Aqueous synthesis and concentration-dependent dermal toxicity of TiO 2 nanoparticles in Wistar rats

Biological Trace Element Research

Volumn 143, Issue 3, 2011, Pages 1682-1694

  Unnithan, Jyotisree ^a   Rehman, Muneeb U ^a   Ahmad, Farhan J ^a   Samim, M ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Acute toxicity; Characterization; TiO 2 nanoparticles; Topical application; Wistar rat

Indexed keywords

CATALASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; LIPOXYGENASE; MALONALDEHYDE; NANOPARTICLE; SUPEROXIDE DISMUTASE; TITANIUM DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DYNAMIC LIGHT SCATTERING; FEMALE; HISTOPATHOLOGY; LIGHT SCATTERING; MALE; METHODOLOGY; NEUTROPHIL; NONHUMAN; PARTICLE SIZE; RAT; SKIN TOXICITY; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY DIFFRACTION;

ANIMALS; FEMALE; MALE; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; RATS, WISTAR; SKIN; SPECTROPHOTOMETRY, ULTRAVIOLET; TITANIUM; WATER; X-RAY DIFFRACTION;

ANIMALIA; MUS; ORYCTOLAGUS CUNICULUS; RATTUS; RATTUS NORVEGICUS;

EID: 82455212084     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-011-9010-4     Document Type: Article

References (41)

1. BK Bernard MR Osheroff A Hofmann, et al. 1990 Toxicology and carcinogenesis studies of dietary titanium dioxide-coated mica in male and female fischer 344 rats J Toxicol Environ Health 29 4 417 429 2325155 10.1080/15287399009531402 1:CAS:528:DyaK3cXitlWisbY%3D (Pubitemid 20138768)
2. 2 using EPR J Phys Chem 107 4545 4549 10.1021/jp0273934 1:CAS:528:DC%2BD3sXjtVWnsrg%3D
3. 2: surface versus lattice mechanisms J Phys Chem 109 977 980 10.1021/jp045395d 1:CAS:528:DC%2BD2cXhtVyqurnJ (Pubitemid 40183588)
4. 2 photocatalytic disinfection Water Res 38 4 1069 1077 14769428 10.1016/j.watres.2003.10.029 1:CAS:528:DC%2BD2cXhtVehtb0%3D (Pubitemid 38177475)
5. R Ackroyd C Kelty N Brown, et al. 2001 The history of photodetection and photodynamic therapy Photochem Photobiol 74 656 669 11723793 10.1562/0031-8655(2001)074<0656:THOPAP>2.0.CO;2 1:CAS:528: DC%2BD3MXosFymtbc%3D
6. Davis JM, Wang A, Shatkin JA et al. (2009) External review draft nanomaterial case studies: nanoscale titanium dioxide in water treatment and in topical sunscreen. US Environmental Protection Agency, Research Triangle Park. pp 5-31
7. PJ Borm D Robbins S Haubold, et al. 2006 The potential risks of nanomaterials: a review carried out for ECETOC Particle Fibre Toxicol 3 11 10.1186/1743-8977-3-11 (Pubitemid 44530044)
8. A Ne T Xia L Madler, et al. 2006 Toxic potential of materials at the nanolevel Science 311 622 627 10.1126/science.1114397 (Pubitemid 43191298)
9. JX Wang GQ Zhou CY Chen, et al. 2007 Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration Toxicol Lett 168 176 185 17197136 10.1016/j.toxlet.2006.12.001 1:CAS:528:DC%2BD2sXltV2nug%3D%3D (Pubitemid 46075175)
10. JS Brown KL Zeman WD Bennett 2002 Ultrafine particle deposition and clearance in the healthy and obstructed lung Am J Respir Crit Care Med 166 1240 1247 12403694 10.1164/rccm.200205-399OC (Pubitemid 35222602)
11. WG Kreyling M Semmler F Erbe, et al. 2002 Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low J Toxicol Environ Health 65 1513 1530 10.1080/00984100290071649 1:CAS:528:DC%2BD38XosF2lsbw%3D (Pubitemid 35217498)
12. G Oberdoerster Z Sharp V Atudorei, et al. 2004 Translocation of inhaled ultrafine particles to the brain Inhal Toxicol 16 437 445 10.1080/ 08958370490439597 1:CAS:528:DC%2BD2cXjvValsbw%3D (Pubitemid 38685135)
13. G Oberdorster E Oberdorster J Oberdorster 2005 Nanotoxicology:an emerging discipline evolving from studies of ultrafine particles Environ Health Perspect 113 823 839 16002369 10.1289/ehp.7339 1:CAS:528:DC%2BD2MXntVyls7Y%3D (Pubitemid 40984181)
14. J Muller F Huaux N Moreau, et al. 2005 Respiratory toxicity of multi-wall carbon nanotubes Toxicol Appl Pharmacol 207 221 231 16129115 10.1016/j.taap.2005.01.008 1:CAS:528:DC%2BD2MXpslyjtrc%3D (Pubitemid 41207915)
15. HW Chen SF Su CT Chien, et al. 2006 Titanium dioxide nanoparticles induce emphysema-like lung injury in mice FASEB J 20 1732 1741
16. 2 particles in mice Biol Trace Elem Res 129 1 170 180 19066734 10.1007/s12011-008-8285-6 1:CAS:528:DC%2BD1MXmtF2ktb8%3D
17. 2 Nanoscale Res Lett 4 1275 2128 20628458 10.1007/s11671-009-9393-8 1:CAS:528:DC%2BD1MXhtlarsrzK
18. YM Duan J Liu LL Ma, et al. 2010 Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice Biomaterials 31 894 899 19857890 10.1016/j.biomaterials.2009.10.003 1:CAS:528:DC%2BD1MXhsVyisrbJ
19. 2 nanoparticles J Biomed Mater Res A 96 1 221 229 10.1002/jbm.a.32976 21105171
20. F Afaq P Abidi R Matin, et al. 1998 Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide J Appl Toxicol 18 307 312 9804429 10.1002/(SICI)1099- 1263(1998090)18:5<307::AID-JAT508>3.0.CO;2-K 1:CAS:528:DyaK1cXmslKlsLs%3D (Pubitemid 28474901)
21. 2 particles: differential responses related to surface properties Toxicology 230 90 104 17196727 10.1016/j.tox.2006.11.002 1:CAS:528:DC%2BD2sXls1OnsA%3D%3D (Pubitemid 46073330)
22. 2 particles as a component of nanoparticle risk management Toxicol Lett 171 99 110 17566673 10.1016/j.toxlet.2007.04.008 1:CAS:528:DC%2BD2sXotVahu7o%3D (Pubitemid 47058824)
23. R Liu LH Yin YP Pu, et al. 2009 Pulmonary toxicity induced by three forms of titanium dioxide nanoparticles via intra-tracheal instillation in rats Prog Nat Sci 19 5 573 579 10.1016/j.pnsc.2008.06.020 1:CAS:528:DC%2BD1MXotFOhs7Y%3D
24. 2. Biol Trace Elem Res, doi: 10.1007/s12011-010-8663-8.
25. AO Gamer E Leibold B Van Ravenzwaay 2006 The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin Toxicol In Vitro 20 301 307 16182508 10.1016/j.tiv.2005.08.008 1:CAS:528:DC%2BD28Xit1Cnsrs%3D (Pubitemid 43343759)
26. B Kiss T Biro G Czifra, et al. 2008 Investigation ofmicronized titanium dioxide penetration in human skin xeno-grafts and its effect on cellular functions of human skin-derived cells Exp Dermatol 10.1111/j.1600-0625.2007. 00683 18312389
27. NANODERM (2007) Quality of skin as a barrier to ultra-fine particles. Final Report. (Project Number: QLK4-CT-2002-02678). Available at: http://www.uni-leipzig.de/*nanoderm/
28. 2 particles at the high energy ion nanoprobe LIPSION Nucl Instrum Methods Phys Res B 219-220 82 86 10.1016/j.nimb.2004.01.032
29. 2-penetration in the epidermis of human skin xenografts Nucl Instrum Methods Phys Res B 231 280 285 10.1016/j.nimb.2005.01.071 1:CAS:528:DC%2BD2MXktFWisbw%3D
30. C Bennat CC Muller-Goymann 2000 Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter Int J Cosmet Sci 22 271 283 18503414 10.1046/j.1467-2494.2000.00009.x 1:CAS:528:DC%2BD3cXmvVChsbs%3D (Pubitemid 30639203)
31. WH Habig MJ Pabst WB Jokoby 1974 Glutathione-S-transferase-the first enzymatic step in mercapturic acid formation J Biol Chem 249 7130 7139 4436300 1:CAS:528:DyaE2MXltlahtg%3D%3D
32. Claiborne A (1985) Catalase activity. In: Greenwald RA (ed) Handbook of methods for oxygen free radical research. CRC Press, Boca Raton, pp 283-284
33. HP Misra I Fridovich 1972 The role of superoxide anion in the auto-oxidation of epinephrine and a simple assay for superoxide dismutase J Biol Chem 247 3170 3175 4623845 1:CAS:528:DyaE38XhsFSntLk%3D
34. JR Wright HD Colby PR Miles 1981 Cytosolic factors which affect microsomal lipid peroxidation in lung and liver Arch Biochem Biophys 206 296 304 7224639 10.1016/0003-9861(81)90095-3 1:CAS:528:DyaL3MXpvVersw%3D%3D (Pubitemid 11102033)
35. OH Lowry NJ Rosebrough AL Farr, et al. 1951 Protein measurement with the folin phenol reagent J Biol Chem 193 265 275 14907713 1:CAS:528: DyaG38XhsVyrsw%3D%3D
36. MD Newman M Stotland J Ellis 2009 The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens J Am Acad Dermatol 61 685 692 19646780 10.1016/j.jaad.2009.02.051 1:CAS:528:DC%2BD1MXhtlWks7zF
37. Shayne CG (2006) Animal models in toxicology, 2nd edn. Taylor & Francis, New York, p 177
38. 2 rods and dots in rats: toxicity is not dependent upon particle size and surface area Toxicol Sci 91 227 236 16495353 10.1093/toxsci/kfj140 1:CAS:528:DC%2BD28Xjtlamu7w%3D
39. RF Domingos N Tufenkji KJ Wilkinson, et al. 2009 Aggregation of titanium dioxide nanoparticles: role of a fulvic acid Environ Sci Technol 43 1282 1286 19350891 10.1021/es8023594 1:CAS:528:DC%2BD1MXotlKktA%3D%3D
40. RA French AR Jacobson B Kim, et al. 2009 Influence of ionic strength, pH, and cation valence on aggregation kinetics of titanium dioxide nanoparticles Environ Sci Technol 43 1354 1359 19350903 10.1021/es802628n 1:CAS:528: DC%2BD1MXotlOksg%3D%3D
41. A Jemec D Drobne M Remskar, et al. 2008 T Effects of ingested nanosized titanium dioxide on terrestrial isopods porcellio scaber Environ Toxicol Chem 27 1904 1914 19086208 10.1897/08-036.1 1:CAS:528:DC%2BD1cXhtVersLnP