Nucleosomes and C1q bound to glomerular endothelial cells serve as targets for autoantibodies and determine complement activation

Molecular Immunology

Volumn 49, Issue 1-2, 2011, Pages 75-83

  O'Flynn, Joseph ^a   Flierman, Roelof ^a   van der Pol, Pieter ^a   Rops, Angelique ^c   Satchell, Simon C ^b   Mathieson, Peter W ^b   van Kooten, Cees ^a   van der Vlag, Johan ^c   Berden, Jo H ^c   Daha, Mohamed R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Autoantibodies; C1q; Lupus nephritis; Nucleosomes; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; COMPLEMENT COMPONENT C1Q; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY;

ARTICLE; CELL SURFACE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GLOMERULAR STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN FUNCTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

AUTOANTIBODIES; AUTOANTIGENS; CELL SEPARATION; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; ENDOTHELIAL CELLS; FLOW CYTOMETRY; HUMANS; KIDNEY GLOMERULUS; LUPUS NEPHRITIS; NUCLEOSOMES;

EID: 82455199165     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.07.020     Document Type: Article

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