Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes

Kidney International

Volumn 80, Issue 12, 2011, Pages 1364-1376

  Naesens, Maarten ^a,b   Khatri, Purvesh ^a   Li, Li ^a   Sigdel, Tara K ^a   Vitalone, Matthew J ^a   Chen, Rong ^a   Butte, Atul J ^a   Salvatierra, Oscar ^a   Sarwal, Minnie M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

adaptive immunity; gene expression; histology; innate immunity; kidney transplantation; microarray; protocol biopsies

Indexed keywords

ADAPTIVE IMMUNITY; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE COURSE; GENE EXPRESSION; GRANULOCYTE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MAST CELL; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 82455164107     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2011.245     Document Type: Article

References (49)

1. Yilmaz S, Tomlanovich S, Mathew T et al. Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studies. J Am Soc Nephrol 2003; 14: 773-779.
2. Nankivell B, Richard J, Borrows R et al. The natural history of chronic allograft nephropathy. New Engl J Med 2003; 349: 2326-2333.
3. Nankivell BJ, Chapman JR. Chronic allograft nephropathy: current concepts and future directions. Transplantation 2006; 81: 643-654.
4. El-Zoghby ZM, Stegall MD, Lager DJ et al. Identifying specific causes of kidney allograft loss. Am J Transplant 2009; 9: 527-535.
5. Ojo AO, Hanson JA, Meier-Kriesche H et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol 2001; 12: 589-597.
6. Naesens M, Lerut E, de Jonge H et al. Donor age and renal P-glycoprotein expression associate with chronic histological damage in renal allografts. J Am Soc Nephrol 2009; 20: 2468-2480.
7. Nankivell BJ, Fenton-Lee CA, Kuypers DR et al. Effects of histological damage on long-term kidney transplant outcome. Transplantation 2001; 71: 515-523.
8. Cosio FG, Grande JP, Wadei H et al. Predicting subsequent decline in kidney allograft function from early surveillance biopsies. Am J Transplant 2005; 5: 2464-2472.
9. Moreso F, Ibernon M, Goma M et al. Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss. Am J Transplant 2006; 6: 747-752.
10. Seron D. Interstitial fibrosis and tubular atrophy in renal allograft protocol biopsies as a surrogate of graft survival. Transplant Proc 2009; 41: 769-770.
11. Halloran PF, De Freitas DG, Einecke G et al. An integrated view of molecular changes, histopathology and outcomes in kidney transplants. Am J Transplant 2010; 10: 2223-2230.
12. Naesens M, Li L, Ying L et al. Expression of complement components differs between kidney allografts from living and deceased donors. J Am Soc Nephrol 2009; 20: 1839-1851.
13. Sarwal M, Chua MS, Kambham N et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125-138.
14. Mueller TF, Einecke G, Reeve J et al. Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant 2007; 7: 2712-2722.
15. Mas V, Maluf D, Archer K et al. Establishing the molecular pathways involved in chronic allograft nephropathy for testing new noninvasive diagnostic markers. Transplantation 2007; 83: 448-457.
16. Park W, Griffin M, Grande JP et al. Molecular evidence of injury and inflammation in normal and fibrotic renal allografts one year posttransplant. Transplantation 2007; 83: 1466-1476.
17. Mengel M, Reeve J, Bunnag S et al. Molecular correlates of scarring in kidney transplants: the emergence of mast cell transcripts. Am J Transplant 2009; 9: 169-178.
18. Nakorchevsky A, Hewel JA, Kurian SM et al. Molecular mechanisms of chronic kidney transplant rejection via large-scale proteogenomic analysis of tissue biopsies. J Am Soc Nephrol 2010; 21: 362-373.
19. Scherer A, Krause A, Walker JR et al. Early prognosis of the development of renal chronic allograft rejection by gene expression profiling of human protocol biopsies. Transplantation 2003; 75: 1323-1330.
20. Scherer A, Gwinner W, Mengel M et al. Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months. Nephrol Dial Transplant 2009; 24: 2567-2575.
21. Vitalone MJ, O'Connell PJ, Wavamunno M et al. Transcriptome changes of chronic tubulointerstitial damage in early kidney transplantation. Transplantation 2010; 89: 537-547.
22. Park WD, Griffin MD, Cornell LD et al. Fibrosis with inflammation at one year predicts transplant functional decline. J Am Soc Nephrol 2010; 21: 1987-1997.
23. Scian MJ, Maluf DG, Archer KJ et al. Gene expression changes are associated with loss of kidney graft function and interstitial fibrosis and tubular atrophy: diagnosis versus prediction. Transplantation 2011; 91: 657-665.
24. Mengel M, Chang J, Kayser D et al. The molecular phenotype of 6-week protocol biopsies from human renal allografts: reflections of prior injury but not future course. Am J Transplant 2010; 11: 708-718.
25. Cosio FG, Grande JP, Larson TS et al. Kidney Allograft Fibrosis and Atrophy Early After Living Donor Transplantation. Am J Transplant 2005; 5: 1130-1136.
26. Ortiz F, Paavonen T, Tornroth T et al. Predictors of renal allograft histologic damage progression. J Am Soc Nephrol 2005; 16: 817-824.
27. Remuzzi G, Cravedi P, Perna A et al. Long-term outcome of renal transplantation from older donors. N Engl J Med 2006; 354: 343-352.
28. Naesens M, Kambham N, Concepcion W et al. The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients. Am J Transplant 2007; 7: 2504-2514.
29. Flechner SM, Kurian SM, Head SR et al. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant 2004; 4: 1475-1489.
30. Hotchkiss H, Chu TT, Hancock WW et al. Differential expression of profibrotic and growth factors in chronic allograft nephropathy. Transplantation 2006; 81: 342-349.
31. Solez K, Colvin RB, Racusen LC et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8: 753-760.
32. Mengel M, Reeve J, Bunnag S et al. Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts. Am J Transplant 2009; 9: 1859-1867.
33. Kim IK, Bedi DS, Denecke C et al. Impact of innate and adaptive immunity on rejection and tolerance. Transplantation 2008; 86: 889-894.
34. Zarkhin V, Kambham N, Li L et al. Characterization of intra-graft B cells during renal allograft rejection. Kidney Int 2008; 74: 664-673.
35. Porcheray F, Wong W, Saidman SL et al. B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans. Am J Transplant 2009; 9: 2126-2135.
36. Blank U, Essig M, Scandiuzzi L et al. Mast cells and inflammatory kidney disease. Immunol Rev 2007; 217: 79-95.
37. Beilke JN, Gill RG. Frontiers in nephrology: the varied faces of natural killer cells in transplantation-contributions to both allograft immunity and tolerance. J Am Soc Nephrol 2007; 18: 2262-2267.
38. van der Touw W, Bromberg JS. Natural killer cells and the immune response in solid organ transplantation. Am J Transplant 2010; 10: 1354-1358.
39. Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007; 449: 419-426.
40. Colvin BL, Matta BM, Thomson AW. Dendritic cells and chemokinedirected migration in transplantation: where are we headed? Clin Lab Med 2008; 28: 375-384.
41. Thomson AW. Tolerogenic dendritic cells: all present and correct? Am J Transplant 2010; 10: 214-219.
42. Roberts IS, Brenchley PE. Mast cells: the forgotten cells of renal fibrosis. J Clin Pathol 2000; 53: 858-862.
43. Jahanyar J, Koerner MM, Loebe M et al. The role of mast cells after solid organ transplantation. Transplantation 2008; 85: 1365-1371.
44. Nickeleit V, Mihatsch M. Kidney transplants, antibodies and rejection: is C4d a magic marker? Nephrol Dial Transplant 2003; 18: 2232-2239.
45. Nickeleit V, Andreoni K. Inflammatory cells in renal allografts. Front Biosci 2008; 13: 6202-6213.
46. Li L, Chang A, Naesens M et al. Steroid-free immunosuppression since 1999: 129 pediatric renal transplants with sustained Graft and patient benefits. Am J Transplant 2009; 9: 1362-1372.
47. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 2001; 98: 31-36.
48. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116-5121.
49. Schwartz GJ, Haycock GB, Edelmann Jr CM et al. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976; 58: 259-263.