Variation in 3β-hydroxysteroid dehydrogenase activity and in pregnenolone supply rate can paradoxically alter androstenedione synthesis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 128, Issue 1-2, 2012, Pages 12-20

  Nguyen, Phuong T T ^a   Lee, Rita S F ^a   Conley, Alan J ^b   Sneyd, James ^c   Soboleva, Tanya K ^d  

^a RUAKURA RESEARCH CENTRE   (New Zealand)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d Ministry for Primary Industries   (New Zealand)

Author keywords

4 pathway; 5 pathway; Enzymatic control; Mathematical model; Steroid synthesis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROSTENEDIONE; CYTOCHROME P450C17; PRASTERONE; PREGNENOLONE; STEROID 17,20 LYASE;

ANDROGEN SYNTHESIS; ARTICLE; COMPETITIVE INHIBITION; COW; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; MATHEMATICAL MODEL; NONHUMAN; PRIMATE; STEADY STATE;

3-HYDROXYSTEROID DEHYDROGENASES; ALGORITHMS; ANDROSTENEDIONE; ANIMALS; CATTLE; COMPUTER SIMULATION; HUMANS; KINETICS; METABOLIC NETWORKS AND PATHWAYS; MODELS, CHEMICAL; PREGNENOLONE; PROGESTERONE; SHEEP; STEROID 17-ALPHA-HYDROXYLASE;

BOVINAE; OVIS; PRIMATES;

EID: 82755162735     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.10.003     Document Type: Article

References (27)

1. 4 pathways of steroidogenesis in mammals Biol. Reprod. 56 1997 789 799 (Pubitemid 27150405)
2. W.L. Miller, and R.J. Auchus The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders Endocr. Rev. 2 1 2011 81 151
3. J.L. Thomas, E.A. Berko, A. Faustino, R.P. Myers, and R.C. Strickler Human placental 3β-hydroxy-5-ene-steroid dehydrogenase and steroid 5 → 4-ene-isomerase: purification from microsomes, substrate kinetics, and inhibition by product steroids J. Steroid Biochem. 31 5 1988 785 793 (Pubitemid 19006893)
4. S.G. Raimondi, N.S. Oliver, L.C. Patrito, and A. Flury Kinetic analysis of 3β-hydroxysteroid dehydrogenase activity in microsomes from complete hydatidiform mole J. Steroid Biochem. 36 1990 149 152 (Pubitemid 20213579)
5. M.S. Breen, D.L. Villeneuve, M. Breen, G.T. Ankley, and R.B. Conolly Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds Ann. Biomed. Eng. 35 6 2007 970 981 (Pubitemid 46828707)
6. M.S. Breen, M. Breen, N. Terasaki, M. Yamazaki, and R.B. Conolly Computational model of steroidogenesis in human H295R cells to predict biochemical response to endocrine-active chemicals: model development for metyrapone Environ. Health Perspect. 118 2 2010 265 272
7. W. Gibb Substrate and nucleotide specificity of placental microsomal 3β-hydroxysteroid dehydrogenase Steroids 37 1 1981 23 31 (Pubitemid 11133125)
8. S.G. Raimondi, N.S. Olivier, L.C. Patrito, and A. Flury Regulation of the 3β-hydroxysteroid dehydrogenase activity in tissue fragments and microsomes from human term placenta: kinetic analysis and inhibition by steroids J. Steroid Biochem. 32 3 1989 413 420 (Pubitemid 19099159)
9. M. Wiener, and S.H.G. Allen Inhibition of placental steroid synthesis by steroid metabolites II: inhibitor specificity Steroids 12 1968 261 273
10. J.L. Thomas, W.L. Duax, A. Addlagatta, S. Brandt, R.R. Fuller, and W. Norris Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3β-hydroxysteroid dehydrogenase/isomerase J. Biol. Chem. 278 37 2003 35483 35490 (Pubitemid 37102319)
11. A.H. Payne, and D.B. Hales Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones Endocr. Rev. 25 6 2004 947 970 (Pubitemid 39657774)
12. J.D. Townsley Inhibition of placental 3β-hydroxysteroid dehydrogenase by naturally occuring steroids. A potential mechanism regulating oestrogen synthesis from unconjugated precursors Acta Endocr. Copenh. 79 1975 740 748
13. P. Soucy, and V. Luu-The Conversion of pregnenolone to DHEA by human 17α-hydroxylase/17,20-lyase (P450c17) Eur. J. Biochem. 267 11 2000 3243 3247
14. D.M. Duffy, D.L. Hess, and R.L. Stouffer Acute administration of a 3β-hydroxysteroid-dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidences for possible autocrine regulation of primate corpus luteum by progesterone J. Clin. Endocrinol. Metab. 79 1994 1587 1597
15. 2α), estradiol-17β and progesterone secretion and pregnancy of 90 days ovariectomized pregnant ewes Prostaglandin Other Lipid Mediators 58 1999 149 158 (Pubitemid 29518458)
16. 2α) or cortisol abort 90-day lutectomized pregnant sheep Prostaglandin Other Lipid Mediators 58 1999 77 86 (Pubitemid 29518452)
17. W.L. Miller Molecular biology of steroid hormone synthesis Endocr. Rev. 9 3 1988 295 318
18. J.L. Thomas, J.I. Mason, S. Brandt, B.R. Spencer, and W. Norris Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3β-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity J. Biol. Chem. 277 45 2002 42795 42801 (Pubitemid 35285654)
19. http://www.uniprot.org/uniprot/Q86TX2, the last access is on 10.09.11.
20. J. Keener, and J. Sneyd Biochemical reactions, in: Mathematical Physiology 2009 Springer New York 1-47
21. 5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer J. Biol. Chem. 273 6 1998 3158 3165 (Pubitemid 28109723)
22. 17α,lyase Biochemistry 37 1998 2800 2806 (Pubitemid 28145733)
23. S. Tsumagari, J. Kamata, K. Takagi, K. Tanemura, A. Yosai, and M. Takeishi 3β-hydroxysteroid dehydrogenase activity and gestagen concentrations in bovine cotyledons and caruncles during gestation and parturition J. Reprod. Fertil. 102 1 1994 35 39
24. 5→4-isomearse expression by adrenocorticotropin in bovine adrenocortical cells Endocrinology 128 1 1991 139 145
25. W.L. Miller Minireview: Regulation of steroidogenesis by electron transfer Endocrinology 146 6 2005 2544 2550 (Pubitemid 40695556)
26. A.J. Conley, C.J. Corbin, J.L. Thomas, N. Gee, B.L. Lasley, B.C. Moeller, S.D. Stanley, T. Berger, Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis, Biol. Reprod., doi:10.1095/biolreprod.111. 094706, in press.
27. C.E. Fluck, D.C. Yaworsky, and W.L. Miller Effects of anticonvulsants on human P450c17 (17α-hydroxylase/17,20 lyase) and 3β-hydroxysteroid dehydrogenase type 2 Epilepsia 46 2005 444 448 (Pubitemid 40365651)