Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis

Biology of Reproduction

Volumn 86, Issue 1, 2012, Pages

  Conley, Alan J ^a   Corbin, Cynthia J ^a   Thomas, James L ^b   Gee, Nancy A ^c   Lasley, Bill L ^c   Moeller, Ben C ^d   Stanley, Scott D ^d   Berger, Trish ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Androgen; Compartmental expression; Estradiol; Estrogen; Follicle; Ovary; P450; Placenta; Reproduction; Sex steroid synthesis; Steroid hormones; Steroidogenesis; Two cell model

Indexed keywords

3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ANDROGEN; ANDROSTENEDIONE; AROMATASE; CYTOCHROME P450 REDUCTASE; ENZYME; ESTROGEN; PREGNENOLONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID 17ALPHA MONOOXYGENASE; TRILOSTANE; CYTOCHROME P450; HYDROXYPROGESTERONE; ISOPROTEIN; RECOMBINANT PROTEIN;

ANDROGEN SYNTHESIS; ARTICLE; BACULOVIRUS; CELL COMPARTMENTALIZATION; CELL POPULATION; CONTROLLED STUDY; ENZYME METABOLISM; ESTROGEN SYNTHESIS; HORMONE RELEASE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; STEROIDOGENESIS; ANIMAL; BIOSYNTHESIS; CELL LINE; ENZYME SPECIFICITY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GRANULOSA CELL; HUMAN; INSECT; METABOLISM; PHYSIOLOGY;

HEXAPODA;

17-ALPHA-HYDROXYPROGESTERONE; ANDROGENS; ANIMALS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GRANULOSA CELLS; HUMANS; INSECTS; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 82755175457     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.111.094706     Document Type: Article

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