Cyclosporine and rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage

Transplantation Proceedings

Volumn 37, Issue 2, 2005, Pages 837-838

  Brook, N R ^a   Waller, J R ^a   Bicknell, G R ^a   Nicholson, M L ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 3; CREATININE; CYCLOSPORIN A; GELATINASE A; GELATINASE B; MESSENGER RNA; PROTEIN; RAPAMYCIN; RNA DIRECTED DNA POLYMERASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE CALCULATION; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG POTENCY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY INJURY; MALE; MEDICAL ASSESSMENT; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM DEPLETION; URINARY EXCRETION;

EID: 17844386098     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2004.12.147     Document Type: Conference Paper

References (4)

1. P.F. Halloran Sirolimus and cyclosporin for renal transplantation Lancet 356 2000 179
2. B.D. Kahan, B.A. Julian, M.D. Pescovitz Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in caucasian recipients of mismatched primary renal allografts: a phase II trial. Rapamune Study Group Transplantation 68 1999 1526
3. P.A. Kelly, H. Wang, K.L. Napoli Metabolism of cyclosporine by cytochromes P450 3A9 and 3A4 Eur J Drug Metab Pharmacokinet 24 1999 321
4. J.A. Thliveris, K. Solez, R.W. Yatscoff A comparison of the effects of rapamycin and cyclosporine on kidney and heart morphology in a rabbit heterotopic heart transplant model Histol Histopathol 10 1995 417