The LMP7-K allele of the immunoproteasome exhibits reduced transcript stability and predicts high risk of colon cancer

Cancer Research

Volumn 71, Issue 23, 2011, Pages 7145-7154

  Fellerhoff, Barbara ^a,c   Gu, Songhai ^c   Laumbacher, Barbara ^c   Nerlich, Andreas G ^c   Weiss, Elisabeth H ^a   Glas, Jürgen ^b   Kopp, Reinhard ^b   Johnson, Judith P ^a   Wank, Rudolf ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c KLINIKUM BOGENHAUSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; IMMUNOPROTEASOME; MEMBRANE PROTEIN; MESSENGER RNA; PROTEASOME; PROTEIN LMP7; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 2; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ANTIGEN PRESENTATION; ARTICLE; CANCER CELL CULTURE; CANCER RISK; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGENETICS; LMP2 GENE; LMP7 GENE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA STABILITY;

ADULT; AGED; ALLELES; ATP-BINDING CASSETTE TRANSPORTERS; CACO-2 CELLS; CELL LINE, TUMOR; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; CYSTEINE ENDOPEPTIDASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; GENES, MHC CLASS I; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HELA CELLS; HLA-B ANTIGENS; HT29 CELLS; HUMANS; IMMUNOGENETICS; INTERFERON-GAMMA; MALE; POLYMORPHISM, GENETIC; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, MESSENGER;

EID: 82655181320     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1883     Document Type: Article

References (41)

1. Bateman AC, Howell WM. Human leukocyte antigens and cancer: is it in our genes? J Pathol 1999;188:231-6. (Pubitemid 29317763)
2. Cabrera T, Lopez-Nevot MA, Gaforio JJ, Ruiz-Cabello F, Garrido F. Analysis of HLA expression in human tumor tissues. Cancer Immunol Immunother 2003;52:1-9. (Pubitemid 36177220)
3. Lee YM, Leu SY, Chiang H, Fung CP, Liu WT. Human papillomavirus type 18 in colorectal cancer. J Microbiol Immunol Infect 2001;34: 87-91. (Pubitemid 32641337)
4. Heemels MT, Schumacher TN, Wonigeit K, Ploegh HL. Peptide translocation by variants of the transporter associated with antigen processing. Science 1993;262:2059-63. (Pubitemid 24041890)
5. Groettrup M, van den Broek M, Schwarz K, Macagno A, Khan S, de Giuli R, et al. Structural plasticity of the proteasome and its function in antigen processing. Crit Rev Immunol 2001;21:339-58. (Pubitemid 34208441)
6. Kesmir C, van Noort V, de Boer RJ, Hogeweg P. Bioinformatic analysis of functional differences between the immunoproteasome and the constitutive proteasome. Immunogenetics 2003;55:437-49. (Pubitemid 37378484)
7. HLA. the Informatics group. 2011. Available from: http://hla.alleles. org/genes/index.html.
8. HUGO. Gene Nomenclature Committee. 2011. Available from: http:// www.genenames.org/data/hgnc-data.php?hgnc-idZ9546,http://www. genenames.org/data/hgnc-data.php?hgnc-idZ9545.
9. Matsui M, Machida S, Itani-Yohda T, Akatsuka T. Downregulation of the proteasome subunits, transporter, and antigen presentation in hepatocellular carcinoma, and their restoration by interferon-gamma. J Gastroenterol Hepatol 2002;17:897-907.
10. Cabrera CM, Jimenez P, Cabrera T, Esparza C, Ruiz-Cabello F, Garrido F. Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: beta2-microglobulin inactivation in MSI-positive tumors and LMP7/TAP2 downregulation in MSI-negative tumors. Tissue Antigens 2003;61:211-9. (Pubitemid 36605543)
11. Deng GY, Muir A, Maclaren NK, She JX. Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies. Am J Hum Genet 1995;56:528-34.
12. Lim JK, Hunter J, Fernandez-Vina M, Mann DL. Characterization of LMP polymorphism in homozygous typing cells and a random population. Hum Immunol 1999;60:145-51. (Pubitemid 29072098)
13. Teisserenc H, Besnault L, Briaud I, Bussson M, Albert E, Bignon JD, et al. TAP, LMP, and HLA-DM polymorphism: 12th International Histocompatibility Workshop study. In 12th International Histocompatibility Workshop and Conference Proceedings. Genetic Diversity of HLA: functional and medical implications. In: Charron D, editor. Paris: EDK; 1997. p. 159-70.
14. Laumbacher B, Muller N, Bondy B, Schlesinger B, Gu S, Fellerhoff B, et al. Significant frequency deviation of the class I polymorphism HLA-A10 in schizophrenic patients. J Med Genet 2003;40: 217-9. (Pubitemid 36315396)
15. Levine JE, Yang SY. SSOP typing of the Tenth International Histocompatibility Workshop reference cell lines for HLA-C alleles. Tissue Antigens 1994;44:174-83. (Pubitemid 24298085)
16. Hopkins LM, Bull PJ, Gerlach JA, Bull RW. Further characterization of HLA homozygous typing cell lines at the LMP2 polymorphic codon 60 by an ARMS typing method. Hum Immunol 1997;53:183-7. (Pubitemid 27176473)
17. Shmuely H, Passaro D, Figer A, Niv Y, Pitlik S, Samra Z, et al. Relationship between Helicobacter pylori CagA status and colorectal cancer. Am J Gastroenterol 2001;96:3406-10. (Pubitemid 34016668)
18. Chisholm SA, Owen RJ. Development and application of a novel screening PCR assay for direct detection of 'Helicobacter heilmannii'-like organisms in human gastric biopsies in Southeast England. Diagn Microbiol Infect Dis 2003;46:1-7. (Pubitemid 36556013)
19. Chisholm SA, Owen RJ, Teare EL, Saverymuttu S. PCR-based diagnosis of Helicobacter pylori infection and real-time determination of clarithromycin resistance directly from human gastric biopsy samples. J Clin Microbiol 2001;39:1217-20. (Pubitemid 32275409)
20. Gravitt PE, Peyton CL, Alessi TQ, Wheeler CM, Coutlee F, Hildesheim A, et al. Improved amplification of genital human papillomaviruses. J Clin Microbiol 2000;38:357-61. (Pubitemid 30043317)
21. Bodaghi S, Yamanegi K, Xiao SY, Da Costa M, Palefsky JM, Zheng ZM. Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res 2005;11:2862-7. (Pubitemid 40525184)
22. Bodaghi S, Yamanegi K, Xiao SY, Da Costa M, Palefsky JM, Zheng ZM. Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res 2005;11:2862-7. (Pubitemid 40525184)
23. Perez LO, Abba MC, Laguens RM, Golijow CD. Analysis of adenocarcinoma of the colon and rectum: detection of human papillomavirus (HPV) DNA by polymerase chain reaction. Colorectal Dis 2005;7: 492-5. (Pubitemid 41223144)
24. Fruh K, Yang Y, Arnold D, Chambers J, Wu L, Waters JB, et al. Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. J Biol Chem 1992;267:22131-40.
25. Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J. The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. Eur J Immunol 1993;23:860-6. (Pubitemid 23101070)
26. Heink S, Fricke B, Ludwig D, Kloetzel PM, Kruger E. Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency. Cancer Res 2006;66:649-52. (Pubitemid 43165925)
27. Faucz FR, Probst CM, Petzl-Erler ML. Polymorphism of LMP2, TAP1, LMP7 and TAP2 in Brazilian Amerindians and Caucasoids: implications for the evolution of allelic and haplotypic diversity. Eur J Immunogenet 2000;27:5-16. (Pubitemid 30105477)
28. Cao B, Tian X, Li Y, Jiang P, Ning T, Xing H, et al. LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China. Carcinogenesis 2005;26:1280-4. Epub 2005 Mar 1217.
29. Mehta AM, Jordanova ES, van Wezel T, Uh HW, Corver WE, Kwappenberg KM, et al. Genetic variation of antigen processing machinery components and association with cervical carcinoma. Genes Chromosomes Cancer 2007;46:577-86. (Pubitemid 46649572)
30. Khu YL, Tan YJ, Lim SG, Hong W, Goh PY. Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity. Biochem J 2004;384:401-9. (Pubitemid 39656253)
31. Apple R, Lin P, Becker TM, Erlich HA, Wheeler CM. Both HLA-B7 and DRB1*1501 are required to confer risk to HPV-16 associated invasive cancer. In genetic diversity of HLA: functional and medical implications. In: Charron D, editor. Paris: EDK; 2000.
32. Perez LO, Abba MC, Dulout FN, Golijow CD. Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina. World J Gastroenterol 2006;12:1426-9.
33. Wang SS, Wheeler CM, Hildesheim A, Schiffman M, Herrero R, Bratti MC, et al. Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica. J Infect Dis 2001;184:1310-4. (Pubitemid 33055576)
34. Wank R, Meulen JT, Luande J, Eberhardt HC, Pawlita M. Cervical intraepithelial neoplasia, cervical carcinoma, and risk for patients with HLA-DQB1*0602,*301,*0303 alleles. Lancet 1993;341:1215. (Pubitemid 23137141)
35. zur Hausen H. Papillomavirus infections-a major cause of human cancers. Biochim Biophys Acta 1996;1288:F55-78.
36. Silins I, Ryd W, Strand A, Wadell G, Tornberg S, Hansson BG, et al. Chlamydia trachomatis infection and persistence of human papillomavirus. Int J Cancer 2005;116:110-5. (Pubitemid 40827763)
37. Meidenbauer N, Zippelius A, Pittet MJ, Laumer M, Vogl S, Heymann J, et al. High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma. Cancer Res 2004;64:6319-26. (Pubitemid 39129437)
38. Fridman WH, Galon J, Dieu-Nosjean MC, Cremer I, Fisson S, Damotte D, et al. Immune infiltration in human cancer: prognostic significance and disease control. Curr Top Microbiol Immunol 2011;344:1-24.
39. Muchamuel T, Basler M, Aujay MA, Suzuki E, Kalim KW, Lauer C, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med 2009;15:781-7.
40. Bright-Thomas RM, Hargest R. APC, beta-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer. Eur J Surg Oncol 2003;29:107-17. (Pubitemid 36367341)
41. Tomlinson I, Bodmer W. Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog. Nat Med 1999;5:11-2. (Pubitemid 29050986)