Expedient multi-step synthesis of organometallic complexes of Tc and Re in high effective specific activity. A new platform for the production of molecular imaging and therapy agents

Inorganic Chemistry

Volumn 47, Issue 18, 2008, Pages 8213-8221

  Causey, Patrick W ^a   Besanger, Travis R ^b   Schaffer, Paul ^a   Valliant, John F ^b,c  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATING AGENT; CROSS LINKING REAGENT; DIAGNOSTIC AGENT; ORGANOMETALLIC COMPOUND; RHENIUM; TECHNETIUM;

ARTICLE; CHEMISTRY; FILTRATION; MICROWAVE RADIATION; POSITRON EMISSION TOMOGRAPHY; SENSITIVITY AND SPECIFICITY; SYNTHESIS;

CHELATING AGENTS; CROSS-LINKING REAGENTS; FILTRATION; MICROWAVES; ORGANOMETALLIC COMPOUNDS; POSITRON-EMISSION TOMOGRAPHY; RHENIUM; SENSITIVITY AND SPECIFICITY; TECHNETIUM;

EID: 52949153535     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic800775w     Document Type: Article

References (27)

1. (a) Iwata, R.; Takashashi, M.; Shinohara, M.; Ido, T. J. Labelled Comp. Radiopharm. 1982, 19, 1350-1351.
2. (b) Alexoff, D. L. In Handbook of radiopharmaceuticals; Welch, M. J., Redvanly, C. S., Eds.; John Wiley and Sons Ltd: England, 2003; pp 283-306.
3. Lee, C.; Sui, G.; Elizarov, A.; Shu, C. J.; Shin, Y. S.; Dooley, A. N.; Huang, J.; Daridon, A.; Wyatt, P.; Stout, D.; Kolb, H. C.; Witte, O. N.; Satyamurthy, N.; Heath, J. R.; Phelps, M. E.; Quake, S. R.; Tseng, H. Science 2005, 310, 1793-1796.
4. Eckelman, W. C.; Richards, P. J. Nucl. Med. 1970, 11, 761.
5. (a) Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine, 7; Mazzi, U., Ed.; Servizi Grafici Editoriali snc: Padova, 2006.
6. (b) Technetium and Rhenium in Chemistry and Nuclear Medicine; Nicolini, M., Bandoli, G., Mazzi, U., Eds.; Raven Press: New York, 1990.
7. (c) Jurisson, S. S.; Lyden, J. D. Chem. Rev. 1999, 99, 2205.
8. (d) Liu, S.; Edwards, O. S. Chem. Rev. 1999, 99, 2235.
9. (e) Dilworth, J. R.; Parrott, S. J. Chem. Soc. Rev. 1998, 27, 43.
10. (f) Horn, R. K.; Katzenellenbogen, J. A. Nucl. Med. Biol. 1997, 24, 485.
11. (g) Eckelman, W. C. Eur. J. Nucl. Med. 1995, 22, 249.
12. (h) Schwochan, K. Angew. Chem., Int. Ed. Engl. 1994, 33, 2258.
13. (a) Mahmood, A.; Jones, A. G. In Handbook of radiopharmaceuticals; Welch, M. J., Redvanly, C. S., Eds.; John Wiley and Sons Ltd: England, 2003; pp 323-362.
14. (b) Funk, T.; Sun, M.; Hasegawa, B. H. Med. Phys. 2004, 31, 2680-2686.
15. Eckelman, W. C. Nucl. Med. Biol. 2006, 33, 449-451.
16. Lazarova, N.; James, S.; Babich, J.; Zubieta, Z. Inorg. Chem. Commun. 2004, 7, 1023-1026.
17. M86-Exx078 APEX2 User Manual; Bruker AXS Inc.: Madison, WI, 2006.
18. Sheldrick, G. M. SHELXTL, Release 6.14; Siemens Crystallographic Research Systems: Madison, WI, 2000.
19. A two-component kit was kindly supplied by Mallinckrodt Medical, Inc. The kit was labeled with rhenium according to instructions supplied by the manufacturer. The radiochemical purity of the material was determined using g-HPLC to assess the percentage of free perrhenate.
20. Misra, P.; Humblet, V.; Pannier, N.; Maison, W.; Frangioni, J. V. J. Nucl. Med. 2007, 48, 1381-1389.
21. Alberto, R.; Ortner, K.; Wheatley, N.; Schibli, R.; Schubiger, A. P. J. Am. Chem. Soc. 2001, 123, 3135-3136.
22. Banerjee, S. R.; Maresca, K. P.; Francesconi, L.; Valliant, J.; Babich, J. W.; Zubieta, J. Nucl. Med. Biol. 2005, 32, 1-20.
23. Schibli, R.; Schwarzbach, R.; Alberto, R.; Ortner, K.; Schmalle, H.; Dumas, C.; Egli, A.; Schubiger, P. A. Bioconjugate Chem 2002, 13, 750-756.
24. Park, S. H.; Seifert, S.; Pietzsch, H. J. Bioconjugate Chem. 2006, 17, 223-225.
25. Banerjee, S. R.; Levadala, M. K.; Lazarova, N.; Wei, L.; Valliant, J. F.; Stephenson, K. A.; Babich, J. W.; Maresca, K. P.; Zubieta, J. Inorg. Chem. 2002, 41, 6417-6425.
26. Ley, S. V.; Massi, A.; Rodriguez, F.; Horwell, D. C.; Lewthwaite, R. A.; Pritchard, M. C.; Reid, A. M. Angew. Chem., Int. Ed. 2001, 40, 1053-1055.
27. Siu, J.; Baxendale, I. R.; Lewthwaite, R. A.; Ley, S. V. Org. Biomol. Chem. 2005, 3, 3140-3160.