Human epicardium: Ultrastructural ancestry of mesothelium and mesenchymal cells

Journal of Cellular and Molecular Medicine

Volumn 13, Issue 9 A, 2009, Pages 2949-2951

  Gherghiceanu, Mihaela ^a   Popescu, L M ^a,b  

^a VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY   (Romania)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

(sub)epicardium; Cardiac regeneration; Epithelial mesenchymal transition (EMT); Interstitial Cajal like cells (ICLCs); Isolated smooth muscle cells; Mesenchymal cells; Mesothelial cells

Indexed keywords

ARTICLE; CELL MOTION; CYTOLOGY; CYTOSKELETON; EPITHELIUM; HUMAN; MESODERM; PERICARDIUM; SMOOTH MUSCLE FIBER; ULTRASTRUCTURE;

CELL MOVEMENT; CYTOSKELETON; EPITHELIUM; HUMANS; MESODERM; MYOCYTES, SMOOTH MUSCLE; PERICARDIUM;

EID: 72849124187     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00869.x     Document Type: Article

References (17)

1. Hay ED. The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Dev Dyn. 2005 233 : 706 720.
2. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009 119 : 1420 1428.
3. Baum B, Settleman J, Quinlan MP. Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol. 2008 19 : 294 308.
4. Mikawa T, Gourdie RG. Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev Biol. 1996 174 : 221 232.
5. Lie-Venema H, van den Akker NM, Bax NA, et al. Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development. Scientific World J. 2007 7 : 1777 1798.
6. van Tuyn J, Atsma DE, Winter EM, et al. Epicardial cells of human adults can undergo an epithelial-to-mesenchymal transition and obtain characteristics of smooth muscle cells in vitro. Stem Cells. 2007 25 : 271 278
7. Wada AM, Smith TK, Osler ME, et al. Epicardial/Mesothelial cell line retains vasculogenic potential of embryonic epicardium. Circ Res. 2003 92 : 525 531.
8. Limana F, Zacheo A, Mocini D, et al. Identification of myocardial and vascular precursor cells in human and mouse epicardium. Circ Res. 2007 101 : 1255 1265.
9. Hinescu ME, Gherghiceanu M, Mandache E, et al. Interstitial Cajal-like cells (ICLC) in atrial myocardium: ultrastructural and immunohistochemical characterization. J Cell Mol Med. 2006 10 : 243 257. (Pubitemid 44874307)
10. Hinescu ME, Popescu LM. Interstitial Cajal like cells (ICLC) in human atrial myocardium. J Cell Mol Med. 2005 9 : 972 975.
11. Kostin S, Popescu LM. A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLC). J Cell Mol Med. 2009 13 : 295 308.
12. Gherghiceanu M, Hinescu ME, Andrei F, et al. Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins. J Cell Mol Med. 2008 12 : 1777 1781.
13. Popescu LM, Gherghiceanu M, Hinescu ME, et al. Insights into the interstitium of ventricular myocardium: interstitial Cajal-like cells (ICLC). J Cell Mol Med. 2006 10 : 429 458. (Pubitemid 44870190)
14. Mandache E, Popescu LM, Gherghiceanu M. Myocardial interstitial Cajal-like cells (ICLC) and their nanostructural relationships with intercalated discs: shed vesicles as intermediates. J Cell Mol Med. 2007 11 : 1175 1184.
15. Suciu L, Popescu LM, Regalia T, et al. Epicardium: interstitial Cajal-like cells (ICLC) highlighted by immunofluorescence. J Cell Mol Med. 2009 13 : 771 777.
16. Popescu LM, Gherghiceanu M, Manole CG, Faussone-Pellegrini MS. Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med. 2009 13 : 866 886.
17. Stamm C, Choi YH, Nasseri B, Hetzer R. A heart full of stem cells: the spectrum of myocardial progenitor cells in the postnatal heart. Ther Adv Cardiovasc Dis. 2009 3 : 215 229.