A peptide derived from herpes simplex virus type 1 glycoprotein H: Membrane translocation and applications to the delivery of quantum dots

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 7, Issue 6, 2011, Pages 925-934

  Falanga, Annarita ^a,b   Vitiello, Maria Teresa ^a   Cantisani, Marco ^a,b   Tarallo, Rossella ^a   Guarnieri, Daniela ^c   Mignogna, Eleonora ^a   Netti, Paolo ^c   Pedone, Carlo ^a,b   Galdiero, Massimiliano ^a   Galdiero, Stefania ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Delivery; Peptide; Quantum dots; Virus

Indexed keywords

CARGO MOLECULES; CELL-PENETRATING PEPTIDE; DELIVERY; ENDOCYTOTIC PATHWAY; HERPES SIMPLEX; HERPES SIMPLEX VIRUS TYPE 1; INTRACELLULAR DELIVERY; INTRACELLULAR DRUG DELIVERY; LIVING CELL; MEMBRANE BILAYERS; MEMBRANE DIFFUSION; MEMBRANE TRANSLOCATION; PHYSIO-CHEMICAL PROPERTIES; QUANTUM DOT; SMALL MOLECULES; VACCINE DEVELOPMENT;

CELL MEMBRANES; CYTOLOGY; DRUG DELIVERY; GENE THERAPY; GLYCOPROTEINS; MEMBRANES; MOLECULES; SEMICONDUCTOR QUANTUM DOTS; VIRUSES;

PEPTIDES;

CELL PENETRATING PEPTIDE; GLYCOPROTEIN H; QUANTUM DOT; UNCLASSIFIED DRUG; VACCINE; VIRUS PROTEIN;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENE THERAPY; HERPES SIMPLEX VIRUS 1; MEMBRANE FUSION; NONHUMAN; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELL-PENETRATING PEPTIDES; DRUG CARRIERS; HELA CELLS; HERPESVIRUS 1, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; QUANTUM DOTS; VIRAL ENVELOPE PROTEINS;

HERPES; HUMAN HERPESVIRUS 1;

EID: 82255175122     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2011.04.009     Document Type: Article

References (45)

1. Chakrabarti R, Wylie DE, Schuster SM Transfer of monoclonal antibodies into mammalian cells by electroporation. J Biol Chem 1989, 264:15494-15500.
2. Arnheiter H, Haller O Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins. EMBO J 1988, 7:1315-1320.
3. Schwarze SR, Dowdy SF In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol Sci 2000, 21:45-48.
4. Vives E, Brodin P, Lebleu B A truncated HIV-1 TAT protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 1997, 272:16010-16017.
5. Dietz GP, Bahr M Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol Cell Neurosci 2004, 27:85-131.
6. Mae M, Langel U Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr Opin Pharmacol 2006, 6:509-514.
7. Stewart KM, Horton KL, Kelley SO Cell-penetrating peptides as delivery vehicles for biology and medicine. Org Biomol Chem 2008, 6:2242-2255.
8. Derossi D, Calvet S, Trembleau A, Brunissen A, Chassaing G, Prochiantz A Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent. J Biol Chem 1996, 271:18188-18193.
9. Elliott G, O'Hare P Intercellular trafficking and protein delivery by a herpes virus structural protein. Cell 1997, 88:223-233.
10. Pooga M, Hallbrink M, Zorko M, Langel U Cell penetration by transportan. FASEB J 1998, 12:67-77.
11. Oehlke J, Scheller A, Wiesner B, Krause E, Beyermann M, Klauschenz E, et al. Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically. Biochim Biophys Acta 1998, 1414:127-139.
12. Rojas M, Donahue JP, Tan Z, Lin YZ Genetic engineering of proteins with cell membrane permeability. Nat Biotechnol 1998, 16:370-375.
13. Futaki S, Suzuki T, Ohashi W, Yagami T, Tanaka S, Ueda K, et al. Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem 2001, 276:5836-5840.
14. Heitz F, Morris MC, Divita G Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Brit J Pharm 2009, 157:195-206.
15. Richard JP, Melikov K, Vives E, Ramos C, Verbeure B, Gait MJ, et al. Cell-penetrating peptides: a re-evaluation of the mechanism of cellular uptake. J Biol Chem 2003, 278:585-590.
16. Suzuki T, Futaki S, Niwa M, Tanaka S, Ueda K, Sugiura Y Possible existence of common internalization mechanisms among arginine-rich peptides. J Biol Chem 2002, 277:2437-2443.
17. Duchardt F, Fotin-Mleczek M, Schwarz H, Fischer R, Brock R A comprehensive model for the cellular uptake of cationic cell-penetrating peptides. Traffic 2007, 8:848-866.
18. Brooks H, Lebleu B, Vives E TAT peptide-mediated cellular delivery: back to basics. Adv Drug Deliv Rev 2005, 57:559-577.
19. Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M Fusogenic domains in herpes simplex virus type 1 glycoprotein H. J Biol Chem 2005, 280:28632-28643.
20. Galdiero S, Falanga A, Vitiello M, Raiola L., Fattorusso R, Browne H, et al. Analysis of a membrane interacting region of Herpes Simplex virus type 1 glycoprotein H. J Biol Chem 2008, 283:29993-30009.
21. Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, et al. A single amino acid addition enhances the fusion promotion activity of a membranotropic region of HSV-1 glycoprotein H. J Biol Chem 2010, 285:17123-17136.
22. Galdiero S, Galdiero M, Pedone C, Falanga A, Vitiello M. Method For Delivery Of Molecules Into Intracellular Targets - Provisional. n°US61/285,619. 12/11/2009.
23. Drin G, Mazel M, Clair P, Mathieu D, Kaczorek M, Temsamani J Physico-chemical requirements for cellular uptake of pAntp peptide: role of lipid-binding affinity. Eur J Biochem 2001, 268:1304-1314.
24. Pinaud F, Clarke S, Sittner A, Dahan M Probing cellular events, one quantum dot at a time. Nat Methods 2010, 7:275-285.
25. Medintz IL, Pons T, Delehanty JB, Susumu K, Brunel FM, Dawson PE, et al. Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides. Bioconjug Chem 2008, 19:1785-1795.
26. Lee H, Kim I-K, Park TG Intracellular trafficking and unpacking of siRNA/quantum dot-PEI complexes modified with and without cell penetrating peptide: confocal and flow cytometric FRET analysis. Bioconjug Chem 2010, 21:289-295.
27. Delehanty JB, Bradburne CE, Boeneman K, Susumu K, Farrell D, Mei BC, et al. Delivering quantum dot-peptide bioconjugates to the cellular cytosol: escaping from the endolysosomal system. Integr Biol 2010, 2:265-277.
28. Yeh H-Y, Yates MV, Mulchandani A, Chen W Molecular beacon-quantum dot-Au nanoparticle hybrid nanoprobes for visualizing virus replication in living cells. Chem Commun 2010, 46:3914-3916.
29. Jung J, Solanki A, Memoli KA, Kamei K, Kim H, Drahl MA, et al. Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery. Angew Chem Int Ed 2010, 49:103-107.
30. Rapaport D, Shai Y Interaction of fluorescently labeled pardaxin and its analogues with lipid bilayers. J Biol Chem 1991, 266:23769-23775.
31. Mosmann T Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
32. Imahashi D Quantitation of LDH isoenzymes by the fluorimetric and colorimetric methods. Can J Med Technol 1968, 30:235-248.
33. Hope MJ, Bally MB, Webb G, Cullis PR Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential. Biochim Biophys Acta 1985, 812:55-65.
34. Fiske CH, SubbaRow Y The colorimetric determination of phosphorus. J Biol Chem 1925, 66:374-389.
35. Cummings JE, Vanderlock TK Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4. Biochim Biophys Acta 2007, 1768:1796-1804.
36. Ellens H, Bentz J, Szoka FC pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry 1984, 23:1532-1538.
37. Parente RA, Nir S, Szoka FC Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry 1990, 29:8713-8719.
38. Matsuzaki K, Murase O, Fujii N, Miyajima K Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore. Biochemistry 1995, 34:6521-6526.
39. Deshayes S, Gerbal-Chaloin S, Morris MC, Aldrian-Herrada G, Charnet P, Divita G, et al. On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids. Biochim Biophys Acta 2004, 1667:141-147.
40. Deshayes S, Heitz A, Morris MC, Charnet P, Divita G, Heitz F Insight into the mechanism of internalization of the cell-penetrating carrier peptide Pep-1 through conformational analysis. Biochemistry 2004, 43:1449-1457.
41. Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, et al. Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process. Biochim Biophys Acta 2010, 1798:579-591.
42. Thorén PE, Persson D, Lincoln P, Nordén B Membrane destabilizing properties of cell-penetrating peptides. Biophys Chem 2005, 114:169-179.
43. McIntyre J, Sleight R Fluorescence assay for phospholipids membrane asymmetry. Biochemistry 1991, 30:11819-11827.
44. Angeletti C, Nichols JW Dithionite quenching rate measurement of the inside-outside membrane bilayer distribution of 7-nitrobenz-2-oxa-1,3-diazol-4-yl-labeled phospholipids. Biochemistry 1998, 37:15114-15119.
45. Drin G, Cottin S, Blanc E, Rees AR, Temsamani J Studies on the internalization mechanism of cationic cell-penetrating peptides. J Bio Chem 2003, 278:31192-31201.