KP, Wemlinger TA, Tejwani GA, Neff NH, Hadjiconstantinou M. Preproenkephalin mRNA and methionine-enkephalin content are increased in mouse striatum after treatment with nicotine. J. Neurochem. 64, 1878-1883 (1995).
    • (1995) J. Neurochem. , vol.64 , pp. 1878-1883
    • Dhatt, R.K.1    Gudehithlu, K.P.2    Wemlinger, T.A.3    Tejwani, G.A.4    Neff, N.H.5    Hadjiconstantinou, M.6
  • 27
    • 0025345075 scopus 로고
    • Nicotine protects against opioid receptor antagonism by b-funaltrexamine: Evidence for nicotine-induced release of endogenous opioids in brain
    • DOI 10.1016/0304-3940(90)90491-Q
    • Davenport KE, Houdi AA, Van Loon GR. Nicotine protects against mu-opioid receptor antagonism by beta-funaltrexamine: evidence for nicotine-induced release of endogenous opioids in brain. Neurosci. Lett. 113, 40-46 (1990). (Pubitemid 20175254)
    • (1990) Neuroscience Letters , vol.113 , Issue.1 , pp. 40-46
    • Davenport, K.E.1    Houdi, A.A.2    Van Loon, G.R.3
  • 28
    • 0036069606 scopus 로고    scopus 로고
    • Presynaptic opioid receptors regulate a late step of the secretory process in rat ventral tegmental area GABAergic neurons
    • DOI 10.1016/S0028-3908(02)00061-8, PII S0028390802000618
    • Bergevin A, Girardot D, Bourque MJ, Trudeau LE. Presynaptic mu-opioid receptors regulate a late step of the secretory process in rat ventral tegmental area GABAergic neurons. Neuropharmacology 42, 1065-1078 (2002). (Pubitemid 34786559)
    • (2002) Neuropharmacology , vol.42 , Issue.8 , pp. 1065-1078
    • Bergevin, A.1    Girardot, D.2    Bourque, M.-J.3    Trudeau, L.-E.4
  • 29
    • 48949096850 scopus 로고    scopus 로고
    • Neuroimaging, genetics, and the treatment of nicotine addiction
    • Ray R, Loughead J, Wang Z et al. Neuroimaging, genetics, and the treatment of nicotine addiction. Behav. Brain Res. 193, 156-169 (2008).
    • (2008) Behav. Brain Res. , vol.193 , pp. 156-169
    • Ray, R.1    Loughead, J.2    Wang, Z.3
  • 30
    • 79952115706 scopus 로고    scopus 로고
    • Imaging receptor changes in human drug abusers
    • Cosgrove K. Imaging receptor changes in human drug abusers. Curr. Top. Behav. Neurosci. 3, 199-217 (2010).
    • (2010) Curr. Top. Behav. Neurosci. , vol.3 , pp. 199-217
    • Cosgrove, K.1
  • 32
    • 0037221274 scopus 로고    scopus 로고
    • A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins
    • DOI 10.1046/j.1360-0443.2003.00295.x
    • Li MD, Cheng R, Ma JZ, Swan GE. A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 98, 23-31 (2003). (Pubitemid 36044333)
    • (2003) Addiction , vol.98 , Issue.1 , pp. 23-31
    • Li, M.D.1    Cheng, R.2    Ma, J.Z.3    Swan, G.E.4
  • 33
    • 0033301678 scopus 로고    scopus 로고
    • The genetic epidemiology of smoking
    • Sullivan PF, Kendler KS. The genetic epidemiology of smoking. Nicotine Tob. Res. 1(Suppl. 2), S51-S57 (1999).
    • (1999) Nicotine Tob. Res. , vol.1 , Issue.SUPPL. 2
    • Sullivan, P.F.1    Kendler, K.S.2
  • 34
    • 20544452286 scopus 로고    scopus 로고
    • Heritability of smoking initiation and nicotine dependence
    • DOI 10.1007/s10519-004-1327-8
    • Vink JM, Willemsen G, Boomsma DI. Heritability of smoking initiation and nicotine dependence. Behav. Genet. 35, 397-406 (2005). (Pubitemid 40848169)
    • (2005) Behavior Genetics , vol.35 , Issue.4 , pp. 397-406
    • Vink, J.M.1    Willemsen, G.2    Boomsma, D.I.3
  • 35
    • 33745698081 scopus 로고    scopus 로고
    • Gender differences in determinants of smoking initiation and persistence in California twins
    • Hamilton AS, Lessov-Schlaggar CN, Cockburn MG et al. Gender differences in determinants of smoking initiation and persistence in California twins. Cancer Epidemiol. Biomarkers Prev. 15, 1189-1197 (2006).
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 1189-1197
    • Hamilton, A.S.1    Lessov-Schlaggar, C.N.2    Cockburn, M.G.3
  • 36
    • 0034752826 scopus 로고    scopus 로고
    • Influence of genes and family environment on adult smoking behavior assessed in an adoption study
    • DOI 10.1002/gepi.1028
    • Osler M, Holst C, Prescott E, Sorensen TI. Influence of genes and family environment on adult smoking behavior assessed in an adoption study. Genet. Epidemiol. 21, 193-200 (2001). (Pubitemid 33021273)
    • (2001) Genetic Epidemiology , vol.21 , Issue.3 , pp. 193-200
    • Osler, M.1    Holst, C.2    Prescott, E.3    Sorensen, T.I.A.4
  • 37
    • 33947135417 scopus 로고    scopus 로고
    • Genes, time to first cigarette and nicotine dependence in a general population sample of young adults
    • DOI 10.1111/j.1360-0443.2007.01746.x
    • Haberstick BC, Timberlake D, Ehringer MA et al. Genes, time to first cigarette and nicotine dependence in a general population sample of young adults. Addiction 102, 655-665 (2007). (Pubitemid 46398839)
    • (2007) Addiction , vol.102 , Issue.4 , pp. 655-665
    • Haberstick, B.C.1    Timberlake, D.2    Ehringer, M.A.3    Lessem, J.M.4    Hopfer, C.J.5    Smolen, A.6    Hewitt, J.K.7
  • 40
    • 33749640220 scopus 로고    scopus 로고
    • Genetic correlations between smoking initiation and smoking behaviors in a twin sample
    • DOI 10.1016/j.addbeh.2006.02.010, PII S0306460306000451
    • Hardie TL, Moss HB, Lynch KG. Genetic correlations between smoking initiation and smoking behaviors in a twin sample. Addict. Behav. 31, 2030-2037 (2006). (Pubitemid 44548191)
    • (2006) Addictive Behaviors , vol.31 , Issue.11 , pp. 2030-2037
    • Hardie, T.L.1    Moss, H.B.2    Lynch, K.G.3
  • 41
    • 75749124555 scopus 로고    scopus 로고
    • Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation
    • Wang J, Li MD. Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. Neuropsychopharmacology 35, 702-719 (2010).
    • (2010) Neuropsychopharmacology , vol.35 , pp. 702-719
    • Wang, J.1    Li, M.D.2
  • 42
    • 79951780037 scopus 로고    scopus 로고
    • Nicotine dependence and pharmacogenetics
    • Steptoe A, Freedland KE, Jennings JR, Llabre MM, Manuck SB, Susman EJ (Eds). Springer, New York, NY, USA
    • Ray R, Schnoll R, Lerman C. Nicotine dependence and pharmacogenetics. In: Handbook of Behavioral Medicine. Steptoe A, Freedland KE, Jennings JR, Llabre MM, Manuck SB, Susman EJ (Eds). Springer, New York, NY, USA, 479-498 (2010).
    • (2010) Handbook of Behavioral Medicine , pp. 479-498
    • Ray, R.1    Schnoll, R.2    Lerman, C.3
  • 43
    • 79951694140 scopus 로고    scopus 로고
    • Genetic vulnerability and susceptibility to substance dependence
    • Beirut LJ. Genetic vulnerability and susceptibility to substance dependence. Neuron 69, 618-627 (2011).
    • (2011) Neuron , vol.69 , pp. 618-627
    • Beirut, L.J.1
  • 44
    • 77951748276 scopus 로고    scopus 로고
    • Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
    • Thorgeirsson TE, Gudbjartsson DF, Surakka I et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat. Genet. 42, 448-453 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 448-453
    • Thorgeirsson, T.E.1    Gudbjartsson, D.F.2    Surakka, I.3
  • 45
    • 77951711343 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify multiple loci associated with smoking behavior
    • Tobacco and Genetics (TAG) Consortium
    • Tobacco and Genetics (TAG) Consortium. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat. Genet. 42, 441-447 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 441-447
  • 47
    • 78649627035 scopus 로고    scopus 로고
    • Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans
    • Saccone NL, Schwantes-An TH, Wang JC, Grucza RA, Breslau N, Hatsukami D. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes Brain Behav. 9, 741-750 (2010).
    • (2010) Genes Brain Behav. , vol.9 , pp. 741-750
    • Saccone, N.L.1    Schwantes-An, T.H.2    Wang, J.C.3    Grucza, R.A.4    Breslau, N.5    Hatsukami, D.6
  • 50
    • 47549112072 scopus 로고    scopus 로고
    • Treating Tobacco Use and Dependence: 2008 Update
    • US Department of Health and Human Services, Public Health Service, Rockville, MD, USA
    • Fiore MC, Jaen CR, Baker TB et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. US Department of Health and Human Services, Public Health Service, Rockville, MD, USA (2008).
    • (2008) Clinical Practice Guideline
    • Fiore, M.C.1    Jaen, C.R.2    Baker, T.B.3
  • 52
    • 68649098999 scopus 로고    scopus 로고
    • Nicotine dependence pharmacogenetics: Role of genetic variation in nicotine-metabolizing enzymes
    • Ray R, Tyndale RF, Lerman C. Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes. J. Neurogenetics 23, 252-261 (2009).
    • (2009) J. Neurogenetics , vol.23 , pp. 252-261
    • Ray, R.1    Tyndale, R.F.2    Lerman, C.3
  • 54
    • 0034534428 scopus 로고    scopus 로고
    • The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit
    • DOI 10.1017/S0003480000008265
    • Gu DF, Hinks LJ, Morton NE, Day IN. The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit. Ann. Hum. Genet. 64, 383-390 (2000). (Pubitemid 32055729)
    • (2000) Annals of Human Genetics , vol.64 , Issue.5 , pp. 383-390
    • Gu, D.F.1    Hinks, L.J.2    Morton, N.E.3    Day, I.N.M.4    Day, I.N.M.5
  • 55
    • 33645056468 scopus 로고    scopus 로고
    • CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation
    • Kubota T, Nakajima-Taniguchi C, Fukuda T et al. CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation. Pharmacogenomics J. 6, 115-119 (2006).
    • (2006) Pharmacogenomics J. , vol.6 , pp. 115-119
    • Kubota, T.1    Nakajima-Taniguchi, C.2    Fukuda, T.3
  • 56
    • 33750531834 scopus 로고    scopus 로고
    • CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during Ad libitum smoking
    • DOI 10.1158/1055-9965.EPI-05-0723
    • Malaiyandi V, Goodz SD, Sellers EM, Tyndale RF. CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer Epidemiol. Biomarkers Prev. 15, 1812-1819 (2006). (Pubitemid 44664253)
    • (2006) Cancer Epidemiology Biomarkers and Prevention , vol.15 , Issue.10 , pp. 1812-1819
    • Malaiyandi, V.1    Goodz, S.D.2    Sellers, E.M.3    Tyndale, R.F.4
  • 58
    • 33846328375 scopus 로고    scopus 로고
    • Prediction methods for nicotine clearance using cotinine and 3-hydroxy-cotinine spot saliva samples II. Model application
    • DOI 10.1007/s10928-006-9026-0
    • Levi M, Dempsey DA, Benowitz NL, Sheiner LB. Prediction methods for nicotine clearance using cotinine and 3-hydroxy-cotinine spot saliva samples. II. Model application. J. Pharmacokinet. Pharmacodyn. 34, 23-34 (2007). (Pubitemid 46122546)
    • (2007) Journal of Pharmacokinetics and Pharmacodynamics , vol.34 , Issue.1 , pp. 23-34
    • Levi, M.1    Dempsey, D.A.2    Benowitz, N.L.3    Sheiner, L.B.4
  • 59
    • 33747673619 scopus 로고    scopus 로고
    • Within-subject variation of the salivary 3HC/COT ratio in regular daily smokers: Prospects for estimating CYP2A6 enzyme activity in large-scale surveys of nicotine metabolic rate
    • Lea RA, Dickson S, Benowitz NL. Within-subject variation of the salivary 3HC/COT ratio in regular daily smokers: prospects for estimating CYP2A6 enzyme activity in large-scale surveys of nicotine metabolic rate. J. Anal. Toxicol. 30, 386-389 (2006). (Pubitemid 44274073)
    • (2006) Journal of Analytical Toxicology , vol.30 , Issue.6 , pp. 386-389
    • Lea, R.A.1    Dickson, S.2    Benowitz, N.L.3
  • 62
    • 58549112185 scopus 로고    scopus 로고
    • Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: A validation study
    • Schnoll RA, Patterson F, Wileyto EP et al. Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study. Pharmacol. Biochem. Behav. 92, 6-11 (2009).
    • (2009) Pharmacol. Biochem. Behav. , vol.92 , pp. 6-11
    • Schnoll, R.A.1    Patterson, F.2    Wileyto, E.P.3
  • 64
    • 70350123751 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch
    • Perkins KA, Lerman C, Mercincavage M, Fonte CA, Briski JL. Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch. Cancer Epidemiol. Biomarkers Prev. 18, 2608-2612 (2009).
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 2608-2612
    • Perkins, K.A.1    Lerman, C.2    Mercincavage, M.3    Fonte, C.A.4    Briski, J.L.5
  • 65
    • 77951110826 scopus 로고    scopus 로고
    • Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence
    • Ray R, Mitra N, Baldwin D et al. Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence. Neuropsychopharmacology 35, 1374-1382 (2010).
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1374-1382
    • Ray, R.1    Mitra, N.2    Baldwin, D.3
  • 69
    • 65549147309 scopus 로고    scopus 로고
    • Lack of association of DRD2 rs1800497 (Taq1A) polymorphism with smoking cessation in a nicotine replacement therapy randomized trial
    • Munafo MR, Johnstone EC, Murphy MF, Aveyard P. Lack of association of DRD2 rs1800497 (Taq1A) polymorphism with smoking cessation in a nicotine replacement therapy randomized trial. Nicotine Tob. Res. 11, 404-407 (2009).
    • (2009) Nicotine Tob. Res. , vol.11 , pp. 404-407
    • Munafo, M.R.1    Johnstone, E.C.2    Murphy, M.F.3    Aveyard, P.4
  • 70
    • 0030933979 scopus 로고    scopus 로고
    • A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia
    • DOI 10.1093/hmg/6.4.577
    • Arinami T, Gao M, Hamaguchi H et al. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum. Mol. Genet. 6, 577-582 (1997). (Pubitemid 27142107)
    • (1997) Human Molecular Genetics , vol.6 , Issue.4 , pp. 577-582
    • Arinami, T.1    Gao, M.2    Hamaguchi, H.3    Toru, M.4
  • 73
    • 33744524335 scopus 로고    scopus 로고
    • Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence
    • DOI 10.1038/sj.tpj.6500358, PII 6500358
    • Dahl JP, Jepson C, Levenson R et al. Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence. Pharmacogenomics J. 6, 194-199 (2006). (Pubitemid 43811571)
    • (2006) Pharmacogenomics Journal , vol.6 , Issue.3 , pp. 194-199
    • Dahl, J.P.1    Jepson, C.2    Levenson, R.3    Wileyto, E.P.4    Patterson, F.5    Berrettini, W.H.6    Lerman, C.7
  • 74
    • 40949133385 scopus 로고    scopus 로고
    • Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: Follow-up of a randomised clinical trial of transdermal nicotine patch
    • DOI 10.1038/sj.tpj.6500447, PII 6500447
    • David SP, Munafo MR, Murphy MF, Proctor M, Walton RT, Johnstone EC. Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation. follow-up of a randomised clinical trial of transdermal nicotine patch. Pharmacogenomics J. 8, 122-128 (2008). (Pubitemid 351411548)
    • (2008) Pharmacogenomics Journal , vol.8 , Issue.2 , pp. 122-128
    • David, S.P.1    Munafo, M.R.2    Murphy, M.F.G.3    Proctor, M.4    Walton, R.T.5    Johnstone, E.C.6
  • 76
    • 0026651968 scopus 로고
    • Multiple dopamine D4 receptor variants in the human population
    • Van Tol HH, Wu CM, Guan HC et al. Multiple dopamine D4 receptor variants in the human population. Nature 358, 149-152 (1992).
    • (1992) Nature , vol.358 , pp. 149-152
    • Van Tol, H.H.1    Wu, C.M.2    Guan, H.C.3
  • 78
    • 0036260343 scopus 로고    scopus 로고
    • No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation
    • DOI 10.1097/00008571-200204000-00011
    • David SP, Johnstone E, Griffiths SE et al. No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation. Pharmacogenetics 12, 265-268 (2002). (Pubitemid 34596791)
    • (2002) Pharmacogenetics , vol.12 , Issue.3 , pp. 265-268
    • David, S.P.1    Johnstone, E.2    Griffiths, S.-E.3    Murphy, M.4    Yudkin, P.5    Mant, D.6    Walton, R.7
  • 82
    • 79957897495 scopus 로고    scopus 로고
    • Pharmacogenetics of smoking cessation in general practice: Results from the Patch II and Patch in Practice trials
    • David SP, Johnstone EC, Churchman M, Aveyard P, Murphy MF, Munafo MR. Pharmacogenetics of smoking cessation in general practice: results from the Patch II and Patch in Practice trials. Nicotine Tob. Res. 13, 157-167 (2011).
    • (2011) Nicotine Tob. Res. , vol.13 , pp. 157-167
    • David, S.P.1    Johnstone, E.C.2    Churchman, M.3    Aveyard, P.4    Murphy, M.F.5    Munafo, M.R.6
  • 83
    • 25444491710 scopus 로고    scopus 로고
    • Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G
    • DOI 10.1074/jbc.M504942200
    • Zhang Y, Wang D, Johnson AD et al. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J. Biol. Chem. 280, 32618-32624 (2005). (Pubitemid 41368304)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.38 , pp. 32618-32624
    • Zhang, Y.1    Wang, D.2    Johnson, A.D.3    Papp, A.C.4    Sadee, W.5
  • 84
    • 79959351336 scopus 로고    scopus 로고
    • Human mu opioid receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers
    • Ray R, Ruparel K, Newberg A et al. Human mu opioid receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers. Proc. Natl Acad. Sci. 108, 9268-9273 (2011).
    • (2011) Proc. Natl Acad. Sci. , vol.108 , pp. 9268-9273
    • Ray, R.1    Ruparel, K.2    Newberg, A.3
  • 87
    • 82755188058 scopus 로고    scopus 로고
    • Genetic variation in mu opioid receptor interacting proteins and smoking cessation in a nicotine replacement therapy trial
    • Orlando, FL, USA, 15-18 February
    • Ray R, Jepson C, Wileyto EP et al. Genetic variation in mu opioid receptor interacting proteins and smoking cessation in a nicotine replacement therapy trial. Presented at: Society for Research on Nicotine and Tobacco Annual Meeting. Orlando, FL, USA, 15-18 February, 2006.
    • (2006) Society for Research on Nicotine and Tobacco Annual Meeting
    • Ray, R.1    Jepson, C.2    Wileyto, E.P.3
  • 89
    • 34047205168 scopus 로고    scopus 로고
    • The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: Follow-up of a randomized controlled trial
    • DOI 10.1080/14622200601078566, PII 770730321
    • David SP, Munafo MR, Murphy MF, Walton RT, Johnstone EC. The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial. Nicotine Tob. Res. 9, 225-231 (2007). (Pubitemid 47009068)
    • (2007) Nicotine and Tobacco Research , vol.9 , Issue.2 , pp. 225-231
    • David, S.P.1    Munafo2    , M.R.3    Murphy, M.F.G.4    Walton, R.T.5    Johnstone, E.C.6
  • 90
    • 50249169818 scopus 로고    scopus 로고
    • Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: New data from the Patch in Practice trial and pooled analyses
    • David SP, Johnstone EC, Murphy MF et al. Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. Drug Alcohol Depend. 98, 77-85 (2008).
    • (2008) Drug Alcohol Depend. , vol.98 , pp. 77-85
    • David, S.P.1    Johnstone, E.C.2    Murphy, M.F.3
  • 91
    • 24944456314 scopus 로고    scopus 로고
    • How does bupropion work as a smoking cessation aid?
    • DOI 10.1080/13556210500222670
    • Warner C, Shoaib M. How does bupropion work as a smoking cessation aid? Addict. Biol. 10, 219-231 (2005). (Pubitemid 41306325)
    • (2005) Addiction Biology , vol.10 , Issue.3 , pp. 219-231
    • Warner, C.1    Shoaib, M.2
  • 93
    • 48949107504 scopus 로고    scopus 로고
    • Toward personalized therapy for smoking cessation: A randomized placebo-controlled trial of bupropion
    • Patterson F, Schnoll R, Wileyto E et al. Toward personalized therapy for smoking cessation: a randomized placebo-controlled trial of bupropion. Clin. Pharmacol. Ther. 84, 320-325 (2008).
    • (2008) Clin. Pharmacol. Ther. , vol.84 , pp. 320-325
    • Patterson, F.1    Schnoll, R.2    Wileyto, E.3
  • 97
    • 1942531624 scopus 로고    scopus 로고
    • Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes
    • DOI 10.1097/00008571-200404000-00002
    • Hesse L, He P, Krishnaswamy S et al. Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes. Pharmacogenetics 14, 225-238 (2004). (Pubitemid 38530514)
    • (2004) Pharmacogenetics , vol.14 , Issue.4 , pp. 225-238
    • Hesse, L.M.1    He, P.2    Krishnaswamy, S.3    Hao, Q.4    Hogan, K.5    Von Moltke, L.L.6    Greenblatt, D.J.7    Court, M.H.8
  • 98
    • 50849143769 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation
    • Conti DV, Lee W, Li D et al. Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Hum. Mol. Genet. 17, 2834-2848 (2008).
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2834-2848
    • Conti, D.V.1    Lee, W.2    Li, D.3
  • 102
    • 34248594556 scopus 로고    scopus 로고
    • Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR
    • DOI 10.1037/0278-6133.26.3.361
    • Swan GE, Jack LM, Valdes AM et al. Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR. Health Psychol. 26, 361-368 (2007). (Pubitemid 46763197)
    • (2007) Health Psychology , vol.26 , Issue.3 , pp. 361-368
    • Swan, G.E.1    Jack, L.M.2    Valdes, A.M.3    Ring, H.Z.4    Ton, C.C.5    Curry, S.J.6    McAfee, T.7
  • 103
    • 33846564325 scopus 로고    scopus 로고
    • Dopamine transporter polymorphisms are associated with short-term response to smoking cessation treatment
    • DOI 10.1097/01.fpc.0000236328.18928.4c, PII 0121301120070100000006
    • O'Gara C, Stapleton J, Sutherland G et al. Dopamine transporter polymorphisms are associated with short-term response to smoking cessation treatment. Pharmacogenet. Genomics 17, 61-67 (2007). (Pubitemid 46183792)
    • (2007) Pharmacogenetics and Genomics , vol.17 , Issue.1 , pp. 61-67
    • O'Gara, C.1    Stapleton, J.2    Sutherland, G.3    Guindalini, C.4    Neale, B.5    Breen, G.6    Ball, D.7
  • 104
    • 84856229702 scopus 로고    scopus 로고
    • Dopamine D4 receptor gene variation moderates the efficacy of bupropion for smoking cessation
    • doi:10.1038/tpj.2010.64 Epub ahead of print
    • Leventhal AM, David SP, Brightman M et al. Dopamine D4 receptor gene variation moderates the efficacy of bupropion for smoking cessation. Pharmacogenomics J. doi:10.1038/tpj.2010.64 (2010) (Epub ahead of print).
    • (2010) Pharmacogenomics J.
    • Leventhal, A.M.1    David, S.P.2    Brightman, M.3
  • 105
  • 106
    • 33745614361 scopus 로고    scopus 로고
    • Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: A randomized controlled trial
    • Gonzales D, Rennard S, Nides M et al. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA 296, 47-55 (2006).
    • (2006) JAMA , vol.296 , pp. 47-55
    • Gonzales, D.1    Rennard, S.2    Nides, M.3
  • 107
    • 33745611449 scopus 로고    scopus 로고
    • Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs. placebo or sustained-release bupropion for smoking cessation: A randomized controlled trial
    • Jorenby DE, Hays JT, Rigotti N et al. Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs. placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial. JAMA 296, 56-63 (2006).
    • (2006) JAMA , vol.296 , pp. 56-63
    • Jorenby, D.E.1    Hays, J.T.2    Rigotti, N.3
  • 108
    • 44049095832 scopus 로고    scopus 로고
    • Varenicline versus transdermal nicotine patch for smoking cessation: Results from a randomised, open-label trial
    • Aubin HJ, Bobak A, Britton JR et al. Varenicline versus transdermal nicotine patch for smoking cessation: results from a randomised, open-label trial. Thorax 63, 717-724 (2008).
    • (2008) Thorax , vol.63 , pp. 717-724
    • Aubin, H.J.1    Bobak, A.2    Britton, J.R.3
  • 109
    • 77955232914 scopus 로고    scopus 로고
    • Characteristics and abstinence outcomes among tobacco quitline enrollees using varenicline or nicotine replacement therapy
    • Biazzo LL, Froshaug DB, Harwell TS et al. Characteristics and abstinence outcomes among tobacco quitline enrollees using varenicline or nicotine replacement therapy. Nicotine Tob. Res. 12, 567-573 (2010).
    • (2010) Nicotine Tob. Res. , vol.12 , pp. 567-573
    • Biazzo, L.L.1    Froshaug, D.B.2    Harwell, T.S.3
  • 110
    • 36849027596 scopus 로고    scopus 로고
    • Varenicline in the routine treatment of tobacco dependence: A pre-post comparison with nicotine replacement therapy and an evaluation in those with mental illness
    • DOI 10.1111/j.1360-0443.2007.02083.x
    • Stapleton JA, Watson L, Spirling LI et al. Varenicline in the routine treatment of tobacco dependence: a pre-post comparison with nicotine replacement therapy and an evaluation in those with mental illness. Addiction 103, 146-154 (2008). (Pubitemid 350233424)
    • (2008) Addiction , vol.103 , Issue.1 , pp. 146-154
    • Stapleton, J.A.1    Watson, L.2    Spirling, L.I.3    Smith, R.4    Milbrandt, A.5    Ratcliffe, M.6    Sutherland, G.7
  • 112
    • 68349128648 scopus 로고    scopus 로고
    • Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition
    • Rollema H, Hajos M, Seymour PA et al. Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition. Biochem. Pharmacol. 78, 813-824 (2009).
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 813-824
    • Rollema, H.1    Hajos, M.2    Seymour, P.A.3
  • 113
    • 57849159726 scopus 로고    scopus 로고
    • Varenicline improves mood and cognition during smoking abstinence
    • Patterson F, Jepson C, Strasser AA et al. Varenicline improves mood and cognition during smoking abstinence. Biol. Psychiatry 65, 144-149 (2009).
    • (2009) Biol. Psychiatry , vol.65 , pp. 144-149
    • Patterson, F.1    Jepson, C.2    Strasser, A.A.3
  • 115
    • 64749107050 scopus 로고    scopus 로고
    • Cognitive and antismoking effects of varenicline in patients with schizophrenia or schizoaffective disorder
    • Smith RC, Lindenmayer JP, Davis JM et al. Cognitive and antismoking effects of varenicline in patients with schizophrenia or schizoaffective disorder. Schizophr. Res. 110, 149-155 (2009).
    • (2009) Schizophr. Res. , vol.110 , pp. 149-155
    • Smith, R.C.1    Lindenmayer, J.P.2    Davis, J.M.3
  • 116
    • 70350303874 scopus 로고    scopus 로고
    • Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans
    • Sofuoglu M, Herman AI, Mooney M, Waters AJ. Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans. Psychopharmacology (Berl.) 207, 153-162 (2009).
    • (2009) Psychopharmacology (Berl.) , vol.207 , pp. 153-162
    • Sofuoglu, M.1    Herman, A.I.2    Mooney, M.3    Waters, A.J.4
  • 117
    • 79951790058 scopus 로고    scopus 로고
    • Physician barriers to incorporating pharmacogenetic treatment strategies for nicotine dependence into clinical practice
    • Schnoll RA, Shields AE. Physician barriers to incorporating pharmacogenetic treatment strategies for nicotine dependence into clinical practice. Clin. Pharmacol. Ther. 89, 345-347 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 345-347
    • Schnoll, R.A.1    Shields, A.E.2
  • 118
    • 77956716688 scopus 로고
    • Preventing Tobacco Use among Young People
    • US Department of Health and Human Services USDHHS, CDC, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta, GA, USA
    • US Department of Health and Human Services. Preventing Tobacco Use Among Young People. A Report of the Surgeon General. USDHHS, CDC, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta, GA, USA (1994).
    • (1994) A Report of the Surgeon General
  • 120
    • 0026720490 scopus 로고
    • Smokers who are hospitalized: A window of opportunity for cessation interventions
    • Emmons KM, Goldstein MG. Smokers who are hospitalized: a window of opportunity for cessation interventions. Prev. Med. 21, 262-269 (1992).
    • (1992) Prev. Med. , vol.21 , pp. 262-269
    • Emmons, K.M.1    Goldstein, M.G.2
  • 122
    • 18044390149 scopus 로고    scopus 로고
    • Barriers to translating emerging genetic research on smoking into clinical practice: Perspectives of primary care physicians
    • DOI 10.1111/j.1525-1497.2005.30429.x
    • Shields AE, Blumenthal D, Weiss KB, Comstock CB, Currivan D, Lerman C. Barriers to translating emerging genetic research on smoking into clinical practice: Perspectives of primary care physicians. J. Gen. Intern. Med. 20, 131-138 (2005). (Pubitemid 40626990)
    • (2005) Journal of General Internal Medicine , vol.20 , Issue.2 , pp. 131-138
    • Shields, A.E.1    Blumenthal, D.2    Weiss, K.B.3    Comstock, C.B.4    Currivan, D.5    Lerman, C.6
  • 124
    • 40949124834 scopus 로고    scopus 로고
    • Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: Are primary care physicians ready?
    • DOI 10.1038/clpt.2008.4, PII CLPT20084
    • Shields AE, Lerman C. Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: are primary care physicians ready? Clin. Pharmacol. Therap. 83, 635-639 (2008). (Pubitemid 351417077)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.4 , pp. 635-639
    • Shields, A.E.1    Lerman, C.2
  • 125
    • 37349110352 scopus 로고    scopus 로고
    • Primary care physicians' concerns about offering a genetic test to tailor smoking cessation treatment
    • DOI 10.1097/GIM.0b013e31815bf953, PII 0012581720071200000007
    • Levy DE, Youatt EJ, Shields AE. Primary care physicians' concerns about offering a genetic test to tailor smoking cessation treatment. Genet. Med. 9, 842-849 (2007). (Pubitemid 350295212)
    • (2007) Genetics in Medicine , vol.9 , Issue.12 , pp. 842-849
    • Levy, D.E.1    Youatt, E.J.2    Shields, A.E.3


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