ReactNMR and reactIR as reaction monitoring and mechanistic elucidation tools: The NCS mediated cascade reaction of α-thioamides to α-thio-β-chloroacrylamides

Journal of Organic Chemistry

Volumn 76, Issue 23, 2011, Pages 9630-9640

  Foley, David A ^a   Doecke, Christopher W ^a   Buser, Jonas Y ^a   Merritt, Jeremy M ^a   Murphy, Linda ^b   Kissane, Marie ^b   Collins, Stuart G ^b   Maguire, Anita R ^b,c   Kaerner, Andreas ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Department of Chemistry ^*  (Ireland)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CASCADE REACTIONS; IN-SITU; MULTI-COMPONENT REACTIONS; N-CHLOROSUCCINIMIDE; REACTION CASCADES; REACTION MONITORING; SOLVENT EFFECTS; SPECTROSCOPIC EVIDENCE; THIOAMIDES;

REACTION KINETICS; SPECTROSCOPY;

REACTION INTERMEDIATES;

ACRYLAMIDE DERIVATIVE; SOLVENT; SUCCINIMIDE; SULFONIUM DERIVATIVE; THIOAMIDE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHLORINATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

ACRYLAMIDES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; SPECTROPHOTOMETRY, INFRARED; SUCCINIMIDES; THIOAMIDES;

EID: 82255170792     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201212p     Document Type: Article

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