Target separation of a new anti-tumor saponin and metabolic profiling of leaves of Panax notoginseng by liquid chromatography with eletrospray ionization quadrupole time-of-flight mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 59, Issue 1, 2012, Pages 67-77

  Mao, Qian ^a   Yang, Jie ^a   Cui, Xiu Ming ^a   Li, Jing Jing ^a   Qi, Yin Tao ^a   Zhang, Ping Hu ^a   Wang, Qiang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

High performance liquid chromatography with quadrupole time of flight mass spectrometers; Leaves of Panax notoginseng; Profiling; Protopanaxadiol ginsenoside; Target separation

Indexed keywords

PROTOPANAXADIOL; SAPONIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PANAX NOTOGINSENG; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MOLECULAR STRUCTURE; PANAX NOTOGINSENG; PLANT LEAVES; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 82255175586     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.10.004     Document Type: Article

References (25)

1. Ma W.G., Mizutani M., Malterud K.E., Lu S.L., Ducrey B., Tahara S. Saponins from the roots of Panax notoginseng. Phytochemistry 1999, 52:1133-1139.
2. Qi L.W., Wang C.Z., Yuan C.S. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem. Pharmacol. 2010, 80:947-954.
3. Wan J.B., Yang F.Q., Li S.P., Wang Y.T., Cui X.M. Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD. J. Pharm. Biomed. Anal. 2006, 41:1596-1601.
4. Chernushevich I.V., Loboda A.V., Thomson B.A. An introduction to quadrupole-time-of-flight mass spectrometry. J. Mass Spectrom. 2001, 36:849-865.
5. Guan J., Lai C.M., Li S.P. A rapid method for the simultaneous determination of 11 saponins in Panax notoginseng using ultra performance liquid chromatography. J. Pharm. Biomed. Anal. 2007, 44:996-1000.
6. Wang S.F., Ye S., Cheng Y.Y. Separation and on-line concentration of saponins from Panax notoginseng by micellar electrokinetic chromatography. J. Chromatogr. A 2006, 1109:279-284.
7. Dua Q.Z., Jerzc G., Waibelb R., Winterhalterc P. Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography. J. Chromatogr. A 2003, 1008:173-180.
8. Liu Y.Y., Li J.B., He J.M., Abliz Z., Qu J., Yu S.S., Ma S.G., Liu J., Du D. Identification of new trace triterpenoid saponins from the roots of Panax notoginseng by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23:667-679.
9. Dan M., Su M., Gao X.F., Zhao T., Zhao A., Xie G.X., Qiu Y.P., Zhou M.M., Liu Z., Jia W. Metabolite profiling of Panax notoginseng using UPLC-ESI-MS. Phytochemistry 2008, 69:2237-2244.
10. Xie G.X., Plumb R., Su M.M., Xu Z.H., Zhao A., Qiu M.F., Long X.B., Liu Z., Jia W. Ultra-performance LC-TOF-MS analysis of medicinal Panax herbs for metabolomicresearch. J. Sep. Sci. 2008, 31:1015-1026.
11. 1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. Cancer Chemother. Pharmacol. 2005, 55:531-540.
12. Li S.L., Lai S.F., Song J.Z., Qiao C.F., Liu X., Zhou Y., Cai H., Cai B.C., Xu H.X. Decocting-induced chemical transformations and global quality of Du-Shen-Tang, the decoction of ginseng evaluated by UPLC-QTOF-MS/MS based chemical profiling approach. J. Pharm. Biomed. Anal. 2010, 53:946-957.
13. Wang W., Zhao Y.Q., Rayburn E.R., Hill D.L., Wang H., Zhang R.W. In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother. Pharmacol. 2007, 59:589-601.
14. Zhao P., Liu Y.Q., Yang C.R. Minor dammarane saponins from Panax notoginseng. Phytochemistry 1996, 41:1419-1422.
15. Qi L.W., Chen C.Y., Li P. Structural characterization and identification of iridoid glycosides, saponins, phenolic acids and flavonoids in Flos Lonicerae Japonicae by a fast liquid chromatography method with diode-array detection and time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23:3227-3242.
16. Li C.Y., Qi L.W., Li P., Wen X.D., Zhu Y.F., Liu E.H., Gong Z., Yang X.L., Ren M.T., Li Y.J., Ge X.X. Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23:1977-1988.
17. Sari{dotless}kahya N.B., Ki{dotless}rmi{dotless}zi{dotless}gul S. Antimicrobial triterpenoid glycosides from Cephalaria scoparia. J. Nat. Prod. 2010, 73:825-830.
18. Zhu G.Y., Li Y.W., Hau D.K.P., Jiang Z.H., Yu Z.L., Fong W.F. Protopanaxatriol-type ginsenosides from the root of Panax ginseng. J. Agric. Food Chem. 2011, 59:200-205.
19. Li G.Y., Zeng Y.M., Meng H., Li X., Wang J.H. A new triterpenoid saponin from the leaves and stems of Panax quinquefolium L. Chin. Chem. Lett. 2009, 20:1207-1210.
20. Christensen L.P. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv. Food Nutr. Res. 2009, 55:1-99.
21. Fuzzati N., Gabetta B., Jayakar K., Pace R., Peterlongo F. Liquid chromatography-electrospray mass spectrometric identification of ginsenosides in Panax ginseng roots. J. Chromatogr. A 1999, 854:69-79.
22. Ma X.Q., Liang X.M., Xu Q., Zhang X.Z., Xiao H.B. Identification of ginsenosides in roots of Panax ginseng by HPLC-APCI/MS. Phytochem. Anal. 2005, 16:181-187.
23. Yoshikawa M., Morikawa T., Kashima Y., Ninomiya K., Matsuda H. Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal ginseng saponins. J. Nat. Prod. 2003, 66:92-927.
24. Yoshikawa M., Murakami T., Ueno T., Yashiro K., Hirokawa N., Murakami N., Yamahara J., Matsuda H., Saijoh R., Tanaka O. Bioactive saponins and glycosides. VIII. Notoginseng (1), new dammaranes-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D from the dried root of Panax notoginseng (Burk.) F.H. Chen. Chem. Pharm. Bull. 1997, 45:1039-1045.
25. Sun B.S., Cu L.J., Fang Z.M., Wang C.Y., Wang Z., Lee M.R., Li Z., Li J.J., Sung C.K. Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC-ELSD. J. Pharm. Biomed. Anal. 2009, 50:15-22.