Calcium fructoborate-potential anti-inflammatory agent

Biological Trace Element Research

Volumn 143, Issue 3, 2011, Pages 1223-1238

  Scorei, Romulus Ion ^a   Rotaru, Petre ^a  

^a UNIVERSITY OF CRAIOVA   (Romania)

Author keywords

Anti inflammatory; Antioxidant; Boron; Calcium fructoborate; Osteoarthritis; Osteoporosis

Indexed keywords

ANTIINFLAMMATORY AGENT; AUTACOID; BORIC ACID; BORON; CALCIUM FRUCTOBORATE; CHONDROITIN SULFATE; CYCLOOXYGENASE 2; GLUCOSAMINE; IBUPROFEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CULTURE MEDIUM; CYTOKINE PRODUCTION; DIETARY INTAKE; DISEASE COURSE; DRUG MECHANISM; DRUG STRUCTURE; DYSLIPIDEMIA; HUMAN; IN VITRO STUDY; MACROPHAGE; NONHUMAN; NUTRITIONAL VALUE; OSTEOARTHRITIS; OSTEOPOROSIS; PAIN; PROTEIN EXPRESSION; TOXICITY TESTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BORATES; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUCTOSE; HUMANS;

EID: 82455219488     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-011-8972-6     Document Type: Article

References (100)

1. Miljkovic D (1998) Boron carbohydrates complexes and uses thereof. October 8, US Patent 5962049
2. D Miljkovic IR Scorei VM Cimpoiasu, et al. 2009 Calcium fructoborate: plant-based dietary boron for human nutrition J Diet Suppl 6 211 226 10.1080/19390210903070772
3. RI Scorei 2011 Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy Front Biosci S3 1 205 215 10.2741/s145 1:CAS:528:DC%2BC3MXivVKltL0%3D
4. R Scorei R Ciubar C Iancu V Mitran, et al. 2007 In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes Biol Trace Elem Res 118 27 37 17848728 10.1007/s12011-007-0019-7 1:CAS:528: DC%2BD2sXhtVSnsLfL (Pubitemid 47509506)
5. RI Scorei C Ciofrangeanu R Ion, et al. 2010 In vitro effects of calcium fructoborate upon production of inflammatory mediators by LPS-stimulated RAW 264.7 macrophages Biol Trace Elem Res 135 334 344 19669712 10.1007/s12011-009- 8488-5 1:CAS:528:DC%2BC3cXlsVGisbk%3D
6. R Scorei VM Cimpoiasu D Iordachescu 2005 In vitro evaluation of the antioxidant activity of calcium fructoborate Biol Trace Elem Res 107 127 134 16217137 10.1385/BTER:107:2:127 1:CAS:528:DC%2BD2MXhtFGkt7nJ
7. R Scorei R Ciubar CM Ciofrangeanu, et al. 2008 Comparative effects of boric acid and calcium fructoborate on breast cancer cells Biol Trace Elem Res 122 197 205 18176783 10.1007/s12011-007-8081-8 1:CAS:528:DC%2BD1cXlvVCmsLo%3D
8. CD Hunt JL Herbel JP Idso 1994 Dietary boron modifies the effects of vitamin D, nutrition on indices of energy substrate utilization and mineral metabolism in the chick J Bone Miner Res 9 171 182 8140930 10.1002/jbmr. 5650090206 1:CAS:528:DyaK2cXis1yrtLY%3D (Pubitemid 24041562)
9. R Scorei R Popa 2010 Boron-containing compounds as preventive and chemotherapeutic agents for cancer Anticancer Agent Med Chem 10 346 351 1:CAS:528:DC%2BC3cXmsVams7k%3D
10. Criste RD, Grossu DV, Scorei R et al (2005) New investigations on the effect of the dietary boron on broilers and layers: boron and food quality. Arch Zoot 8:65-78. Available at http://www.ibna.ro/arhiva/AZ%208/AZ%208- 06%20RCriste.pdf
11. H Hu SG Penn CB Lebrilla, et al. 1997 Isolation and characterization of soluble boron complexes in higher plants Plant Physiol 113 649 655 9046600 10.1104/pp.113.2.649 1:CAS:528:DyaK2sXht1Ghurg%3D
12. S Yamaki 1995 Physiology and metabolism of fruit development: biochemistry of sugar metabolism and compartmentation in fruits Acta Hort 398 109 120 1:CAS:528:DyaK2sXhvFylsb8%3D
13. 11B NMR observation of plant tissue Anal Sci 11 889 892 10.2116/analsci.11.889 1:CAS:528:DyaK2MXpvFaisr4%3D
14. 14C sorbitol in apple shoots Biotronics 26 73 83 1:CAS:528:DyaK2sXhsFajurk%3D (Pubitemid 28163529)
15. PH Brown BJ Shelp 1997 Boron mobility in plants Plant Soil 193 85 101 10.1023/A:1004211925160 1:CAS:528:DyaK2sXmtFaltLg%3D (Pubitemid 27392916)
16. WG Woods 1996 Review of possible boron speciation relating to its essentiality J Trace Elem Exp Med 9 153 163 10.1002/(SICI)1520-670X(1996)9: 4<153::AID-JTRA3>3.0.CO;2-S 1:CAS:528:DyaK2sXisFyqu7Y%3D (Pubitemid 27168599)
17. M Kobayashi T Matoh JI Azuma 1996 Two chains of rhamnogalacturonan II are cross-linked by borate-diol ester bonds in higher plant cell walls Plant Physiol 110 1017 1020 12226238 1:CAS:528:DyaK28Xhs1Gitrs%3D
18. P Rotaru R Scorei A Hǎrǎbor, et al. 2010 Thermal analysis of a calcium fructoborate sample Thermochim Acta 506 8 13 10.1016/j.tca.2010.04. 006 1:CAS:528:DC%2BC3cXotlyltrc%3D
19. S Söderholm YH Roos N Meinander, et al. 1999 Raman spectra of fructose and glucose in the amorphous and crystalline states J Raman Spectrosc 30 1009 1018 10.1002/(SICI)1097-4555(199911)30:11<1009::AID-JRS436>3.0. CO;2-#
20. H Pelmore MCR Symons 1986 N.M.R. studies of complexes formed by d-fructose and borate ions in aqueous solution Carbohyd Res 155 206 211 10.1016/S0008-6215(00)90147-2 1:CAS:528:DyaL2sXhslKkt70%3D
21. NH Kim H-J Kim D Kang, et al. 2008 Conversion shift of d-fructose to d-psicose for enzyme-catalyzed epimerization by addition of borate Appl Environ Microbiol 74 3008 3013 18378642 10.1128/AEM.00249-08 1:CAS:528: DC%2BD1cXmsVOktLk%3D (Pubitemid 351747004)
22. M Tǎtucu P Rotaru I Rǎu, et al. 2010 Thermal behaviour and spectroscopic investigation of some methyl 2-pyridyl ketone complexes J Therm Anal Calorim 100 1107 1114 10.1007/s10973-009-0276-0
23. M Olczak-Kobza 2004 Synthesis and thermal characterization of zinc(II) di(o-aminobenzoate) complexes of imidazole and its methyl derivatives Thermochim Acta 419 67 71 10.1016/j.tca.2004.01.017 1:CAS:528:DC%2BD2cXmvFOnsrg%3D
24. M Badea R Olar D Marinescu, et al. 2007 Thermal stability of some new complexes bearing ligands with polymerizable groups J Therm Anal Calorim 88 317 321 10.1007/s10973-006-8031-2 1:CAS:528:DC%2BD2sXlt1Kmsbk%3D (Pubitemid 46752064)
25. M Badea R Olar D Marinescu, et al. 2008 Thermal stability of new complexes bearing both acrylate and aliphatic amine as ligands J Therm Anal Calorim 92 205 208 10.1007/s10973-007-8765-5 1:CAS:528:DC%2BD1cXlslChtL4%3D
26. E Szunyogová D Mudronová K Györyová, et al. 2007 The physicochemical and biological properties of zinc(II) complexes J Therm Anal Calorim 88 355 361 10.1007/s10973-006-8115-z (Pubitemid 46752070)
27. ZR Tian JA Voigt J Jun Liu, et al. 2003 Complex and oriented ZnO nanostructures Nat Mater 2 821 826 14634640 10.1038/nmat1014 1:CAS:528:DC%2BD3sXptlemt74%3D
28. LP Bauermann J Bill F Aldinger 2006 Bio-friendly synthesis of ZnO nanoparticles in aqueous solution at near-neutral pH and low temperature J Phys Chem B 110 5182 5185 16539445 10.1021/jp056830m 1:CAS:528:DC%2BD28XhsFeju78%3D
29. A Kropidłowska A Rotaru M Strankowski, et al. 2008 Heteroleptic cadmium(II) complex, potential precursor for semiconducting CdS layers. Thermal stability and non-isothermal decomposition kinetics J Therm Anal Calorim 91 903 909 10.1007/s10973-007-8553-2
30. A Rotaru A Mietlarek-Kropidłowska C Constantinescu, et al. 2009 CdS thin films obtained by thermal treatment of cadmium(II) complex precursor deposited by MAPLE technique Appl Surf Sci 255 6786 6789 10.1016/j.apsusc.2009. 02.062 1:CAS:528:DC%2BD1MXls1yqurs%3D
31. A Rotaru C Constantinescu A Mândruleanu, et al. 2010 Matrix assisted pulsed laser evaporation of zinc benzoate for ZnO thin films and non-isothermal decomposition kinetics Thermochim Acta 498 81 91 10.1016/j.tca.2009.10.006 1:CAS:528:DC%2BD1MXhs1SktL7I
32. MD Dumitru D Miljkovic RI Scorei, et al. 2010 FT-IR and Raman spectroscopic analysis of a calcium fructoborate sample Physics AUC 20 113 119
33. 4 via pyrolysis of calcium fructoborate Mater Res 11 493 494 1:CAS:528: DC%2BD1MXnsVWku7Y%3D
34. CC Wagner V Ferraresi Curotto R Pis Diez, et al. 2008 Experimental and theoretical studies of calcium fructoborate Biol Trace Elem Res 122 64 72 18227977 10.1007/s12011-007-8060-0 1:CAS:528:DC%2BD1cXjvVaitrc%3D
35. K Yoshimura Y Mayazaki S Sawada, et al. 1996 B- NMR studies on complexation of borate with linear and crosslinked polysaccharides J Chem Soc Faraday Trans 92 651 656 10.1039/ft9969200651 1:CAS:528:DyaK28XhsFegsrg%3D (Pubitemid 126836731)
36. PP Power WG Woods 1997 The chemistry of boron and its speciation in plants Plant Soil 193 1 13 10.1023/A:1004231922434 1:CAS:528:DyaK2sXmtFalsbc%3D (Pubitemid 27392910)
37. M Mazurek AS Perlin 1963 Borate complexing by 5-membered-ring vic-diols Can J Chemistry 41 2403 2411 10.1139/v63-354 1:CAS:528:DyaF3sXks12gtLg%3D
38. FH Nielsen 1997 Boron in human and animal nutrition Plant Soil 193 199 208 10.1023/A:1004276311956 1:CAS:528:DyaK2sXmtFalu7c%3D (Pubitemid 27392922)
39. FH Nielsen 19998 Boron-an overlooked element of potential nutritional importance Nutr Today 23 4 7 10.1097/00017285-198801000-00001
40. CJ Rainey LA Nyquist RE Christensen, et al. 1999 Daily intake of boron from the American diet J Amer Dietetic Assoc 99 335 341 10.1016/S0002-8223(99) 00085-1 1:CAS:528:DyaK1MXivVGlt7Y%3D (Pubitemid 29186043)
41. RF Moseman 1994 Chemical disposition of boron in animals and humans Environ Health Perspect 102 113 117 7889870 1:CAS:528:DyaK2MXjsVaht74%3D
42. T Devirian S Volpe 2003 The physiological effects of dietary boron Crit Rev Food Sci Nutr 43 219 223 12705642 10.1080/10408690390826491 1:CAS:528:DC%2BD3sXjtlKgsbc%3D (Pubitemid 38552308)
43. C Rainey L Nyquist 1998 Multicountry estimation of dietary boron intake Biol Trace Elem Res 66 79 86 10050910 10.1007/BF02783128 1:CAS:528: DyaK1MXht1Cit7g%3D (Pubitemid 29093973)
44. National Academy of Sciences, Institute of Medicine, Food and Nutrition Board (2002a) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. National Academy, Washington
45. SG Penn H Hu PH Brown, et al. 1997 Direct analysis of sugar alcohol borate complexes in plant extracts by matrix-assisted laser desorption/ ionization Fourier transform mass spectrometry Anal Chem 69 2471 2477 9212709 10.1021/ac970101o 1:CAS:528:DyaK2sXjsVOhsb4%3D
46. Bielski RI (2003) Sugar alcohols. In: Lewus FA, Tanner W (eds) Encyclopedia of plant physiology, new series. V13A plant carbohydrates. I. Intercellular carbohydrates. Springer, New York, pp 158-192
47. T Fuleki E Pelayo RB Palabay 1994 Sugar composition of varietal juices produced from fresh and stored apples J Agric Food Chem 42 1266 1275 10.1021/jf00042a003 1:CAS:528:DyaK2cXktVOktL4%3D
48. M Suni M Nyman NA Eriksson, et al. 2000 Carbohydrate composition and content of organic acids in fresh and stored apples J Sci Food Agric 80 1538 1544 10.1002/1097-0010(200008)80:10<1538::AID-JSFA678>3.0.CO;2-A 1:CAS:528:DC%2BD3cXltl2ns7s%3D (Pubitemid 30597638)
49. SJ Baker CZ Ding T Akama 2009 Therapeutic potential of boron-containing compounds Future Med Chem 1 1275 1288 21426103 10.4155/fmc.09.71 1:CAS:528:DC%2BD1MXhtlOisL7E
50. WD Loomis RM Durst 1992 Chemistry and biology of boron Biofactors 3 229 239 1605832 1:CAS:528:DyaK38XksVWqtL8%3D
51. SS Tate A Meister 1978 Serine-borate complex as a transition-state inhibitor of y-glutamyl transpeptidase Proc Natl Acad Sci USA 75 4806 4809 33382 10.1073/pnas.75.10.4806 1:CAS:528:DyaE1MXjsFGhtw%3D%3D (Pubitemid 9048623)
52. F Frantzen K Grimsrud D-E Heggli, et al. 1995 Protein-boronic acid conjugates and their binding to low-molecular-mass cis-diols and glycated hemoglobin J Chromatogr B Biomed Appl 670 37 45 7493083 10.1016/0378-4347(95) 00141-5 1:CAS:528:DyaK2MXnsFWmtL0%3D
53. W Holak 1971 Atomic absorption determination of boron in foods J Assoc Off Anal Chem 54 1138 1139 5151674 1:CAS:528:DyaE3MXltVylsr0%3D
54. W Holak 1971 Collaborative study of the determination of boric acid in foods by atomic absorption spectrophotometry J Assoc Off Anal Chem 55 890 891
55. CA Zittle 1951 Reaction of borate with substances of biological interest Adv Enzymol 12 493 527 1:CAS:528:DyaG38XitVOrtQ%3D%3D
56. JN Dupre MJ Keenan M Hegsted, et al. 1994 Effects of dietary boron in rats fed a vitamin D-deficient diet Environ Health Perspect 102 55 58 7889882 1:CAS:528:DyaK2MXjsVahtL8%3D
57. FH Nielsen TR Shuler SK Gallagher 1990 Effects of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium-low diet J Trace Elem Exp Med 3 45 54 1:CAS:528:DyaK3cXltlSqur4%3D (Pubitemid 20080766)
58. CD Hunt 1989 Dietary boron modified the effects of magnesium and molybdenum on mineral metabolism in the cholecalciferol-deficient chick Biol Trace Elem Res 22 201 220 2484240 10.1007/BF02916650 1:CAS:528: DyaL1MXmtlWis7g%3D (Pubitemid 19267776)
59. SL Meacham LJ Taper SL Volpe 1994 Effects of boron supplementation on bone mineral density and dietary, blood, and urinary calcium, phosphorus, magnesium, and boron in female athletes Environ Health Perspect 102 79 82 7889886 1:CAS:528:DyaK2MXjsVahtro%3D
60. FH Nielsen 1994 Biochemical and physiologic consequences of boron deprivation in humans Environ Health Perspect 102 59 63 7889883 1:CAS:528:DyaK2MXjsVahtLw%3D
61. FH Nielsen TR Shuler TJ Zimmerman, et al. 1998 Magnesium and methionine deprivation affect the response of rats to boron deprivation Biol Trace Elem Res 17 91 107 10.1007/BF02795449
62. FH Nielsen CD Hunt LM Mullen, et al. 1987 Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women FASEB J 1 394 397 3678698 1:CAS:528:DyaL2sXmtlGhtbg%3D (Pubitemid 18033759)
63. CD Hunt 1998 Regulation of enzymatic activity: one possible role of dietary boron in higher animals and humans Biol Trace Elem Res 66 205 225 10050921 10.1007/BF02783139 1:CAS:528:DyaK1MXht1CitLk%3D (Pubitemid 29093984)
64. M Benderdour T Van Bui K Hess 2000 Effects of boron derivatives on extracellular matrix formation J Trace Element Med Biol 14 168 173 10.1016/S0946-672X(00)80006-1 1:CAS:528:DC%2BD3MXot12hsw%3D%3D
65. CP Turner AM Toye OTG Jones 1998 Keratinocyte superoxide generation Free Radical Biol Med 24 401 407 10.1016/S0891-5849(97)00270-0 1:CAS:528: DyaK2sXotVSjtbs%3D (Pubitemid 28008784)
66. DC Hunt JP Idso 1999 Dietary boron as a physiological regulator of the normal inflammatory response: a review and current research progress J Trace Elem Exp Med 12 221 233 10.1002/(SICI)1520-670X(1999)12:3<221::AID- JTRA6>3.0.CO;2-X 1:CAS:528:DyaK1MXltVSrtL4%3D (Pubitemid 29376065)
67. R Kettritz RJ Falk JC Jennette, et al. 1977 Neutrophil superoxide release is required for spontaneous and fMLP-mediated but not for TNFα-mediated apoptosis J Am Soc Nephrol 8 1091 1100
68. 2+ influx and activation of the neutrophil respiratory burst. Different regulation of plasma membrane- and granule-localized NADPH-oxidase J Leukoc Biol 71 611 617 11927647 1:CAS:528:DC%2BD38XivFGktro%3D
69. K Uchimura A Nagasaka R Hayashi, et al. 1999 Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus J Diabet Comp 13 264 270 10.1016/S1056-8727(99)00053-7 1:STN:280:DC%2BD3c3ivFGjsw%3D%3D (Pubitemid 30182606)
70. A Zychlinsky C Fitting JM Cavaillon, et al. 1994 Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri J Clin Invest 94 1328 1332 8083373 10.1172/JCI117452 1:CAS:528:DyaK2cXlslOnsbg%3D (Pubitemid 24286479)
71. J Cao L Jiang X Zhang, et al. 2008 Boric acid inhibits LPS-induced TNF-alpha formation through a thiol-dependent mechanism in THP-1 cells J Trace Elem Med Biol 22 189 195 18755394 10.1016/j.jtemb.2008.03.005 1:CAS:528:DC%2BD1cXhtlSgurjN
72. TA Armstrong JW Spears KE Lloyd 2001 Inflammatory response, growth, and thyroid hormone concentrations are affected by long-term boron supplementation in gilts J Anim Sci 79 1549 1556 11424693 1:CAS:528:DC%2BD3MXksFKntL0%3D (Pubitemid 33620432)
73. TA Armstrong JW Spears 2003 Effect of boron supplementation of pig diets on the production of tumor necrosis factor-alpha and interferon-gamma J Anim Sci 81 2552 2561 14552383 1:CAS:528:DC%2BD3sXnsFKnsbk%3D (Pubitemid 38571659)
74. M Benderdour K Hess M Dzondo-Gadet, et al. 1998 Boron modulates extracellular matrix and TNFα synthesis in human fibroblasts Biochem Biophys Res Commun 246 746 751 9618283 10.1006/bbrc.1998.8688 1:CAS:528:DyaK1cXjsFGmtb0%3D (Pubitemid 28420929)
75. M Benderdour K Hess M Dzondo-Gadet, et al. 1997 Effect of boric acid solution on cartilage metabolism Biochem Biophys Res Commun 234 263 268 9169000 10.1006/bbrc.1997.6621 1:CAS:528:DyaK2sXjt1yntrs%3D (Pubitemid 27267571)
76. S Pradervand MR Maurya S Subramaniam 2006 Identification of signaling components required for the prediction of cytokine release in RAW 264.7 macrophages Genome Biol 7 R11 16507166 10.1186/gb-2006-7-2-r11 (Pubitemid 43879099)
77. PC Calder 2003 N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic Lipids 38 343 352 12848278 10.1007/s11745-003- 1068-y 1:CAS:528:DC%2BD3sXkvFShsro%3D (Pubitemid 36724290)
78. D Rees EA Miles T Banerjee, et al. 2006 Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men Am J Clin Nutr 83 331 342 16469992 1:CAS:528: DC%2BD28Xhs1ehsb4%3D (Pubitemid 44713195)
79. I Hardardóttir JE Kinsella 1992 Increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio increases tumor necrosis factor production by murine resident peritoneal macrophages without an effect on elicited peritoneal macrophages J Nutr 122 1942 1951 1527636
80. L Ferrucci A Cherubini S Bandinelli, et al. 2006 Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers J Clin Endocrinol Metab 91 439 446 16234304 10.1210/jc.2005-1303 1:CAS:528: DC%2BD28XhsFKntLs%3D (Pubitemid 43236907)
81. Nielsen FH (2003) Does boron have an essential function similar to an omega-3 fatty acid function? In: Anke, M, Muller R, Schafer U, Stoeppler M (eds) 21st Workshop on Macro and Trace elements, Friedrich Schiller University, Jena, Germany, October 18-19. Schubert, Leipzig, pp 1238-1250
82. C Nathan QW Xie 1994 Nitric oxide syntheses. Roles, tolls, and controls Cell 78 915 918 7522969 10.1016/0092-8674(94)90266-6 1:CAS:528: DyaK2cXmsV2jsLg%3D (Pubitemid 24292319)
83. JE Albina S Cui RB Mateo, et al. 1993 Nitric oxide-mediated apoptosis in murine peritoneal macrophages J Immunol 150 5080 5085 7684418 1:CAS:528:DyaK3sXkslSgsbg%3D (Pubitemid 23150375)
84. R van den Berg JA Peters H van Bekkum 1994 The structure and (local) stability constants of borate esters of mono- and di-saccharides as studied by 11B and 13C NMR spectroscopy Carbohydr Res 253 1 12 8156542 10.1016/0008- 6215(94)80050-2 (Pubitemid 24096056)
85. Q Luan T Desta L Chehab, et al. 2008 Inhibition of experimental periodontitis by a topical boron-based antimicrobial J Dent Res 87 148 152 18218841 10.1177/154405910808700208 1:STN:280:DC%2BD1c%2FmsFKjsQ%3D%3D
86. LH Mattingly A Ruth M Gault, et al. 2007 Use of systemic proteasome inhibition as an immune modulating agent in disease Endocr Metab Immune Disord Drug Targets 7 29 34 17346202 1:CAS:528:DC%2BD2sXisFCmsLg%3D (Pubitemid 46380416)
87. FH Nielsen 2008 Is boron nutritionally relevant? Nutr Rev 66 183 191 18366532 10.1111/j.1753-4887.2008.00023.x (Pubitemid 351666641)
88. FH Nielsen LM Mullen EJ Nielsen 1991 Dietary boron affects blood cell counts and hemoglobin concentrations in humans J Trace Elem Exp Med 4 211 223 1:CAS:528:DyaK38Xkt1Git7c%3D
89. RL Travers GC Rennie RE Newnham 1990 Boron and arthritis: the result of a double-blind pilot study J Nutr Med 1 127 132 10.3109/13590849009003147
90. RE Newnham 1994 The role of boron in human nutrition J Appl Nutr 46 81 85 1:CAS:528:DyaK2MXjvFWit7g%3D
91. FH Nielsen 2004 Dietary fat composition modifies the effect of boron on bone characteristics and plasma lipids in rats Biofactors 20 161 170 15665386 10.1002/biof.5520200305 1:CAS:528:DC%2BD2MXkt1artA%3D%3D
92. TA Amstrong JVV Spears TD Crenshaw, et al. 2000 Boron supplementation of a semipurified diet for weanling pigs improves feed efficiency and bone strength characteristics and alters plasma lipid metabolites J Nutr 130 2575 2581
93. T Richart Y Li J Staessen 2007 Renal versus extra renal activation of vitamin D in relations to atherosclerosis, arterial stiffening and hypertension Am J Hypetens 20 1007 1015 10.1016/j.amjhyper.2007.03.017 1:CAS:528: DC%2BD2sXpvF2qt70%3D (Pubitemid 47313623)
94. S Bord A Horner CA Beeton, et al. 1999 Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) distribution in normal and pathological human bone Bone 24 229 235 10071915 10.1016/S8756-3282(98)00174-4 1:CAS:528: DyaK1MXhslCrurs%3D (Pubitemid 29094565)
95. TD Spector DJ Hart D Nandra Doyle, et al. 2005 Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease Arthritis Rheum 40 4 723 727 10.1002/art.1780400419
96. PH Dessein AE Stanwix 2001 Inflammatory arthritis and cardiovascular disease may share a common predisposition Rheumatology 40 703 704 11426032 10.1093/rheumatology/40.6.703 1:STN:280:DC%2BD3MzmsFCjtQ%3D%3D (Pubitemid 32621813)
97. W Khovidhunkit M Kim R Memon, et al. 2004 Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host J Lipid Res 45 1169 1196 15102878 10.1194/jlr.R300019-JLR200 1:CAS:528:DC%2BD2cXltFyqs78%3D (Pubitemid 38802622)
98. PM Ridker N Rifai L Rose, et al. 2009 Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events N Engl J Med 347 1557 1565 10.1056/NEJMoa021993
99. WS An SE Kim KH Kim, et al. 2009 Associations between oxidized LDL to LDL ratio, HDL and vascular calcification in the feet of hemodialysis patients J Korean Med Sci 24 115 120 10.3346/jkms.2009.24.S1.S115
100. World Health Organization (2010) International clinical trials registry platform search portal. Identifier ISRCTN46679573. A double-blind, placebo-controlled pilot study to evaluate calcium fructoborate effect on systemic inflammation and dyslipidaemia markers in middle-aged people with primary osteoarthritis. World Health Organization, Geneva. Available at http://apps.who.int/trialsearch/trial.aspx?trialid=ISRCTN46679573