Emerging technologies for point-of-care CD4 T-lymphocyte counting

Trends in Biotechnology

Volumn 30, Issue 1, 2012, Pages 45-54

  Boyle, David S ^a   Hawkins, Kenneth R ^a   Steele, Matthew S ^a   Singhal, Mitra ^a   Cheng, Xuanhong ^b  

^a PATH   (United States)

^b Lehigh University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRALS; DEVELOPING WORLD; EMERGING TECHNOLOGIES; PATIENT CARE; POINT OF CARE; TECHNOLOGY DEVELOPMENT; URBAN AREAS;

DEVELOPING COUNTRIES; RURAL AREAS;

PATIENT TREATMENT;

FLUORESCEIN ISOTHIOCYANATE; NANOPARTICLE;

ACCURACY; ACQUIRED IMMUNE DEFICIENCY SYNDROME; BIOSENSOR; CATALYSIS; CD3+ T LYMPHOCYTE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL MOTILITY; CELL SIZE; CHEMOLUMINESCENCE; DISEASE COURSE; ELECTROCHEMICAL DETECTION; ELECTRON TRANSPORT; ELECTROPHORESIS; FLOW CYTOMETRY; FLUORESCENCE; FOLLOW UP; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDRODYNAMICS; IMPEDANCE; LIGHT EMITTING DIODE; LYMPHOCYTE SUBPOPULATION; MICROFLUIDICS; PATIENT CARE; PERIPHERAL BLOOD MONONUCLEAR CELL; POINT OF CARE TESTING; PRIORITY JOURNAL; QUALITY CONTROL; QUARTZ CRYSTAL MICROBALANCE; REVIEW; RURAL AREA;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-HIV AGENTS; BIOLOGICAL ASSAY; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; FOLLOW-UP STUDIES; HEALTH SERVICES NEEDS AND DEMAND; HIV INFECTIONS; HUMANS; SENSITIVITY AND SPECIFICITY;

EID: 82555162620     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2011.06.015     Document Type: Review

References (62)

1. UNAIDS AIDS Epidemic Update 2009, UN.
2. WHO Interim WHO Clinical Staging of HIV/AIDS and HIV/AIDS Case Definitions for Surveillance,Africa Region 2005, World Health Organization.
3. Sterne J.A., et al. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet 2009, 373:1352-1363.
4. WHO Antiretroviral Therapy for HIV Infection in Adults and Adolescents. Recommendations for a Public Health Approach 2010, World Health Organization.
5. Aina O., et al. Reference values of CD4 T lymphocytes in human immunodeficiency virus-negative adult Nigerians. Clin. Diagn. Lab. Immunol. 2005, 12:525-530.
6. Davis K.A., et al. Determination of CD4 antigen density on cells: role of antibody valency, avidity, clones, and conjugation. Cytometry 1998, 33:197-205.
7. Gilks C.F., et al. The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings. Lancet 2006, 368:505-510.
8. Mtapuri-Zinyowera S., et al. Evaluation of the PIMA point-of-care CD4 analyzer in VCT clinics in Zimbabwe. J. Acquir. Immune Defic. Syndr. 2010, 55:1-7.
9. Anderson D.A., et al. Point-of-care testing. Curr. HIV/AIDS Rep. 2011, 8:31-37.
10. Zachariah R., et al. Viewpoint: why do we need a point-of-care CD4 test for low-income countries?. Trop. Med. Int. Health 2011, 16:37-41.
11. WHO Technical Brief on CD4 Technologies 2010, WHO.
12. Cassens U., et al. Simplified volumetric flow cytometry allows feasible and accurate determination of CD4 T lymphocytes in immunodeficient patients worldwide. Antivir. Ther. 2004, 9:395-405.
13. Balakrishnan P., et al. An inexpensive, simple, and manual method of CD4 T-cell quantitation in HIV-infected individuals for use in developing countries 25. J. Acquir. Immune Defic. Syndr. 2004, 36:1006-1010.
14. Diagbouga S., et al. Successful implementation of a low-cost method for enumerating CD4+ T lymphocytes in resource-limited settings: the ANRS 12-26 study. AIDS 2003, 17:2201-2208.
15. Didier J.M., et al. Comparative assessment of five alternative methods for CD4+ T-lymphocyte enumeration for implementation in developing countries. J. Acquir. Immune Defic. Syndr. 2001, 26:193-195.
16. Lutwama F., et al. Evaluation of Dynabeads and Cytospheres compared with flow cytometry to enumerate CD4+ T cells in HIV-infected Ugandans on antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 2008, 48:297-303.
17. Lyamuya E.F., et al. Evaluation of the FACS count, TRAx CD4 and Dynabeads methods for CD4 lymphocyte determination. J. Immunol. Methods 1996, 195:103-112.
18. Bi X., et al. Modified Dynabeads method for enumerating CD4+ T-lymphocyte count for widespread use in resource-limited situations. J. Acquir. Immune Defic. Syndr. 2005, 38:1-4.
19. Yari A., et al. SMARThivCD4mos: a complexity-free and cost effective model technology for monitoring HIV patients CD4 number in resource-poor settings. Bioinformation 2008, 2:257-259.
20. Briggs C., et al. Measurement of CD4+ T cells in point-of-care settings with the Sysmex pocH-100i haematological analyser. Int. J. Lab. Hematol. 2009, 31:169-179.
21. Thorslund S., et al. A PDMS-based disposable microfluidic sensor for CD4(+) lymphocyte counting. Biomed. Microdevices 2008, 851-857.
22. Thorslund S., et al. Bioactive heparin immobilized onto microfluidic channels in poly(dimethylsiloxane) results in hydrophilic surface properties. Colloids Surf. B Biointerfaces 2005, 46:240-247.
23. Thorslund S., et al. Bioactivated PDMS microchannel evaluated as sensor for human CD4+ cells: the concept of a point-of-care method for HIV monitoring. Sensors Actuators B 2007, 123:847-855.
24. Lumb R., et al. Not all microscopes are equal. Int. J. Tuberc. Lung Dis. 2006, 10:227-229.
25. Ymeti A., et al. A single platform image cytometer for resource-poor settings to monitor disease progression in HIV infection. Cytometry A 2007, 71:132-142.
26. Li X., et al. An immunomagnetic single-platform image cytometer for cell enumeration based on antibody specificity. Clin. Vaccine Immunol. 2007, 14:412-419.
27. Li X., et al. Clinical evaluation of a simple image cytometer for CD4 enumeration on HIV-infected patients. Cytometry B Clin. Cytom. 2010, 78:31-36.
28. Bae S.Y., et al. Absolute CD4+ cell count using a plastic microchip and a microscopic cell counter. Cytometry B Clin. Cytom. 2009, 76:345-353.
29. Kiesel P., et al. Spatially modulated emission advances point-of-care diagnostics. Laser Focus World 2010, 15:47-50.
30. Janossy G., Shapiro H. Simplified cytometry for routine monitoring of infectious diseases. Cytometry B Clin. Cytom. 2008, 74(Suppl. 1):S6-S10.
31. Shapiro H.M. Cellular astronomy: a foreseeable future in cytometry. Cytometry A 2004, 60:115-124.
32. Tibbe A.G., et al. Imaging technique implemented in CellTracks system. Cytometry 2002, 47:248-255.
33. Wang Z., et al. Microfluidic CD4+ T-cell counting device using chemiluminescence-based detection. Anal. Chem. 2010, 82:36-40.
34. Ozcan A., Demirci U. Ultra wide-field lens-free monitoring of cells on-chip. Lab Chip 2008, 8:98-106.
35. Gohring J.T., Fan X. Label free detection of CD4+ and CD8+ T cells using the optofluidic ring resonator. Sensors 2010, 10:5798-5808.
36. Yun H., et al. Simultaneous counting of two subsets of leukocytes using fluorescent silica nanoparticles in a sheathless microchip flow cytometer. Lab Chip 2010, 10:3243-3254.
37. Stybayeva G., et al. Lensfree holographic imaging of antibody microarrays for high-throughput detection of leukocyte numbers and function. Anal. Chem. 2010, 82:3736-3744.
38. Thangawng A.L., et al. A hard microflow cytometer using groove-generated sheath flow for multiplexed bead and cell assays. Anal. Bioanal. Chem. 2010, 398:1871-1881.
39. Lin Y.H., Lee G.B. Optically induced flow cytometry for continuous microparticle counting and sorting. Biosens. Bioelectron. 2008, 24:572-578.
40. Wang M.M., et al. Microfluidic sorting of mammalian cells by optical force switching. Nat. Biotechnol. 2005, 23:83-87.
41. Mao X., et al. Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing. Lab Chip 2009, 9:1583-1589.
42. Church C., et al. Electrokinetic focusing and filtration of cells in a serpentine microchannel. Biomicrofluidics 2009, 3:44109.
43. Goddard G.R., et al. Analytical performance of an ultrasonic particle focusing flow cytometer. Anal. Chem. 2007, 79:8740-8746.
44. Wang Y.N., et al. On-chip counting the number and the percentage of CD4+ T lymphocytes. Lab Chip 2008, 8:309-315.
45. Kiesel P., et al. Spatially modulated fluorescence emission from moving particles. Appl. Phys. Lett. 2009, 94:041107.
46. Watkins N.N., et al. A microfabricated electrical differential counter for the selective enumeration of CD4+ T lymphocytes. Lab Chip 2011, 11:1437-1447.
47. Coulter W. Proc. Natl. Electron. Conf. 1956, 12:1034.
48. Watkins N., et al. A robust electrical microcytometer with 3-dimensional hydrofocusing. Lab Chip 2009, 9:3177-3184.
49. Holmes D., et al. Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry. Lab Chip 2009, 9:2881-2889.
50. Holmes D., Morgan H. Single cell impedance cytometry for identification and counting of CD4 T-cells in human blood using impedance labels. Anal. Chem. 2010, 82:1455-1461.
51. Mishra N.N., et al. On-chip micro-biosensor for the detection of human CD4(+) cells based on AC impedance and optical analysis. Biosens. Bioelectron. 2005, 21:696-704.
52. Jiang X., Spencer M.G. Electrochemical impedance biosensor with electrode pixels for precise counting of CD4+ cells: a microchip for quantitative diagnosis of HIV infection status of AIDS patients. Biosens. Bioelectron. 2010, 25:1622-1628.
53. Bachelder E.M., et al. Utilizing a quartz crystal microbalance for quantifying CD4(+) T cell counts. Sensor Lett. 2005, 3:211-215.
54. Wu X., et al. Simultaneous particle counting and detecting on a chip. Lab Chip 2008, 8:1943-1949.
55. Wu X., et al. Microfluidic differential resistive pulse sensors. Electrophoresis 2008, 29:2754-2759.
56. Zhe J., et al. A micromachined high throughput Coulter counter for bioparticle detection and counting. J. Micromech. Microeng. 2007, 17:304-313.
57. Jani I.V., et al. Accurate CD4 T-cell enumeration and antiretroviral drug toxicity monitoring in primary healthcare clinics using point-of-care testing. AIDS 2011, 25:807-812.
58. Cheng X., et al. A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. J. Acquir. Immune Defic. Syndr. 2007, 45:257-261.
59. Cheng X., et al. Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices. Lab Chip 2007, 7:746-755.
60. Willyard C. Simpler tests for immune cells could transform AIDS care in Africa. Nat. Med. 2007, 13:1131.
61. Kiesel P., et al. Monitoring CD4 in whole blood with an opto-fluidic detector based on spatially modulated fluorescence emission. Cytometry A 2011, 79:317-324.
62. Redd A.D., et al. T-cell enumeration from dried blood spots by quantifying rearranged T-cell receptor-beta genes. J. Immunol. Methods 2010, 354:40-44.