Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats

Physiology and Behavior

Volumn 68, Issue 5, 2000, Pages 707-713

  Suzuki, Masatoshi ^a   Bannai, Makoto ^a   Matsumuro, Mie ^a   Furuhata, Yasufumi ^a   Ikemura, Ryota ^a   Kuranaga, Erina ^a   Kaneda, Yasufumi ^b   Nishihara, Masugi ^a   Takahashi, Michio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Antisense oligodeoxynucleotide; Granulin; Sex steroid; Sexual differentiation of the brain

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN MATURATION; COITUS; CONTROLLED STUDY; COPULATION; EJACULATION; GENE EXPRESSION; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SEXUAL BEHAVIOR; TESTOSTERONE BLOOD LEVEL;

EID: 0034068419     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(99)00241-3     Document Type: Article

References (38)

1. Arnold A.P., Gorski R.A. Gonadal steroid induction of structural sex differences in the central nervous system. Annu Rev Neurosci. 7:1984;413-442.
2. MacLusky N.J., Naftolin F. Sexual differentiation of the central nervous system. Science. 211:1981;1294-1302.
3. McEwen B.S., Lieberburg I., Chaptal C., Krey L.C. Aromatization. important for sexual differentiation of the neonatal rat brain Horm Behav. 9:1977;249-263.
4. Duenas M., Torres-Aleman I., Naftolin F., Garcia-Segura L.M. Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation. Neuroscience. 74:1996;531-539.
5. Toran-Allerand C.D. Mechanisms of estrogen action during neuronal development. mediation by interactions with the neurotrophins and their receptor? J Steroid Biochem Mol Biol. 56:1996;169-178.
6. Suzuki M., Yoshida S., Nishihara M., Takahashi M. Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus. Neurosci Lett. 242:1998;127-130.
7. Bateman A., Belcourt D., Bennet H., Lazure C., Solomon S. Granulins, a novel class of peptide from leukocytes. Biochem Biophys Res Commun. 173:1990;1161-1168.
8. Shoyb M., McDonald V.L., Byles C., Todaro G.J., Plowman G.D. Epithelin 1 and 2. isolation and characterization of two cysteine-rich growth-modulating proteins Proc Natl Acad Sci USA. 87:1990;7912-7916.
9. Arai Y., Matsumoto A. Synaptic formation of the hypothalamic arcuate nucleus during post-natal development in the female rat and its modification by neonatal estrogen treatment. Psychoneuroendocrinology. 3:1978;31-45.
10. Matsumoto A., Arai Y. Male-female difference in synaptic organization of the ventromedial nucleus of the hypothalamus in the rat. Neuroendocrinology. 42:1980;232-236.
11. Pozzo Miller L.D., Aoki A. Stereological analysis of the hypothalamic ventromedial nucleus II. Hormone induced changes in the synaptogenetic pattern. Dev Brain Res. 61:1991;189-196.
12. Eck S.L., York D.A. Antisense oligodeoxynucleotides for therapeutic intervention. Curr Opin Biotechnol. 2:1991;897-904.
13. Uhlmann E., Peyman A. Antisense oligodeoxynucleotides. a new therapeutic pulinciple Chem Rev. 90:1990;544-583.
14. Katoh S., Mitsui Y., Kitani K., Suzuki T. Nerve growth factor rescues PC12 cells from apoptosis by increasing amount of bcl-2. Biochem Biophys Res Commun. 229:1996;653-657.
15. Zheng H., Sahai B., Kilgannon P., Fotedar A., Green D.R. Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor. Proc Natl Acad Sci USA. 86:1989;3758-3762.
16. McCarthy M.M., Schlenker E.H., Pfaff D.W. Enduring consequences of neonatal treatment with antisense oligodeoxynucleotides to estrogen receptor messenger ribonucleic acid on sexual differentiation of rat brain. Endocrinology. 133:1993;433-439.
17. Aguan K., Mahesh V.B., Ping L., Bhat G., Brann D.W. Evidence for a physiological role for nitric oxide in the regulation of the LH surge. effect of central administration of antisense oligonuculeotides to nitric oxide synthase Neuroendocrinology. 64:1996;449-455.
18. Bannai M., Ichikawa M., Nishihara M., Takahashi M. Effect of injection of antisense oligodeoxynucleotides of GAD isozymes into rats ventromedial hypothalamus on food intake and locomotor activity. Brain Res. 784:1998;305-315.
19. Sakai R.R., Ma L.Y., Zhang D.M., McEwen B.S., Fluharty S.J. Intracerebral administration of mineralcorticoid receptor antisense oligonucleotides attenuate adrenal steroid-induced salt appetite in rats. Neuroendocrinology. 64:1996;425-429.
20. Yamada K., Moriguchi A., Morishita R., Aoki M., Nakamura Y., Mikami H., Oshima T., Ninomiya M., Kaneda Y., Higaki J., Ogihara T. Efficient oligonuleotide delivery using the HVJ-liposome method in the central nervous system. Am J Physiol. 271:1996;R1212-R1220.
21. Bhandari V., Glaid A., Bateman A. The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor. Endocrinology. 133:1993;2682-2689.
22. Morishita R., Gibbons G.H., Ellison K.E., Nakajima M., Leyen H.V.D., Zhang L., Kaneda Y., Ogihara T., Dzau V.J. Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides. J Clin Invest. 93:1994;1458-1464.
23. Kitajima I., Hanyu N., Soejima Y., Hirano R., Arahira S., Yamaoka S., Yamada R., Maruyama I., Kaneda Y. Efficient transfer of synthetic ribozymes into cells using Hemagglutinating Virus of Japan (HVJ)-cationic liposomes. J Biol Chem. 272:1997;27099-27106.
24. Hayashi S. Failure of intrahypothalamic implants of antiestrogen, MER-25, to inhibit androgen-sterlization in female rats. Endocrinol. 21:1974;453-457.
25. Suzuki M., Nishihara M., Takahashi M. Hypothalamic gonadotropin-releasing hormone gene expression during rat estrous cycle. Endocr J. 42:1995;789-796.
26. Kondo Y., Yamanouchi K. Potentiation of ejaculation activity by median raphe nucleus lesions in male rats. effects of p-chlorophenylalanine Endocr J. 44:1997;873-879.
27. Bloch G.J., Gorski R.A. Cytoarchitectonic analysis of the SDN-POA of the intact and gonadectomized rat. J Comp Neurol. 275:1988;604-612.
28. Bhandari V., Palfree R.G.E., Bateman A. Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cystein-rich granulin domains. Proc Natl Acad Sci USA. 89:1992;1715-1719.
29. Desire L., Head M.W., Fayein N.A., Courtois Y., Jeanny J.C. Suppression of fibroblast growth factor 2 expression by antisense oligodeoxynucleotides inhibits embryonic chick neural retina cell differentiation and survival in vivo. Dev Dynam. 212:1998;63-74.
30. Engelhard H., Narang C., Homer R., Duncan H. Urokinase antisense oligodeoxynucleotides as a novel therapeutic agent for malignant glioma. in vitro and in vivo studies of uptake, effects and toxicity Biochem Biophys Res Commun. 227:1996;400-405.
31. Meisel R.L., Sachs B.D. The physiology of male sexual behavior. Knobil E., Neill J.D. The Physiology of Reproduction. 1994;3-105 Raven Press, New York.
32. Saito T.R. Effects of LHRH on copulatory behavior and locomotor activity in sexually inexperienced male rats. Exp Anim. 37:1988;489-492.
33. Christensen L.W., Nance D.M., Gorski R.A. Effects of hypothalamic and preoptic lesions on reproductive behavior in male rats. Brain Res Bull. 2:1977;137-141.
34. Pfaff D.W., Sakuma Y. Facilitation of the lordosis reflex of female rats from the ventromedial nucleus of the hypothalamus. J Physiol. 288:1979;189-202.
35. Gorski R.A., Harlan R.E., Jacobson C.D., Shryne J.E., Southam A.M. Evidence for the existence of a sexually dimorphic nuclueus in the preoptic area of the rat. J Comp Neurol. 193:1980;529-539.
36. Rhees R.W., Shryne J.E., Gorski R.A. Termination of the hormone-sensitive period of differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats. Dev Brain Res. 52:1990;17-2331.
37. Barraclough C.A. Production of anovulatory, sterile rats by single injections of testosterone propionate. Endocrinology. 68:1961;62-67.
38. Madrid J.A., Lopez-Bote C., Martin E. Effect of neonatal androgenization on the circadian rhythm of feeding behavior in rats. Physiol Behav. 53:1993;329-335.