Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice

Clinical and Experimental Immunology

Volumn 104, Issue 2, 1996, Pages 241-246

  Hogarth, M B ^a   Norsworthy, P J ^a   Allen, P J ^a   Trinder, P K E ^b   Loos, M ^b   Morley, B J ^a   Walport, M J ^a   Davies, K A ^a,c  

^a RPMS   (United Kingdom)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Anti C1q antibodies; BXSB; Lupus; MRL lpr; NZB W

Indexed keywords

AUTOANTIBODY; COMPLEMENT COMPONENT C1Q; DNA ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ETIOLOGY; FEMALE; IONIC STRENGTH; LUPUS VULGARIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029939091     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.19725.x     Document Type: Article

References (25)

1. Wener MH, Uwatoko S, Mannik M. Antibodies to the collagen-like region of C1q in sera of patients with autoimmune rheumatic disease. Arthritis Rheum 1989; 32:544-51.
2. Prada AE, Strife CF. IgG subclass restriction of autoantibody to solid-phase C1q in membranoproliferative and lupus glomerulonephritis. Clin Immunol Immunopathol 1992; 63:84-88.
3. Strife CF, Leahy AE, West CD. Antibody to a cryptic, solid phase C1q antigen in membranoproliferative nephritis. Kidney Int 1989; 35:836-42.
4. Siegert CEH, Daha MR, van der Voort EAM, Breedveld FC. IgG and IgA antibodies to the collagen-like region of C1q in rheumatoid vasculitis. Arthritis Rheum 1990; 33:1646-54.
5. Marder RJ, Potempa LA, Verrier Jones J, Toriumi D, Schmid FR, Gewurz H. Assay purification and further characterisation of 7s C1q-precipitins (C1q-p) in hypocomplementaemic vasculitis urticaria syndrome and systemic lupus erythematosus. Acta Pathol Micobiol Immunol Scand 1984; 92:25-34.
6. Wisnieski JJ, Naff GB. Serum IgG antibodies to C1q in hypocomplentaemic urticarial vasculitis syndrome. Arthritis Rheum 1989; 32:1119-27.
7. Siegert CEH, Daha MR, Halma C, Breedveld FC. IgG and IgA autantibodies to C1q in systemic and renal diseases. Clin Exp Rheum 1992; 10:19-23.
8. Coremans IEM, Daha MR, Van Der Voort EAM, Muizert Y, Breedveld FC. Antibodies against C1q in anti-glomerular basement membrane nephritis. Clin Exp Immunol 1992; 87:256-60.
9. Siegert CEH, Daha MR, Westedt ML, van der Voort EAM, Breedveld FC. Nephritis and dermatitis in systemic lupus erythematosus (SLE) are strongly associated with the occurance of IgG autoantibodies (C1qab) against the first subcomponent of complement. Arthritis Rheum 1989, 32 (Suppl. 4): S74.
10. Uwatoko S, Aotsuka S, Okawa M et al. Characterisation of C1q binding IgG complexes in SLE. Clin Immunol Immunopathol 1984; 30:104-6.
11. Siegert C, Daha M, Westedt ML, Breedveld F. IgG autoantibodies against C1q are correlated with nephritis, hypocomplementaemia and dsDNA antibodies in systemic lupus erythematosus. J Rheumatol 1991; 18:230-3.
12. Siegert CEH, Daha MR, Tseng CMES, Coremans IEM, van Es LA, Breedveld FC. Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus. Annals Rheum Dis 1993; 52:851-6.
13. Andrews BS, Eisenburg RA, Theofilopoulos AG et al. Spontaneous murine lupus-like syndromes. J Exp Med 1978; 148:1198-215.
14. Theofilopoulos AG, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol 1985; 37:269-391.
15. Petry F, Reid KBM, Loos M. Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. J Immunol 1991; 147:3988-93.
16. Petry F, Reid KBM, Loos M. Molecular cloning and characterization of the complementary DNA coding for the B-chain of murine C1q. Eur J Biochem 1989; 258:89-93.
17. Petry F, Reid KBM, Loos M. Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q. Eur J Biochem 1992; 209:129-34.
18. Stemmer F, Loos M. Purification and characterization of human, guinea pig and mouse C1q by fast protein liquid chromatography (FPLC). J Immunol Methods 1984; 74:9-16.
19. Reid KBM. Isolation by partial pepsin digestion, of the three collagen-like regions present in subcomponent C1q of the first component of human complement. Biochem J 1976; 155:5-17.
20. Trinder PKE, Maeurer MJ, Schorlemmer HU, Loos M. Autoreactivity to mouse C1q in a murine model of SLE. Rheumatol Int 1995; 15:117-20.
21. Isenberg DA, Dudeney C, Williams W et al. Measurement of anti-DNA antibodies: a reappraisal using five different methods. Ann Rheum Dis 1987; 46:448-56.
22. Ahmed SA. Autoimmune lesions: is the C57BL/6 mouse strain normal or autoimmune prone? Immunol Today 1994; 15:389.
23. Rordorf-Adam C, Serban D, Pataki A, Gruninger M. Serum amyloid P component and autoimmune parameters in the assessment of arthritis activity in MRL/lpr/lpr mice. Clin Exp Immunol 1985; 61:509-16.
24. Uwatoko S, Mannik M, Oppliger IR et al. C1q-binding immunoglobulin in MRL/lpr mice consisits of immune complexes containing antibodies to DNA. Clin Immunol Immunopathol 1995; 75:140-6.
25. Cameron JS, Lessof MH, Ogg CS, Williams BD, Williams DG. Disease activity in the nephritis of systemic lupus erythematosus in relation to serum complement concentration. DNA-binding capacity to precipitate anti-DNA antibody. Clin Exp Immunol 1976; 25:418-27.