Large scale mtDNA sequencing reveals sequence and functional conservation as major determinants of homoplasmic mtDNA variant distribution

Mitochondrion

Volumn 11, Issue 6, 2011, Pages 964-972

  Voets, A M ^a   van den Bosch, B J C ^a,b   Stassen, A P ^a,b   Hendrickx, A T ^b   Hellebrekers, D M ^b   Van Laer, L ^c   Van Eyken, E ^c   Van Camp, G ^c   Pyle, A ^d   Baudouin, S V ^e   Chinnery, P F ^d   Smeets, H J M ^a,b,f  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Distribution; MitoChip; MtDNA variants; Pathogenicity

Indexed keywords

AMINO ACID; MITOCHONDRIAL DNA; TRANSFER RNA;

ADULT; AGED; ARTICLE; ATP6 GENE; ATP8 GENE; COI GENE; COII GENE; COIII GENE; CONTROLLED STUDY; CYB GENE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA EXTRACTION; DNA SEQUENCE; GENE; GENE MUTATION; GENETIC CONSERVATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; ND1 GENE; ND2 GENE; ND3 GENE; ND4 GENE; ND4L GENE; ND5 GENE; ND6 GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RNR1 GENE; RNR2 GENE; SEQUENCE ANALYSIS; TRNA GENE; TRNC GENE; TRND GENE; TRNE GENE; TRNF GENE; TRNG GENE; TRNH GENE; TRNI GENE; TRNK GENE; TRNL1 GENE; TRNL2 GENE; TRNM GENE; TRNN GENE; TRNP GENE; TRNQ GENE; TRNR GENE; TRNS1 GENE; TRNS2 GENE; TRNT GENE; TRNV GENE; TRNW GENE; TRNY GENE;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CONSERVED SEQUENCE; DNA, MITOCHONDRIAL; HUMANS; INFANT; MIDDLE AGED; NUCLEIC ACID CONFORMATION; POLYMORPHISM, GENETIC; RNA, TRANSFER; SEQUENCE ANALYSIS, DNA; YOUNG ADULT;

EID: 82755160635     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2011.09.003     Document Type: Article

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