Antidiabetic activity of standardized extract of Quassia amara in nicotinamide-streptozotocin-induced diabetic rats

Phytotherapy Research

Volumn 25, Issue 12, 2011, Pages 1806-1812

  Husain, Gulam Mohammed ^a   Singh, Paras Nath ^a   Singh, Rakesh Kumar ^b   Kumar, Vikas ^a  

^a BANARAS HINDU UNIVERSITY   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

diabetes; dyslipidemia; glucose tolerance; Quassia amara

Indexed keywords

CHOLESTEROL; GLIBENCLAMIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; QUASSIA AMARA EXTRACT; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; INSULIN BLOOD LEVEL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; QUASSIA; QUASSIA AMARA; RAT; STREPTOZOCIN DIABETES; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; GLYBURIDE; HYPOGLYCEMIC AGENTS; MALE; NIACINAMIDE; PHYTOTHERAPY; PLANT EXTRACTS; QUASSIA; RATS; STREPTOZOCIN; TRIGLYCERIDES;

ANIMALIA; QUASSIA AMARA; RATTUS; SIMAROUBACEAE;

EID: 82155201676     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3491     Document Type: Article

References (27)

1. American Diabetes Association. 2007. Diagnosis and classification of diabetes mellitus. Diabetes Care 30: S42-S47.
2. Barbetti P, Grandolini G, Fardella G, Chiappini I,. 1993. Quassinoids from Quassia amara. Phytochemistry 32: 1007-1013.
3. Bolzan AD, Bianchi MS,. 2003. Genotoxicity of streptozotocin. Mutat Res 512: 121-134. (Pubitemid 35441051)
4. Code of Federal Regulations. 2010. US Title 21-Food and Drugs, Section: 172.510 Natural flavoring substances and natural substances used in conjunction with flavors. Available at: [Last accessed on March 29, 2011].
5. DeFilipps RA, Maina SL, Crepin J,. 2004. Medicinal Plants of Guianas (Guyana, Surinam, French Guiana). Department of Botany, National Museum of Natural History, Smithsonian Institution: Washington, D.C., 263-264.
6. Felter HW,. 1922. The Eclectic Materia Medica, Pharmacology and Therapeutics. Reprinted and abridged by Southwest School of Botanical Medicine: Bisbee, Arizona, 373-374.
7. Friedewald WT, Levy RI, Fredrickson DS,. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
8. Groop L, Orho-Melander M,. 2008. New insights into impaired muscle glycogen synthesis. PLoS Med 5: e25.
9. Husain GM, Singh PN, Kumar V,. 2009a. Beneficial effects of a standardized Hypericum perforatum extract in rats with experimentally induced hyperglycemia. Drug Discov Ther 3: 215-220.
10. Husain GM, Singh PN, Kumar V,. 2009b. Antidiabetic activity of standardized extract of Picrorhiza kurroa in rat model of NIDDM. Drug Discov Ther 3: 88-92.
11. International Diabetes Federation. 2009. IDF Diabetes Atlas Fourth Edition, 2009. Available at:.
12. Kahn SE, Hull RL, Utzschneider KM,. 2006. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846. (Pubitemid 46024990)
13. Krishnamurthi A., (Chief Editor). 1969. The Wealth of India. Raw Materials. Vol. VIII (Ph-Re). Publication & Information Directorate, CSIR: New Delhi, 345-346.
14. Marles RJ, Farnsworth NR,. 1995. Antidiabetic plants and their active constituents. Phytomedicine 2: 137-189.
15. Masiello P, Broca C, Gross R, et al., 1998. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 47: 224-229. (Pubitemid 28079978)
16. Mastrocola R, Reffo P, Penna F, et al., 2008. Muscle wasting in diabetic and in tumor-bearing rats: Role of oxidative stress. Free Radic Biol Med 44: 584-593.
17. NoorShahida A, Wong TW, Choo CY,. 2009. Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds. J Ethnopharmacol 124: 586-591.
18. Parveen S, Das S, Kundra CP, Pereira BMJ,. 2003. A comprehensive evaluation of the reproductive toxicity of Quassia amara in male rats. Reprod Toxicol 17: 45-50. (Pubitemid 36285761)
19. Rader DJ,. 2007. Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med 120 (3Suppl 1): S12-S18.
20. Russell ST, Rajani S, Dhadda RS, Tisdale MJ,. 2009. Mechanism of induction of muscle protein loss by hyperglycaemia. Exp Cell Res 315: 16-25.
21. Swanston-Flat SK, Day C, Bailey CJ, Flatt PR,. 1990. Traditional plant treatment for diabetes: studies in normal and streptozotocin diabetic mice. Diabetologia 33: 462-464. (Pubitemid 20254867)
22. Toma W, Gracioso JS, Andrade FDP, Hiruma-Lima CA, Vilegas W, Souza Brito ARM,. 2002. Antiulcerogenic activity of four extracts obtained from the bark wood of Quassia amara L. (Simaroubaceae). Biol Pharm Bull 25: 1151-1155. (Pubitemid 39655154)
23. Tropical Plant Database. Amargo (Quassia amara). Available at: (Last accessed on January 07, 2011).
24. Van Andel T, Westers P,. 2010. Why Surinamese migrants in the Netherlands continue to use medicinal herbs from their home country. J Ethnopharmacol 127: 694-701.
25. Van der vies J,. 1953. Two methods for the determination of glycogen in liver. J Biol Chem 57: 410-416.
26. Wu KK, Huan Y,. 2008. Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol 40: 1-14.
27. Yki-Jarvinen H, Mott D, Young AA, Stone K, Bogardus C,. 1987. Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. J Clin Invest 80: 95-100. (Pubitemid 17097521)