The synthesis, magnetic purification and evaluation of 99mTc-labeled microbubbles

Nuclear Medicine and Biology

Volumn 38, Issue 8, 2011, Pages 1111-1118

  Lazarova, Neva ^a   Causey, Patrick W ^a   Lemon, Jennifer A ^a   Czorny, Shannon K ^c   Forbes, John R ^a   Zlitni, Aimen ^c   Genady, Afaf ^c   Foster, F Stuart ^b   Valliant, John F ^a,c  

^a Centre for Probe Development and Commercialization   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Microbubbles; SPECT; Tc 99m; Ultrasound

Indexed keywords

BIOTINYLAMIDO PROPYL (DIPICOLYL)AMINE TC 99M; RADIOISOTOPE; STREPTAVIDIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG PURIFICATION; DRUG SYNTHESIS; ECHOGRAPHY; FEMALE; ISOTOPE LABELING; LIVER; MICROBUBBLE; MOUSE; NONHUMAN; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMALL INTESTINE; SPLEEN;

ANIMALS; CONTRAST MEDIA; FEMALE; INTESTINE, SMALL; LIVER; MICE; MICE, INBRED C57BL; MICROBUBBLES; ORGANOTECHNETIUM COMPOUNDS; SPLEEN; TISSUE DISTRIBUTION; TOMOGRAPHY, X-RAY COMPUTED; URINARY BLADDER;

EID: 82655162229     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.04.008     Document Type: Article

References (25)

1. Cosgrove D., Harvey C. Clinical uses of microbubbles in diagnosis and treatment. Med Biol Eng Comp 2009, 47:813-826.
2. Lindner J.R. Molecular imaging of cardiovascular disease with contrast-enhanced ultrasonography. Nat Rev Cardiol 2009, 6:475-481.
3. Jayaweera A.R., Edwards N., Glasheen W.P., Villanueva F.S., Abbott R.D., Kaul S. In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells. Circul Res 1994, 74:1157-1165.
4. Klibanov A.L. Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. Bioconj Chem 2005, 16:9-17.
5. Tinkov S., Bekeredjian R., Winter G., Coester C. Microbubbles as ultrasound triggered drug carriers. J Pharm Sci 2009, 98:1935-1961.
6. Klibanov A.L. Preparation of targeted microbubbles: ultrasound contrast agents for molecular imaging. Med Biol Eng Comp 2009, 47:875-882.
7. Laing S.T., McPherson D.D. Cardiovascular therapeutic uses of targeted ultrasound contrast agents. Cardiovas Res 2009, 83:626-635.
8. Meikle S.R., Kench P., Kassiou M., Banati R.B. Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol 2005, 50:R45-R61.
9. Willmann J.K., Cheng Z., Davis C., Lutz A.M., Schipper M.L., Nielsen C.H., et al. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic micro-PET in mice. Radiology 2008, 249:212-219.
10. Meszaros L.K., Dose A., Biagini S.C.G., Blower P.J. Hydrazinonicotinic acid (HYNIC) - Coordination chemistry and applications in radiopharmaceutical chemistry. Inorg Chim Acta 2010, 363:1059-1069.
11. 111In-labeling of small biomolecules: bifunctional chelators and related coordination chemistry. Curr Top Med Chem 2010, 10:1113-1134.
12. Troyer G.L., Schenter R.E. Medical isotope development and supply opportunities in the 21st century. J Radioanal Nucl Chem 2009, 282:243-246.
13. Bartholoma M.D., Louie A.S., Valliant J.F., Zubieta J. Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era. Chem Rev 2010, 110:2903-2920.
14. +. J Am Chem Soc 2001, 123:3135-3136.
15. 2Br]. Inorg Chem Commun 2004, 7:1023-1026.
16. Causey P.W., Besanger T.R., Schaffer P., Valliant J.F. Expedient multi-step synthesis of organometallic complexes of Tc and Re in high effective specific activity. A new platform for the production of molecular imaging and therapy agents. Inorg Chem 2008, 47:8213-8221.
17. James S., Maresca K.P., Allis D.G., et al. Extension of the single amino acid chelate concept (SAAC) to bifunctional biotin analogues for complexation of the M(CO)3+1 core (M=Tc and Re): syntheses, characterization, biotinidase stability, and avidin binding. Bioconj Chem 2006, 17:579-589.
18. Loening A.M., Gambhir S.S. AMIDE: a free software tool for multimodality medical image analysis. Mol Imag 2003, 2:131-137.
19. Upadhya K, Khattak IK, Bashar Mullah B. Oxidation of Biotin During Oligonucleotide Synthesis. Nucleosides, nucleotides and nucleic acids. 2005;24:919-922.
20. Schutt E.G., Klein D.H., Mattrey R.M., Riess J.G. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals. Angew. Chem. Int. Ed. 2003, 42:3218-3235.
21. Kabalnov A., Bradley J., Flaim S., Klein D., Pelura T., Peters B., et al. Dissolution of multicomponent microbubbles in the bloodstream: 2. Experiment. Ultrasound Med Biol. 1998, 24:751-760.
22. Weller G.E.R., Villanueva F.S., Tom E.M., Wagner W.R. Targeted ultrasound contrast agents: in vitro assessment of endothelial dysfunction and multi-targeting to ICAM-1 and sialyl Lewis X. Biotechnol Bioeng 2005, 92:780-788.
23. Tinkov S., Winter G., Coester C., Bekeredjian R. New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: Part I. Formulation development and in vitro characterization. J Controlled Release 2010, 143:143-150.
24. Xu R.X., Huang J., Xu J.S., Sun D., Hinkle G.H., Martin E.W., et al. Fabrication of indocyanine green encapsulated biodegradable microbubbles for structural and functional imaging of cancer. J Biomed Optics 2009, 14:1-6.
25. Bartholomae M., Valliant J., Maresca K.P., Babich J., Zubieta J. Single amino acid chelates: a strategy for the design of technetium and rhenium radiopharmaceuticals. Chem Commun 2009, 5:493-512.