Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: Identification of the cycloalkylcarboxylic acids

Journal of Medicinal Chemistry

Volumn 54, Issue 23, 2011, Pages 8099-8109

  Lamarche, Matthew J ^a   Leeds, Jennifer A ^a   Amaral, Kerri ^a   Brewer, Jason T ^a   Bushell, Simon M ^a   Dewhurst, Janetta M ^a   Dzink Fox, Joanne ^a   Gangl, Eric ^a   Goldovitz, Julie ^a   Jain, Akash ^b   Mullin, Steve ^a   Neckermann, Georg ^a   Osborne, Colin ^a   Palestrant, Deborah ^a   Patane, Michael A ^a   Rann, Elin M ^a   Sachdeva, Meena ^a   Shao, Jian ^a   Tiamfook, Stacey ^a   Whitehead, Lewis ^a   Yu, Donghui ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CYCLOALKYLCARBOXYLIC ACID; GE 2270A; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; CARBOXYLIC ACIDS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, BACTERIAL; FEMALE; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; MALE; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 82555185533     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200938f     Document Type: Article

References (18)

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