FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells

American Journal of Physiology - Renal Physiology

Volumn 301, Issue 6, 2011, Pages

  Lubarski, Irina ^a   Asher, Carol ^a   Garty, Haim ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Adherence junction; Fxyd proteins; Ric; Tight junction

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BETA CATENIN; DYSADHERIN; PROTEIN ZO1;

ANIMAL CELL; ARTICLE; CELL CONTACT; CELL MEMBRANE PERMEABILITY; ELECTRIC RESISTANCE; KIDNEY COLLECTING TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; TIGHT JUNCTION;

EID: 82755177467     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00142.2011     Document Type: Article

References (41)

1. Bab-Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk KE, Karlish SJ. A C-terminal lobe of the beta subunit of Na,K-ATPase and H,KATPase resembles cell adhesion molecules. Biochemistry 48: 8684-8691, 2009.
2. Barwe SP, Anilkumar G, Moon SY, Zheng Y, Whitelegge JP, Rajasekaran SA, Rajasekaran AK. Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol Biol Cell 16: 1082-1094, 2005.
3. Batistatou A, Charalabopoulos AK, Scopa CD, Nakanishi Y, Kappas A, Hirohashi S, Agnantis NJ, Charalabopoulos K. Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma. Virchows Arch 448: 763-767, 2006.
4. Bibert S, Aebischer D, Desgranges F, Roy S, Schaer D, Kharoubi-Hess S, Horisberger JD, Geering K. A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells. Mol Biol Cell 20: 1132-1140, 2009.
5. Blanco G, Mercer RW. Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function. Am J Physiol Renal Physiol 275: F633-F650, 1998.
6. Capaldo CT, Nusrat A. Cytokine regulation of tight junctions. Biochim Biophys Acta 1788: 864-871, 2009.
7. Fu X, Kamps MP. E2a-Pbx1 induces aberrant expression of tissuespecific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol 17: 1503-1512, 1997.
8. Garty H, Lindzen M, Scanzano R, Aizman R, Fuzesi M, Goldshleger R, Farman N, Blostein R, Karlish SJ. A functional interaction between CHIF and Na-K-ATPase: implication for regulation by FXYD proteins. Am J Physiol Renal Physiol 283: F607-F615, 2002.
9. Garty H, Karlish SJ. Role of FXYD proteins in ion transport. Annu Rev Physiol 68: 431-459, 2006.
10. Geering K. FXYD proteins: new regulators of Na-K-ATPase. Am J Physiol Renal Physiol 290: F241-F250, 2006.
11. Gloor S, Antonicek H, Sweadner KJ, Pagliusi S, Frank R, Moos M, Schachner M. The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase. J Cell Biol 110: 165-174, 1990.
12. Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 1778: 660-669, 2008.
13. Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc Natl Acad Sci USA 99: 365-370, 2002.
14. Jewell EA, Lingrel JB. Comparison of the substrate dependence properties of the rat Na,K-ATPase alpha 1, alpha 2, and alpha 3 isoforms expressed in HeLa cells. J Biol Chem 266: 16925-16930, 1991.
15. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
16. Kaplan JH. A moving new role for the sodium pump in epithelial cells and carcinomas. Sci STKE 2005: pe31, 2005.
17. Kobielak A, Fuchs E. Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat Rev Mol Cell Biol 5: 614-625, 2004.
18. Lubarski I, Pihakaski-Maunsbach K, Karlish SJ, Maunsbach AB, Garty H. Interaction with the Na, K ATPase and tissue distribution of FXYD5 (related to ion channel). J Biol Chem 280: 37717-37724, 2005.
19. Lubarski I, Karlish SJD, Garty H. Structural and functional interactions between FXYD5 and the Na+-K+-ATPase. Am J Physiol Renal Physiol 293: F1818-F1826, 2007.
20. Madara JL, Pappenheimer JR. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J Membr Biol 100: 149-164, 1987.
21. Miller TJ, Davis PB. S163 is critical for FXYD5 modulation of wound healing in airway epithelial cells. Wound Repair Regen 16: 791-799, 2008.
22. Miller TJ, Davis PB. FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia. Am J Physiol Lung Cell Mol Physiol 294: L654-L664, 2008.
23. Nam JS, Kang MJ, Suchar AM, Shimamura T, Kohn EA, Michalowska AM, Jordan VC, Hirohashi S, Wakefield LM. Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells. Cancer Res 66: 7176-7184, 2006.
24. Nam JS, Hirohashi S, Wakefield LM. Dysadherin: a new player in cancer progression. Cancer Lett 255: 161-169, 2007.
25. Pappenheimer JR. Intestinal absorption of hexoses and amino acids: from apical cytosol to villus capillaries. J Membr Biol 184: 233-239, 2001.
26. Pierre SV, Xie Z. The Na,K-ATPase receptor complex: its organization and membership. Cell Biochem Biophys 46: 303-316, 2006.
27. Rajasekaran SA, Palmer LG, Quan K, Harper JF, Ball WJ Jr, Bander NH, Peralta Soler A, and Rajasekaran AK. Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility. Mol Biol Cell 12: 279-295, 2001.
28. Rajasekaran SA, Barwe SP, Rajasekaran AK. Multiple functions of Na,K-ATPase in epithelial cells. Semin Nephrol 25: 328-334, 2005.
29. Rajasekaran SA, Barwe SP, Gopal J, Ryazantsev S, Schneeberger EE, Rajasekaran AK. Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Am J Physiol Gastrointest Liver Physiol 292: G124-G133, 2007.
30. Shimamura T, Sakamoto M, Ino Y, Sato Y, Shimada K, Kosuge T, Sekihara H, Hirohashi S. Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to e-cadherin expression. J Clin Oncol 21: 659-667, 2003.
31. Shimamura T, Yasuda J, Ino Y, Gotoh M, Tsuchiya A, Nakajima A, Sakamoto M, Kanai Y, Hirohashi S. Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells. Cancer Res 64: 6989-6995, 2004.
32. Shimon MB, Goldshleger R, Karlish SJ. Specific Cu2+-catalyzed oxidative cleavage of Na,K-ATPase at the extracellular surface. J Biol Chem 273: 34190-34195, 1998.
33. Shinoda T, Ogawa H, Cornelius F, Toyoshima C. Crystal structure of the sodium-potassium pump at 2.4 A resolution. Nature 459: 446-450, 2009.
34. Shoshani L, Contreras RG, Roldan ML, Moreno J, Lazaro A, Balda MS, Matter K, Cereijido M. The polarized expression of Na+,K+- ATPase in epithelia depends on the association between beta-subunits located in neighboring cells. Mol Biol Cell 16: 1071-1081, 2005.
35. Stamatovic SM, Keep RF, Wang MM, Jankovic I, Andjelkovic AV. Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J Biol Chem 284: 19053-19066, 2009.
36. Stoos BA, Naray-Fejes-Toth A, Carretero OA, Ito S, Fejes-Toth G. Characterization of a mouse cortical collecting duct cell line. Kidney Int 39: 1168-1175, 1991.
37. Sweadner KJ, Arystarkhova E, Donnet C, Wetzel RK. FXYD proteins as regulators of the Na,K-ATPase in the kidney. Ann NY Acad Sci 986: 382-387, 2003.
38. Tsuiji H, Takasaki S, Sakamoto M, Irimura T, Hirohashi S. Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinomaassociated antigen, and facilitates cell-cell adhesion. Glycobiology 13: 521-527, 2003.
39. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9: 799-809, 2009.
40. Vagin O, Tokhtaeva E, Sachs G. The role of the beta1 subunit of the Na,K-ATPase and its glycosylation in cell-cell adhesion. J Biol Chem 281: 39573-39587, 2006.
41. Vagin O, Sachs G, Tokhtaeva E. The roles of the Na,K-ATPase beta 1 subunit in pump sorting and epithelial integrity. J Bioenerg Biomembr 39: 367-372, 2007.