Protopanaxatriol-type ginsenosides from the root of Panax ginseng

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 1, 2011, Pages 200-205

  Zhu, Guo Yuan ^a   Li, Ying Wei ^a   Hau, Desmond Kwok Po ^a   Jiang, Zhi Hong ^a   Yu, Zhi Ling ^a   Fong, Wang Fun ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Araliaceae; ginsenoside; ginsenosides Re1 Re6; Panax ginseng; protopanaxatriol

Indexed keywords

ARALIACEAE; GINSENOSIDES; GINSENOSIDES RE1-RE6; PANAX GINSENG; PROTOPANAXATRIOL;

MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; RESONANCE; RHENIUM; SPECTROSCOPIC ANALYSIS; SUGARS;

PHARMACODYNAMICS;

GINSENOSIDE; PLANT EXTRACT; PROTOPANAXATRIOL; SAPOGENIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; GINSENG; PLANT ROOT;

GINSENOSIDES; MOLECULAR STRUCTURE; PANAX; PLANT EXTRACTS; PLANT ROOTS; SAPOGENINS;

ARALIACEAE; PANAX; PANAX GINSENG;

EID: 78651107135     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf1037932     Document Type: Article

References (25)

1. Yue, P. Y.; Mak, N. K.; Cheng, Y. K.; Leung, K. W.; Ng, T. B.; Fan, D. T.; Yeung, H. W.; Wong, R. N. Pharmacogenomics and the Yin/Yang actions of ginseng: Anti-tumor, angiomodulating and steroid-like activities of ginsenosides Chin. Med. 2007, 2, 6
2. Hofseth, L. J.; Wargovich, M. J. Inflammation, cancer, and targets of ginseng J. Nutr. 2007, 137, 183S-185S
3. Chen, C. F.; Chiou, W. F.; Zhang, J. T. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium Acta. Pharmacol. Sin. 2008, 29 (9) 1103-1108
4. Christensen, L. P. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects Adv. Food Nutr. Res. 2009, 55, 1-99
5. 2, new dammarane saponins of ginseng roots Chem. Pharm. Bull. 1982, 30 (7) 2380-2385
6. Kasai, R.; Besso, H.; Tanaka, O.; Saruwatari, Y.; Fuwa, T. Saponins of red ginseng Chem. Pharm. Bull. 1983, 31 (6) 2120-2125
7. Kim, D.-S.; Chang, Y.-J.; Zedk, U.; Zhao, P.; Liu, Y.-Q.; Yang, C.-R. Dammarane saponins from Panax ginseng Phytochemistry 1995, 40 (5) 1493-1497
8. Park, J. D.; Rhee, D. K.; Lee, Y. H. Biological activities and chemistry of saponins from Panax ginseng C. A. Meyer Phytochem. Rev. 2005, 4 (2-3) 159-175
9. Wang, J. R.; Leung, C. Y.; Ho, H. M.; Chai, S.; Yau, L. F.; Zhao, Z. Z.; Jiang, Z. H. Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng Chem. Biodiversity 2010, 7 (4) 975-983
10. Wang, J. R.; Yamasaki, Y.; Tanaka, T.; Kouno, I.; Jiang, Z. H. Dammarane-type triterpene saponins from the flowers of Panax notoginseng Molecules 2009, 14 (6) 2087-2094
11. Wong, V. K.; Cheung, S. S.; Li, T.; Jiang, Z. H.; Wang, J. R.; Dong, H.; Yi, X. Q.; Zhou, H.; Liu, L. Asian ginseng extract inhibits in vitro and in vivo growth of mouse Lewis lung carcinoma via modulation of ERK-p53 and NF-κB signaling J. Cell Biochem. 2010, 111 (4) 899-910
12. Tanaka, T.; Nakashima, T.; Ueda, T.; Tomii, K.; Kouno, I. Facile discrimination of aldose enantiomers by reversed-phase HPLC Chem. Pharm. Bull. 2007, 55, 899-901
13. 13C NMR data for nine protopanaxatriol glycosides Magn. Reson. Chem. 2002, 40 (7) 483-488
14. 1 Chem. Pharm. Bull. 1981, 29 (10) 2844-2850
15. 3 and 20-glucoginsenoside Rf Chem. Pharm. Bull. 1978, 26 (6) 1694-1697
16. Yoshikawa, M.; Morikawa, T.; Yashiro, K.; Murakami, T.; Matsuda, H. Bioactive saponins and glycosides. XIX. Notoginseng (3): Immunological adjuvant activity of notoginsenosides and related saponins: Structures of notoginsenosides-L, -M, and -N from the roots of Panax notoginseng (Burk.) F. H. Chen Chem. Pharm. Bull. 2001, 49 (11) 1452-1456
17. Zou, K.; Zhu, S.; Tohda, C.; Cai, S.; Komatsu, K. Dammarane-type triterpene saponins from Panax japonicus J. Nat. Prod. 2002, 65 (3) 346-351
18. Koike, K.; Jia, Z.; Nikaido, T. New triterpenoid saponins and sapogenins from Saponaria officinalis J. Nat. Prod. 1999, 62 (12) 1655-1659 (Pubitemid 30030608)
19. Danieli, B.; Falcone, L.; Monti, D.; Riva, S.; Gebhardt, S.; Schubert-Zsilavecz, M. Regioselective enzymatic glycosylation of natural polyhydroxylated compounds: Galactosylation and glucosylation of protopanaxatriol ginsenosides J. Org. Chem. 2001, 66 (1) 262-269
20. Tian, Y.; Guo, H.; Han, J.; Guo, D. Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus J. Nat. Prod. 2005, 68 (5) 678-680 (Pubitemid 40825274)
21. 1 on stimulation of glucose uptake in 3T3-L1 adipocytes J. Agric. Food Chem. 2010, 58 (10) 6039-6047
22. 1 protects dopaminergic neurons in a rat model of Parkinson's disease through the IGF-I receptor signalling pathway Br. J. Pharmacol. 2009, 158 (3) 738-748
23. 1 exerts estrogen-like activities via ligand-independent activation of ERα pathway J. Steroid Biochem. Mol. Biol. 2008, 108 (1-2) 64-71
24. Leung, K. W.; Leung, F. P.; Huang, Y.; Mak, N. K.; Wong, R. N. Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor FEBS Lett. 2007, 581 (13) 2423-2428
25. 1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis J. Cell. Biochem. 2009, 108 (1) 117-124