Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosistubular atrophy (IFTA) at 6 months

Nephrology Dialysis Transplantation

Volumn 24, Issue 8, 2009, Pages 2567-2575

  Scherer, Andreas ^a,b   Gwinner, Wilfried ^c   Mengel, Michael ^d   Kirsch, Torsten ^c   Raulf, Friedrich ^a   Szustakowski, Joseph D ^a   Hartmann, Nicole ^a   Staedtler, Frank ^a   Engel, Guenter ^a   Klupp, Jochen ^a   Korn, Alexander ^a   Kehren, Jeanne ^a   Haller, Hermann ^c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Spheromics ^*  (Finland)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

Author keywords

Gene expression profiling; IFTA; Protocol biopsy

Indexed keywords

RNA; TRANSCRIPTOME;

ARTICLE; ATROPHY; B LYMPHOCYTE ACTIVATION; CHRONIC ALLOGRAFT NEPHROPATHY; CONTROLLED STUDY; DNA MICROARRAY; FIBROSING ALVEOLITIS; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SCORING SYSTEM; T LYMPHOCYTE ACTIVATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ATROPHY; BIOLOGICAL MARKERS; BIOPSY; CHILD; FEMALE; FIBROSIS; GENE EXPRESSION PROFILING; GENOME, HUMAN; GRAFT REJECTION; HUMANS; IMMUNOENZYME TECHNIQUES; KIDNEY TRANSPLANTATION; KIDNEY TUBULES; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 67651083506     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp183     Document Type: Article

References (40)

1. USRDS (United States Renal Data System). https://www.usrds.org
2. Seron D, Fulladosa X, Moreso F. Risk factors associated with the deterioration of renal function after kidney transplantation. Kidney Int Suppl 2005; 99: S113-S117
3. Racusen LC, Solez K, Colvin R. Fibrosis and atrophy in the renal allograft: interim report and new directions. Am J Transplant 2002; 2: 203
4. Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999; 55: 713-723
5. Halloran PF, Langone AJ, Helderman JH et al. Assessing long-term nephron loss: is it time to kick the CAN grading system? Am J Transplant 2004; 4:1729-1730
6. Yates PJ, Nicholson ML. The aetiology and pathogenesis of chronic allograft nephropathy. Transpl Immunol 2006; 16: 148 - 157
7. Furness PN, Taub N, Assmann KJ et al. International variation in histologic grading is large, and persistent feedback does not improve reproducibility. Am J Surg Pathol 2003; 27: 805-810
8. Sarwal M, Chua MS, Kambham N et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125-138
9. Storey JD. The positive false discovery rate: a Bayesian interpretation and the q-value. Ann Statist 2003; 31: 2013-2035
10. Mootha VK, Lindgren CM, Eriksson KF et al. PGC-1 alpha-repsonsive genes involved in oxidative phosphorylation are coordi-nately downregulated in human diabetes. Nat Genet 2003; 34: 267 - 273
11. Szustakowski JD, Lee JH, Marrese CA et al. Identification of a novel pathway regulation during myogenic differentiation. Genomics 2006; 87:129-138
12. Solez K, Colvin RB, Racusen LC et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8: 753-760
13. Nangaku M, Shankland SJ, Couser WG. Cellular response to injury in membranous nephropathy. J Am SocNephrol 2005; 16: 1195-1204
14. Salmi M, Koskinene K, Henttinen T et al. CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium. Blood 2004; 104: 3849-3857
15. Simon DI, Dhen Z, Seifert P et al. Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty. J Clin Invest 2000; 105: 293-300
16. Schaefer L, Raslik I, Groene H-J et al. Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin. FASEB J 2001; 15:559-561
17. Wahab NA, Mason RM. A critical look at growth factors and epithelial-to-mesenchymal transition in the adult kidney. Nephron Exp Nephrol 2006; 104: 129-134
18. Zeisberg M, Kalluri R. The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 2000; 82: 175-181
19. Mengel M, Gwinner W, Schwarz A et al. Infiltrates in protocol biopsies from renal allografts. Am J Transplant 2007; 7: 356-365
20. Regele H, Boehmig GA. Tissue injury and repair in allografts: novel perspectives. Curr Opin Nephrol Hypertens 2003; 12: 259-266
21. Hall AM, Unwin RJ. The not so 'Mighty Chondrion': emergence of renal diseases due to mitochondrial dysfunction. Nephron Physiol 2007; 105: 1-10
22. Galkina E, Ley K. Leukocyte recruitment and vascular injury in diabetic nephropathy. J Am Soc Nephrol 2006; 17: 368-377
23. Lee BH, Bae JS, Park RW et al. Betaig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through alphavneta5 integrin. Exp Mol Med 2006; 38: 153-161
24. Abderrahim-Ferkoune A, Bezy O, Astri-Roques S et al. Transdiffer-entiation of preadipose cells into smooth muscle-like cells: role of carboxypeptidase-like protein. Exp Cell Res 2004; 293: 219-228
25. Pichler RH, Hugo C, Shankland SJ et al. SPARC is expressed in renal interstitial fibrosis and in renal vascular injury. Kidney Int 1996; 50: 1978-1989
26. Nishimoto S, Hamajiama Y, Toda Y et al. Identification of a novel smooth muscle associated protein, smap2, upregulated during neoin-tima formation in a rat carotid endarterectomy model. Biochim Bio-phys Acta 2002; 1576: 225-230
27. Rahmani M, Wong BW, Ang L et al. Versican: signaling to transcrip-tional control pathways. Can J Physiol Pharmacol 2006; 84: 77 - 92
28. Yook JI, Li XY, Ota I et al. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 2006; 8:1398-1406
29. Wu YJ, Lapierre D, Wu J et al. The interaction of versican with its binding partners. Cell Res 2005; 15: 483-494
30. Sibalic V, Fan X, Loffing J et al. Upregulated renal tubular CD44, hyaluronan, and osteopontin in kdkd mice with interstitial nephritis. Nephrol Dial Transplant 1997; 12: 1344-1353
31. Rouschop KM, Sewnath ME, Claessen N et al. CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy. J Am Soc Nephrol 2004; 15: 674-686
32. Song E, Zou H, Yao Y et al. Early application of Met-RANTES ameliorates chronic allograft nephropathy. Kidney Int 2002; 61: 676 - 685
33. Grandaliano G, Di Paolo S, Monno R et al. Protease-activated receptor 1 and plasminogen activated inhibitor 1 expression in chronic allograft nephropathy: the role of coagulation and fibrinolysis in renal graft fibrosis. Transplantation 2001; 72: 1437-1443
34. Bijian K, Cybulsky A. Stress proteins in glomerular epithelial cell injury. Contrib Nephrol 2005; 148: 8-20
35. Razzaque MS, Le VT, Taguchi T. Heat shock protein 47 and renal fibrogenesis. Contrib Nephrol 2005; 148: 57-69
36. Vongwiwatana A, Tasanarong A, Rayner DC et al. Epithelial to mes-enchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 2005; 5:1367-1374
37. Hertig A, Anglicheau D, Verine J et al. Early epithelial phenotypic changes predict graft fibrosis. J Am Soc Nephrol 2008; 19: 1584-1591
38. Scherer A, Krause A, Walker JR et al. Early prognosis of the development of renal chronic allograft rejection by gene expression profiling of human protocol biopsies. Transplantation 2003; 75: 1323 - 1330
39. Wu X, Chen H, Parker B et al. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition. Cancer Res 2006; 66: 9527-9534
40. Yu G, Boone T, Delaney J et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol 2000; 1:252-256