Post-lumpectomy intracavitary retention and lymph node targeting of 99mTc-encapsulated liposomes in nude rats with breast cancer xenograft

Breast Cancer Research and Treatment

Volumn 130, Issue 1, 2011, Pages 97-107

  Li, Shihong ^a   Goins, Beth ^a   Phillips, William T ^a   Saenz, Marcela ^a   Otto, Pamela M ^a   Bao, Ande ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Brachytherapy; Breast cancer; Intracavitary; Locoregional retention; Lymph node; Radioactive liposomes

Indexed keywords

ANION; CATION; LIPOSOME TC 99M; N,N BIS(2 MERCAPTOETHYL) N',N' DIETHYLETHYLENEDIAMINE TECHNETIUM TC 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRACHYTHERAPY; BREAST CANCER; CANCER CELL CULTURE; CANCER STAGING; CELL STRAIN MDA MB 231; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; ENCAPSULATION; FEASIBILITY STUDY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; LYMPH NODE; NON INVASIVE MEASUREMENT; NONHUMAN; NUDE RAT; PARTIAL MASTECTOMY; PRIORITY JOURNAL; RAT; STEREOMICROSCOPY; SURFACE CHARGE; TUMOR XENOGRAFT;

ANIMALS; BRACHYTHERAPY; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; LIPOSOMES; LYMPH NODES; MASTECTOMY, SEGMENTAL; MICROSCOPY, FLUORESCENCE; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; RATS; RATS, NUDE; TECHNETIUM; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 82455218977     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1309-x     Document Type: Article

References (61)

1. Early Breast Cancer Trialists' Collaborative Group (1995) Effects of radiotherapy and surgery in early breast cancer. An overview of the randomized trials. N Engl J Med 333:1444-1455
2. Forrest AP, Stewart HJ, Everington D, Prescott RJ, McArdle CS, Harnett AN, Smith DC, George WD (1996) Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial Scottish Cancer Trials Breast Group. Lancet 348:708-713. doi:10.1016/S0140-6736 (96) 02133-2 (Pubitemid 26302305)
3. Liljegren G, Holmberg L, Bergh J, Lindgren A, Tabar L, Nordgren H, Adami HO (1999) 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol 17:2326-2333 (Pubitemid 29368230)
4. Van de Steene J, Vinh-Hung V, Cutuli B, Storme G (2004) Adjuvant radiotherapy for breast cancer: effects of longer followup. Radiother Oncol 72:35-43. doi:10.1016/j.radonc.2004.04.004 (Pubitemid 38952857)
5. Veronesi U, Marubini E, Mariani L, Galimberti V, Luini A, Veronesi P, Salvadori B, Zucali R (2001) Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol 12:997-1003 (Pubitemid 32725776)
6. Polgar C, Strnad V, Major T (2005) Brachytherapy for partial breast irradiation: the European experience. Semin Radiat Oncol 15:116-122. doi:10.1016/j.semradonc.2004.10.004 (Pubitemid 40432416)
7. Vicini FA, Arthur DW (2005) Breast brachytherapy: North American experience. Semin Radiat Oncol 15:108-115. doi: 10.1016/j.semradonc.2004.10.005 (Pubitemid 40432415)
8. Arthur D (2003) Accelerated partial breast irradiation: a change in treatment paradigm for early stage breast cancer. J Surg Oncol 84:185-191. doi:10.1002/jso.10318 (Pubitemid 37484782)
9. Dirbas FM (2009) Accelerated partial breast irradiation: where do we stand? J Natl Compr Cancer Netw 7:215-225
10. Vaidya JS, Tobias JS, Baum M, Wenz F, Kraus-Tiefenbacher U, D'souza D, Keshtgar M, Massarut S, Hilaris B, Saunders C, Joseph D (2005) TARGeted Intraoperative radiotherapy (TAR-GIT): an innovative approach to partial-breast irradiation. Semin Radiat Oncol 15:84-91. doi:10.1016/j.semradonc.2004.10.007 (Pubitemid 40432412)
11. Veronesi U, Orecchia R, Luini A, Galimberti V, Gatti G, Intra M, Veronesi P, Leonardi MC, Ciocca M, Lazzari R, Caldarella P, Simsek S, Silva LS, Sances D (2005) Full-dose intraoperative radiotherapy with electrons during breast-conserving surgery: experience with 590 cases. Ann Surg 242:101-106. doi: 10.1097/01.sla.0000167927.82353.bc (Pubitemid 40917973)
12. Vicini FA, Baglan KL, Kestin LL, Mitchell C, Chen PY, Frazier RC, Edmundson G, Goldstein NS, Benitez P, Huang RR, Martinez A (2001) Accelerated treatment of breast cancer. J Clin Oncol 19:1993-2001 (Pubitemid 32702544)
13. Arthur DW, Vicini FA, Kuske RR, Wazer DE, Nag S (2003) Accelerated partial breast irradiation: an updated report from the American Brachytherapy Society. Brachytherapy 2:124-130. doi: 10.1016/S1538-4721 (03) 00107-7 (Pubitemid 36960130)
14. Baglan KL, Sharpe MB, Jaffray D, Frazier RC, Fayad J, Kestin LL, Remouchamps V, Martinez AA, Wong J, Vicini FA (2003) Accelerated partial breast irradiation using 3D conformal radiation therapy (3D-CRT). Int J Radiat Oncol Biol Phys 55:302-311. doi:10.1016/S0360-3016 (02) 03811-7 (Pubitemid 36074881)
15. Weed DW, Edmundson GK, Vicini FA, Chen PY, Martinez AA (2005) Accelerated partial breast irradiation: a dosimetric comparison of three different techniques. Brachytherapy 4:121-129. doi:10.1016/j.brachy.2004.12.005 (Pubitemid 40693687)
16. Vaidya JS, Baum M, Tobias JS, D'Souza DP, Naidu SV, Morgan S, Metaxas M, Harte KJ, Sliski AP, Thomson E (2001) Targeted intra-operative radiotherapy (Targit): an innovative method of treatment for early breast cancer. Ann Oncol 12:1075-1080 (Pubitemid 32834487)
17. Veronesi U, Gatti G, Luini A, Intra M, Orecchia R, Borgen P, Zelefsky M, McCormick B, Sacchini V (2003) Intraoperative radiation therapy for breast cancer: technical notes. Breast J 9:106-112. doi:10.1046/j.1524-4741.2003.09208. x (Pubitemid 37051578)
18. Ivaldi GB, Leonardi MC, Orecchia R, Zerini D, Morra A, Galimberti V, Gatti G, Luini A, Veronesi P, Ciocca M, Sangalli C, Fodor C, Veronesi U (2008) Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women. Int J Radiat Oncol Biol Phys 72:485-493. doi:10.1016/j.ijrobp. 2007.12.038
19. Edmundson GK, Vicini FA, Chen PY, Mitchell C, Martinez AA (2002) Dosimetric characteristics of the MammoSite RTS, a new breast brachytherapy applicator. Int J Radiat Oncol Biol Phys 52:1132-1139. doi:10.1016/S0360-3016 (01) 02773-0 (Pubitemid 34219036)
20. Keisch M, Vicini F, Kuske RR, Hebert M, White J, Quiet C, Arthur D, Scroggins T, Streeter O (2003) Initial clinical experience with the MammoSite breast brachytherapy applicator in women with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 55:289-293. doi: 10.1016/S0360-3016 (02) 04277-3 (Pubitemid 36069086)
21. Lawenda BD, Taghian AG, Kachnic LA, Hamdi H, Smith BL, Gadd MA, Mauceri T, Powell SN (2003) Dose-volume analysis of radiotherapy for T1N0 invasive breast cancer treated by local excision and partial breast irradiation by low-dose-rate interstitial implant. Int J Radiat Oncol Biol Phys 56:671-680. doi:10.1016/S0360-3016 (03) 00071-3 (Pubitemid 36677359)
22. Pignol JP, Keller B, Rakovitch E, Sankreacha R, Easton H, Que W (2006) First report of a permanent breast 103Pd seed implant as adjuvant radiation treatment for early-stage breast cancer. Int J Radiat Oncol Biol Phys 64:176-181. doi:10.1016/j.ijrobp. 2005. 06.031 (Pubitemid 41831224)
23. Vicini FA, Kestin L, Chen P, Benitez P, Goldstein NS, Martinez A (2003) Limited-field radiation therapy in the management of early-stage breast cancer. J Natl Cancer Inst 95:1205-1210. doi: 10.1093/jnci/djg023
24. King TA, Bolton JS, Kuske RR, Fuhrman GM, Scroggins TG, Jiang XZ (2000) Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T (is, 1, 2) breast cancer. Am J Surg 180:299-304. doi:10.1016/S0002-9610 (00) 00454-2
25. Wazer DE, Berle L, Graham R, Chung M, Rothschild J, Graves T, Cady B, Ulin K, Ruthazer R, DiPetrillo TA (2002) Preliminary results of a phase I/II study of HDR brachytherapy alone for T1/T2 breast cancer. Int J Radiat Oncol Biol Phys 53:889-897. doi: 10.1016/S0360-3016 (02) 02824-9 (Pubitemid 34722633)
26. Paganelli G, De Cicco C, Ferrari ME, Carbone G, Pagani G, Leonardi MC, Cremonesi M, Ferrari A, Pacifici M, Di DA, De SR, Galimberti V, Luini A, Orecchia R, Zurrida S, Veronesi U (2010) Intraoperative avidination for radionuclide treatment as a radiotherapy boost in breast cancer: results of a phase II study with (90) Y-labeled biotin. Eur J Nucl Med Mol Imaging 37:203-211. doi:10.1007/s00259-009-1260-4
27. Bao A, Phillips WT, Goins B, Zheng X, Sabour S, Natarajan M, Ross WF, Zavaleta C, Otto RA (2006) Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection. Int J Pharm 316:162-169. doi:10.1016/j.ijpharm.2006. 02.039 (Pubitemid 43765700)
28. Harrington KJ, Rowlinson-Busza G, Syrigos KN, Uster PS, Vile RG, Stewart JS (2000) Pegylated liposomes have potential as vehicles for intratumoral and subcutaneous drug delivery. Clin Cancer Res 6:2528-2537 (Pubitemid 30399225)
29. Lammers T, Peschke P, Kuhnlein R, Subr V, Ulbrich K, Huber P, Hennink W, Storm G (2006) Effect of intratumoral injection on the biodistribution and the therapeutic potential of HPMA copolymer-based drug delivery systems. Neoplasia 8:788-795 (Pubitemid 44564834)
30. Liu LL, Smith MJ, Sun BS, Wang GJ, Redmond HP, Wang JH (2009) Combined IFN-gamma-endostatin gene therapy and radiotherapy attenuates primary breast tumor growth and lung metastases via enhanced CTL and NK cell activation and attenuated tumor angiogenesis in a murine model. Ann Surg Oncol 16:1403-1411. doi:10.1245/s10434-009-0343-6
31. Liu W, MacKay JA, Dreher MR, Chen M, McDaniel JR, Simnick AJ, Callahan DJ, Zalutsky MR, Chilkoti A (2010) Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. J Control Release 144:2-9. doi:10.1016/j.jconrel.2010.01.032
32. Luboldt W, Pinkert J, Matzky C, Wunderlich G, Kotzerke J (2009) Radiopharmaceutical tracking of particles injected into tumors: a model to study clearance kinetics. Curr Drug Deliv 6:255-260
33. Zentner GM, Rathi R, Shih C, McRea JC, Seo MH, Oh H, Rhee BG, Mestecky J, Moldoveanu Z, Morgan M, Weitman S (2001) Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J Control Release 72:203-215. doi: 10.1016/S0168-3659 (01) 00276-0 (Pubitemid 32522358)
34. Ma G, Yang J, Zhang L, Song C (2010) Effective antitumor activity of paclitaxel-loaded poly (epsilon-caprolactone)/pluronic F68 nanoparticles after intratumoral delivery into the murine breast cancer model. Anticancer Drugs 21:261-269. doi:10.1097/CAD.0b013e32833410a2
35. Kikumori T, Kobayashi T, Sawaki M, Imai T (2009) Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes. Breast Cancer Res Treat 113:435-441. doi:10.1007/s10549-008- 9948-x
36. Kwak C, Hong SK, Seong SK, Ryu JM, Park MS, Lee SE (2005) Effective local control of prostate cancer by intratumoral injection of 166Ho-chitosan complex (DW-166HC) in rats. Eur J Nucl Med Mol Imaging 32:1400-1405. doi:10.1007/s00259-005-1892-y (Pubitemid 41746843)
37. Ko YT, Falcao C, Torchilin VP (2009) Cationic liposomes loaded with proapoptotic peptide D- (KLAKLAK) (2) and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy. Mol Pharm 6:971-977. doi:10.1021/ mp900006h
38. Soundararajan A, Bao A, Phillips WT, Perez R III, Goins BA (2009) [186Re]Liposomal doxorubicin (Doxil): in vitro stability, pharmacokinetics, imaging and biodistribution in a head and neck squamous cell carcinoma xenograft model. Nucl Med Biol 36:515-524. doi:10.1016/j.nucmedbio.2009.02.004
39. Wang SX, Bao A, Herrera SJ, Phillips WT, Goins B, Santoyo C, Miller FR, Otto RA (2008) Intraoperative 186Re-liposome radionuclide therapy in a head and neck squamous cell carcinoma xenograft positive surgical margin model. Clin Cancer Res 14:3975-3983. doi:10.1158/1078-0432. CCR-07-4149
40. Torchilin VP (2007) Targeted pharmaceutical nanocarriers for cancer therapy and imaging. AAPS J 9: E128-E147
41. Elbayoumi TA, Torchilin VP (2010) Current trends in liposome research. Methods Mol Biol 605:1-27. doi:10.1007/978-1-60327-360-2
42. Phillips WT, Medina LA, Klipper R, Goins B (2002) A novel approach for the increased delivery of pharmaceutical agents to peritoneum and associated lymph nodes. J Pharmacol Exp Ther 303:11-16. doi:10.1124/jpet.102.037119
43. Parker RJ, Hartman KD, Sieber SM (1981) Lymphatic absorption and tissue disposition of liposome-entrapped [14C]adriamycin following intraperitoneal administration to rats. Cancer Res 41:1311-1317 (Pubitemid 11146757)
44. Mangat S, Patel HM (1985) Lymph node localization of nonspecific antibody-coated liposomes. Life Sci 36:1917-1925. doi: 10.1016/0024-3205 (85) 90440-0 (Pubitemid 15113252)
45. Moghimi M, Moghimi SM (2008) Lymphatic targeting of immuno-PEG-liposomes: evaluation of antibody-coupling procedures on lymph node macrophage uptake. J Drug Target 16:586-590. doi: 10.1080/10611860802228905
46. Oussoren C, Storm G (2001) Liposomes to target the lymphatics by subcutaneous administration. Adv Drug Deliv Rev 50:143-156. doi:10.1016/S0169- 409X (01) 00154-5 (Pubitemid 32727280)
47. Osborne MP, Richardson VJ, Jeyasingh K, Ryman BE (1979) Radionuclide-labelled liposomes-a new lymph node imaging agent. Int J Nucl Med Biol 6:75-83. doi:10.1016/0047-0740 (79) 90001-9 (Pubitemid 10225538)
48. Harrington KJ, Mohammadtaghi S, Uster PS, Glass D, Peters AM, Vile RG, Stewart JS (2001) Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res 7:243-254 (Pubitemid 32183025)
49. Phillips WT, Goins BA, Bao A (2009) Radioactive liposomes. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:69-83. doi: 10.1002/wnan. 3
50. Wang SX, Bao A, Phillips WT, Goins B, Herrera SJ, Santoyo C, Miller FR, Otto RA (2009) Intraoperative therapy with liposomal drug delivery: retention and distribution in human head and neck squamous cell carcinoma xenograft model. Int J Pharm 373:156-164. doi:10.1016/j.ijpharm.2009.02.009
51. French JT, Goins B, Saenz M, Li S, Garcia-Rojas X, Phillips WT, Otto RA, Bao A (2010) Interventional therapy of head and neck cancer with lipid nanoparticle-carried rhenium 186 radionuclide. J Vasc Interv Radiol. doi:10.1016/j.jvir.2010.02.027
52. Hamoudeh M, Kamleh MA, Diab R, Fessi H (2008) Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer. Adv Drug Deliv Rev 60:1329-1346. doi:10.1016/j.addr. 2008.04.013
53. Zweit J (1996) Radionuclides and carrier molecules for therapy. Phys Med Biol 41:1905-1914. doi:10.1088/0031-9155/41/10/004 (Pubitemid 26333630)
54. Bao A, Goins B, Klipper R, Negrete G, Phillips WT (2003) 186Re-liposome labeling using 186Re-SNS/S complexes: in vitro stability, imaging, and biodistribution in rats. J Nucl Med 44:1992-1999 (Pubitemid 40022146)
55. Bao A, Goins B, Klipper R, Negrete G, Mahindaratne M, Phillips WT (2003) A novel liposome radiolabeling method using 99mTc- "SNS/S" complexes: in vitro and in vivo evaluation. J Pharm Sci 92:1893-1904. doi:10.1002/jps.10441 (Pubitemid 37071821)
56. Li S, Goins B, Phillips WT, Bao A (2010) Remote-loading labeling of liposomes with 99mTc-BMEDA and its stability evaluation: effects of lipid formulation and pH/chemical gradient. J Liposome Res. doi:10.3109/ 08982101003699036
57. Jones MN, Nicholas AR (1991) The effect of blood serum on the size and stability of phospholipid liposomes. Biochim Biophys Acta 1065:145-152. doi:10.1016/0005-2736 (91) 90224-V
58. Cullis PR, Chonn A, Semple SC (1998) Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo. Adv Drug Deliv Rev 32:3-17. doi: 10.1016/S0169-409X (97) 00128-2 (Pubitemid 28277172)
59. Moghimi SM, Moghimi M (2008) Enhanced lymph node retention of subcutaneously injected IgG1-PEG2000-liposomes through pentameric IgM antibody-mediated vesicular aggregation. Biochim Biophys Acta 1778:51-55. doi:10.1016/j.bbamem.2007. 08.033
60. Oussoren C, Zuidema J, Crommelin DJ, Storm G (1997) Lymphatic uptake and biodistribution of liposomes after subcutaneous injection. II. Influence of liposomal size, lipid compostion and lipid dose. Biochim Biophys Acta 1328:261-272. doi:10.1016/S0005-2736 (97) 00122-3 (Pubitemid 27376453)
61. Chambers AF, Groom AC, MacDonald IC (2002) Metastasis: dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2:563-572. doi:10.1038/nrc865 (Pubitemid 37328923)