VEGF protects rat cortical neurons from mechanical trauma injury induced apoptosis via the MEK/ERK pathway

Brain Research Bulletin

Volumn 86, Issue 5-6, 2011, Pages 441-446

  Ma, Yihui ^a   Liu, Wenbo ^a   Wang, Yuan ^a   Chao, Xiaodong ^a   Qu, Yan ^a   Wang, Kai ^a   Fei, Zhou ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

ERK; Neuron; Neuroprotection; Traumatic brain injury; VEGF

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CASPASE 3; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; VASCULOTROPIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BRAIN INJURIES; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEURONS; RATS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 82755193685     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2011.07.007     Document Type: Article

References (38)

1. Carey R.G., Li B., DiCicco-Bloom E. Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity. J. Neurosci. 2002, 22:1583-1591.
2. Chodobski A., Chung I., Kozniewska E., Ivanenko T., Chang W., Harrington J.F., Duncan J.A., Szmydynger-Chodobska J. Early neutrophilic expression of vascular endothelial growth factor after traumatic brain injury. Neuroscience 2003, 122:853-867.
3. Chong Z.Z., Kang J.Q., Maiese K. Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br. J. Pharmacol. 2003, 138:1107-1118.
4. Citron B.A., Zhang S.X., Smirnova I.V., Festoff B.W. Apoptotic, injury-induced cell death in cultured mouse murine motor neurons. Neurosci. Lett. 1997, 230:25-28.
5. Dressler J., Hanisch U., Kuhlisch E., Geiger K.D. Neuronal and glial apoptosis in human traumatic brain injury. Int. J. Legal Med. 2007, 121:365-375.
6. Jiang Q., Gu Z., Zhang G., Jing G. Diphosphorylation and involvement of extracellular signal-regulated kinases (ERK1/2) in glutamate-induced apoptotic-like death in cultured rat cortical neurons. Brain Res. 2000, 857:71-77.
7. Jin K., Mao X.O., Batteur S.P., McEachron E., Leahy A., Greenberg D.A. Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor. Neuroscience 2001, 108:351-358.
8. Jin K.L., Mao X.O., Greenberg D.A. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:10242-10247.
9. Keane R.W., Kraydieh S., Lotocki G., Alonso O.F., Aldana P., Dietrich W.D. Apoptotic and antiapoptotic mechanisms after traumatic brain injury. J. Cereb. Blood Flow Metab. 2001, 21:1189-1198.
10. Kim D.H., Ko I.G., Kim B.K., Kim T.W., Kim S.E., Shin M.S., Kim C.J., Kim H., Kim K.M., Baek S.S. Treadmill exercise inhibits traumatic brain injury-induced hippocampal apoptosis. Physiol. Behav. 2010, 101:660-665.
11. Koh J.Y., Choi D.W. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods 1987, 20:83-90.
12. Lau A., Arundine M., Sun H.S., Jones M., Tymianski M. Inhibition of caspase-mediated apoptosis by peroxynitrite in traumatic brain injury. J. Neurosci. 2006, 26:11540-11553.
13. Lee C., Agoston D.V. Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injury. Exp. Neurol. 2009, 220:400-403.
14. Lee C., Agoston D.V. Vascular endothelial growth factor is involved in mediating increased de novo hippocampal neurogenesis in response to traumatic brain injury. J. Neurotrauma 2010, 27:541-553.
15. Lee H.T., Chang Y.C., Tu Y.F., Huang C.C. CREB activation mediates VEGF-A's protection of neurons and cerebral vascular endothelial cells. J. Neurochem. 2010, 113:79-91.
16. Lin J., Li G., Den X., Xu C., Liu S., Gao Y., Liu H., Zhang J., Li X., Liang S. VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X(/) receptor of primary sensory neurons. Brain Res. Bull. 2010, 83:284-291.
17. Lu K.T., Sun C.L., Wo P.Y., Yen H.H., Tang T.H., Ng M.C., Huang M.L., Yang Y.L. Hippocampal Neurogenesis after traumatic brain injury is mediated by vascular endothelial growth factor receptor-2 and the Raf/MEK/ERK cascade. J. Neurotrauma 2011.
18. Lu K.T., Wang Y.W., Wo Y.Y., Yang Y.L. Extracellular signal-regulated kinase-mediated IL-1-induced cortical neuron damage during traumatic brain injury. Neurosci. Lett. 2005, 386:40-45.
19. Lu Y.P., Liu S.Y., Sun H., Wu X.M., Li J.J., Zhu L. Neuroprotective effect of astaxanthin on H(2)O(2)-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo. Brain Res. 2010, 1360:40-48.
20. Ma Y., Qu Y., Fei Z. Vascular endothelial growth factor in cerebral ischemia. J. Neurosci. Res. 2011, 89:969-978.
21. Matsuzaki H., Tamatani M., Yamaguchi A., Namikawa K., Kiyama H., Vitek M.P., Mitsuda N., Tohyama M. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J. 2001, 15:1218-1220.
22. Mori T., Wang X., Jung J.C., Sumii T., Singhal A.B., Fini M.E., Dixon C.E., Alessandrini A., Lo E.H. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J. Cereb. Blood Flow Metab. 2002, 22:444-452.
23. Park E.M., Cho S. Enhanced ERK dependent CREB activation reduces apoptosis in staurosporine-treated human neuroblastoma SK-N-BE(2)C cells. Neurosci. Lett. 2006, 402:190-194.
24. Park E.M., Joh T.H., Volpe B.T., Chu C.K., Song G., Cho S. A neuroprotective role of extracellular signal-regulated kinase in N-acetyl-O-methyldopamine-treated hippocampal neurons after exposure to in vitro and in vivo ischemia. Neuroscience 2004, 123:147-154.
25. Patel N.Y., Hoyt D.B., Nakaji P., Marshall L., Holbrook T., Coimbra R., Winchell R.J., Mikulaschek A.W. Traumatic brain injury: patterns of failure of nonoperative management. J. Trauma 2000, 48:367-374. discussion 374-365.
26. Payette D.J., Xie J., Shirwany N., Guo Q. Exacerbation of apoptosis of cortical neurons following traumatic brain injury in par-4 transgenic mice. Int. J. Clin. Exp. Pathol. 2008, 1:44-56.
27. Shiote M., Nagano I., Ilieva H., Murakami T., Narai H., Ohta Y., Nagata T., Shoji M., Abe K. Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia. Neuroscience 2005, 132:175-182.
28. Skold M.K., Risling M., Holmin S. Inhibition of vascular endothelial growth factor receptor 2 activity in experimental brain contusions aggravates injury outcome and leads to early increased neuronal and glial degeneration. Eur. J. Neurosci. 2006, 23:21-34.
29. Skold M.K., von Gertten C., Sandberg-Nordqvist A.C., Mathiesen T., Holmin S. VEGF and VEGF receptor expression after experimental brain contusion in rat. J. Neurotrauma 2005, 22:353-367.
30. Sun Y., Jin K., Xie L., Childs J., Mao X.O., Logvinova A., Greenberg D.A. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 2003, 111:1843-1851.
31. Sundberg L.M., Herrera J.J., Narayana P.A. Effect of vascular endothelial growth factor treatment in experimental traumatic spinal cord injury: in vivo longitudinal assessment. J. Neurotrauma 2011, 28:565-578.
32. Svensson B., Peters M., Konig H.G., Poppe M., Levkau B., Rothermundt M., Arolt V., Kogel D., Prehn J.H. Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism. J. Cereb. Blood Flow Metab. 2002, 22:1170-1175.
33. Thau-Zuchman O., Shohami E., Alexandrovich A.G., Leker R.R. Vascular endothelial growth factor increases neurogenesis after traumatic brain injury. J. Cereb. Blood Flow Metab. 2010, 30:1008-1016.
34. Tolosa L., Mir M., Asensio V.J., Olmos G., Llado J. Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase. J. Neurochem. 2008, 105:1080-1090.
35. Tolosa L., Mir M., Olmos G., Llado J. Vascular endothelial growth factor protects motoneurons from serum deprivation-induced cell death through phosphatidylinositol 3-kinase-mediated p38 mitogen-activated protein kinase inhibition. Neuroscience 2009, 158:1348-1355.
36. Wang X., Mori T., Jung J.C., Fini M.E., Lo E.H. Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J. Neurotrauma 2002, 19:615-625.
37. Xia Y., Wang C.Z., Liu J., Anastasio N.C., Johnson K.M. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology 2010, 58:330-336.
38. Zheng X.R., Zhang S.S., Yang Y.J., Yin F., Wang X., Zhong L., Yu X.H. Adenoviral vector-mediated transduction of VEGF improves neural functional recovery after hypoxia-ischemic brain damage in neonatal rats. Brain Res. Bull. 2010, 81:372-377.