메뉴 건너뛰기




Volumn 65, Issue 3, 2010, Pages 579-587

Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients

Author keywords

Cetuximab; Chemotherapy; Gastric cancer; K ras; Performance status; Predictor; Skin rash

Indexed keywords

CETUXIMAB; CISPLATIN; DOCETAXEL; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DRUG DERIVATIVE; KRAS PROTEIN, HUMAN; MONOCLONAL ANTIBODY; ONCOPROTEIN; RAS PROTEIN;

EID: 75549087436     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1067-9     Document Type: Article
Times cited : (34)

References (45)
  • 1
    • 14944385553 scopus 로고    scopus 로고
    • Global cancer statistics, 2002
    • 10.3322/canjclin.55.2.74 15761078
    • DM Parkin F Bray J Ferlay P Pisani 2005 Global cancer statistics, 2002 CA Cancer J Clin 55 74 108 10.3322/canjclin.55.2.74 15761078
    • (2005) CA Cancer J Clin , vol.55 , pp. 74-108
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 3
    • 0028959887 scopus 로고
    • Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer
    • 1:STN:280:DyaK2M7os1ertg%3D%3D 7533517
    • S Pyrhonen T Kuitunen P Nyandoto M Kouri 1995 Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer Br J Cancer 71 587 591 1:STN:280:DyaK2M7os1ertg%3D%3D 7533517
    • (1995) Br J Cancer , vol.71 , pp. 587-591
    • Pyrhonen, S.1    Kuitunen, T.2    Nyandoto, P.3    Kouri, M.4
  • 4
    • 33745547767 scopus 로고    scopus 로고
    • Chemotherapy in advanced gastric cancer: A systematic review and meta-analysis based on aggregate data
    • DOI 10.1200/JCO.2005.05.0245
    • AD Wagner W Grothe J Haerting G Kleber A Grothey WE Fleig 2006 Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data J Clin Oncol 24 2903 2909 10.1200/JCO.2005.05.0245 1:CAS:528:DC%2BD28XntV2gs7s%3D 16782930 (Pubitemid 46630593)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.18 , pp. 2903-2909
    • Wagner, A.D.1    Grothe, W.2    Haerting, J.3    Kleber, G.4    Grothey, A.5    Fleig, W.E.6
  • 5
    • 48849094297 scopus 로고    scopus 로고
    • Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction
    • 10.1093/annonc/mdn166 1:STN:280:DC%2BD1cvotFCmtA%3D%3D 18558665
    • M Dank J Zaluski C Barone, et al. 2008 Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction Ann Oncol 19 1450 1457 10.1093/annonc/mdn166 1:STN:280:DC%2BD1cvotFCmtA%3D%3D 18558665
    • (2008) Ann Oncol , vol.19 , pp. 1450-1457
    • Dank, M.1    Zaluski, J.2    Barone, C.3
  • 6
    • 41149154862 scopus 로고    scopus 로고
    • Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: A study of the Arbeitsgemeinschaft Internistische Onkologie
    • 10.1200/JCO.2007.13.9378 1:CAS:528:DC%2BD1cXkslKqsL8%3D 18349393
    • SE Al-Batran JT Hartmann S Probst, et al. 2008 Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie J Clin Oncol 26 1435 1442 10.1200/JCO.2007.13.9378 1:CAS:528:DC%2BD1cXkslKqsL8%3D 18349393
    • (2008) J Clin Oncol , vol.26 , pp. 1435-1442
    • Al-Batran, S.E.1    Hartmann, J.T.2    Probst, S.3
  • 7
    • 33750096084 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine/cisplatin (XP) vs. continuous infusion of 5-FU/cisplatin (FP) as first-line therapy in patients (pts) with advanced gastric cancer (AGC): Efficacy and safety results
    • (abstr LBA4018)
    • Y Kang WK Kang DB Shin, et al. 2006 Randomized phase III trial of capecitabine/cisplatin (XP) vs. continuous infusion of 5-FU/cisplatin (FP) as first-line therapy in patients (pts) with advanced gastric cancer (AGC): efficacy and safety results Proc Am Soc Clin Oncol 24 183s (abstr LBA4018)
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Kang, Y.1    Kang, W.K.2    Shin, D.B.3
  • 9
    • 38049047178 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • 10.1056/NEJMoa073149 1:CAS:528:DC%2BD1cXisFSktg%3D%3D 18172173
    • D Cunningham N Starling S Rao, et al. 2008 Capecitabine and oxaliplatin for advanced esophagogastric cancer N Engl J Med 358 36 46 10.1056/NEJMoa073149 1:CAS:528:DC%2BD1cXisFSktg%3D%3D 18172173
    • (2008) N Engl J Med , vol.358 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3
  • 11
    • 0028907863 scopus 로고
    • Clinical significance of epidermal growth factor (EGF), EGF receptor, and c-erbB-2 in human gastric cancer
    • 10.1002/1097-0142(19950315)75:6+<1418::AID-CNCR2820751505>3.0. CO;2-Y 1:STN:280:DyaK2M7ps1Wmuw%3D%3D 7889468
    • A Tokunaga M Onda T Okuda, et al. 1995 Clinical significance of epidermal growth factor (EGF), EGF receptor, and c-erbB-2 in human gastric cancer Cancer 75 1418 1425 10.1002/1097-0142(19950315)75:6+<1418::AID-CNCR2820751505>3. 0.CO;2-Y 1:STN:280:DyaK2M7ps1Wmuw%3D%3D 7889468
    • (1995) Cancer , vol.75 , pp. 1418-1425
    • Tokunaga, A.1    Onda, M.2    Okuda, T.3
  • 12
    • 42649133793 scopus 로고    scopus 로고
    • EGFR in gastric carcinomas: Prognostic significance of protein overexpression and high gene copy number
    • DOI 10.1111/j.1365-2559.2008.03021.x
    • MA Kim HS Lee HE Lee YK Jeon HK Yang WH Kim 2008 EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number Histopathology 52 738 746 10.1111/j.1365-2559.2008.03021.x 1:CAS:528:DC%2BD1cXks1Wht70%3D 18397279 (Pubitemid 351600058)
    • (2008) Histopathology , vol.52 , Issue.6 , pp. 738-746
    • Kim, M.A.1    Lee, H.S.2    Lee, H.E.3    Jeon, Y.K.4    Yang, H.K.5    Kim, W.H.6
  • 13
    • 49649101837 scopus 로고    scopus 로고
    • Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer
    • 10.1158/1078-0432.CCR-07-1898 1:CAS:528:DC%2BD1cXmtVCmtLc%3D 18483367
    • J Matsubara Y Yamada Y Hirashima, et al. 2008 Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer Clin Cancer Res 14 3022 3029 10.1158/1078-0432.CCR-07-1898 1:CAS:528:DC%2BD1cXmtVCmtLc%3D 18483367
    • (2008) Clin Cancer Res , vol.14 , pp. 3022-3029
    • Matsubara, J.1    Yamada, Y.2    Hirashima, Y.3
  • 15
    • 61749089272 scopus 로고    scopus 로고
    • Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: Epidermal growth factor receptor (EGFR) associated with favourable survival
    • 10.1038/sj.bjc.6604936 1:CAS:528:DC%2BD1MXisFensLw%3D 19259093
    • JS Kim MA Kim TM Kim, et al. 2009 Biomarker analysis in stage III-IV (M0) gastric cancer patients who received curative surgery followed by adjuvant 5-fluorouracil and cisplatin chemotherapy: epidermal growth factor receptor (EGFR) associated with favourable survival Br J Cancer 100 732 738 10.1038/sj.bjc.6604936 1:CAS:528:DC%2BD1MXisFensLw%3D 19259093
    • (2009) Br J Cancer , vol.100 , pp. 732-738
    • Kim, J.S.1    Kim, M.A.2    Kim, T.M.3
  • 16
  • 17
    • 38849142020 scopus 로고    scopus 로고
    • Synergy between cetuximab and chemotherapy in tumors of the gastrointestinal tract
    • DOI 10.1634/theoncologist.2006-0049
    • RL Mahtani JS Macdonald 2008 Synergy between cetuximab and chemotherapy in tumors of the gastrointestinal tract Oncologist 13 39 50 10.1634/ theoncologist.2006-0049 1:CAS:528:DC%2BD1cXivFGrt70%3D 18245011 (Pubitemid 351206695)
    • (2008) Oncologist , vol.13 , Issue.1 , pp. 39-50
    • Mahtani, R.L.1    Macdonald, J.S.2
  • 20
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • DOI 10.1200/JCO.2004.10.182
    • LB Saltz NJ Meropol PJ Loehrer Sr MN Needle J Kopit RJ Mayer 2004 Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor J Clin Oncol 22 1201 1208 10.1200/JCO.2004.10.182 1:CAS:528:DC%2BD2cXpsVGktLw%3D 14993230 (Pubitemid 41079832)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 22
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • 10.1158/0008-5472.CAN-06-0191 1:CAS:528:DC%2BD28XjsFSlsb0%3D 16618717
    • A Lievre JB Bachet D Le Corre, et al. 2006 KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer Cancer Res 66 3992 3995 10.1158/0008-5472.CAN-06-0191 1:CAS:528:DC%2BD28XjsFSlsb0%3D 16618717
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 23
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • 10.1056/NEJMoa0805019 19339720
    • E Van Cutsem CH Kohne E Hitre, et al. 2009 Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer N Engl J Med 360 1408 1417 10.1056/NEJMoa0805019 19339720
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 24
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • 10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D 19114683
    • C Bokemeyer I Bondarenko A Makhson, et al. 2009 Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer J Clin Oncol 27 663 671 10.1200/JCO.2008.20.8397 1:CAS:528:DC%2BD1MXjsVCjsrk%3D 19114683
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 26
    • 34848837034 scopus 로고    scopus 로고
    • Cetuximab plus weekly oxaliplatin/5FU/FA (FUFOX) in 1st line metastatic gastric cancer, Final results from a multicenter phase II study of the AIO upper GI study group
    • (abstr 4526)
    • F Lordick S Lorenzen S Hegewisch-Becker, et al. 2007 Cetuximab plus weekly oxaliplatin/5FU/FA (FUFOX) in 1st line metastatic gastric cancer, Final results from a multicenter phase II study of the AIO upper GI study group Proc Am Soc Clin Oncol 25 204s (abstr 4526)
    • (2007) Proc Am Soc Clin Oncol , vol.25
    • Lordick, F.1    Lorenzen, S.2    Hegewisch-Becker, S.3
  • 28
    • 77958581775 scopus 로고    scopus 로고
    • A prospective phase II study of cetuximab in combination with capecitabine and oxaliplatin (XELOX) in patients with metastatic and/or recurrent advanced gastric cancer
    • 15-17 Jan 2009 (abstr 89)
    • Kim C, Lee J, Ryu M et al (2009) A prospective phase II study of cetuximab in combination with capecitabine and oxaliplatin (XELOX) in patients with metastatic and/or recurrent advanced gastric cancer. In: Proceedings of American society of clinical oncology 2009 gastrointestinal cancers symposium, 15-17 Jan 2009 (abstr 89)
    • (2009) Proceedings of American Society of Clinical Oncology 2009 Gastrointestinal Cancers Symposium
    • Kim, C.1    Lee, J.2    Ryu, M.3
  • 29
    • 77649184728 scopus 로고    scopus 로고
    • Phase II study of cetuximab plus weekly cisplatin and 24-hour infusion of high-dose 5-fluorouracil and leucovorin for the first-line treatment of advanced gastric cancer
    • 15-17 Jan 2009 (abstr 60)
    • Yeh K, Hsu C, Hsu C et al (2009) Phase II study of cetuximab plus weekly cisplatin and 24-hour infusion of high-dose 5-fluorouracil and leucovorin for the first-line treatment of advanced gastric cancer. In: Proceedings of American society of clinical oncology 2009 gastrointestinal cancers symposium, 15-17 Jan 2009 (abstr 60)
    • (2009) Proceedings of American Society of Clinical Oncology 2009 Gastrointestinal Cancers Symposium
    • Yeh, K.1    Hsu, C.2    Hsu, C.3
  • 30
    • 67349281373 scopus 로고    scopus 로고
    • Oxaliplatin, irinotecan and cetuximab in advanced gastric cancer: First results of a multicenter phase II trial (AGMT Gastric-2)
    • (abstr 15587)
    • E Woell R Greil W Eisterer, et al. 2008 Oxaliplatin, irinotecan and cetuximab in advanced gastric cancer: first results of a multicenter phase II trial (AGMT Gastric-2) Proc Am Soc Clin Oncol 26 662s (abstr 15587)
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Woell, E.1    Greil, R.2    Eisterer, W.3
  • 31
    • 77649185700 scopus 로고    scopus 로고
    • Cetuximab with irinotecan/Na-Fa/5-FU as first-line treatment in advanced gastric cancer: Preliminary results of a nonrandomised multi-centre AIO phase II study. In: Proceedings of American society of clinical oncology 2008 gastrointestinal cancers symposium, 25-27 Jan 2008 (abstract 102)
    • AIO Gastric group, Germany
    • AIO Gastric group, Germany, Moehler MH, Trarbach T et al (2008) Cetuximab with irinotecan/Na-Fa/5-FU as first-line treatment in advanced gastric cancer: preliminary results of a nonrandomised multi-centre AIO phase II study. In: Proceedings of American society of clinical oncology 2008 gastrointestinal cancers symposium, 25-27 Jan 2008 (abstract 102)
    • (2008) Moehler MH, Trarbach T, et Al
  • 32
    • 58749089260 scopus 로고    scopus 로고
    • Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer
    • 10.1038/sj.bjc.6604861 1:CAS:528:DC%2BD1MXpsVSrtg%3D%3D 19127259
    • SW Han DY Oh SA Im, et al. 2009 Phase II study and biomarker analysis of cetuximab combined with modified FOLFOX6 in advanced gastric cancer Br J Cancer 100 298 304 10.1038/sj.bjc.6604861 1:CAS:528:DC%2BD1MXpsVSrtg%3D%3D 19127259
    • (2009) Br J Cancer , vol.100 , pp. 298-304
    • Han, S.W.1    Oh, D.Y.2    Im, S.A.3
  • 33
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors, European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • 10.1093/jnci/92.3.205 1:STN:280:DC%2BD3c7it1Gitg%3D%3D 10655437
    • P Therasse SG Arbuck EA Eisenhauer, et al. 2000 New guidelines to evaluate the response to treatment in solid tumors, European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 205 216 10.1093/jnci/92.3.205 1:STN:280:DC%2BD3c7it1Gitg%3D%3D 10655437
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 35
    • 67349122733 scopus 로고    scopus 로고
    • ATTAX2: Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophago-gastric cancer-final results of a multicentre phase II trial by the AGITG
    • (abstr 15554)
    • NC Tebbutt T Sourjina AH Strickland, et al. 2008 ATTAX2: docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophago-gastric cancer-final results of a multicentre phase II trial by the AGITG Proc Am Soc Clin Oncol 26 659s (abstr 15554)
    • (2008) Proc Am Soc Clin Oncol , vol.26
    • Tebbutt, N.C.1    Sourjina, T.2    Strickland, A.H.3
  • 36
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group Study
    • DOI 10.1200/JCO.2005.02.4646
    • B Burtness MA Goldwasser W Flood B Mattar AA Forastiere 2005 Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study J Clin Oncol 23 8646 8654 10.1200/JCO.2005.02.4646 16314626 (Pubitemid 46211507)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 37
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
    • DOI 10.1200/JCO.2004.12.040
    • HQ Xiong A Rosenberg A LoBuglio, et al. 2004 Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial J Clin Oncol 22 2610 2616 10.1200/JCO.2004.12.040 1:CAS:528:DC%2BD2cXpsVWksLY%3D 15226328 (Pubitemid 41103748)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.13 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    LoBuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6    Needle, M.7    Abbruzzese, J.L.8
  • 38
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining?
    • DOI 10.1200/JCO.2005.00.6916
    • R Perez-Soler L Saltz 2005 Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining? J Clin Oncol 23 5235 5246 10.1200/JCO.2005.00.6916 16051966 (Pubitemid 46224035)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.22 , pp. 5235-5246
    • Perez-Soler, R.1    Saltz, L.2
  • 40
    • 0842263902 scopus 로고    scopus 로고
    • Mutational analysis of BRAF and K-ras in gastric cancers: Absence of BRAF mutations in gastric cancers
    • DOI 10.1007/s00439-003-1027-0
    • IJ Kim JH Park HC Kang, et al. 2003 Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers Hum Genet 114 118 120 10.1007/s00439-003-1027-0 1:CAS:528:DC%2BD3sXovFOisbk%3D 14513361 (Pubitemid 38165543)
    • (2003) Human Genetics , vol.114 , Issue.1 , pp. 118-120
    • Kim, I.-J.1    Park, J.-H.2    Kang, H.C.3    Shin, Y.4    Park, H.-W.5    Park, H.-R.6    Ku, J.-L.7    Lim, S.-B.8    Park, J.-G.9
  • 41
    • 0035878802 scopus 로고    scopus 로고
    • DNA aneuploidy and high proliferative activity but not K-ras-2 mutations as independent predictors of clinical outcome in operable gastric carcinoma: Results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study
    • DOI 10.1002/1097-0142(20010715)92:2<294::AID-CNCR1322>3.0.CO;2-9
    • A Russo V Bazan M Migliavacca, et al. 2001 DNA aneuploidy and high proliferative activity but not K-ras-2 mutations as independent predictors of clinical outcome in operable gastric carcinoma: results of a 5-year Gruppo Oncologico dell'Italia Meridonale (GDIM) prospective study Cancer 92 294 302 10.1002/1097-0142(20010715)92:2<294::AID-CNCR1322>3.0.CO;2-9 1:STN:280:DC%2BD3Mvhs1yrug%3D%3D 11466682 (Pubitemid 32664435)
    • (2001) Cancer , vol.92 , Issue.2 , pp. 294-302
    • Russo, A.1    Bazan, V.2    Migliavacca, M.3    Tubiolo, C.4    Macaluso, M.5    Zanna, I.6    Corsale, S.7    Latteri, F.8    Valerio, M.R.9    Pantuso, G.10    Morello, V.11    Dardanoni, G.12    Latteri, M.A.13    Colucci, G.14    Tomasino, R.M.15    Gebbia, N.16
  • 42
    • 0036770443 scopus 로고    scopus 로고
    • Ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas
    • 1:CAS:528:DC%2BD3sXhtVyntLs%3D 12204060
    • J Yoo SY Park RA Robinson SJ Kang WS Ahn CS Kang 2002 ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas Arch Pathol Lab Med 126 1096 1100 1:CAS:528:DC%2BD3sXhtVyntLs%3D 12204060
    • (2002) Arch Pathol Lab Med , vol.126 , pp. 1096-1100
    • Yoo, J.1    Park, S.Y.2    Robinson, R.A.3    Kang, S.J.4    Ahn, W.S.5    Kang, C.S.6
  • 43
    • 0029041377 scopus 로고
    • Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy
    • 1:CAS:528:DyaK2MXmtlWrt7s%3D 7780983
    • T Hongyo GS Buzard D Palli, et al. 1995 Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy Cancer Res 55 2665 2672 1:CAS:528:DyaK2MXmtlWrt7s%3D 7780983
    • (1995) Cancer Res , vol.55 , pp. 2665-2672
    • Hongyo, T.1    Buzard, G.S.2    Palli, D.3
  • 44
    • 0032490124 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The multicenter "rASCAL" study
    • 10.1093/jnci/90.9.675 1:CAS:528:DyaK1cXjtlSiu7s%3D 9586664
    • HJ Andreyev AR Norman D Cunningham JR Oates PA Clarke 1998 Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study J Natl Cancer Inst 90 675 684 10.1093/jnci/90.9.675 1:CAS:528: DyaK1cXjtlSiu7s%3D 9586664
    • (1998) J Natl Cancer Inst , vol.90 , pp. 675-684
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3    Oates, J.R.4    Clarke, P.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.