Hawthorn special extract WS ® 1442 increases red blood cell NO-formation without altering red blood cell deformability

Phytomedicine

Volumn 19, Issue 1, 2011, Pages 20-24

  Rieckeheer, Eva ^a   Schwinger, Robert H G ^b   Bloch, Wilhelm ^a,b   Brixius, Klara ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b Klinikum Weiden   (Germany)

Author keywords

Crataegus spezz.; DAF; Deformability; Hawthorn; Nitric oxide; Red blood cell

Indexed keywords

CRATAEGUS EXTRACT; NITRIC OXIDE SYNTHASE; SERINE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRATAEGUS; DENSITOMETRY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ERYTHROCYTE DEFORMABILITY; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; NORMAL HUMAN; PRIORITY JOURNAL; SHEAR STRESS; SINGLE CELL ANALYSIS;

CARDIOTONIC AGENTS; CRATAEGUS; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTES; FLAVONOIDS; FLOWERS; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; SERINE;

CRATAEGUS;

EID: 82755160802     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.08.059     Document Type: Article

References (41)

1. E. Anselm, V.F. Socorro, S. Dal-Ros, C. Schott, C. Bronner, and V.B. Schini-Kerth Crataegus special extract WS 1442 causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of endothelial NO synthase but not via activation of estrogen receptors J. Cardiovasc. Pharmacol. 53 March (3) 2009 253 260
2. E. Bassenge Antiplatelet effects of endothelium-derived relaxing factor and nitric oxide donors Eur. Heart J. November (12 Suppl. E) 1991 12 15 (Review)
3. 1179 by Akt-independent mechanisms: role of protein kinase A J. Biol. Chem. 277 February (5) 2002 3388 3396 (Pubitemid 34953207)
4. M. Bor-Kucukatay, R.B. Wenby, H.J. Meiselman, and O.K. Baskurt Effects of nitric oxide on red blood cell deformability Am. J. Physiol. Heart Circ. Physiol. 284 May (5) 2003 H1577 H1584 (Pubitemid 36460769)
5. K. Brixius, S. Willms, and A. Napp Crataegus special extract WS 1442 induces an endothelium-dependent. NO-mediated vasorelaxation via eNOS-phosphorylation at serine 1177 Cardiovasc. Drugs Ther. 20 June (3) 2006 177 184 (Pubitemid 44099815)
6. W.R. Busse, W. Juretzek, and E. Koch Hawthorn (crataegus) P. Coates, M.R. Blackman, G. Cragg, al. et, Encyclopedia of Dietary Supplements 2005 Marcel Dekker New York 337 347
7. H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, and M.J. Quon Adiponectin stimulates production of nitric oxide in vascular endothelial cells J. Biol. Chem. 278 November (45) 2003 45021 45026 (Pubitemid 37377262)
8. T.L. Cornwell, E. Arnold, N.J. Boerth, and T.M. Lincoln Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP Am. J. Physiol. 267 November (5 Pt 1) 1994 C1405 C1413
9. F.C. Czygan A short cultural history in retrospect. Crataegus as a cardiac agent Pharm. Unserer. Zeit. 34 1 2005 10 13 (in German)
10. R.F. Furchgott, and J.V. Zawadzki The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 November (5789) 1980 373 376 (Pubitemid 11169009)
11. J.I. Garcia, A.B. Seabra, R. Kennedy, and A.M. English Nitrite and nitroglycerin induce rapid release of the vasodilator ATP from erythrocytes: relevance to the chemical physiology of local vasodilation J. Inorg. Biochem. Mar. 104 3 2010 289 296
12. D.S. Gélinas, P.N. Bernatchez, S. Rollin, N.G. Bazan, and M.G. Sirois Immediate and delayed VEGF-mediated NO synthesis in endothelial cells role of PI3K, PKC and PLC pathways Br. J. Pharmacol. 137 December (7) 2002 1021 1030 (Pubitemid 35440742)
13. G.H. Gibbons Endothelial function as a determinant of vascular function and structure: a new therapeutic target Am. J. Cardiol. 79 March (5A) 1997 3 8 (Review) (Pubitemid 27157072)
14. X. Guo, X. Lu, H. Ren, E.R. Levin, and G.S. Kassab Estrogen modulates the mechanical homeostasis of mouse arterial vessels through nitric oxide Am. J. Physiol. Heart Circ. Physiol. 290 May (5) 2006 H1788 H1797
15. M.R. Hardeman, P.T. Goedhart, J.G.G. Dobbe, and K.P. Lettinga Laser assisted Optical Rotational Cell Analyser (L.O.R.C.A.): a new instrument for measurement of various structural hemorheological parameters Clin. Hemorheol. 14 4 1994 605 618 (Pubitemid 24239378)
16. C. Heiss, T. Lauer, and A. Dejam Plasma nitroso compounds are decreased in patients with endothelial dysfunction J. Am. Coll. Cardiol. 47 February (3) 2006 573 579 (Pubitemid 43170846)
17. K. Hisamoto, M. Ohmichi, and H. Kurachi Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells J. Biol. Chem. 276 February (5) 2001 3459 3467
18. S. Kanwar, and P. Kubes Nitric oxide is an antiadhesive molecule for leukocytes New Horiz. 3 February (1) 1995 93 104 (Review)
19. J.A. Kim, M. Montagnani, K.K. Koh, and M.J. Quon Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms Circulation 113 April (15) 2006 1888 1904 (Review) (Pubitemid 43739401)
20. S.H. Kim, K.W. Kang, K.W. Kim, and N.D. Kim Procyanidins in crataegus extract evoke endothelium-dependent vasorelaxation in rat aorta Life Sci. 67 2 2000 121 131 (Pubitemid 30414479)
21. P. Kleinbongard, R. Schulz, and T. Rassaf Red blood cells express a functional endothelial nitric oxide synthase Blood 107 April (7) 2006 2943 2951
22. T. Kobayashi, K. Taguchi, T. Yasuhiro, T. Matsumoto, and K. Kamata Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model Hypertension 44 December (6) 2004 956 962 (Pubitemid 39577428)
23. H. Kojima, K. Sakurai, and K. Kikuchi Development of a fluorescent indicator for nitric oxide based on the fluorescein chromophore Chem. Pharm. Bull. (Tokyo) 46 February (2) 1998 373 375 (Pubitemid 28124233)
24. G.K. Kolluru, J.H. Simawala, and S. Chatterjee eNOS phosphorylation in health and disease Biochimie April 2010 (Review) Pubmed PMID: 20363286
25. E. Konstantinova, L. Ivanova, T. Tolstaya, and E. Mironova Rheological properties of blood and parameters of platelets aggregation in arterial hypertension Clin. Hemorheol. Microcirc. 35 1-2 2006 135 138 (Pubitemid 44126489)
26. Y. Kureishi, Z. Luo, and I. Shiojima The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat. Med. 6 September (9) 2000 1004 1010 Erratum in: Nat. Med. 2001 January;7(1):129
27. S. Llorens, J. Jordán, and E. Nava The nitric oxide pathway in the cardiovascular system J. Physiol. Biochem. 58 September (3) 2002 179 188 (Review) (Pubitemid 36192882)
28. B. Ludolph, W. Bloch, M. Kelm, R. Schulz, and P. Kleinbongard Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity Vasc. Health Risk Manag. 3 6 2007 1069 1073
29. R. Mesquita, I. Pires, C. Saldanha, and J. Martins-Silva Effects of acetylcholine and spermineNONOate on erythrocyte hemorheologic and oxygen carrying properties Clin. Hemorheol. Microcirc. 25 3-4 2001 153 163 (Pubitemid 34258586)
30. B.J. Michell, J.E. Griffiths, and K.I. Mitchelhill The Akt kinase signals directly to endothelial nitric oxide synthase Curr. Biol. 9 15 1999 845 848 (Pubitemid 29375190)
31. R. Mikulski, C. Tu, E.R. Swenson, and D.N. Silverman Reactions of nitrite in erythrocyte suspensions measured by membrane inlet mass spectrometry Free Radical Biol. Med. 48 January (2) 2010 325 331
32. 2+ but requires phosphorylation by Akt at Ser(1179) J. Biol. Chem. 276 August (32) 2001 30392 30398
33. J.J. Naoum, S. Zhang, and K.J. Woodside Aortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of rapamycin and simvastatin Surgery 136 August (2) 2004 323 328 (Pubitemid 39037672)
34. J.R. Pawloski, D.T. Hess, and J.S. Stamler Export by red blood cells of nitric oxide bioactivity Nature 409 February (6820) 2001 622 626 (Pubitemid 32154814)
35. M.H. Pittler, R. Guo, and E. Ernst Hawthorn extract for treating chronic heart failure Cochrane Database Syst. Rev. 1 2008 10.1002/14651858.CD005312.pub2 Art. No.: CD005312 (Review) (Pubitemid 351807566)
36. Reidenbach, C., Rieckeheer, E., Schwinger, R.H.G., et al. Nebivololinduzierte NO-Freisetzung aus Erythrozyten. Naunyn-Schmiedebergs Arch Pharmacol 379(Suppl. 1), A33550. Frühjahrstagung der Deutschen Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, Mainz, 10.-12.3.2009.
37. V.B. Schini-Kerth Vascular biosynthesis of nitric oxide: effect on hemostasis and fibrinolysis Transfus. Clin. Biol. 6 December (6) 1999 355 363 (Review) (Pubitemid 30021958)
38. S. Shin, Y. Ku, N. Babu, and M. Singh Erythrocyte deformability and its variation in diabetes mellitus Indian J. Exp. Biol. 45 January (1) 2007 121 128 (Review)
39. P. Ulker, L. Sati, C. Celik-Ozenci, H.J. Meiselman, and O.K. Baskurt Mechanical stimulation of nitric oxide synthesizing mechanisms in erythrocytes Biorheology 46 2 2009 121 132
40. C. Vecchione, A. Maffei, and S. Colella Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway Diabetes 51 January (1) 2002 168 173 (Pubitemid 34517994)
41. A. Wennmalm, G. Benthin, and A.S. Petersson Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin Br. J. Pharmacol. 106 July (3) 1992 507 508