Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling

Medical Engineering and Physics

Volumn 33, Issue 10, 2011, Pages 1193-1202

  Giridharan, G A ^a   Lederer, C ^b   Berthe, A ^c   Goubergrits, L ^c   Hutzenlaub, J ^d   Slaughter, M S ^a   Dowling, R D ^e   Spence, P A ^e   Koenig, S C ^a  

^a University of Louisville School of Medicine   (United States)

^b LB Engineering   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d Mecora Medizintechnik GmbH   (Germany)

^e SCR Inc   (United States)

Author keywords

CFD; Counterpulsation device; Flow visualization; Heart failure; Hemolysis; PIV

Indexed keywords

BIOCHEMICAL MARKERS; BLOOD PUMP; BLOOD SAMPLES; COUNTERPULSATION; EJECTION PHASE; FLOW DYNAMICS; HEART FAILURE; HEMOLYSIS; HEPATIC FUNCTION; HIGH INCIDENCE; LAMINAR SHEAR STRESS; PARTICLE IMAGE VELOCIMETRIES; PIV; RENAL FUNCTIONS; TEMPORAL CHANGE; THROMBUS FORMATION; TIME COURSE;

ANIMALS; BIOCHEMISTRY; BLOOD; BLOOD VESSELS; DYNAMICS; EXPERIMENTS; FLOW VISUALIZATION; HEMOGLOBIN; SHEAR FLOW; SHEAR STRESS; VELOCITY MEASUREMENT; WASHING;

COMPUTATIONAL FLUID DYNAMICS;

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CREATININE; HEMOGLOBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BIOCOMPATIBILITY; BLOOD STAGNATION; BLOOD WASHING; CALF (BOVINE); CARDIOVASCULAR EQUIPMENT; CAROTID ARTERY INJURY; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; COUNTERPULSATION; COUNTERPULSATION DEVICE; EQUIPMENT DESIGN; GEOMETRY; HEMATOCRIT; HEMODYNAMIC PARAMETERS; HEMOLYSIS; HISTOPATHOLOGY; KIDNEY FUNCTION; LIVER FUNCTION; MALE; MINIMALLY INVASIVE CARDIAC SURGERY; NONHUMAN; PARTICLE IMAGE VELOCIMETRY; PRIORITY JOURNAL; SHEAR STRESS; SIMULATION; THROMBOCYTE COUNT; THROMBOGENESIS; TREATMENT DURATION; VELOCITY; VELOCITY VECTOR; VENOUS BLOOD;

ANIMALS; ARTIFICIAL ORGANS; CATTLE; COMPUTER SIMULATION; COUNTERPULSATION; HEMOLYSIS; HYDRODYNAMICS; MALE; MATERIALS TESTING; REPRODUCIBILITY OF RESULTS; RHEOLOGY; STRESS, MECHANICAL; THROMBOSIS; TIME FACTORS;

EID: 82755161022     PISSN: 13504533     EISSN: 18734030     Source Type: Journal    
DOI: 10.1016/j.medengphy.2011.05.008     Document Type: Article

References (31)

1. Rose E.A., Gelijns A.C., Moskowitz A.J., Heitjan D.F., Stevenson L.W., Dembitsky W., et al. Long-term use of a left ventricular assist device for end-stage heart failure. N. Engl. J. Med. 2001, 345(20):1435-1443.
2. Burkhoff D., Klotz S., Mancini D.M. LVAD-induced reverse remodeling: basic and clinical implications for myocardial recovery. J. Card. Fail. 2006, 12(3):227-239.
3. Goldstein D.J., Oz M.C., Rose E.A. Implantable left ventricular assist devices. N. Engl. J. Med. 1998, 339(21):1522-1533.
4. Trost J.C., Hillis L.D. Intra-aortic balloon counterpulsation. Am. J. Cardiol. 2006, 97(9):1391-1398.
5. Birks E.J., Yacoub M.H., Banner N.R., Khaghani A. The role of bridge to transplantation: should LVAD patients be transplanted?. Curr. Opin. Cardiol. 2004, 19(2):148-153.
6. Chinn R., Dembitsky W., Eaton L., Chillcott S., Stahovich M., Rasmusson B., et al. Multicenter experience: prevention and management of left ventricular assist device infections. ASAIO J. 2005, 51(4):461-470.
7. Mancini D., Burkhoff D. Mechanical device-based methods of managing and treating heart failure. Circulation 2005, 112(3):438-448.
8. Giridharan G.A., Pantalos G.M., Litwak K.N., Spence P.A., Koenig S.C. Predicted hemodynamic benefits of counterpulsation therapy using a superficial surgical approach. ASAIO J. 2006, 52(1):39-46.
9. Koenig S.C., Spence P.A., Pantalos G.M., Dowling R.D., Litwak K.N. Development and early testing of a simple subcutaneous counterpulsation device. ASAIO J. 2006, 52(4):362-367.
10. Koenig S.C., Pantalos G.M., Litwak K.N., Gillars K.J., Giridharan G.A., Maguire M., et al. Hemodynamic and left ventricular pressure-volume responses to counterpulsation in mock circulation and acute large animal models. Conf Proc IEEE Eng Med Biol Soc 2004, 5:3761-3764.
11. Koenig S.C., Litwak K.N., Giridharan G.A., Pantalos G.M., Dowling R.D., Prabhu S.D., et al. Acute hemodynamic efficacy of a 32-ml subcutaneous counterpulsation device in a calf model of diminished cardiac function. ASAIO J. 2008, 54(6):578-584.
12. Billy G.G., Miller C.A., Pallone M.N., Donachy J.H., Pierce W.S. Hemolytic differences among artificial cardiac valves used in a ventricular assist pump. Artif. Organs 1995, 19(4):339-343.
13. Noon G. Clinical use of cardiac assist devices. Heart replacement: artificial heart 1993, vol. 4:195-204. Springer-Verlag, Tokyo; New York.
14. Goubergrits L., Affeld K., Kertzscher U. Innovative developments of the heart valves designed for use in ventricular assist devices. Expert Rev Med Devices 2005, 2(1):61-71.
15. Mitamura Y., Nakamura H., Sekine K., Kim D., Yozu R., Kawada S., et al. Prediction of hemolysis in rotary blood pumps with computational fluid dynamics analysis. J Congest Heart Fail Circ Support 2001, 1(4):331-336.
16. Arvand A., Hormes M., Reul H. A validated computational fluid dynamics model to estimate hemolysis in a rotary blood pump. Artif. Organs 2005, 29(7):531-540.
17. Huijbregts H.J., Blankestijn P.J., Caro C.G., Cheshire N.J., Hoedt M.T., Tutein Nolthenius R.P., et al. A helical PTFE arteriovenous access graft to swirl flow across the distal anastomosis: results of a preliminary clinical study. Eur. J. Vasc. Endovasc. Surg. 2007, 33(4):472-475.
18. Day S.W., McDaniel J.C., Wood H.G., Allaire P.E., Landrot N., Curtas A. Particle image velocimetry measurements of blood velocity in a continuous flow ventricular assist device. ASAIO J. 2001, 47(4):406-411.
19. Mussivand T., Day K.D., Naber B.C. Fluid dynamic optimization of a ventricular assist device using particle image velocimetry. ASAIO J. 1999, 45(1):25-31.
20. Deutsch S., Tarbell J.M., Manning K.B., Rosenberg G., Fontaine A.A. Experimental fluid mechanics of pulsatile artificial blood pumps. Annu Rev Fluid Mech 2006, 38:65-86.
21. Shu F.J., Parks R., Maholtz J., Ash S., Antaki J.F. Multimodal flow visualization and optimization of pneumatic blood pump for sorbent hemodialysis system. Artif. Organs 2009, 33(4):334-345.
22. Behbahani M., Behr M., Hormes M., Steinseifer U., Arora D., Coronado O., et al. A review of computational fluid dynamics analysis of blood pumps. Eur J Appl Math 2009, 20:363-397.
23. Paul R., Apel J., Klaus S., Schugner F., Schwindke P., Reul H. Shear stress related blood damage in laminar couette flow. Artif. Organs 2003, 27(6):517-529.
24. Ge L., Dasi L.P., Sotiropoulos F., Yoganathan A.P. Characterization of hemodynamic forces induced by mechanical heart valves: Reynolds vs. viscous stresses. Ann. Biomed. Eng. 2008, 36(2):276-297.
25. Antiga L., Steinman D.A. Rethinking turbulence in blood. Biorheology 2009, 46(2):77-81.
26. Doyle M.G., Vergniaud J.B., Tavoularis S., Bourgault Y. Numerical simulations of blood flow in artificial and natural hearts with fluid-structure interaction. Artif. Organs 2008, 32(11):870-879.
27. Avrahami I., Rosenfeld M., Raz S., Einav S. Numerical model of flow in a sac-type ventricular assist device. Artif. Organs 2006, 30(7):529-538.
28. Imachi K. Artificial heart research and present status of clinical application in Japan. ASAIO J. 2006, 52(1):9-16.
29. Grinda J.M., Latremouille C.H., Chevalier P., D'Attelis N., Boughenou F., Guillemain R., et al. Bridge to transplantation with the DeBakey VAD axial pump: a single center report. Eur. J. Cardiothorac. Surg. 2002, 22(6):965-970.
30. Ohashi Y., de Andrade A., Nose Y. Hemolysis in an electromechanical driven pulsatile total artificial heart. Artif. Organs 2003, 27(12):1089-1093.
31. Luckraz H., Woods M., Large S.R. And hemolysis goes on: ventricular assist device in combination with veno-venous hemofiltration. Ann. Thorac. Surg. 2002, 73(2):546-548.