Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ 1 receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7612-7622

  Ferorelli, Savina ^a   Abate, Carmen ^a   Pedone, Maria P ^a   Colabufo, Nicola A ^a   Contino, Marialessandra ^a   Perrone, Roberto ^a   Berardi, Francesco ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

8 7 Sterol isomerase binding; Binding; 1 Ligands; 3,3 Dimethylpiperidines; Structure activity relationship

Indexed keywords

1 [3 (1 BENZOFURAN 4 YL)PROPYL] 3,3 DIMETHYLPIPERIDINE; 1 [3 (1 BENZOTHIOPHEN 4 YL)PROPYL] 3,3 DIMETHYLPIPERIDINE; 2 CHLOROMETHYL 1 BENZOFURAN; 3 (1H 1,2,3 BENZOTRIAZOL 1 YL)PROPIONIC ACID ETHYL ESTER; 3 (1H INDOL 1 YL)PROPAN 1 OL; 3 (INDOL 1 YL)PROPIONIC ACID ETHYL ESTER; 3,3 DIMETHYL 1 [(1 BENZOFURAN 2 YL)METHYL]PIPERIDINE; 3,3 DIMETHYL 1 [3 (1H 4,5,6,7 TETRAHYDROINDOL 4 YL)PROPYL]PIPERIDINE; 3,3 DIMETHYL 1 [3 (4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHEN 4 YL)PROPYL]PIPERIDINE; 3,3 DIMETHYL 1 [3 (6,7,8,9 TETRAHYDRO 5H BENZO[7]ANNULEN 5 YL)PROPYL]PIPERIDINE; 3,3 DIMETHYL 1 [4 (6,7,8,9 TETRAHYDRO 5H BENZO[7]ANNULEN 5 YL)BUTYL]PIPERIDINE; 3,3 DIMETHYL 1 [5 (4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHEN 4 YL)PENTYL]PIPERIDINE; 3,3 DIMETHYLPIPERIDINE DERIVATIVE; 4 (3 BROMOPROPYL) 1 BENZOFURAN; 4 (3 BROMOPROPYL) 1 BENZOTHIOPHENE; 4 (3 BROMOPROPYL) 1 TOSYL 1H 4,5,6,7 TETRAHYDROINDOLE; 4 (3 BROMOPROPYL) 4,5,6,7 TETRAHYDROBENZOFURAN; 4 (5 CHLOROPHENYL) 4,5,6,7 TETRAHYDRO 1 BENZOTHIOPHENE; 4 [3 (3,3 DIMETHYLPIPERIDIN 1 YL)PROPYL] 1 TOSYL 1H 4,5,6,7 TETRAHYDROINDOLE; 5 (3 BROMOPROPYL) 6,7,8,9 TETRAHYDROBENZO[7]ANNULENE; 5 (4 CHLOROBUTYL) 6,7,8,9 TETRAHYDROBENZO[7]ANNULENE; HETEROCYCLIC COMPOUND; ISOMERASE; N TOSYL 6,7 DIHYDRO 1H INDOL 4(5H) ONE; PIPERIDINE DERIVATIVE; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; STEROL ISOMERASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DERIVATIZATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HYDROPHILICITY; LIPOPHILICITY; MALE; NONHUMAN; RACEMIC MIXTURE; RADIOASSAY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; GUINEA PIGS; LIGANDS; PIPERIDINES; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA; STEROID ISOMERASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 82255175450     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.023     Document Type: Article

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