Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment

Bone

Volumn 44, Issue 2, 2009, Pages 357-363

  Kayal, Rayyan A ^a   Alblowi, Jazia ^a   McKenzie, Erin ^a   Krothapalli, Nanarao ^a   Silkman, Lee ^b   Gerstenfeld, Louis ^b   Einhorn, Thomas A ^b   Graves, Dana T ^a  

^a BOSTON UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cartilage; Diabetes; Femur; Fracture; Healing; Hyperglycemia; Insulin

Indexed keywords

ADAM PROTEIN; INSULIN; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN ADAMTS 4; PROTEIN ADAMTS 5; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE; CALLUS; CARTILAGE; CARTILAGE CELL; CONTROLLED STUDY; DIABETES MELLITUS; ENCHONDRAL OSSIFICATION; FEMUR FRACTURE; FRACTURE HEALING; GLUCOSE BLOOD LEVEL; INSULIN TREATMENT; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; PRIMORDIUM; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; BONY CALLUS; CARTILAGE; CELL COUNT; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; FEMORAL FRACTURES; FRACTURE HEALING; GENE EXPRESSION REGULATION; INSULIN; MALE; MICE; OSTEOCLASTS; OSTEOGENESIS; RNA, MESSENGER;

EID: 58249098394     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.10.042     Document Type: Article

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