Remote-loading labeling of liposomes with 99mTc-BMEDA and its stability evaluation: Effects of lipid formulation and pH/chemical gradient

Journal of Liposome Research

Volumn 21, Issue 1, 2011, Pages 17-27

  Li, Shihong ^a   Goins, Beth ^a   Phillips, William T ^a   Bao, Ande ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

distribution; encapsulation; imaging; Radiolabeling

Indexed keywords

AMMONIUM SULFATE; CITRIC ACID; GLUTATHIONE; LIPOSOME; N,N BIS(2 MERCAPTOETHYL) N',N' DIETHYL ETHYLENEDIAMINE TC 99M; PHOSPHATE BUFFERED SALINE; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; IN VITRO STUDY; ISOTOPE LABELING; MOLECULAR STABILITY; PARTICLE SIZE; PH; PRIORITY JOURNAL; SURFACE CHARGE; TEMPERATURE;

DRUG STABILITY; HYDROGEN-ION CONCENTRATION; LIPIDS; LIPOSOMES; ORGANOTECHNETIUM COMPOUNDS; TECHNETIUM;

EID: 79551650516     PISSN: 08982104     EISSN: 15322394     Source Type: Journal    
DOI: 10.3109/08982101003699036     Document Type: Article

References (45)

1. Ahl, P. L., Bhatia, S. K., Meers, P., Roberts, P., Stevens, R., Dause, R., et al. (1997). Enhancement of the in vivo circulation lifetime of L-alpha-distearoylphosphatidylcholine liposomes: importance of liposomal aggregation versus complement opsonization. Biochim Biophys Acta 1329:370-382.
2. Bally, M. B., Masin, D., Nayar, R., Cullis, P. R., Mayer, L. D. (1994). Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumor-bearing mice. Cancer Chemother Pharmacol 34:137-146.
3. Bangham, A. D. (1992). Liposomes: realizing their promise. Hosp Pract (Off Ed) 27:51-52.
4. Bao, A., Goins, B., Klipper, R., Negrete, G., Mahindaratne, M., Phillips, W. T. (2003a). A novel liposome radiolabeling method using 99mTc-'SNS/S' complexes: in vitro and in vivo evaluation. J Pharm Sci 92:1893-1904.
5. Bao, A., Goins, B., Klipper, R., Negrete, G., Phillips, W. T. (2003b). 186Reliposome labeling using 186Re-SNS/S complexes: in vitro stability, imaging, and biodistribution in rats. J Nucl Med 44:1992-1999.
6. Bao, A., Goins, B., Klipper, R., Negrete, G., Phillips, W. T. (2004). Direct 99mTc labeling of pegylated liposomal doxorubicin (Doxil) for pharmacokinetic and noninvasive imaging studies. J Pharmacol Exp Ther 308:419-425.
7. Barron, L. G., Gagne, L., Szoka F. C., Jr. (1999). Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration. Hum Gene Ther 10:1683-1694.
8. Bonte, F., Juliano, R. L. (1986). Interactions of liposomes with serum proteins. Chem Phys Lipids 40:359-372.
9. Botelho, M. F., Gomes, C. M., de Lima, J. J. (2003). Visualising deep lung lymphatic drainage with radioliposomes. Eur J Nucl Med Mol Imaging 30:937.
10. Choice, E., Ayyobi, A. F., Pritchard, P. H., Madden, T. D. (1999). Separation of liposomes from plasma components using fast protein liquid chromatography. Anal Biochem 270:1-8.
11. Chonn, A., Semple, S. C., Cullis, P. R. (1991). Separation of large unilamellar liposomes from blood components by a spin column procedure: towards identifying plasma proteins which mediate liposome clearance in vivo. Biochim Biophys Acta 1070:215-222.
12. Corvera, E., Mouritsen, O. G., Singer, M. A., Zuckermann, M. J. (1992). The permeability and the effect of acyl-chain length for phospholipids bilayers containing cholesterol: theory and experiment. Biochim Biophys Acta 1107:261-270.
13. Cullis, P. R., Chonn, A., Semple, S. C. (1998). Interactions of liposomes and lipid-based carrier systems with blood proteins: relation to clearance behaviour in vivo. Adv Drug Deliv Rev 32:3-17.
14. Cullis, P. R., Hope, M. J., Bally, M. B., Madden, T. D., Mayer, L. D., Fenske, D. B. (1997). Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides, and metal ions into large unilamellar vesicles. Biochim Biophys Acta 1331:187-211.
15. Dagar, S., Krishnadas, A., Rubinstein, I., Blend, M. J., Onyuksel, H. (2003). VIP-grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies. J Contr Rel 91:123-133.
16. Drummond, D. C., Meyer, O., Hong, K., Kirpotin, D. B., Papahadjopoulos, D. (1999). Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol Rev 51:691-743.
17. Foradada, M., Manzano, A., Roig, T., Estelrich, J., Bermudez, J. (1997). Serum-liposome interaction is an oxygen-dependent process. Biochim Biophys Acta 1345:43-55.
18. Gabizon, A., Chemla, M., Tzemach, D., Horowitz, A. T., Goren, D. (1996). Liposome longevity and stability in circulation: effects on the in vivo delivery to tumors and therapeutic efficacy of encapsulated anthracyclines. J Drug Targ 3:391-398.
19. Goins, B., Klipper, R., Rudolph, A. S., Cliff, R. O., Blumhardt, R., Phillips, W. T. (1993). Biodistribution and imaging studies of technetium-99m-labeled liposomes in rats with focal infection. J Nucl Med 34:2160-2168.
20. Goins, B., Klipper, R., Rudolph, A. S., Phillips, W. T. (1994). Use of technetium-99m-liposomes in tumor imaging. J Nucl Med 35:1491-1498.
21. Kleiter, M. M., Yu, D., Mohammadian, L. A., Niehaus, N., Spasojevic, I., Sanders, L. et al. (2006). A tracer dose of technetium- 99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. Clin Cancer Res 12:6800-6807.
22. Medina, O. P., Kairemo, K., Valtanen, H., Kangasniemi, A., Kaukinen, S., Ahonen, I., et al. (2005). Radionuclide imaging of tumor xenografts in mice using a gelatinase-targeting peptide. Anticancer Res 25:33-42.
23. Mirahmadi, N., Babaei, M. H., Vali, A. M., Daha, F. J., Kobarfard, F., Dadashzadeh, S. (2008). 99mTc-HMPAO-labeled liposomes: an investigation into the effects of some formulation factors on labeling efficiency and in vitro stability. Nucl Med Biol 35: 387-392.
24. Moghimi, S. M., Patel, H. M. (1989). Serum opsonins and phagocytosis of saturated and unsaturated phospholipid liposomes. Biochim Biophys Acta 984:384-387.
25. Nagayasu, A., Uchiyama, K., Kiwada, H. (1999). The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs. Adv Drug Deliv Rev 40:75-87.
26. New, R. R. C. (1995). Influence of liposome characteristics on their properties and fate. In: Philippot, J. R., Schuber, F. (Eds.), Liposomes as tools in basic research and industry (pp 3-20). Boca Raton, Florida, USA: CRC.
27. Nock, B. A., Maina, T., Yannoukakos, D., Pirmettis, I. C., Papadopoulos, M. S., Chiotellis, E. (1999). Glutathione-mediatedmetabolism of technetium-99m SNS/S mixed ligand complexes: a proposed mechanism of brain retention. J Med Chem 42:1066-1075. (Pubitemid 29153435)
28. Papahadjopoulos, D., Cowden, M., Kimelberg, H. (1973). Role of cholesterol in membranes. Effects on phospholipid-protein interactions, membrane permeability, and enzymatic activity. Biochim Biophys Acta 330:8-26.
29. Park, Y. S., Maruyama, K., Huang, L. (1992). Some negatively charged phospholipid derivatives prolong the liposome circulation in vivo. Biochim Biophys Acta 1108:257-260.
30. Phillips, W. T. (1999). Delivery of gamma-imaging agents by liposomes. Adv Drug Deliv Rev 37:13-32.
31. Phillips, W. T., Andrews, T., Liu, H., Klipper, R., Landry, A. J., Blumhardt, R. et al. (2001). Evaluation of [99mTc] liposomes as lymphoscintigraphic agents: comparison with [99mTc] sulfur colloid and [99mTc] human serum albumin. Nucl Med Biol 28:435-444.
32. Phillips, W. T., Rudolph, A. S., Goins, B., Timmons, J. H., Klipper, R., Blumhardt, R. (1992). A simple method for producing a technetium- 99m-labeled liposome which is stable in vivo. Int J Rad Appl Instrum B 19:539-547.
33. Pires, P., Simoes, S., Nir, S., Gaspar, R., Duzgunes, N., Pedroso de Lima, M. C. (1999). Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells. Biochim Biophys Acta 1418:71-84.
34. Semple, S. C., Chonn, A., Cullis, P. R. (1996). Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry 35:2521-2525.
35. Stewart, J. C. M. (1980). Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal Biochem 104:10-14.
36. Szucs, M., Tilcock, C. (1995). Lyophilization and rehydration of polymer- coated lipid vesicles containing a lipophilic chelator in the presence of sucrose: labeling with 99mTc and biodistribution studies. Nucl Med Biol 22:263-268.
37. Tilcock, C. (1999). Delivery of contrast agents for magnetic resonance imaging, computed tomography, nuclear medicine, and ultrasound. Adv Drug Deliv Rev 37:33-51.
38. Tilcock, C., Ahkong, Q. F., Fisher, D. (1993). Polymer-derivatized technetium 99mTc-labeled liposomal blood pool agents for nuclear medicine applications. Biochim Biophys Acta 1148:77-84.
39. Tilcock, C., Ahkong, Q. F., Fisher, D. (1994). 99mTc-labeling of lipid vesicles containing the lipophilic chelator PE-DTTA: effect of tin-to-chelate ratio, chelate content, and surface polymer on labeling efficiency and biodistribution behavior. Nucl Med Biol 21:89-96.
40. Tilcock, C., Ahkong, Q. F., Koenig, S. H., Brown, R. D., 3rd, Davis, M., Kabalka, G. (1992). The design of liposomal paramagnetic MR agents: effect of vesicle size upon the relaxivity of surface-incorporated lipophilic chelates. Magn Res Med 27:44-51.
41. Tilcock, C., Yap, M., Szucs, M., Utkhede, D. (1994). PEG-coated lipid vesicles with encapsulated technetium-99m as blood pool agents for nuclear medicine. Nucl Med Biol 21:165-170.
42. Torchilin, V. P. (1996). Liposomes as delivery agents for medical imaging. Mol Med Today 2:242-249.
43. Vemuri, S., Rhodes, C. T. (1995). Preparation and characterization of liposomes as therapeutic delivery systems: a review. Pharm Acta Helv 70:95-111.
44. Wang, S. X., Bao, A., Herrera, S. J., Phillips, W. T., Goins, B., Santoyo, C., et al. (2008). Intraoperative 186Re-liposome radionuclide therapy in a head and neck squamous cell carcinoma xenograft positive surgical margin model. Clin Cancer Res 14: 3975-3983.
45. Zheng, J. G., Tan, T. Z. (2004). Antisense imaging of colon cancerbearing nude mice with liposome-entrapped 99m-technetiumlabeled antisense oligonucleotides of c-myc mRNA. World J Gastroenterol 10:2563-2566.