Structure of the C-terminal domain of Neisseria Heparin Binding Antigen (NHBA), one of the main antigens of a novel vaccine against Neisseria meningitidis

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41767-41775

  Esposito, Veronica ^a   Musi, Valeria ^a   De Chiara, Cesira ^a   Veggi, Daniele ^b   Serruto, Davide ^b   Scarselli, Maria ^b   Kelly, Geoff ^a   Pizza, Mariagrazia ^b   Pastore, Annalisa ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL DOMAINS; C-TERMINAL REGIONS; CLINICAL TRIAL; H-BINDING; HEPARIN BINDING; IMMUNOGENICITY; IMMUNOLOGICAL PROPERTIES; MENINGITIDIS; MULTICOMPONENTS; NEISSERIA MENINGITIDIS; SINGLE SPECIES; STRUCTURAL SIMILARITY; THREE-DIMENSIONAL STRUCTURE; TRANSFERRIN-BINDING PROTEINS; VACCINOLOGY;

ANIMALS; MAGNETIC DOMAINS; PLANTS (BOTANY); POLYSACCHARIDES; SOAPS (DETERGENTS); VACCINES;

ANTIGENS;

BACTERIAL ANTIGEN; BACTERIAL VACCINE; BINDING PROTEIN; DETERGENT; FACTOR H BINDING PROTEIN; NEISSERIA HEPARIN BINDING ANTIGEN; TRANSFERRIN BINDING PROTEIN B; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG STRUCTURE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; IMMUNOGENICITY; NEISSERIA MENINGITIDIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; SEQUENCE ANALYSIS; STRUCTURAL HOMOLOGY;

ANTIGENS, BACTERIAL; CLINICAL TRIALS, PHASE III AS TOPIC; HUMANS; MENINGOCOCCAL VACCINES; NEISSERIA MENINGITIDIS, SEROGROUP B; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 82355164193     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.289314     Document Type: Article

References (51)

1. Stephens, D. S., Greenwood, B., and Brandtzaeg, P. (2007) Lancet 369, 2196-2210
2. Caugant, D. A., and Maiden, M. C. (2009) Vaccine 27, Suppl. 2, B64-70
3. Virji, M. (2009) Nat. Rev. Microbiol. 7, 274-286
4. Pace, D. (2009) Expert Rev. Vaccines 8, 529-542
5. Finne, J., Bitter-Suermann, D., Goridis, C., and Finne, U. (1987) J. Immunol. 138, 4402-4407
6. Holst, J., Martin, D., Arnold, R., Huergo, C. C., Oster, P., O'Hallahan, J., and Rosenqvist, E. (2009) Vaccine 27, Suppl. 2, B3-12
7. Bai, X., Findlow, J., and Borrow, R. (2011) Expert Opin. Biol. Ther. 11, 969-985
8. Giuliani, M. M., Santini, L., Brunelli, B., Biolchi, A., Aricò, B, Di Marcello, F., Cartocci, E., Comanducci, M., Masignani, V., Lozzi, L., Savino, S., Scarselli, M., Rappuoli, R., and Pizza, M. (2005) Infect. Immun. 73, 1151-1160
9. Desvaux, M., Parham, N. J., and Henderson, I. R. (2004) Curr. Issues Mol. Biol. 6, 111-124
10. Cantini, F., Veggi, D., Dragonetti, S., Savino, S., Scarselli, M., Romagnoli, G., Pizza, M., Banci, L., and Rappuoli, R. (2009) J. Biol. Chem. 284, 9022-9026
11. Mascioni, A., Bentley, B. E., Camarda, R., Dilts, D. A., Fink, P., Gusarova, V., Hoiseth, S. K., Jacob, J., Lin, S. L., Malakian, K., McNeil, L. K., Mininni, T., Moy, F., Murphy, E., Novikova, E., Sigethy, S., Wen, Y., Zlotnick, G. W., and Tsao, D. H. (2009) J. Biol. Chem. 284, 8738-8746
12. Capecchi, B., Adu-Bobie, J., Di Marcello, F., Ciucchi, L., Masignani, V., Taddei, A., Rappuoli, R., Pizza, M., and Aricò, B. (2005) Mol. Microbiol. 55, 687-698
13. Litt, D. J., Savino, S., Beddek, A., Comanducci, M., Sandiford, C., Stevens, J., Levin, M., Ison, C., Pizza, M., Rappuoli, R., and Kroll, J. S. (2004) Infect Dis. 190, 1488-1497
14. Masignani, V., Comanducci, M., Giuliani, M. M., Bambini, S., Adu-Bobie, J., Arico, B., Brunelli, B., Pieri, A., Santini, L., Savino, S., Serruto, D., Litt, D., Kroll, S., Welsch, J. A., Granoff, D. M., Rappuoli, R., and Pizza, M. (2003) J. Exp. Med. 197, 789-799
15. Fletcher, L. D., Bernfield, L., Barniak, V., Farley, J. E., Howell, A., Knauf, M., Ooi, P., Smith, R. P., Weise, P., Wetherell, M., Xie, X., Zagursky, R., Zhang, Y., and Zlotnick, G. W. (2004) Infect. Immun. 72, 2088-2100
16. Jacobsson, S., Mölling, P., and Olcén, P. (2009) Vaccine 27, 5755-5759
17. Madico, G., Welsch, J. A., Lewis, L. A., McNaughton, A., Perlman, D. H., Costello, C. E., Ngampasutadol, J., Vogel, U., Granoff, D. M., and Ram, S. (2006) J. Immunol. 177, 501-510
18. Schneider, M. C., Exley, R. M., Chan, H., Feavers, I., Kang, Y. H., Sim, R. B., and Tang, C. M. (2006) J. Immunol. 176, 7566-7575
19. Scarselli, M., Cantini, F., Santini, L., Veggi, D., Dragonetti, S., Donati, C., Savino, S., Giuliani, M. M., Comanducci, M., Di Marcello, F., Romagnoli, G., Pizza, M., Banci, L., and Rappuoli, R.(2009) J. Mol. Biol. 386, 97-108
20. Schneider, M. C., Prosser, B. E., Caesar, J. J., Kugelberg, E., Li, S., Zhang, Q., Quoraishi, S., Lovett, J. E., Deane, J. E., Sim, R. B., Roversi, P., Johnson, S., Tang, C. M., and Lea, S. M. (2009) Nature 458, 890-893
21. Giuliani, M. M., Adu-Bobie, J., Comanducci, M., Aricò, B., Savino, S., Santini, L., Brunelli, B., Bambini, S., Biolchi, A., Capecchi, B., Cartocci, E., Ciucchi, L., Di Marcello, F., Ferlicca, F., Galli, B., Luzzi, E., Masignani, V., Serruto, D., Veggi, D., Contorni, M., Morandi, M., Bartalesi, A., Cinotti, V., Mannucci, D., Titta, F., Ovidi, E., Welsch, J. A., Granoff, D., Rappuoli, R., and Pizza, M. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 10834-10839
22. Donnelly, J., Medini, D., Boccadifuoco, G., Biolchi, A., Ward, J., Frasch, C., Moxon, E. R., Stella, M., Comanducci, M., Bambini, S., Muzzi, A., Andrews, W., Chen, J., Santos, G., Santini, L., Boucher, P., Serruto, D., Pizza, M., Rappuoli, R., and Giuliani, M. M. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 19490-19495
23. Pizza, M., Scarlato, V., Masignani, V., Giuliani, M. M., Aricò, B., Comanducci, M., Jennings, G. T., Baldi, L., Bartolini, E., Capecchi, B., Galeotti, C. L., Luzzi, E., Manetti, R., Marchetti, E., Mora, M., Nuti, S., Ratti, G., Santini, L., Savino, S., Scarselli, M., Storni, E., Zuo, P., Broeker, M., Hundt, E., Knapp, B., Blair, E., Mason, T., Tettelin, H., Hood, D. W., Jeffries, A. C., Saunders, N. J., Granoff, D. M., Venter, J. C., Moxon, E. R., Grandi, G., and Rappuoli, R. (2000) Science 287, 5459, 1816-1820
24. Serruto, D., Spadafina, T., Ciucchi, L., Lewis, L. A., Ram, S., Tontini, M., Santini, L., Biolchi, A., Seib, K. L., Giuliani, M. M., Donnelly, J. J., Berti, F., Savino, S., Scarselli, M., Costantino, P., Kroll, J. S., O'Dwyer, C., Qiu, J., Plaut, A. G., Moxon, R., Rappuoli, R., Pizza, M., and Aricò, B. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 3770-3775
25. Esposito, V., Musi, V., Veggi, D., Pastore, A., and Pizza, M. G. (2010) Biomol. NMR Assign. 4, 107-109
26. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR. 6, 277-293
27. Zwahlen, C., Legault, P., Vincent, S. J. F., Greenblatt, J., Konrat, R., and Kay, L. E. (1997) J. Am. Chem. Soc. 119, 6711-6721
28. Shen, Y., Delaglio, F., Cornilescu, G., and Bax, A (2009) J. Biomol.NMR44, 213-223
29. Linge, J. P., O'Donoghue, S. I., and Nilges, M. (2001) Methods Enzymol. 339, 71-90
30. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
31. Folmer, R. H., Hilbers, C. W., Konings, R. N., and Nilges, M. (1997) J. Biomol. NMR. 9, 245-258
32. Linge, J. P., Habeck, M., Rieping, W., and Nilges, M. (2004) J. Magn. Res. 167, 334-342
33. Linge, J. P., Williams, M. A., Spronk, C. A., Bonvin, A. M., and Nilges, M. (2003) Proteins 50, 496-506
34. Koradi, R., Billeter, M., and Wüthrich, K. (1996) J. Mol. Graph. 14, 51-5, 29-32
35. Tompa, P. (2005) FEBS Lett. 579, 3346-3354
36. Vuilleumier, S., Sancho, J., Loewenthal, R., and Fersht, A. R. (1993) Biochemistry 32, 10303-10313
37. Strickland, E. H. (1974) CRC Crit. Rev. Biochem. 2, 113-175
38. Flower, D. R. (2000) Biochim. Biophys. Acta 1482, 46-56
39. Flower, D. R., North, A. C., and Sansom, C. E. (2000) Biochim. Biophys. Acta 1482, 9-24
40. Holm, L., and Sander, C. (1996) Science 273, 595-603
41. Moraes, T. F., Yu, R. H., Strynadka, N. C., and Schryvers, A. B. (2009) Mol. Cell 35, 523-533
42. Calmettes, C., Yu, R. H., Silva, L. P., Curran, D., Schriemer, D. C., Schryvers, A. B., and Moraes, T. F. (2011) J. Biol. Chem. 286, 12683-12692
43. Cantini, F., Savino, S., Scarselli, M., Masignani, V., Pizza, M., Romagnoli, G., Swennen, E., Veggi, D., Banci, L., and Rappuoli, R. (2006) J. Biol. Chem. 281, 7220-7227
44. Vandeputte-Rutten, L., Bos, M. P., Tommassen, J., and Gros, P. (2003) J. Biol. Chem. 278, 24825-24830
45. Cendron, L., Veggi, D., Girardi, E., and Zanotti, G. (2011) Acta Crystallogr. F 67, 531-535
46. Snape, M. D., and Kelly, D. F. (2011) Lancet 377, 1809-1810
47. Lewis, S., Sadarangani, M., Hoe, J. C., and Pollard, A. J. (2009) Expert Rev. Vaccines 8, 729-745
48. Bambini S, Muzzi, A., Olcen, P., Rappuoli, R., Pizza, M., and Comanducci, M. (2009) Vaccine 27, 2794-2803
49. Lucidarme, J., Comanducci, M., Findlow, J., Gray, S. J., Kaczmarski, E. B., Guiver, M., Kugelberg, E., Vallely, P. J., Oster, P., Pizza, M., Bambini, S., Muzzi, A., Tang, C. M., and Borrow, R. (2010) J. Clin. Microbiol. 47, 3577-3585
50. Thomas, D., and Pastore, A. (2005) Acta Crystallogr. D 61, 112-116
51. Lee, W., Westler, W. M., Bahrami, A., Eghbalnia, H. R., and Markley, J. L. (2009) Bioinformatics 25, 2085-2087