Generation of new benanomicin analogues by biotransformation using Escherichia coli expressing actinomycete cytochrome P450

Journal of Antibiotics

Volumn 61, Issue 6, 2008, Pages 394-399

  Kumagai, Hiroyuki ^a,b   Umekita, Maya ^a   Sawa, Ryuichi ^a   Takahashi, Yoshikazu ^a   Arisawa, Akira ^b   Isshiki, Kunio ^b   Nishimura, Yoshio ^a   Akamatsu, Yuzuru ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b MERCIAN CORPORATION   (Japan)

Author keywords

Actinomycete; Benanomicin; Biotransformation; E. coli; P450

Indexed keywords

10 HYDROXYBENANOMICIN A; 11 O NORBENANOMICIN A; ANTIFUNGAL AGENT; BENANOMICIN A; CHOP GENE; CYTOCHROME P450; UNCLASSIFIED DRUG; ANTHRACYCLINE; CYTOCHROME P 450 CYP105C1 (STREPTOMYCES GRISEOLUS); CYTOCHROME P-450 CYP105C1 (STREPTOMYCES GRISEOLUS);

ACTINOBACTERIA; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOTRANSFORMATION; DRUG TRANSFORMATION; ESCHERICHIA COLI; GENE EXPRESSION SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; FUNGUS; GENETIC TRANSFECTION; GENETICS; METABOLISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ACTINOBACTERIA; ANTHRACYCLINES; ANTIFUNGAL AGENTS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; FUNGI; TRANSFECTION;

EID: 56149095235     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.55     Document Type: Article

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