Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets

Virology

Volumn 422, Issue 1, 2012, Pages 125-131

  Meunier, Isabelle ^a   Embury Hyatt, Carissa ^b   Stebner, Shane ^c   Gray, Michael ^c   Bastien, Nathalie ^c   Li, Yan ^c   Plummer, Francis ^c,d   Kobinger, Gary P ^c,d   Von Messling, Veronika ^a,e  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

^b CANADIAN FOOD INSPECTION AGENCY   (Canada)

^c PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^d UNIVERSITY OF MANITOBA   (Canada)

^e DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Ferret model; H1N1 2009 pandemic influenza; Histopathological differences; Inflammatory host response profile; Mild and severe strains; Pathogenesis comparison

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FERRET; INFLUENZA A (H1N1); INTESTINE; LUNG INJURY; NONHUMAN; PANDEMIC INFLUENZA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY SYSTEM; UPREGULATION; VIRAL CLEARANCE; VIROGENESIS; VIRUS DETECTION; VIRUS GENOME; VIRUS ISOLATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; VIRUS VIRULENCE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; FERRETS; INFLAMMATION; INFLUENZA A VIRUS, H1N1 SUBTYPE; ORTHOMYXOVIRIDAE INFECTIONS; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTIONS;

ANIMALIA; MUSTELA;

EID: 82355190103     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.10.018     Document Type: Article

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