Pneumocystis S-adenosylmethionine transport: A potential drug target

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 6, 2011, Pages 1142-1146

  Perez Leal, Oscar ^a   Moncada, Camilo ^a   Clarkson, Allen B ^b   Merali, Salim ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Mitochondrial transporter; PCP pneumonia; PcPET8; PET8; Pneumocystis; S adenosylmethionine

Indexed keywords

S ADENOSYLMETHIONINE; SINEFUNGIN;

ARTICLE; CONTROLLED STUDY; DRUG TARGETING; FUNGAL GENE; FUNGAL STRAIN; GENE EXPRESSION; MITOCHONDRION; NONHUMAN; PCPET8 GENE; PNEUMOCYSTIS; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE;

ADENOSINE; ANIMALS; ANTIFUNGAL AGENTS; BIOLOGICAL TRANSPORT; DRUG DELIVERY SYSTEMS; FUNGAL PROTEINS; HUMANS; METHIONINE ADENOSYLTRANSFERASE; PNEUMOCYSTIS CARINII; PNEUMONIA, PNEUMOCYSTIS; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE; SACCHAROMYCES CEREVISIAE;

EID: 82755165245     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0009OC     Document Type: Article

References (23)

1. Laakkonen J. Pneumocystis carinii in wildlife. Int J Parasitol 1998;28: 241-252. (Pubitemid 28097657)
2. Chabe M, Aliouat-Denis CM, Delhaes L, el Aliouat M, Viscogliosi E, Dei-Cas E. Pneumocystis: from a doubtful unique entity to a group of highly diversified fungal species. FEM Yeast Res 2011;11:2-17.
3. Sepkowitz KA. Opportunistic infections in patients with and patients without acquired immunodeficiency syndrome. Clin Infect Dis 2002; 34:1098-1107. (Pubitemid 34289683)
4. McLennan G, Antic R, Seymour AE, Frith PA, Clarkson AR. Pneumocystis carinii pneumonitis successfully treated with trimethoprim-sulphamethoxazole. Aust N Z J Med 1977;7:299-301. (Pubitemid 8161742)
5. Wilkin A, Feinberg J. Pneumocystis carinii pneumonia: a clinical review. Am Fam Phys 1999;60:1699-1708, 1713-1694.
6. Walker DJ, Meshnick SR. Drug resistance in Pneumocystis carinii: an emerging problem. Drug Resist Updat 1998;1:201-204.
7. Walzer PD, Evans HE, Copas AJ, Edwards SG, Grant AD, Miller RF. Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985-2006. Clin Infect Dis 2008;46:625-633. (Pubitemid 351263506)
8. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 2011;52:e56-e93.
9. Merali S, Vargas D, Franklin M, Clarkson AB Jr. S-adenosylmethionine and Pneumocystis carinii. J Biol Chem 2000;275:14958-14963. (Pubitemid 30337212)
10. Kutty G, Hernandez-Novoa B, Czapiga M, Kovacs JA. Pneumocystis encodes a functional S-adenosylmethionine synthetase gene. Eukaryot Cell 2008;7:258-267. (Pubitemid 351959692)
11. Laakkonen J, Sundell J, Soveri T. Lung parasites of least weasels in Finland. J Wildl Dis 1998;34:816-819. (Pubitemid 128689371)
12. Merali S, Clarkson AB Jr. S-adenosylmethionine and Pneumocystis. FEMS Microbiol Lett 2004;237:179-186. (Pubitemid 39099188)
13. Moncada CA, Clarkson A, Perez-Leal O, Merali S. Mechanism and tissue specificity of nicotine-mediated lung S-adenosylmethionine reduction. J Biol Chem 2008;283:7690-7696.
14. Skelly M, Hoffman J, Fabbri M, Holzman RS, Clarkson AB, Merali S. S-adenosylmethionine concentrations in diagnosis of Pneumocystis carinii pneumonia. Lancet 2003;361:1267-1268. (Pubitemid 36428582)
15. Skelly MJ, Holzman RS, Merali S. S-adenosylmethionine levels in the diagnosis of Pneumocystis carinii pneumonia in patients with HIV infection. Clin Infect Dis 2008;46:467-471. (Pubitemid 351263534)
16. Murphy JT, Spence KD. Transport of S-adenosylmethionine in Saccharomyces cerevisiae. J Bacteriol 1972;109:499-504.
17. Merali S. Pneumocystis carinii polyamine catabolism. J Biol Chem 1999; 274:21017-21022.
18. Sheff MA, Thorn KS. Optimized cassettes for fluorescent protein tagging in Saccharomyces cerevisiae. Yeast 2004;21:661-670. (Pubitemid 38868184)
19. Sohn S, Eagan J, Sepkowitz KA. Safety-engineered device implementation: does it introduce bias in percutaneous injury reporting? Infect Control Hosp Epidemiol 2004;25:543-547. (Pubitemid 38954483)
20. Claros MG, von Heijne G. TopPred II: an improved software for membrane protein structure predictions. Comput Appl Biosci 1994;10: 685-686.
21. Stringer JR, Wakefield AE, Cushion MT, Dei-Cas E. Pneumocystis taxonomy and nomenclature: an update. J Eukaryot Microbiol 1997; 44:5S-6S. (Pubitemid 28037824)
22. Walshe LJ, Malak SF, Eagan J, Sepkowitz KA. Complication rates among cancer patients with peripherally inserted central catheters. J Clin Oncol 2002;20:3276-3281. (Pubitemid 34831526)
23. Zheng S, Shuman S, Schwer B. Sinefungin resistance of Saccharomyces cerevisiae arising from SAM3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA CAP guanine-N7 methyltransferase. Nucleic Acids Res 2007; 35:6895-6903. (Pubitemid 350201808)