Involvement of progranulin in hypothalamic glucose sensing and feeding regulation

Endocrinology

Volumn 152, Issue 12, 2011, Pages 4672-4682

  Kim, Hyun Kyong ^a   Shin, Mi Seon ^a   Youn, Byung Soo ^b   Namkoong, Churl ^a   Gil, So Young ^a   Kang, Gil Myoung ^a   Yu, Ji Hee ^a   Kim, Min Seon ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b AdipoGen Inc   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; ANTIOBESITY AGENT; DEOXYGLUCOSE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NEUROPEPTIDE Y; PROGRANULIN; PROOPIOMELANOCORTIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; APPETITE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENDOCRINE FUNCTION; ENERGY BALANCE; ENZYME ACTIVITY; FEEDING BEHAVIOR; FOOD INTAKE; HUMAN; HYPERPHAGIA; HYPOTHALAMIC GLUCOSE SENSING; HYPOTHALAMUS; IMMUNOREACTIVITY; LIPID DIET; MALE; MICROGLIA; MOLECULAR INTERACTION; MOUSE; NERVE CELL; NONHUMAN; NUTRITIONAL STATUS; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; STARVATION; SUGAR INTAKE; TANYCYTE; TASTE AVERSION; WEIGHT GAIN; WEIGHT REDUCTION;

AGOUTI-RELATED PROTEIN; ANIMALS; APPETITE REGULATION; BODY WEIGHT; EATING; GLUCOSE; HYPOTHALAMUS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROGLIA; NEUROPEPTIDE Y; OBESITY;

EID: 82355188227     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1221     Document Type: Article

References (42)

1. Oomura Y, Ono T, Ooyama H, Wayner MJ 1969 Glucose and osmosensitive neurones of the rat hypothalamus. Nature 222:282-284
2. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI 1995 Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184
3. Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI 1997 Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 99:361-365 (Pubitemid 27053991)
4. Schuit FC, Huypens P, Heimberg H, Pipeleers DG 2001 Glucose sensing in pancreatic β-cells: a model for the study of other glucoseregulated cells in gut, pancreas, and hypothalamus. Diabetes 50:1-11 (Pubitemid 32047973)
5. Thorens B 2001 GLUT2 in pancreatic and extra-pancreatic glucodetection (review). Mol Membr Biol 18:265-273
6. García MA, Millán C, Balmaceda-Aguilera C, Castro T, Pastor P, Montecinos H, Reinicke K, Zúñiga F, Vera JC, Oñate SA, Nualart F 2003 Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing. J Neurochem 86:709-724 (Pubitemid 36897451)
7. Marty N, Dallaporta M, Foretz M, Emery M, Tarussio D, Bady I, Binnert C, Beermann F, Thorens B 2005 Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors. J Clin Invest 115:3545-3553 (Pubitemid 43121842)
8. Horstmann E 1954 [The fiber glia of selacean brain]. Z Zellforsch Mikrosk Anat 39:588-617 (German)
9. Rodríguez EM, Blázquez JL, Pastor FE, Peláez B, Peña P, Peruzzo B, Amat P 2005 Hypothalamic tanycytes: a key component of brainendocrine interaction. Int Rev Cytol 247:89-164 (Pubitemid 41782012)
10. Akmayev IG, Fidelina OV 1976 Morphological aspects of the hypothalamic- hypophyseal system. VI. The tanycytes: their relation to the sexual differentiation of the hypothalamus. An enzyme-histochemical study. Cell Tissue Res 173:407-416
11. Rodríguez EM, González CB, Delannoy L 1979 Cellular organization of the lateral and postinfundibular regions of the median eminence in the rat. Cell Tissue Res 201:377-408 (Pubitemid 10196038)
12. Akmayev IG, Fidelina OV, Kabolova ZA, Popov AP, Schitkova TA 1973 Morphological aspects of the hypothalamic-hypophyseal system. IV. Medial basal hypothalamus. An experimental morphological study. Z Zellforsch Mikrosk Anat 137:493-512
13. Sanders NM, Dunn-Meynell AA, Levin BE 2004 Third ventricular alloxan reversibly impairs glucose counterregulatory responses. Diabetes 53:1230-1236 (Pubitemid 38569008)
14. Bhandari V, Giaid A, Bateman A 1993 The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor. Endocrinology 133:2682-2689 (Pubitemid 24000720)
15. He Z, Ong CH, Halper J, Bateman A 2003 Progranulin is a mediator of the wound response. Nat Med 9:225-229 (Pubitemid 36227726)
16. Daniel R, He Z, Carmichael KP, Halper J, Bateman A 2000 Cellular localization of gene expression for progranulin. J Histochem Cytochem 48:999-1009 (Pubitemid 30421564)
17. Bateman A, Bennett HP 1998 Granulins: the structure and function of an emerging family of growth factors. J Endocrinol 158:145-151 (Pubitemid 28342057)
18. He Z, Bateman A 1999 Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo. Cancer Res 59:3222-3229 (Pubitemid 29316026)
19. Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM, Lacomis L, Erdjument-Bromage H, Tempst P, Wright CD, Ding A 2002 Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 111:867-878 (Pubitemid 36106407)
20. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M 2006 Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442:916-919 (Pubitemid 44285946)
21. Ahmed Z, Mackenzie IR, Hutton ML, Dickson DW 2007 Progranulin in frontotemporal lobar degeneration and neuroinflammation. J Neuroinflammation 4:7
22. Suzuki M, Yonezawa T, Fujioka H, Matuamuro M, Nishihara M 2001 Induction of granulin precursor gene expression by estrogen treatment in neonatal rat hypothalamus. Neurosci Lett 297:199-202 (Pubitemid 32011308)
23. Kayasuga Y, Chiba S, Suzuki M, Kikusui T, Matsuwaki T, Yamanouchi K, Kotaki H, Horai R, Iwakura Y, Nishihara M 2007 Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene. Behav Brain Res 185:110-118 (Pubitemid 47633696)
24. Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, Kim KS, Kim SW, Kim HS, Park JY, Kim YB, Lee KU 2006 Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci 9:901-906 (Pubitemid 43980504)
25. Rushing PA, Seeley RJ, Air EL, Lutz TA, Woods SC 2002 Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences. Peptides 23:985-988 (Pubitemid 34655400)
26. Petkau TL, Neal SJ, Orban PC, MacDonald JL, Hill AM, Lu G, Feldman HH, Mackenzie IR, Leavitt BR 2010 Progranulin expression in the developing and adult murine brain. J Comp Neurol 518:3931-3947
27. Kim HK, Youn BS, Shin MS, Namkoong C, Park KH, Baik JH, Kim JB, Park JY, Lee KU, Kim YB, Kim MS 2010 Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes 59:2772-2780
28. Davies SP, Carling D, Hardie DG 1989 Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur J Biochem 186:123-128 (Pubitemid 20015134)
29. Smith GP, Epstein AN 1969 Increased feeding in response to decreased glucose utilization in the rat and monkey. Am J Physiol 217:1083-1087
30. Miselis RR, Epstein AN 1975 Feeding induced by intracerebroventricular 2-deoxy-D-glucose in the rat. Am J Physiol 229:1438-1447
31. Hardie DG, Carling D, Carlson M 1998 The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67:821-855 (Pubitemid 28411146)
32. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU 2004 Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 10:727-733 (Pubitemid 38937638)
33. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB 2004 AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569-574 (Pubitemid 38480541)
34. Kim MS, Lee KU 2005 Role of hypothalamic 5′-AMP-activated protein kinase in the regulation of food intake and energy homeostasis. J Mol Med 83:514-520
35. Youn BS, Bang SI, Klöting N, Park JW, Lee N, Oh JE, Pi KB, Lee TH, Ruschke K, Fasshauer M, Stumvoll M, Blüher M 2009 Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue. Diabetes 58:627-636
36. Horvath TL, Sarman B, García-Cáceres C, Enriori PJ, Sotonyi P, Shanabrough M, Borok E, Argente J, Chowen JA, Perez-Tilve D, Pfluger PT, Brönneke HS, Levin BE, Diano S, Cowley MA, Tschöp MH 2010 Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci USA 107:14875-14880
37. Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S 1996 Anovel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 224:855-862 (Pubitemid 26278674)
38. Suzuki M, Yoshida S, Nishihara M, Takahashi M 1998 Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus. Neurosci Lett 242:127-130 (Pubitemid 28275512)
39. Suzuki M, Bannai M, Matsumuro M, Furuhata Y, Ikemura R, Kuranaga E, Kaneda Y, Nishihara M, Takahashi M 2000 Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats. Physiol Behav 68:707-713 (Pubitemid 30182471)
40. Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A, Strittmatter SM 2010 Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron 68:654-667
41. Vercellino M, Grifoni S, Romagnolo A, Masera S, Mattioda A, Trebini C, Chiavazza C, Caligiana L, Capello E, Mancardi GL, Giobbe D, Mutani R, Giordana MT, Cavalla P 25 May 2011 Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis. Mult Scler 10.1177/1352458511406164
42. Frederich RC, Hamann A, Anderson S, Löllmann B, Lowell BB, Flier JS 1995 Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1:1311-1314