In vivo assessment of antiemetic drugs and mechanism of lycorine-induced nausea and emesis

Archives of Toxicology

Volumn 85, Issue 12, 2011, Pages 1565-1573

  Kretzing, Sascha ^a   Abraham, Getu ^a   Seiwert, Bettina ^a   Ungemach, Fritz Rupert ^a   Krügel, Ute ^a   Teichert, Jens ^a   Regenthal, Ralf ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alkaloid; Amaryllidaceae; Diphenhydramine; Dogs; Emesis; Lycorine; Maropitant; Mechanism; Metoclopramide; Ondansetron; Scopolamine; Toxicity

Indexed keywords

DIPHENHYDRAMINE; DOPAMINE RECEPTOR; HEVERT; LYCORINE; MAROPITANT; MCP RATIOPHARM; METOCLOPRAMIDE; MUSCARINIC RECEPTOR; NEUROKININ; NEUROKININ 1; ONDANSETRON; SCOPOLAMINE; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG TARGETING; FEMALE; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NAUSEA AND VOMITING; NONHUMAN; PLANT INTOXICATION; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMARYLLIDACEAE ALKALOIDS; ANIMALS; ANTIEMETICS; CROSS-OVER STUDIES; DOGS; DRUG DELIVERY SYSTEMS; FEMALE; INJECTIONS, SUBCUTANEOUS; MALE; NAUSEA; PHENANTHRIDINES; RANDOM ALLOCATION; RECEPTORS, NEUROKININ-1; RECEPTORS, SEROTONIN, 5-HT3; TIME FACTORS; VOMITING;

AMARYLLIDACEAE; ANIMALIA; CANIS FAMILIARIS;

EID: 82355173642     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0719-9     Document Type: Article

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