Lidocaine induces endoplasmic reticulum stress-associated apoptosis in vitro and in vivo

International Journal of Molecular Sciences

Volumn 12, Issue 11, 2011, Pages 7652-7661

  Hong, Dae Young ^a   Kwon, Kisang ^b   Lee, Kyeong Ryong ^a   Choi, Young Jin ^b   Goo, Tae Won ^c   Yu, Kweon ^d   Kim, Seung Whan ^e   Kwon, O Yu ^b  

^a Konkuk University Hospital   (South Korea)

^b Chungnam National University   (South Korea)

^c National Institute of Animal Science   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^e Chungnam National University College of Medicine   (South Korea)

Author keywords

Apoptosis; Endoplasmic reticulum (ER) stress; ER chaperone; ER stress sensor; Lidocaine

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CALNEXIN; CALRETICULIN; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; LIDOCAINE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN DISULFIDE ISOMERASE; PROTEIN IRE1; PROTEIN KINASE; PROTEIN KINASE RNA LIKE ENDOPLASMIC RETICULUM KINASE; S 7101; UNCLASSIFIED DRUG; ADPRT PROTEIN, RAT; ATF6 PROTEIN, RAT; BAK1 PROTEIN, RAT; BAX PROTEIN, RAT; DNA BINDING PROTEIN; ERN2 PROTEIN, RAT; HEAT SHOCK PROTEIN; HSPA5 PROTEIN, RAT; MEMBRANE PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PERK KINASE; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ACTIVATING TRANSCRIPTION FACTOR 6 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAK GENE; BAX GENE; BCL 2 GENE; BCL XL GENE; BIP GENE; CALNEXIN GENE; CALRETICULIN GENE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE; GENE CONTROL; GENE EXPRESSION; HISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; IRE1 GENE; MALE; NONHUMAN; PERK GENE; PROTEIN CLEAVAGE; PROTEIN DISULFIDE ISOMERASE GENE; PROTEIN PHOSPHORYLATION; RAT; RNA SPLICING; UPREGULATION; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; PC12 CELL LINE; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CALNEXIN; CALRETICULIN; DNA-BINDING PROTEINS; DOWN-REGULATION; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; LIDOCAINE; MALE; MEMBRANE PROTEINS; PC12 CELLS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RNA SPLICING; RNA, MESSENGER; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 82255183337     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12117652     Document Type: Article

References (17)

1. Schmidtmayer, J.; Ulbricht, W. Interaction of lidocaine and benzocaine in blocking sodium channels. Pflugers Arch. Eur. J. Physiol. 1980, 387, 47-54.
2. Cox, B.; Durieux, M.E; Marcus, M.A. Toxicity of local anaesthetics. Best Pract. Res. Clin. Anaesthesiol. 2003, 17, 111-136.
3. Rademaker, A.W.; Kellen, J.; Tam, Y.K.; Wyse, D.G. Character of adverse effects of prophylactic lidocaine in the coronary care unit. Clin. Pharmacol. Ther. 1986, 40, 71-80.
4. Chopra, M.P.; Thadani, U.; Portal, R.W.; Aber, C.P. Lignocaine therapy for ventricular ectopic activity after acute myocardial infarction: A double-blind trial. Br. Med. J. 1971, 3, 668-670.
5. Gianelly, R.; von der Groeben, J.O.; Spivack, A.P.; Harrison, D.C. Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease. N. Engl. J. Med. 1967, 277, 1215-1219.
6. Lown, B.; Vassaux, C. Lidocaine in acute myocardial infarction. Am. Heart J. 1968, 76, 586-587.
7. Karpie, J.C.; Chu, C.R. Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro. Am. J. Sports Med. 2007, 35, 1621-1627.
8. Niederreiter, L.; Kaser, A. Endoplasmic reticulum stress and inflammatory bowel disease. Acta Gastroenterol. Belg. 2011, 74, 330-333.
9. Tsai, Y.C.; Weissman, A.M. The unfolded protein response, degradation from endoplasmic reticulum and cancer. Genes Cancer 2010, 1, 764-778.
10. Hiramatsu, N.; Joseph, V.T.; Lin, J.H. Monitoring and manipulating mammalian unfolded protein response. Methods Enzymol. 2011, 491, 183-198.
11. Inagi, R. Endoplasmic reticulum stress as a progression factor for kidney injury. Curr. Opin. Pharmacol. 2010, 10, 156-165.
12. Kimata, Y.; Kohno, K. Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells. Curr. Opin. Cell Biol. 2011, 23, 135-142.
13. Tabas, I.; Ron, D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 2011, 13, 184-190.
14. Jian, B.; Hsieh, C.H.; Chen, J.; Choudhry, M.; Bland, K.; Chaudry, I.; Raju, R. Activation of endoplasmic reticulum stress response following trauma-hemorrhage. Biochim. Biophys. Acta 2008, 1782, 621-626.
15. Hassa, P.O. The molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival. Front. Biosci. 2009, 14, 72-111.
16. Ji, Y.; Tulin, A.V. The roles of PARP1 in gene control and cell differentiation. Curr. Opin. Genet Dev. 2010, 20, 512-518.
17. Madison, D.L.; Stauffer, D.; Lundblad, J.R. The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest. DNA Repair (Amst) 2011, 10, 1003-1013.