Additive effect of GHRd3 and COLIA1 polymorphisms on the GH-substitution dose in GH-deficient adults

Pharmacogenomics

Volumn 12, Issue 12, 2011, Pages 1653-1661

  Hartleb, Silke ^a   Plöckinger, Ursula ^a   Stalla, Günter K ^a   Tuschy, Ulrich ^a   Weber, Matthias M ^a   Pfützner, Andreas ^a   Kann, Peter Herbert ^a  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

collagen; collagen type I a 1; growth hormone; growth hormone deficiency; growth hormone receptor; growth hormone receptor exon 3 deletion; growth hormone substitution

Indexed keywords

GROWTH HORMONE RECEPTOR; HUMAN GROWTH HORMONE; SOMATOMEDIN C;

ADULT; ANTHROPOMETRY; ARTICLE; COL1A1 GENE; CONTROLLED STUDY; DRUG DOSE TITRATION; EXON; FEMALE; GENE; GENE DELETION; GENETIC POLYMORPHISM; GENOTYPE; GERMANY; GHRD3 GENE; GROWTH HORMONE DEFICIENCY; HETEROZYGOTE; HOMOZYGOSITY; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PILOT STUDY; PROTEIN BLOOD LEVEL; TREATMENT DURATION;

ADULT; ALLELES; CARRIER PROTEINS; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; DWARFISM, PITUITARY; FEMALE; GENETIC ASSOCIATION STUDIES; HOMOZYGOTE; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROGNOSIS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS;

EID: 82255166922     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.11.113     Document Type: Article

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