Behavioral and neuromorphological characterization of a novel Tuba1 mutant mouse

Behavioural Brain Research

Volumn 227, Issue 1, 2012, Pages 167-174

  Furuse, Tamio ^a   Yamada, Ikuko ^a   Kushida, Tomoko ^a   Masuya, Hiroshi ^a   Miura, Ikuo ^a   Kaneda, Hideki ^a   Kobayashi, Kimio ^a   Wada, Yumiko ^a   Yuasa, Shigeki ^b   Wakana, Shigeharu ^a  

^a RIKEN BIORESOURCE CENTER   (Japan)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Animal model; Behavior; D,l Methylphenidate; ENU mutagenesis; Neurodevelopmental disorder; Tubulin alpha 1

Indexed keywords

ETHYLNITROSOUREA; METHYLPHENIDATE; TUBA1 PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

ADULT ANIMAL; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; BEHAVIOR DISORDER; CONTROLLED STUDY; EMBRYO; FEMALE; GENE; HETEROZYGOTE; HISTOPATHOLOGY; LOCOMOTION; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROGENY; TUBA1 GENE;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ASPARTIC ACID; ATTENTION; BEHAVIOR, ANIMAL; BROMODEOXYURIDINE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMOSOME MAPPING; DARK ADAPTATION; DEVELOPMENTAL DISABILITIES; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ETHYLNITROSOUREA; EXPLORATORY BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION; GLYCINE; HOMING BEHAVIOR; MALE; METHYLPHENIDATE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MUTAGENESIS; MUTAGENS; NEOCORTEX; NEURONS; PHENOTYPE; TIME FACTORS; TUBULIN;

EID: 82255169319     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.11.002     Document Type: Article

References (28)

1. Kohler S.W., Provost G.S., Fieck A., Kretz P.L., Bullock W.O., Sorge J.A., et al. Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc Natl Acad Sci USA 1991, 88:7958-7962.
2. Provost G.S., Short J.M. Characterization of mutations induced by ethylnitrosourea in seminiferous tubule germ cells of transgenic B6C3F1 mice. Proc Natl Acad Sci USA 1994, 91:6564-6568.
3. Justice M.J., Noveroske J.K., Weber J.S., Zheng B., Bradley A. Mouse ENU mutagenesis. Hum Mol Genet 1999, 8:1955-1963.
4. Hrabé de Angelis M.H., Flaswinkel H., Fuchs H., Rathkolb B., Soewarto D., Marschall S., et al. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 2000, 25:444-447.
5. Nolan P.M., Peters J., Strivens M., Rogers D., Hagan J., Spurr N., et al. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 2000, 25:440-443.
6. Masuya H., Nishida K., Furuichi T., Toki H., Nishimura G., Kawabata H., et al. A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice. Hum Mol Genet 2007, 16:2366-2375.
7. Furuse T., Wada Y., Hattori K., Yamada I., Kushida T., Shibukawa Y., et al. Phenotypic characterization of a new Grin1 mutant mouse generated by ENU mutagenesis. Eur J Neurosci 2010, 31:1281-1291.
8. Keays D.A., Tian G., Poirier K., Huang G.J., Siebold C., Cleak J., et al. Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. Cell 2007, 128:45-57.
9. Wada Y., Furuse T., Yamada I., Masuya H., Kushida T., Shibukawa Y., et al. Exp Anim 2010, 59:495-510.
10. Masuya H., Shimizu K., Sezutsu H., Sakuraba Y., Nagano J., Shimizu A., et al. Enamelin (Enam) is essential for amelogenesis: ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI). Hum Mol Genet 2005, 14:575-583.
11. Kobayashi N., Toyoda T. Statistical search on the Semantic Web. Bioinformatics 2008, 24:1002-1010.
12. Tomihara K., Soga T., Nomura M., Korach K.S., Gustafsson J.A., Pfaff D.W., et al. Effect of ER-beta gene disruption on estrogenic regulation of anxiety in female mice. Physiol Behav 2009, 96:300-306.
13. Yuasa S., Hattori K., Yagi T. Defective neocortical development in Fyn-tyrosine-kinase-deficient mice. Neuroreport 2004, 15:819-822.
14. Terashima T., Ochiishi T., Yamauchi T. Anat Embryol (Berl) 1995, 192:123-136.
15. Mimura N., Yuasa S., Soma M., Jin H., Kimura K., Goto S., et al. Altered quality control in the endoplasmic reticulum causes cortical dysplasia in knock-in mice expressing a mutant BiP. Mol Cell Biol 2008, 28:293-301.
16. Tischfield M.A., Cederquist G.Y., Gupta M.L., Engle E.C. Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations. Curr Opin Genet Dev 2011, 21:286-294.
17. Lowe J., Li H., Downing K.H., Nogales E. Refined structure of alpha beta-tubulin at 3.5Å resolution. J Mol Biol 2001, 313:1045-1057.
18. Francis F., Meyer G., Fallet-Bianco C., Moreno S., Kappeler C., Socorro A.C., et al. Human disorders of cortical development: from past to present. Eur J Neurosci 2006, 23:877-893.
19. Corbo J.C., Deuel T.A., Long J.M., LaPorte P., Tsai E., Wynshaw-Boris A., et al. Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci 2002, 22:7548-7557.
20. Paylor R., Hirotsune S., Gambello M.J. Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice. Learn Mem 1999, 6:521-537.
21. Leventer RJ Genotype-phenotype correlation in lissencephaly and subcortical band heterotopia: the key questions answered. J Child Neurol 2005, 20:307-312.
22. Greenhill L.L. Pharmacologic treatment of attention deficit hyperactivity disorder. Psychiatr Clin North Am 1992, 15:1-27.
23. Barkley R.A. Attention deficit hyperactivity disorder: a handbook for diagnosis and treatment 1990, Guiford, New York.
24. Cantwell D.P.J. Am Acad Child Adolsec 1996, 13:978-987.
25. Siesser W.B., Zhao J., Miller L.R., Cheng S.Y., McDonald M.P. Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive. Genes Brain Behav 2006, 5:282-297.
26. Wilson M.C. Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder. Neurosci Biobehav Rev 2000, 24:51-57.
27. Beaulieu J.M., Sotnikova T.D., Gainetdinov R.R., Caron M.G. Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. J Biol Chem 2006, 281:32072-32080.
28. Fallet-Bianco C., Loeuillet L., Poirier K., Loget P., Chapon F., Pasquier L., et al. Neuropathological phenotype of a distinct form of lissencephaly associated with mutations in TUBA1A. Brain 2008, 131:2304-2320.