Immunization with the RTS,S/AS malaria vaccine induces IFN-γ +CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge

Vaccine

Volumn 29, Issue 48, 2011, Pages 8847-8854

  Schwenk, Robert ^a   Lumsden, Joanne M ^a   Rein, Lisa E ^a   Juompan, Laure ^a,b   Kester, Kent E ^a   Heppner, D Gray ^a   Krzych, Urszula ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

CD4 T cells; RTS,S; Specificities

Indexed keywords

CIRCUMSPOROZOITE PROTEIN; EPITOPE; GAMMA INTERFERON; HLA DR ANTIGEN; HLA DR11 ANTIGEN; HLA DR4 ANTIGEN; MALARIA VACCINE; THROMBOSPONDIN;

ARTICLE; ATTENUATION; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; HAPLOTYPE; HUMAN; IMMUNIZATION; PRIORITY JOURNAL; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; SPOROZOITE;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGENS, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; EPITOPES, T-LYMPHOCYTE; HLA-DR SEROLOGICAL SUBTYPES; HLA-DR4 ANTIGEN; HUMANS; IMMUNIZATION, SECONDARY; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MALARIA VACCINES; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; T-CELL ANTIGEN RECEPTOR SPECIFICITY; THROMBOSPONDIN 1;

EID: 82455188057     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.09.098     Document Type: Article

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