Regeneration of Three Layers Vascular Wall by using BMP2-Treated MSC Involving HIF-1α and Id1 Expressions Through JAK/STAT Pathways

Stem Cell Reviews and Reports

Volumn 7, Issue 4, 2011, Pages 847-859

  Belmokhtar, Karim ^a   Bourguignon, Thierry ^a   Worou, Morel E ^a   Khamis, Georges ^a   Bonnet, Pierre ^a   Domenech, Jorge ^a   Eder, Véronique ^a  

^a UNIVERSITÉ DE TOURS   (France)

Author keywords

Bone marrow mesenchymal stem cell; Hypoxia inducible factor 1 ; Regeneration; rh BMP2; SERCA2a; Vascular grafts

Indexed keywords

BIOLOGICAL MARKER; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; CYTOSKELETON PROTEIN; GREEN FLUORESCENT PROTEIN; HIF1A PROTEIN, RAT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ID1 PROTEIN, RAT; INHIBITOR OF DIFFERENTIATION 1; JANUS KINASE; MUSCLE PROTEIN; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; SMOOTH MUSCLE PROTEIN, RAT;

ABDOMINAL AORTA; ANGIOGENESIS; ANIMAL; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PROSTHESIS; CELL DIFFERENTIATION; COCULTURE; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; METHODOLOGY; RAT; REGENERATION; SIGNAL TRANSDUCTION; TIME; TRANSPLANTATION; WISTAR RAT;

ANIMALS; AORTA, ABDOMINAL; BIOLOGICAL MARKERS; BLOOD VESSEL PROSTHESIS; BONE MORPHOGENETIC PROTEIN 2; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CYTOSKELETAL PROTEINS; ENDOTHELIAL CELLS; GREEN FLUORESCENT PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITOR OF DIFFERENTIATION PROTEIN 1; JANUS KINASES; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MODELS, ANIMAL; MUSCLE PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REGENERATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

RATTUS; RATTUS NORVEGICUS;

EID: 82355168922     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-011-9254-6     Document Type: Article

References (33)

1. Zdrahala, R. J. (1996). Small caliber vascular grafts. Part I: state of the art. Journal of Biomaterials Applications, 10(4), 309-29.
2. Pittenger, M. F., & Martin, B. J. (2004). Mesenchymal stem cells and their potential as cardiac therapeutics. Circulation Research, 95(1), 9-20.
3. Bhatia, R., & Hare, J. M. (2005). Mesenchymal stem cells: future source for reparative medicine. Congestive Heart Failure, 11(2), 87-91. quiz 2-3.
4. Huang, N. F., & Li, S. (2008). Mesenchymal stem cells for vascular regeneration. Regenerative Medicine, 3(6), 877-92.
5. L'Heureux, N., Dusserre, N., Konig, G., et al. (2006). Human tissue-engineered blood vessels for adult arterial revascularization. Natural Medicines, 12(3), 361-5.
6. Hashi, C. K., Zhu, Y., Yang, G. Y., et al. (2007). Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts. Proceedings of the National Academy of Sciences of the United States of America, 104(29), 11915-20.
7. Kanki-Horimoto, S., Horimoto, H., Mieno, S., et al. (2006). Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation, 114(1 Suppl), I181-5.
8. Zhang, L., Zhou, J., Lu, Q., Wei, Y., & Hu, S. (2008). A novel small-diameter vascular graft: in vivo behavior of biodegradable three-layered tubular scaffolds. Biotechnology and Bioengineering, 99(4), 1007-15.
9. Schmidt, A., Ladage, D., Schinkothe, T., et al. (2006). Basic fibroblast growth factor controls migration in human mesenchymal stem cells. Stem Cells, 24(7), 1750-8.
10. Lin, H., Shabbir, A., Molnar, M., et al. (2008). Adenoviral expression of vascular endothelial growth factor splice variants differentially regulate bone marrow-derived mesenchymal stem cells. Journal of Cellular Physiology, 216(2), 458-68.
11. Schlange, T., Andree, B., Arnold, H. H., & Brand, T. (2000). BMP2 is required for early heart development during a distinct time period. Mechanisms of Development, 91(1-2), 259-70.
12. Chen, D., Zhao, M., & Mundy, G. R. (2004). Bone morphogenetic proteins. Growth Factors, 22(4), 233-41.
13. Gupta, S., Zhu, H., Zon, L. I., & Evans, T. (2006). BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis. Development, 133(11), 2177-87.
14. Semenza, G. L. (2000). HIF-1: mediator of physiological and pathophysiological responses to hypoxia. Journal of Applied Physiology, 88(4), 1474-80.
15. Lee, T. K., Poon, R. T., Yuen, A. P., et al. (2006). Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. Clinical Cancer Research, 12(23), 6910-9.
16. Bonnet, P., Awede, B., Rochefort, G. Y., et al. (2008). Electrophysiological maturation of rat mesenchymal stem cells after induction of vascular smooth muscle cell differentiation in vitro. Stem Cells and Development, 17(6), 1131-40.
17. Mirza, A., Hyvelin, J. M., Rochefort, G. Y., et al. (2008). Undifferentiated mesenchymal stem cells seeded on a vascular prosthesis contribute to the restoration of a physiologic vascular wall. Journal of Vascular Surgery, 47(6), 1313-21.
18. Schweitzer, K. M., Vicart, P., Delouis, C., et al. (1997). Characterization of a newly established human bone marrow endothelial cell line: distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells. Laboratory Investigation, 76(1), 25-36.
19. Macera, M. J., Szabo, P., Wadgaonkar, R., Siddiqui, M. A., & Verma, R. S. (1992). Localization of the gene coding for ventricular myosin regulatory light chain (MYL2) to human chromosome 12q23-q24. 3. Genomics, 13(3), 829-31.
20. Jung, J. E., Kim, H. S., Lee, C. S., et al. (2008). STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination. Experimental & Molecular Medicine, 40(5), 479-85.
21. Wood, A. D., Chen, E., Donaldson, I. J., et al. (2009). ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling. Blood, 114(9), 1820-30.
22. Sorrell, J. M., Baber, M. A., & Caplan, A. I. (2009). Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Engineering. Part A, 15(7), 1751-61.
23. Diefenderfer, D. L., & Brighton, C. T. (2000). Microvascular pericytes express aggrecan message which is regulated by BMP-2. Biochemical and Biophysical Research Communications, 269(1), 172-8.
24. Au, P., Tam, J., Fukumura, D., & Jain, R. K. (2008). Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood, 111(9), 4551-8.
25. Kotch, L. E., Iyer, N. V., Laughner, E., & Semenza, G. L. (1999). Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Developmental Biology, 209(2), 254-67.
26. Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., et al. (2004). Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Natural Medicines, 10(8), 858-64.
27. Raida, M., Clement, J. H., Leek, R. D., et al. (2005). Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. Journal of Cancer Research and Clinical Oncology, 131(11), 741-50.
28. Wang, G. L., & Semenza, G. L. (1993). General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proceedings of the National Academy of Sciences of the United States of America, 90(9), 4304-8.
29. Wincewicz, A., Sulkowska, M., Koda, M., Lesniewicz, T., Kanczuga-Koda, L., & Sulkowski, S. (2007). STAT3, HIF-1alpha, EPO and EPOR-signaling proteins in human primary ductal breast cancers. Folia Histochemica et Cytobiologica, 45(2), 81-6.
30. Su, Y., Zheng, L., Wang, Q., Bao, J., Cai, Z., & Liu, A. The PI3K/Akt pathway upregulates Id1 and integrin alpha4 to enhance recruitment of human ovarian cancer endothelial progenitor cells. BMC Cancer, 10, 459.
31. Grote, K., Luchtefeld, M., & Schieffer, B. (2005). JANUS under stress-role of JAK/STAT signaling pathway in vascular diseases. Vascular Pharmacology, 43(5), 357-63.
32. Jiang, H., Patel, P. H., Kohlmaier, A., Grenley, M. O., McEwen, D. G., & Edgar, B. A. (2009). Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell, 137(7), 1343-55.
33. Pan, J., Fukuda, K., Saito, M., et al. (1999). Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes. Circulation Research, 84(10), 1127-36.