Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats

Journal of Steroid Biochemistry and Molecular Biology

Volumn 128, Issue 1-2, 2012, Pages 62-68

  Keiler, Annekathrin Martina ^a   Papke, Anja ^a   Kretzschmar, Georg ^a   Zierau, Oliver ^a   Vollmer, Günter ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Bone; femi loges ; Gene expression; Ovariectomized rat; Peripheral quantitative computed tomography; Uterus

Indexed keywords

ERR 731; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BONE DENSITOMETRY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; ENDOMETRIUM HYPERPLASIA; FEMALE; GENE EXPRESSION; HOMEOSTASIS; MEDICINAL PLANT; METAPHYSIS; NONHUMAN; OSTEOLYSIS; OVARIECTOMY; RAT; RHEUM RHAPONTICUM; UTERUS GROWTH;

ANIMALS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CELL PROLIFERATION; COLLAGEN TYPE I; COMPLEMENT C3; ENDOMETRIUM; ESTRADIOL; ESTROGENS; FEMALE; GENE EXPRESSION; HUMANS; KI-67 ANTIGEN; MENOPAUSE; ORGAN SIZE; OSTEOCALCIN; OVARIECTOMY; PLANT EXTRACTS; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, WISTAR; RHEUM;

RATTUS; RHEUM RHAPONTICUM; RHEUM X HYBRIDUM;

EID: 82755182576     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.08.016     Document Type: Article

References (31)

1. H.D. Nelson Menopause Lancet 371 9614 2008 760 770 (Pubitemid 351288876)
2. Osteoporosis prevention, diagnosis, and therapy NIH Consens. Statement 17 1 2000 1 45
3. V. Beral Breast cancer and hormone-replacement therapy in the Million Women Study Lancet 362 9382 2003 419 427 (Pubitemid 36999703)
4. H.D. Nelson, L.L. Humphrey, P. Nygren, S.M. Teutsch, and J.D. Allan Postmenopausal hormone replacement therapy: scientific review JAMA 288 7 2002 872 881
5. F. Al-Azzawi, and M. Wahab Effectiveness of phytoestrogens in climacteric medicine Ann. N. Y. Acad. Sci. 1205 2010 262 267
6. F. Borrelli, and E. Ernst Alternative and complementary therapies for the menopause Maturitas 66 4 2010 333 343
7. P. Cos, T. De Bruyne, S. Apers, D. Vanden Berghe, L. Pieters, and A.J. Vlietinck Phytoestrogens: recent developments Planta Med. 69 7 2003 589 599 (Pubitemid 37041052)
8. M. Heger, B.M. Ventskovskiy, I. Borzenko, K.C. Kneis, R. Rettenberger, M. Kaszkin-Bettag, and P.W. Heger Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial Menopause 13 5 2006 744 759 (Pubitemid 44435029)
9. I. Hasper, B.M. Ventskovskiy, R. Rettenberger, P.W. Heger, D.S. Riley, and M. Kaszkin-Bettag Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms Menopause 16 1 2009 117 131
10. J. Wober, F. Moller, T. Richter, C. Unger, C. Weigt, A. Jandausch, O. Zierau, R. Rettenberger, M. Kaszkin-Bettag, and G. Vollmer Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds J. Steroid Biochem. Mol. Biol. 107 3-5 2007 191 201 (Pubitemid 47393556)
11. F. Moller, O. Zierau, A. Jandausch, R. Rettenberger, M. Kaszkin-Bettag, and G. Vollmer Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells Phytomedicine 14 11 2007 716 726 (Pubitemid 47554506)
12. A. Papke, G. Kretzschmar, O. Zierau, M. Kaszkin-Bettag, and G. Vollmer Effects of the special extract ERr 731 from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats J. Steroid Biochem. Mol. Biol. 117 4-5 2009 176 184
13. J.A. Gustafsson An update on estrogen receptors Semin. Perinatol. 24 1 2000 66 69
14. N. Sugiyama, R.P. Barros, M. Warner, and J.A. Gustafsson ERbeta: recent understanding of estrogen signaling Trends Endocrinol. Metab. 21 9 2010 545 552
15. D.N. Kalu The ovariectomized rat model of postmenopausal bone loss Bone Miner. 15 3 1991 175 191
16. P.P. Lelovas, T.T. Xanthos, S.E. Thoma, G.P. Lyritis, and I.A. Dontas The laboratory rat as an animal model for osteoporosis research Comp. Med. 58 5 2008 424 430
17. R.T. Turner, A. Maran, S. Lotinun, T. Hefferan, G.L. Evans, M. Zhang, and J.D. Sibonga Animal models for osteoporosis Rev. Endocr. Metab. Disord. 2 1 2001 117 127 (Pubitemid 33643898)
18. D.J. Leeming, P. Alexandersen, M.A. Karsdal, P. Qvist, S. Schaller, and L.B. Tanko An update on biomarkers of bone turnover and their utility in biomedical research and clinical practice Eur. J. Clin. Pharmacol. 62 10 2006 781 792 (Pubitemid 44521426)
19. M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res. 29 9 2001 e45
20. M. Kaszkin-Bettag, B.M. Ventskovskiy, A. Kravchenko, R. Rettenberger, A. Richardson, P.W. Heger, and M. Heger The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women Menopause 14 2 2007 270 283 (Pubitemid 46673479)
21. M. Kaszkin-Bettag, S. Beck, A. Richardson, P.W. Heger, and A.M. Beer Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study Altern. Ther. Health Med. 14 6 2008 32 38
22. M. Kaszkin-Bettag, B.M. Ventskovskiy, S. Solskyy, S. Beck, I. Hasper, A. Kravchenko, R. Rettenberger, A. Richardson, and P.W. Heger Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms Altern. Ther. Health Med. 15 1 2009 24 34
23. P. Diel, S. Schmidt, and G. Vollmer In vivo test systems for the quantitative and qualitative analysis of the biological activity of phytoestrogens J. Chromatogr. B: Analyt. Technol. Biomed. Life. Sci. 777 1-2 2002 191 202 (Pubitemid 35257872)
24. D. Rachon, D. Seidlova-Wuttke, T. Vortherms, and W. Wuttke Effects of dietary equol administration on ovariectomy induced bone loss in Sprague-Dawley rats Maturitas 58 3 2007 308 315 (Pubitemid 350086841)
25. P. Diel, R.B. Geis, A. Caldarelli, S. Schmidt, U.L. Leschowsky, A. Voss, and G. Vollmer The differential ability of the phytoestrogen genistein and of estradiol to induce uterine weight and proliferation in the rat is associated with a substance specific modulation of uterine gene expression Mol. Cell. Endocrinol. 221 1-2 2004 21 32 (Pubitemid 38829720)
26. T. Hertrampf, M.J. Gruca, J. Seibel, U. Laudenbach, K.H. Fritzemeier, and P. Diel The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity Bone 40 6 2007 1529 1535 (Pubitemid 46779003)
27. S. Nilsson, and J.A. Gustafsson Estrogen receptors: therapies targeted to receptor subtypes Clin. Pharmacol. Ther. 89 1 2011 44 55
28. D.M. Roesch Effects of selective estrogen receptor agonists on food intake and body weight gain in rats Physiol. Behav. 87 1 2006 39 44 (Pubitemid 41797720)
29. I.N. Wegorzewska, K. Walters, M.J. Weiser, D.F. Cruthirds, E. Ewell, D.O. Larco, R.J. Handa, and T.J. Wu Postovariectomy weight gain in female rats is reversed by estrogen receptor alpha agonist, propylpyrazoletriol Am. J. Obstet. Gynecol. 199 1 2008 67 e1-67 e5
30. J.I. Francisco, Y. Yu, R.A. Oliver, and W.R. Walsh Relationship between age, skeletal site, and time post-ovariectomy on bone mineral and trabecular microarchitecture in rats J. Orthop. Res. 29 2 2010 189 196
31. B.C. van der Eerden, J. Emons, S. Ahmed, H.W. van Essen, C.W. Lowik, J.M. Wit, and M. Karperien Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation J. Endocrinol. 175 2 2002 277 288 (Pubitemid 35414376)