Molecular correlates of scarring in kidney transplants: The emergence of mast cell transcripts

American Journal of Transplantation

Volumn 9, Issue 1, 2009, Pages 169-178

  Mengel, M ^a,b   Reeve, J ^a   Bunnag, S ^a   Einecke, G ^a   Sis, B ^a,b   Mueller, T ^a   Kaplan, B ^c   Halloran, P F ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Banff schema; Inflammation; Interstitial fibrosis; Microarrays; Pathology of renal transplantation; Tubular atrophy

Indexed keywords

GAMMA INTERFERON;

ARTICLE; B LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GRAFT SURVIVAL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY INJURY; KIDNEY SCAR; KIDNEY TUBULE DISORDER; MACROPHAGE; MAJOR CLINICAL STUDY; MAST CELL; MICROARRAY ANALYSIS; PLASMA CELL; PRIORITY JOURNAL; PROGNOSIS; SCAR FORMATION; TISSUE REACTION;

BIOPSY; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TRANSPLANTATION; MAST CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER;

EID: 58049217488     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02462.x     Document Type: Article

References (38)

1. Dammin GJ. The kidney as a homograft and its host. Med Bull (Ann Arbor) 1960 26 : 278 283.
2. Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999 55 : 713 723.
3. Solez K, Colvin RB, Racusen LC et al. Banff '05 Meeting report: Differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007 7 : 518 526.
4. Solez K, Colvin RB, Racusen LC et al. Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 2008 8 : 753 760.
5. Meier-Kriesche HU, Schold JD, Srinivas TR, Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant 2004 4 : 378 383.
6. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR. The natural history of chronic allograft nephropathy. N Engl J Med 2003 349 : 2326 2333.
7. Nankivell BJ, Chapman JR. Chronic allograft nephropathy: Current concepts and future directions. Transplant 2006 81 : 643 654.
8. Halloran PF, Langone AJ, Helderman JH, Kaplan B. Assessing long-term nephron loss: Is it time to kick the CAN grading system? Am J Transplant 2004 4 : 1729 1730.
9. Bohle A, Wehrmann M, Bogenschutz O et al. The long-term prognosis of the primary glomerulonephritides. A morphological and clinical analysis of 1747 cases. Pathol Res Pract 1992 188 : 908 924.
10. Wynn T. Cellular and molecular mechanisms of fibrosis. J Pathol 2008 214 : 199 210.
11. Cosio FG, Grande JP, Wadei H, Larson TS, Griffin MD, Stegall MD. Predicting subsequent decline in kidney allograft function from early surveillance biopsies. Am J Transplant 2005 5 : 2464 2472.
12. Moreso F, Ibernon M, Goma M et al. Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss. Am J Transplant 2006 6 : 747 752.
13. Shishido S, Asanuma H, Nakai H et al. The impact of repeated subclinical acute rejection on the progression of chronic allograft nephropathy. J Am Soc Nephrol 2003 14 : 1046 1052.
14. Racusen LC, Colvin RB, Solez K et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003 3 : 708 714.
15. Mengel M, Gwinner W, Schwarz A et al. Infiltrates in protocol biopsies from renal allografts. Am J Transplant 2007 7 : 356 365.
16. Mueller TF, Einecke G, Reeve J et al. Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant 2007 7 : 2712 2722.
17. Einecke G, Melk A, Ramassar V et al. Expression of CTL associated transcripts precedes the development of tubulitis in T-cell mediated kidney graft rejection. Am J Transplant 2005 5 : 1827 1836.
18. Einecke G, Mueller TF, Famulski KS, Ramassar V, Sis B, Halloran PF. Cytotoxic T cells, Interferon gamma and the renal response: Pathogenesis-based transcript sets have high diagnostic value in human kidney allograft rejection. Am J Transplant 2006 6 (Suppl 2 65 472.
19. Famulski KS, Einecke G, Reeve J et al. Changes in the transcriptome in allograft rejection: IFN-γ induced transcripts in mouse kidney allografts. Am J Transplant 2006 6 : 1342 1354.
20. Einecke G, Broderick G, Sis B, Halloran PF. Early loss of renal transcripts in kidney allografts: Relationship to the development of histologic lesions and alloimmune effector mechanisms. Am J Transplant 2007 7 : 1121 1130.
21. Famulski KS, Broderick G, Hay K et al. Transcriptome analysis reveals heterogeneity in the injury response of kidney transplants. Am J Transplant 2007 7 : 2483 2495.
22. Einecke G, Reeve J, Mengel M et al. Expression of B cell and immunoglobulin transcripts is a feature of inflammation in late allografts. Am J Transplant 2008 8 : 1434 1443.
23. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976 16 : 31 41.
24. Simon R. Development and evaluation of therapeutically relevant predictive classifiers using gene expression profiling. J Natl Cancer Inst 2006 98 : 1169 1171.
25. Mengel M, Sis B, Halloran PF. SWOT analysis of Banff: Strengths, weaknesses, opportunities, and threats of the international Banff consensus process and classification system for renal allograft pathology. Am J Transplant 2007 7 : 2221 2226.
26. Hippen BE, DeMattos A, Cook WJ, Kew CE, Gaston RS. Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts. Am J Transplant 2005 5 : 2248 2252.
27. Kayler LK, Lakkis FG, Morgan C et al. Acute cellular rejection with CD20-positive lymphoid clusters in kidney transplant patients following lymphocyte depletion. Am J Transplant 2007 7 : 949 954.
28. Moreso F, Seron D, O'Valle F et al. Immunephenotype of glomerular and interstitial infiltrating cells in protocol renal allograft biopsies and histological diagnosis. Am J Transplant 2007 7 : 2739 2747.
29. Sarwal M, Chua MS, Kambham N et al. Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003 349 : 125 138.
30. Steinmetz OM, Lange-Husken F, Turner JE et al. Rituximab removes intrarenal B cell clusters in patients with renal vascular allograft rejection. Transplant 2007 84 : 842 850.
31. Hasegawa M, Hamaguchi Y, Yanaba K et al. B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. Am J Pathol 2006 169 : 954 966.
32. Novobrantseva TI, Majeau GR, Amatucci A et al. Attenuated liver fibrosis in the absence of B cells. J Clin Invest 2005 115 : 3072 3082.
33. Bhogal RK, Bona CA. B cells: No longer bystanders in liver fibrosis. J Clin Invest 2005 115 : 2962 2965.
34. Blank U, Essig M, Scandiuzzi L, Benhamou M, Kanamaru Y. Mast cells and inflammatory kidney disease. Immunol Rev 2007 217 : 79 95.
35. Goto E, Honjo S, Yamashita H, Shomori K, Adachi H, Ito H. Mast cells in human allografted kidney: Correlation with interstitial fibrosis. Clin Transplant 2002 16 (Suppl 8 7 11.
36. Roberts IS, Brenchley PE. Mast cells: The forgotten cells of renal fibrosis. J Clin Pathol 2000 53 : 858 862.
37. Colvin RB, Dvorak HF. Letter: Basophils and mast cells in renal allograft rejection. Lancet 1974 1 : 212 214.
38. Cheng J, Grande JP. Cyclic nucleotide phosphodiesterase (PDE) inhibitors: Novel therapeutic agents for progressive renal disease. Exp Biol Med (Maywood) 2007 232 : 38 51.