Activation of GABAA or 5HT1A receptors in the raphé pallidus abolish the cardiovascular responses to exogenous stress in conscious rats

Brain Research Bulletin

Volumn 86, Issue 5-6, 2011, Pages 360-366

  Pham Le, Nhut Minh ^a   Cockburn, Chelsea ^a   Nowell, Katherine ^a   Brown, Justin ^a  

^a JAMES MADISON UNIVERSITY   (United States)

Author keywords

5HT1A; Blood pressure; Heart rate; Raph pallidus; Serotonin; Sudden Infant Death Syndrome (SIDS)

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 AMINOBUTYRIC ACID A RECEPTOR; MUSCIMOL; SEROTONIN 1A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MONITORING; CARDIOVASCULAR RESPONSE; CEREBROSPINAL FLUID; CONTROLLED STUDY; HEART RATE; IMMOBILIZATION STRESS; MALE; MENTAL STRESS; NONHUMAN; NUCLEUS RAPHE PALLIDUS; PHYSICAL STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRESS; TELEMETRY; ANIMAL; BLOOD PRESSURE; DRUG EFFECT; HISTOLOGY; METABOLISM; METHODOLOGY; MICROINJECTION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; RANDOMIZATION; RAPHE NUCLEUS; SPRAGUE DAWLEY RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BLOOD PRESSURE; GABA-A RECEPTOR AGONISTS; HEART RATE; MALE; MICROINJECTIONS; MUSCIMOL; RANDOM ALLOCATION; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, GABA-A; SEROTONIN; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL; TELEMETRY;

EID: 82755189301     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2011.09.018     Document Type: Article

References (38)

1. Broadbelt K.G., Paterson D.S., Rivera K.D., Trachtenberg F.L., Kinney H.C. Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medulla. Autonomic Neuroscience: Basic & Clinical 2010, 154(1-2):30-41.
2. Brown J.W., Sirlin E.A., Benoit A.M., Hoffman J.M., Darnall R.A. Activation of 5-HT1A receptors in medullary raphe disrupts sleep and decreases shivering during cooling in the conscious piglet. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2008, 294(3):R884-R894.
3. Cao W.H., Morrison S.F. Disinhibition of rostral raphe pallidus neurons increases cardiac sympathetic nerve activity and heart rate. Brain Research 2003, 980(1):1-10.
4. Clement M.E., McCall R.B. Studies on the site and mechanism of the sympatholytic action of 8-OH DPAT. Brain Research 1990, 525(2):232-241.
5. Coleman M.J., Dampney R.A. Powerful depressor and sympathoinhibitory effects evoked from neurons in the caudal raphe pallidus and obscurus. The American Journal of Physiology 1995, 268(5 Pt 2):R1295-R1302.
6. The Biochemical Basis of Neuropharmacology 2003, Oxford University Press. 8th ed. J.R. Cooper, F.E. Bloom, R. Roth (Eds.).
7. Di Francesco G.F., Petty M.A., Fozard J.R. Antihypertensive effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in conscious dogs. European Journal of Pharmacology 1988, 147(2):287-290.
8. DiMicco J.A., Sarkar S., Zaretskaia M.V., Zaretsky D.V. Stress-induced cardiac stimulation and fever: common hypothalamic origins and brainstem mechanisms. Autonomic Neuroscience: Basic & Clinical 2006, 126-127:106-119.
9. Fozard J.R., Mir A.K., Middlemiss D.N. Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis. Journal of Cardiovascular Pharmacology 1987, 9(3):328-347.
10. Gradin K., Pettersson A., Hedner T., Persson B. Acute administration of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT-receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat and in the spontaneously hypertensive rat. Journal of Neural Transmission 1985, 62(3-4):305-319.
11. Gross C., Santarelli L., Brunner D., Zhuang X., Hen R. Altered fear circuits in 5-HT(1A) receptor KO mice. Biological Psychiatry 2000, 48(12):1157-1163.
12. Helke C.J., Capuano S., Tran N., Zhuo H. Immunocytochemical studies of the 5-HT(1A) receptor in ventral medullaryneurons that project to the intermediolateral cell column and contain serotonin or tyrosine hydroxylase immunoreactivity. The Journal of Comparative Neurology 1997, 379(2):261-270.
13. Hof R.P., Fozard J.R. 8-OH-DPAT, flesinoxan and guanfacine: systemic and regional haemodynamic effects of centrally acting antihypertensive agents in anaesthetized rabbits. British Journal of Pharmacology 1989, 96(4):864-871.
14. Horiuchi J., McDowall L.M., Dampney R.A. Role of 5-HT(1A) receptors in the lower brainstem on the cardiovascular response to dorsomedial hypothalamus activation. Autonomic Neuroscience: Basic & Clinical 2008, 142(1-2):71-76.
15. Horiuchi J., Wakabayashi S., Dampney R.A. Activation of 5-hydroxytryptamine 1A receptors suppresses the cardiovascular response evoked from the dorsomedial hypothalamic nucleus. Hypertension 2005, 46(1):173-179.
16. Kolbasa K.P., McCall R.B., Ludens J.H. Effect of chronic treatment on the cardiovascular and behavioral responses of 8-OH-DPAT in conscious normotensive rats. European Journal of Pharmacology 1991, 193(3):275-281.
17. Lovick T.A. Systemic and regional haemodynamic responses to microinjection of 5-HT agonists in the rostral ventrolateral medulla in the rat. Neuroscience Letters 1989, 107(1-3):157-161.
18. Lovick T.A. The medullary raphe nuclei: a system for integration and gain control in autonomic and somatomotor responsiveness?. Experimental Physiology 1997, 82(1):31-41.
19. Lundberg J., Borg J., Halldin C., Farde L. A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain. Psychopharmacology 2007, 195(3):425-433.
20. McAllen R.M., May C.N., Shafton A.D. Functional anatomy of sympathetic premotor cell groups in the medulla. Clinical and Experimental Hypertension (New York, N.Y.: 1993) 1995, 17(1-2):209-221.
21. McCall R.B., Clement M.E., Harris L.T. Studies on the mechanism of the sympatholytic effect of 8-OH DPAT: lack of correlation between inhibition of serotonin neuronal firing and sympathetic activity. Brain Research 1989, 501(1):73-83.
22. McNay E.C., Sherwin R.S. From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements. Journal of Neuroscience Methods 2004, 132(1):35-43.
23. Morrison S.F. Activation of 5-HT1A receptors in raphe pallidus inhibits leptin-evoked increases in brown adipose tissue thermogenesis. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2004, 286(5):R832-R837.
24. Morrison S.F., Sved A.F., Passerin A.M. GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. The American Journal of Physiology 1999, 276(2 Pt 2):R290-R297.
25. Nakamura K., Matsumura K., Hubschle T., Nakamura Y., Hioki H., Fujiyama F., Boldogköi Z., König M., Thiel H.J., Gerstberger R., Kobayashi S., Kaneko T. Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2004, 24(23):5370-5380.
26. Nakamura K., Matsumura K., Kobayashi S., Kaneko T. Sympathetic premotor neurons mediating thermoregulatory functions. Neuroscience Research 2005, 51(1):1-8.
27. Nakamura K., Morrison S.F. Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2007, 292(1):R127-R136.
28. Nalivaiko E., Ootsuka Y., Blessing W.W. Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2005, 289(2):R596-R604.
29. Nosjean A., Guyenet P.G. Role of ventrolateral medulla in sympatholytic effect of 8-OHDPAT in rats. The American Journal of Physiology 1991, 260(3 Pt 2):R600-R609.
30. Osborn J.W. Hypothesis: set-points and long-term control of arterial pressure. A theoretical argument for a long-term arterial pressure control system in the brain rather than the kidney. Clinical and Experimental Pharmacology & Physiology 2005, 32(5-6):384-393.
31. Paterson D.S., Trachtenberg F.L., Thompson E.G., Belliveau R.A., Beggs A.H., Darnall R., Chadwick A.E., Krous H.F., Kinney H.C. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. The Journal of the American Medical Association 2006, 296(17):2124-2132.
32. Pattij T., Groenink L., Hijzen T.H., Oosting R.S., Maes R.A., van der Gugten J., Olivier B. Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 2002, 27(3):380-390.
33. The rat brain in stereotaxic coordinates 1998, Academic Press, New York. 8th ed. G. Paxinos, C. Watson (Eds.).
34. Rodriguez-Pallares J., Caruncho H.J., Lopez-Real A., Wojcik S., Guerra M.J., Labandeira-Garcia J.L. Rat brain cholinergic, dopaminergic, noradrenergic and serotonergic neurons express GABAA receptors derived from the alpha3 subunit. Receptors & Channels 2001, 7(6):471-478.
35. Stornetta R.L., Rosin D.L., Simmons J.R., McQuiston T.J., Vujovic N., Weston M.C., Guyenet P.G. Coexpression of vesicular glutamate transporter-3 and gamma-aminobutyric acidergic markers in rat rostral medullary raphe and intermediolateral cell column. The Journal of Comparative Neurology 2005, 492(4):477-494.
36. Tada M., Kakita A., Toyoshima Y., Onodera O., Ozawa T., Morita T., Nishizawa M., Takahashi H. Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death. Brain: A Journal of Neurology 2009, 132(Pt 7):1810L 1819.
37. van den Buuse M., Wegener N. Involvement of serotonin1A receptors in cardiovascular responses to stress: a radio-telemetry study in four rat strains. European Journal of Pharmacology 2005, 507(1-3):187-198.
38. Vianna D.M., Allen C., Carrive P. Cardiovascular and behavioral responses to conditioned fear after medullary raphe neuronal blockade. Neuroscience 2008, 153(4):1344-1353.