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Volumn 7, Issue 4, 2011, Pages 761-774

Do we Still Need Human Embryonic Stem Cells for Stem Cell-Based Therapies? Epistemic and Ethical Aspects

Author keywords

Ethical controversy; Human embryonic stem cells; Human induced pluripotent stem cells; Patient safety; Treatment accessibility; Treatment efficacy

Indexed keywords

ARTICLE; CYTOLOGY; EMBRYONIC STEM CELL; ETHICS; HUMAN; PLURIPOTENT STEM CELL; STEM CELL RESEARCH; STEM CELL TRANSPLANTATION; TRANSLATIONAL RESEARCH; TRANSPLANTATION;

EID: 82355161200     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-011-9257-3     Document Type: Article
Times cited : (20)

References (61)
  • 1
    • 67650366923 scopus 로고    scopus 로고
    • Perspectives on human stem cell research
    • Jung, K. W. (2009). Perspectives on human stem cell research. Journal of Cellular Physiology, 220, 535-537.
    • (2009) Journal of Cellular Physiology , vol.220 , pp. 535-537
    • Jung, K.W.1
  • 2
    • 60649084367 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: current progress and potential for regenerative medicine
    • Amabile, G., & Meissner, A. (2009). Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends in Molecular Medicine, 15, 59-68.
    • (2009) Trends in Molecular Medicine , vol.15 , pp. 59-68
    • Amabile, G.1    Meissner, A.2
  • 3
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 4
    • 66749113976 scopus 로고    scopus 로고
    • Rapid development of pluripotent stem cells as a potential therapeutic modality
    • Williams, D. A. (2009). Rapid development of pluripotent stem cells as a potential therapeutic modality. Molecular Therapy, 17, 929-930.
    • (2009) Molecular Therapy , vol.17 , pp. 929-930
    • Williams, D.A.1
  • 6
    • 46649120298 scopus 로고    scopus 로고
    • European values-and others. Europe's shared values: towards and ever-closer union?
    • Hermerén, G. (2008). European values-and others. Europe's shared values: towards and ever-closer union? European Review, 16, 373-385.
    • (2008) European Review , vol.16 , pp. 373-385
    • Hermerén, G.1
  • 7
    • 74949133926 scopus 로고    scopus 로고
    • Progress toward the clinical application of patient-specific pluripotent stem cells
    • Kiskinis, E., & Eggan, K. (2010). Progress toward the clinical application of patient-specific pluripotent stem cells. The Journal of Clinical Investigation, 120, 51-59.
    • (2010) The Journal of Clinical Investigation , vol.120 , pp. 51-59
    • Kiskinis, E.1    Eggan, K.2
  • 8
    • 84952668949 scopus 로고    scopus 로고
    • The obstacles on the road to clinical applications of stem cell-based therapies: what has been done and what remains to be done?
    • K. Hug, G. Hermerén (Eds.), New York: Springer
    • Hovatta, O. (2011). The obstacles on the road to clinical applications of stem cell-based therapies: what has been done and what remains to be done? In K. Hug & G. Hermerén (Eds.), Translational stem cell research: Issues beyond the debate on the moral status of the human embryo (pp. 103-111). New York: Springer.
    • (2011) Translational Stem Cell Research: Issues beyond the Debate on the Moral Status of the Human Embryo , pp. 103-111
    • Hovatta, O.1
  • 9
    • 73649108566 scopus 로고    scopus 로고
    • Are induced pluripotent stem cells the future of cell-based regenerative therapies for spinal cord injury?
    • Salewski, R. P. F., Eftekharpour, E., & Fehlings, M. G. (2010). Are induced pluripotent stem cells the future of cell-based regenerative therapies for spinal cord injury? Journal of Cellular Physiology, 222, 515-521.
    • (2010) Journal of Cellular Physiology , vol.222 , pp. 515-521
    • Salewski, R.P.F.1    Eftekharpour, E.2    Fehlings, M.G.3
  • 10
    • 74949118218 scopus 로고    scopus 로고
    • Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: current state and problems
    • Hwang, D.-Y., Kim, D.-S., & Kim, D.-W. (2010). Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: current state and problems. Journal of Cellular Biochemistry, 109, 292-301.
    • (2010) Journal of Cellular Biochemistry , vol.109 , pp. 292-301
    • Hwang, D.-Y.1    Kim, D.-S.2    Kim, D.-W.3
  • 11
    • 77951095119 scopus 로고    scopus 로고
    • Is iPS cell the Panacea?
    • Ou, L., Wang, X., & Zou, F. (2010). Is iPS cell the Panacea? IUBMB Life, 62, 170-175.
    • (2010) IUBMB Life , vol.62 , pp. 170-175
    • Ou, L.1    Wang, X.2    Zou, F.3
  • 12
    • 75349094565 scopus 로고    scopus 로고
    • Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?
    • Ronaghi, M., Erceg, S., Moreno-Manzano, V., & Stojkovic, M. (2010). Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells? Stem Cells, 28, 93-99.
    • (2010) Stem Cells , vol.28 , pp. 93-99
    • Ronaghi, M.1    Erceg, S.2    Moreno-Manzano, V.3    Stojkovic, M.4
  • 14
    • 73049104550 scopus 로고    scopus 로고
    • Will iPS cells enhance therapeutic applicability of cord blood cells and banking?
    • Broxmeyer, H. E. (2010). Will iPS cells enhance therapeutic applicability of cord blood cells and banking? Cell Stem Cell, 6, 21-24.
    • (2010) Cell Stem Cell , vol.6 , pp. 21-24
    • Broxmeyer, H.E.1
  • 15
    • 38849209222 scopus 로고    scopus 로고
    • A seismic shift for stem cell research
    • Holden, C., & Vogel, G. (2008). A seismic shift for stem cell research. Science, 319, 560-563.
    • (2008) Science , vol.319 , pp. 560-563
    • Holden, C.1    Vogel, G.2
  • 18
    • 71049168277 scopus 로고    scopus 로고
    • Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by Cytotoxic T Lymphocytes despite low expression of major histocompatibility complex class I molecules
    • Dressel, R., Guan, K., Nolte, J., et al. (2009). Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by Cytotoxic T Lymphocytes despite low expression of major histocompatibility complex class I molecules. Biology Direct, 4, 31-50.
    • (2009) Biology Direct , vol.4 , pp. 31-50
    • Dressel, R.1    Guan, K.2    Nolte, J.3
  • 21
    • 84859104110 scopus 로고    scopus 로고
    • Clarifying the president's council's clarification of the Obama stem cell policy
    • Diverse Commentary on Issues in Bioethics [cited 2010 April 9]; Available from: URL
    • Hyun, I. (2009). Clarifying the president's council's clarification of the Obama stem cell policy. In Bioethics Forum. Diverse Commentary on Issues in Bioethics [cited 2010 April 9]; Available from: URL: http://www.thehastingscenter.org/Bioethicsforum/Post.aspx?id=3308.
    • (2009) Bioethics Forum
    • Hyun, I.1
  • 22
    • 74149083449 scopus 로고    scopus 로고
    • Restorative approaches in Parkinson's disease: which cell type wins the race?
    • Meyer, A. K., Maisel, M., & Hermann, A. (2010). Restorative approaches in Parkinson's disease: which cell type wins the race? Journal of the Neurological Sciences, 289, 93-104.
    • (2010) Journal of the Neurological Sciences , vol.289 , pp. 93-104
    • Meyer, A.K.1    Maisel, M.2    Hermann, A.3
  • 23
    • 77949512138 scopus 로고    scopus 로고
    • Viable iPSC mice: a step closer to therapeutic applications in humans?
    • Betts, D. H., & Kalionis, B. (2010). Viable iPSC mice: a step closer to therapeutic applications in humans? Molecular Human Reproduction, 16, 57-62.
    • (2010) Molecular Human Reproduction , vol.16 , pp. 57-62
    • Betts, D.H.1    Kalionis, B.2
  • 24
    • 65249121330 scopus 로고    scopus 로고
    • Ontological and ethical implications of direct nuclear reprogramming
    • Magill, G., & Neaves, W. B. (2009). Ontological and ethical implications of direct nuclear reprogramming. Kennedy Institute of Ethics Journal, 19, 23-32.
    • (2009) Kennedy Institute of Ethics Journal , vol.19 , pp. 23-32
    • Magill, G.1    Neaves, W.B.2
  • 25
    • 69949104478 scopus 로고    scopus 로고
    • Adult mice generated from induced pluripotent stem cells
    • Boland, M. J., Hazen, J. L., Nazor, K. L., et al. (2009). Adult mice generated from induced pluripotent stem cells. Nature, 461, 91-94.
    • (2009) Nature , vol.461 , pp. 91-94
    • Boland, M.J.1    Hazen, J.L.2    Nazor, K.L.3
  • 26
    • 67651204314 scopus 로고    scopus 로고
    • Ontological and ethical implications of direct nuclear reprogramming: response to Magill and Neaves
    • Condic, M. L., Lee, P., & George, R. P. (2009). Ontological and ethical implications of direct nuclear reprogramming: response to Magill and Neaves. Kennedy Institute of Ethics Journal, 19, 33-40.
    • (2009) Kennedy Institute of Ethics Journal , vol.19 , pp. 33-40
    • Condic, M.L.1    Lee, P.2    George, R.P.3
  • 27
    • 84859106989 scopus 로고    scopus 로고
    • "Of Mice and Men": making babies from stem cells
    • Peters, T. (2009). "Of Mice and Men": making babies from stem cells. Theology and Science, 7, 311-314.
    • (2009) Theology and Science , vol.7 , pp. 311-314
    • Peters, T.1
  • 28
    • 84859106058 scopus 로고    scopus 로고
    • Response to Cynthia B. Cohen and Bruce P. Brandhorst. Getting Clear on the Ethics of iPS Cells. 02/01/2008
    • Diverse Commentary on Issues in Bioethics [cited 2010 April 9]; Available from: URL
    • Kaebnick, G. E. (2008). Response to Cynthia B. Cohen and Bruce P. Brandhorst. Getting Clear on the Ethics of iPS Cells. 02/01/2008. In Bioethics Forum. Diverse Commentary on Issues in Bioethics [cited 2010 April 9]; Available from: URL: http://www.thehastingscenter.org/Bioethicsforum/Post.aspx?id=706.
    • (2008) Bioethics Forum
    • Kaebnick, G.E.1
  • 29
    • 79957759191 scopus 로고    scopus 로고
    • Getting clear on the ethics of iPS cells
    • Diverse Commentary on Issues in Bioethics [cited 2010 April 9]; Available from: URL
    • Cohen, C. B., & Brandhorst, B. P. (2008). Getting clear on the ethics of iPS cells. In Bioethics Forum. Diverse Commentary on Issues in Bioethics [cited 2010 April 9]; Available from: URL: http://www.thehastingscenter.org/Bioethicsforum/Post.aspx?id=710&terms=iPS+and+%23filename+*.html.
    • (2008) Bioethics Forum
    • Cohen, C.B.1    Brandhorst, B.P.2
  • 30
    • 73049105190 scopus 로고    scopus 로고
    • Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning
    • Lo, B., Parham, L., Alvarez-Buylla, A., et al. (2010). Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning. Cell Stem Cell, 6, 16-20.
    • (2010) Cell Stem Cell , vol.6 , pp. 16-20
    • Lo, B.1    Parham, L.2    Alvarez-Buylla, A.3
  • 31
    • 67849133023 scopus 로고    scopus 로고
    • iPS cells can support full-term development of tetraploid blastocyst-complemented embryos
    • Kang, L., Wang, J., Zhang, Y., Kou, Z., & Gao, S. (2009). iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell, 5, 135-138.
    • (2009) Cell Stem Cell , vol.5 , pp. 135-138
    • Kang, L.1    Wang, J.2    Zhang, Y.3    Kou, Z.4    Gao, S.5
  • 32
    • 69949089630 scopus 로고    scopus 로고
    • iPS cells produce viable mice through tetraploid complementation
    • Zhao, X.-Y., Li, W., Lv, Z., et al. (2009). iPS cells produce viable mice through tetraploid complementation. Nature, 461, 86-90.
    • (2009) Nature , vol.461 , pp. 86-90
    • Zhao, X.-Y.1    Li, W.2    Lv, Z.3
  • 33
    • 74049144159 scopus 로고    scopus 로고
    • Primer: induced pluripotency
    • De Souza, N. (2010). Primer: induced pluripotency. Nature Methods, 7, 20-22.
    • (2010) Nature Methods , vol.7 , pp. 20-22
    • de Souza, N.1
  • 34
    • 82355194343 scopus 로고    scopus 로고
    • Embryonic and adult education on stem cells
    • Liu, S. V. (2009). Embryonic and adult education on stem cells. Correspondence. Logical Biology, 9, 8-9.
    • (2009) Correspondence. Logical Biology , vol.9 , pp. 8-9
    • Liu, S.V.1
  • 35
    • 70349327679 scopus 로고    scopus 로고
    • What to do with the Grail now that we have it? iPSCs, potentiality, and public policy
    • Erratum in: Cell Stem Cell (2009), 5, 567
    • Testa, G. (2009). What to do with the Grail now that we have it? iPSCs, potentiality, and public policy. Cell Stem Cell, 5, 358-359. Erratum in: Cell Stem Cell (2009), 5, 567.
    • (2009) Cell Stem Cell , vol.5 , pp. 358-359
    • Testa, G.1
  • 36
    • 82355193515 scopus 로고    scopus 로고
    • The race toward Ethically universally acceptable human pluripotent (Embryonic-Like) stem cells: Only a problem of sources?
    • [Epub ahead of print]. Article first published online: 30 NOV 2009
    • Neri, D. (2009). The race toward Ethically universally acceptable human pluripotent (Embryonic-Like) stem cells: only a problem of sources? Bioethics [Epub ahead of print]. Article first published online: 30 NOV 2009.
    • (2009) Bioethics
    • Neri, D.1
  • 37
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
    • Urbach, A., Bar-Nur, O., Daley, G. Q., & Benvenisty, N. (2010). Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell, 6, 407-411.
    • (2010) Cell Stem Cell , vol.6 , pp. 407-411
    • Urbach, A.1    Bar-Nur, O.2    Daley, G.Q.3    Benvenisty, N.4
  • 38
    • 72049114493 scopus 로고    scopus 로고
    • Induced pluripotent stem (iPS) cells and their future in psychiatry
    • Kim, K.-S. (2010). Induced pluripotent stem (iPS) cells and their future in psychiatry. Neuropsychopharmacology, 35, 346-349.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 346-349
    • Kim, K.-S.1
  • 39
    • 58249097160 scopus 로고    scopus 로고
    • Stem cells: tailor-made diseased neurons
    • Sendtner, M. (2009). Stem cells: tailor-made diseased neurons. Nature, 457, 269-271.
    • (2009) Nature , vol.457 , pp. 269-271
    • Sendtner, M.1
  • 40
    • 84859109072 scopus 로고    scopus 로고
    • The European Parliament and the Council of the European Union. (2001). Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use [cited 2010 March 12]; Available from: URL
    • The European Parliament and the Council of the European Union. (2001). Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001 on the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use [cited 2010 March 12]; Available from: URL: http://www.wctn.org.uk/downloads/EU_Directive/Directive.pdf.
  • 41
    • 84859102392 scopus 로고    scopus 로고
    • The European Parliament and the Council. (2004). Directive 2004/23/EC of the European Parliament and of the Council of 31 March 2004 on Setting Standards of Quality and Safety for the Donation, Procurement, Testing, Processing, Preservation, Storage and Distribution of Human Tissues and Cells [cited 2010 March 12]; Available from: URL
    • The European Parliament and the Council. (2004). Directive 2004/23/EC of the European Parliament and of the Council of 31 March 2004 on Setting Standards of Quality and Safety for the Donation, Procurement, Testing, Processing, Preservation, Storage and Distribution of Human Tissues and Cells [cited 2010 March 12]; Available from: URL: http://www.who.int/ethics/en/ETH_EU_Directive_2004_23_EC.pdf.
  • 42
    • 84859109070 scopus 로고    scopus 로고
    • The European Parliament. (2007). Regulation (EC) No 1394/2007 of the European Parliament and of the Council of 13 November 2007 on Advanced Therapy Medicinal Products and Amending Directive 2001/83/EC and Regulation (EC) No 726/2004 [cited 2010 March 14]; Available from: URL
    • The European Parliament. (2007). Regulation (EC) No 1394/2007 of the European Parliament and of the Council of 13 November 2007 on Advanced Therapy Medicinal Products and Amending Directive 2001/83/EC and Regulation (EC) No 726/2004 [cited 2010 March 14]; Available from: URL: http://ec.europa.eu/enterprise/pharmaceuticals/eudralex/vol-1/reg_2007_1394/reg_2007_1394_en.pdf.
  • 43
    • 84859109069 scopus 로고    scopus 로고
    • Council of Europe. (1950). Convention for the Protection of Human Rights and Fundamental Freedoms as amended by Protocol No. 11 [cited 2010 March 17]; Available from
    • Council of Europe. (1950). Convention for the Protection of Human Rights and Fundamental Freedoms as amended by Protocol No. 11 [cited 2010 March 17]; Available from: http://www.echr.coe.int/NR/rdonlyres/D5CC24A7-DC13-4318-B457-5C9014916D7A/0/EnglishAnglais.pdf.
  • 45
    • 0003491133 scopus 로고    scopus 로고
    • The World Medical Association, [cited 2010 March 14]; Available from: URL
    • The World Medical Association. (2008). Declaration of Helsinki 2008 [cited 2010 March 14]; Available from: URL: http://www.wma.net/e/ethicsunit/helsinki.htm.
    • (2008) Declaration of Helsinki 2008
  • 46
    • 0003433351 scopus 로고    scopus 로고
    • Council for International Organizations of Medical Sciences (CIOMS), [cited 2010 March 12]; Available from: URL
    • Council for International Organizations of Medical Sciences (CIOMS). (2002). International Ethical Guidelines for Biomedical Research Involving Human Subjects [cited 2010 March 12]; Available from: URL: http://www.cioms.ch/frame_guidelines_nov_2002.htm.
    • (2002) International Ethical Guidelines For Biomedical Research Involving Human Subjects
  • 47
    • 70449521274 scopus 로고    scopus 로고
    • International Society for Stem Cell Research, December 3 [cited 2010 March 12]; Available from: URL
    • International Society for Stem Cell Research. (2008). ISSCR Guidelines for the Clinical Translation of Stem Cells. December 3 [cited 2010 March 12]; Available from: URL: http://www.isscr.org/clinical_trans/pdfs/ISSCRGLClinicalTrans.pdf.
    • (2008) ISSCR Guidelines For the Clinical Translation of Stem Cells
  • 48
    • 84859109068 scopus 로고    scopus 로고
    • Presidents of the European Parliament, the Council and the Commission at the European Council. (2000). Charter of Fundamental Rights of the European Union (2000/C 364/01). 7 December 2000 [cited 2010 March 12]; Available from: URL
    • Presidents of the European Parliament, the Council and the Commission at the European Council. (2000). Charter of Fundamental Rights of the European Union (2000/C 364/01). 7 December 2000 [cited 2010 March 12]; Available from: URL: http://www.europarl.europa.eu/charter/pdf/text_en.pdf.
  • 49
    • 84859109067 scopus 로고    scopus 로고
    • European Medicines Agency. (2002). CPMP/ICH/135/95. ICH Topic E 6 (R1). Guideline for Good Clinical Practice. Note for Guidance on Good Clinical Practice, July [cited 2010 March 15]; Available from: URL
    • European Medicines Agency. (2002). CPMP/ICH/135/95. ICH Topic E 6 (R1). Guideline for Good Clinical Practice. Note for Guidance on Good Clinical Practice, July [cited 2010 March 15]; Available from: URL: http://www.emea.europa.eu/pdfs/human/ich/013595en.pdf.
  • 50
    • 27244448853 scopus 로고    scopus 로고
    • Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside
    • Yim, R. (2005). Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside. Transfusion, 45, 144S-158S.
    • (2005) Transfusion , vol.45
    • Yim, R.1
  • 51
    • 59349092083 scopus 로고    scopus 로고
    • Clinical trials in stem cell transplantation: guidelines for scientific and ethical review
    • Lo, B., Kriegstein, A., & Grady, D. (2008). Clinical trials in stem cell transplantation: guidelines for scientific and ethical review. Clinical Trials, 5, 517-522.
    • (2008) Clinical Trials , vol.5 , pp. 517-522
    • Lo, B.1    Kriegstein, A.2    Grady, D.3
  • 52
    • 34447292138 scopus 로고    scopus 로고
    • Ethics and stem cell therapeutics for cardiovascular disease
    • Sugarman, J. (2007). Ethics and stem cell therapeutics for cardiovascular disease. Progress in Cardiovascular Diseases, 50, 1-6.
    • (2007) Progress in Cardiovascular Diseases , vol.50 , pp. 1-6
    • Sugarman, J.1
  • 55
    • 45849125045 scopus 로고    scopus 로고
    • Expedited industry-sponsored translational research: a seductive but hazardous cocktail?
    • Marks, J. H. (2008). Expedited industry-sponsored translational research: a seductive but hazardous cocktail? The American Journal of Bioethics, 8, 56-58.
    • (2008) The American Journal of Bioethics , vol.8 , pp. 56-58
    • Marks, J.H.1
  • 57
    • 0003560902 scopus 로고
    • Cambridge: Cambridge University Press
    • Singer, P. (1993). Practical ethics. Cambridge: Cambridge University Press.
    • (1993) Practical Ethics
    • Singer, P.1
  • 58
    • 78649652408 scopus 로고    scopus 로고
    • Human dignity, ethical pluralism, and the regulation of modern biotechnologies
    • T. Murphy (Ed.), Oxford: Oxford University Press
    • Brownsword, R. (2009). Human dignity, ethical pluralism, and the regulation of modern biotechnologies. In T. Murphy (Ed.), New technologies and human rights (pp. 19-84). Oxford: Oxford University Press.
    • (2009) New Technologies and Human Rights , pp. 19-84
    • Brownsword, R.1
  • 59
    • 48149114631 scopus 로고
    • Abortion and arguments from potential
    • R. Gillon (Ed.), Chichester: John Wiley & Sons
    • Fagot-Largeault, A. (1994). Abortion and arguments from potential. In R. Gillon (Ed.), Principles of health care ethics (pp. 577-586). Chichester: John Wiley & Sons.
    • (1994) Principles of Health Care Ethics , pp. 577-586
    • Fagot-Largeault, A.1
  • 61
    • 77952385324 scopus 로고    scopus 로고
    • Beyond access vs. protection in trials of innovative therapies
    • London, A. J., Kimmelman, J., & Emborg, M. E. (2010). Beyond access vs. protection in trials of innovative therapies. Science, 328, 829-830.
    • (2010) Science , vol.328 , pp. 829-830
    • London, A.J.1    Kimmelman, J.2    Emborg, M.E.3


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