Application of flow NMR to an open-access pharmaceutical environment

Analytical Chemistry

Volumn 75, Issue 8, 2003, Pages 1954-1957

  Leo, Gregory C ^a   Krikava, Aaron ^a   Caldwell, Gary W ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEDICINAL CHEMISTRY;

CONTAMINATION; NUCLEAR MAGNETIC RESONANCE; OPTIMIZATION; SOLVENTS;

DRUG PRODUCTS PLANTS;

DEUTERIUM OXIDE; PROTON; SOLVENT;

ANALYTIC METHOD; ANALYTICAL ERROR; ARTICLE; AUTOMATION; AUTOSAMPLER; CHEMISTRY; CONTAMINATION; DRUG INDUSTRY; ECONOMIC ASPECT; INSTRUMENT; MAGNET; MATERIALS HANDLING; MECHANICAL PROBE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAMETER; SAMPLE SIZE; TUBE;

AUTOMATION; CHEMISTRY, PHARMACEUTICAL; MAGNETIC RESONANCE SPECTROSCOPY; TECHNOLOGY, PHARMACEUTICAL;

EID: 0037446575     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac026389l     Document Type: Article

References (9)

1. Albert, K. On-line LCNMR and Related Techniques; John Wiley and Sons: New York, 2002.
2. Lindon, J. C.; Nicholson, J. K.; Wilson, I. D. Adv. Chromatogr. 1996, 35, 315-82.
3. Lindon, J. C., Nicholson, J. K.; Sielmann, U. G.; Wilson, I. D. Drug Metab. Rev. 1997, 29, 705-746.
4. Lindon, J. C.; Nicholson, J. K.; Holmes, E.; Everett, J. R. Concepts Magn. Reson. 2000, 12, 289-320.
5. Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Science 1996 274, 1531-1534.
6. Stockman, B. J.; Farley, K. A.; Angwin, D. T. Methods Enzymol. 2001, 338, 230-246.
7. Kiefer, P. A.; Smallcombe, S. H.; Williams, E. H.; Salomon, K. E.; Mendez, G.; Belletire, J. L.; Moore, C. D. J. Comb. Chem. 2000, 2, 151-171.
8. Nicholson, J. K.; Lindon, J. C.; Holmes, E. Xenobiotica 1999, 29, 1181-1189.
9. Spraul, M.; Hofmann, M.; Ackerman, M.; Nicholls, A. W.; Damment, S. J. P.; Haselden, J. N.; Shockcor, J. P.; Nicholson, J. K.; Lindon, J. C. Analyst (Cambridge, U.K) 1997, 122, 339-341.